DK1102776T3 - Vandoplöselige prodrugs af hindrede phenoler - Google Patents

Vandoplöselige prodrugs af hindrede phenoler

Info

Publication number
DK1102776T3
DK1102776T3 DK99939030T DK99939030T DK1102776T3 DK 1102776 T3 DK1102776 T3 DK 1102776T3 DK 99939030 T DK99939030 T DK 99939030T DK 99939030 T DK99939030 T DK 99939030T DK 1102776 T3 DK1102776 T3 DK 1102776T3
Authority
DK
Denmark
Prior art keywords
water
hindered phenols
soluble prodrugs
prodrugs
soluble
Prior art date
Application number
DK99939030T
Other languages
English (en)
Inventor
Valentino J Stella
Jan J Zygmunt
Ingrid Gunda Georg
Muhammed S Safadi
Original Assignee
Univ Kansas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Kansas filed Critical Univ Kansas
Application granted granted Critical
Publication of DK1102776T3 publication Critical patent/DK1102776T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
    • C07F9/6552—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a six-membered ring
    • C07F9/65522—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a six-membered ring condensed with carbocyclic rings or carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Anesthesiology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Compounds Of Unknown Constitution (AREA)
DK99939030T 1998-08-07 1999-08-06 Vandoplöselige prodrugs af hindrede phenoler DK1102776T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/131,385 US6204257B1 (en) 1998-08-07 1998-08-07 Water soluble prodrugs of hindered alcohols

Publications (1)

Publication Number Publication Date
DK1102776T3 true DK1102776T3 (da) 2006-07-10

Family

ID=22449234

Family Applications (1)

Application Number Title Priority Date Filing Date
DK99939030T DK1102776T3 (da) 1998-08-07 1999-08-06 Vandoplöselige prodrugs af hindrede phenoler

Country Status (27)

Country Link
US (4) US6204257B1 (da)
EP (2) EP1683803A1 (da)
JP (1) JP4554081B2 (da)
KR (1) KR100662799B1 (da)
CN (2) CN1198834C (da)
AT (1) ATE319723T1 (da)
AU (1) AU769755B2 (da)
BR (1) BR9912853A (da)
CA (1) CA2339834C (da)
CY (1) CY1105043T1 (da)
CZ (1) CZ304020B6 (da)
DE (1) DE69930269T2 (da)
DK (1) DK1102776T3 (da)
ES (1) ES2268876T3 (da)
HK (1) HK1047939B (da)
HU (1) HU229401B1 (da)
IL (1) IL141316A (da)
MX (1) MXPA01001431A (da)
NO (1) NO330357B1 (da)
NZ (1) NZ509795A (da)
PL (1) PL198141B1 (da)
PT (1) PT1102776E (da)
RU (1) RU2235727C2 (da)
TR (1) TR200100772T2 (da)
UA (1) UA73479C2 (da)
WO (1) WO2000008033A1 (da)
ZA (1) ZA200101039B (da)

Families Citing this family (108)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6204257B1 (en) * 1998-08-07 2001-03-20 Universtiy Of Kansas Water soluble prodrugs of hindered alcohols
IL141095A0 (en) * 1998-08-19 2002-02-10 Rtp Pharma Inc Injectable aqueous dispersions of propofol
US6362172B2 (en) 2000-01-20 2002-03-26 Bristol-Myers Squibb Company Water soluble prodrugs of azole compounds
US6362234B1 (en) * 2000-08-15 2002-03-26 Vyrex Corporation Water-soluble prodrugs of propofol for treatment of migrane
US6448401B1 (en) * 2000-11-20 2002-09-10 Bristol-Myers Squibb Company Process for water soluble azole compounds
IL158385A0 (en) * 2001-04-20 2004-05-12 Debiopharm Sa Modified cyclosporin which can be used as a pro-drug and use thereof
EP1430017A2 (en) * 2001-09-26 2004-06-23 Theravance, Inc. Substituted phenol compounds useful for anesthesia and sedation
AU2002360682B2 (en) * 2001-12-21 2008-06-26 Eisai Inc. Process for preparing water-soluble phosphonooxymethyl derivatives of alcohol and phenol
CN1329036C (zh) * 2001-12-28 2007-08-01 Mgigp公司 普鲁泊福水溶性前药的以水为基质的药物制剂
WO2003086413A1 (en) * 2002-04-08 2003-10-23 Guilford Pharmaceuticals, Inc. Pharmaceutical compositions containing water-soluble prodrugs of propofol and methods of administering same
ITRM20020306A1 (it) 2002-05-31 2003-12-01 Sigma Tau Ind Farmaceuti Esteri in posizione 20 di camptotecine.
AU2002950713A0 (en) 2002-08-09 2002-09-12 Vital Health Sciences Pty Ltd Carrier
ZA200504940B (en) * 2003-01-28 2006-09-27 Xenoport Inc Amino acid derived prodrugs of propofol, compositions and uses thereof
AU2003901815A0 (en) * 2003-04-15 2003-05-01 Vital Health Sciences Pty Ltd Phosphate derivatives
US7230003B2 (en) * 2003-09-09 2007-06-12 Xenoport, Inc. Aromatic prodrugs of propofol, compositions and uses thereof
CA2543166A1 (en) * 2003-10-24 2005-05-19 Auspex Pharmaceuticals, Inc. Ph sensitive prodrugs of 2,6-diisopropylphenol
US7834043B2 (en) * 2003-12-11 2010-11-16 Abbott Laboratories HIV protease inhibiting compounds
US20070202158A1 (en) * 2003-12-17 2007-08-30 Mgi Gp, Inc. Methods Of Administering Water-Soluble Prodrugs Of Propofol For Extended Sedation
ATE494298T1 (de) 2004-04-15 2011-01-15 Proteolix Inc Verbindungen zur proteasomenzymhemmung
US8198270B2 (en) * 2004-04-15 2012-06-12 Onyx Therapeutics, Inc. Compounds for proteasome enzyme inhibition
US7232818B2 (en) 2004-04-15 2007-06-19 Proteolix, Inc. Compounds for enzyme inhibition
WO2005111009A2 (en) * 2004-05-10 2005-11-24 Proteolix, Inc. Synthesis of amino acid keto-epoxides
SI2030981T1 (sl) 2004-05-10 2014-11-28 Onyx Therapeutics, Inc. Spojine za inhibiranje proteasomskega encima
KR101229431B1 (ko) 2004-07-06 2013-02-04 아보트 러보러터리즈 Ｈｉｖ 프로테아제 억제제의 프로드럭
EP1781596B1 (en) * 2004-07-12 2008-10-08 Xenoport, Inc. Amino acid derived prodrugs of propofol compositions and uses thereof
WO2006017351A1 (en) * 2004-07-12 2006-02-16 Xenoport, Inc. Prodrugs of propofol, compositions and uses thereof
US20060014677A1 (en) * 2004-07-19 2006-01-19 Isotechnika International Inc. Method for maximizing efficacy and predicting and minimizing toxicity of calcineurin inhibitor compounds
MX2007002210A (es) * 2004-08-26 2007-05-07 Nicholas Piramal India Ltd Profarmacos que contienen enlazantes bioescindibles novedosos.
WO2006033911A2 (en) * 2004-09-17 2006-03-30 Mgi Gp, Inc. Methods of administering water-soluble prodrugs of propofol
CA2586410A1 (en) * 2004-12-23 2006-07-06 Xenoport, Inc. Serine amino acid derived prodrugs of propofol, compositions, uses and crystalline forms thereof
ES2557475T3 (es) 2005-06-17 2016-01-26 Vital Health Sciences Pty Ltd. Un portador que comprende uno o más derivados di- y/o monofosfato de agentes de transferencia de electrones
CA2614185A1 (en) * 2005-07-12 2007-01-18 Mgi Gp, Inc. Methods of dosing propofol prodrugs for inducing mild to moderate levels of sedation
WO2007022437A2 (en) * 2005-08-18 2007-02-22 Auspex Pharmaceuticals, Inc. Therapeutic agents for the treatment of cancer and metabolic disorders
EP3170515A1 (en) 2005-08-18 2017-05-24 Zimmer GmbH Ultra high molecular weight polyethylene articles and methods of forming ultra high molecular weight polyethylene articles
US7589239B2 (en) * 2005-09-02 2009-09-15 Auspex Pharmaceuticals Therapeutic agents for the treatment of cancer, metabolic diseases and skin disorders
JP4981673B2 (ja) * 2005-09-13 2012-07-25 エーザイ・アール・アンド・ディー・マネジメント株式会社 安定性が改善されたクロロメチルフォスフェイト誘導体を含む組成物およびその製造方法
EP1948678B1 (en) 2005-11-09 2013-05-01 Onyx Therapeutics, Inc. Compounds for enzyme inhibition
AU2007261345B2 (en) 2006-06-19 2012-02-23 Onyx Therapeutics, Inc. Peptide epoxyketones for proteasome inhibition
WO2008045189A2 (en) * 2006-10-05 2008-04-17 Eisai Corporation Of North America Aqueous based pharmaceutical formulations of water-soluble prodrugs of propofol
US20080161400A1 (en) * 2006-10-26 2008-07-03 Xenoport, Inc. Use of forms of propofol for treating diseases associated with oxidative stress
US8664290B2 (en) 2007-04-10 2014-03-04 Zimmer, Inc. Antioxidant stabilized crosslinked ultra-high molecular weight polyethylene for medical device applications
EP2486948B1 (en) 2007-04-10 2018-02-21 Zimmer, Inc. An antioxidant stabilized crosslinked ultra-high molecular weight polyethylene for medical device applications
EP2152651B1 (en) 2007-05-09 2012-01-04 Pharmacofore, Inc. Therapeutic compounds
PT2146946E (pt) 2007-05-09 2011-02-14 Pharmacofore Inc Estereoisómeros (-) de 2,6-di-sec-butilfenol e seus análogos
WO2008157627A1 (en) * 2007-06-21 2008-12-24 Xenoport, Inc. Use of propofol prodrugs for treating alcohol withdrawal, central pain, anxiety or pruritus
FI20070574A0 (fi) * 2007-07-30 2007-07-30 Kuopion Yliopisto Vesiliukoinen propofolin etylideenifosfaatti-aihiolääke
CN101842938B (zh) * 2007-09-13 2014-11-05 天文电子学爱罗莎特股份有限公司 有宽带天线的通信***
US8427384B2 (en) 2007-09-13 2013-04-23 Aerosat Corporation Communication system with broadband antenna
US20090076141A1 (en) * 2007-09-14 2009-03-19 Xenoport, Inc. Use of Propofol Prodrugs for Treating Neuropathic Pain
US20090075947A1 (en) * 2007-09-17 2009-03-19 Protia, Llc Deuterium-enriched fospropofol
MX2010003732A (es) 2007-10-04 2010-08-09 Onyx Therapeutics Inc Inhibidores de peptido cetona epoxi de proteasa cristalina y la sintesis de ceto-epoxidos de aminoacido.
US20090098209A1 (en) * 2007-10-15 2009-04-16 University Of Kansas Pharmaceutical compositions containing water-soluble derivatives of propofol and methods of administering same via pulmonary administration
WO2009120162A1 (ru) * 2008-03-25 2009-10-01 Zhukovskij Oleg Igorevich Субстанция "ua' orion"
AU2009249069A1 (en) * 2008-05-20 2009-11-26 Neurogesx, Inc. Carbonate prodrugs and methods of using the same
BRPI0912326A2 (pt) 2008-05-20 2015-10-06 Neurogesx Inc análogos de acetaminofeno hidrossolúveis
US20100069441A1 (en) 2008-09-02 2010-03-18 Mikhail Fedorovich Gordeev Antimicrobial indoline compounds for treatment of bacterial infections
MX2011004225A (es) 2008-10-21 2011-06-21 Onyx Therapeutics Inc Terapia de combinacion con epoxicetonas peptidicas.
CN101798302B (zh) 2009-02-06 2014-11-05 上海盟科药业有限公司 抗生素类药物1-(邻-氟苯基)二氢吡啶酮的合成及生产的方法和工艺
TWI504598B (zh) 2009-03-20 2015-10-21 Onyx Therapeutics Inc 結晶性三肽環氧酮蛋白酶抑制劑
CN101845057B (zh) * 2009-03-27 2013-10-23 四川大学 取代苯酚的甲缩醛磷酸盐麻醉镇静药用化合物及制备方法
GB0905834D0 (en) 2009-04-03 2009-05-20 Seps Pharma Nv Phosphonyl-containing phenolic derivatives useful as medicaments
WO2010129918A1 (en) * 2009-05-07 2010-11-11 Regents Of The University Of Minnesota Triptolide prodrugs
US9150600B2 (en) 2009-05-07 2015-10-06 Regents Of The University Of Minnesota Triptolide prodrugs
CN101648973B (zh) * 2009-09-03 2012-05-30 漆又毛 水溶性紫杉烷及制备方法
EP2498793B1 (en) 2009-11-13 2019-07-10 Onyx Therapeutics, Inc. Oprozomib for use in metastasis suppression
US10071030B2 (en) 2010-02-05 2018-09-11 Phosphagenics Limited Carrier comprising non-neutralised tocopheryl phosphate
CN102153607B (zh) * 2010-02-11 2015-07-15 湖南方盛华美医药科技有限公司 水溶性喜树碱衍生物及包含其的药物组合物
KR20130075723A (ko) 2010-03-01 2013-07-05 오닉스 세라퓨틱스, 인크. 면역프로테아좀 저해를 위한 화합물
BR112012024835A2 (pt) 2010-03-30 2016-06-07 Phosphagenics Ltd adesivo de distribuição transdérmica
KR20130094185A (ko) 2010-04-07 2013-08-23 오닉스 세라퓨틱스, 인크. 결정성 펩티드 에폭시케톤 면역프로테아좀 저해제
US8399535B2 (en) * 2010-06-10 2013-03-19 Zimmer, Inc. Polymer [[s]] compositions including an antioxidant
US20120065170A1 (en) 2010-09-10 2012-03-15 Micurx Pharmaceuticals, Inc. Antimicrobial Cyclocarbonyl Heterocyclic Compounds For Treatment Of Bacterial Infections
US8609637B2 (en) * 2010-12-02 2013-12-17 The University Of Kansas Prodrugs of 6-cyclohexyl-1-hydroxy-4-methylpyridin-2-(1H)-one and derivatives thereof
EP2685992A4 (en) 2011-03-15 2014-09-10 Phosphagenics Ltd AMINO-QUINOLINES AS KINASE INHIBITORS
ITMI20110580A1 (it) * 2011-04-08 2012-10-09 Chemelectiva S R L Iintermedi utili per la preparazione di fospropofol e processo per la loro preparazione
UY34072A (es) 2011-05-17 2013-01-03 Novartis Ag Derivados sustituidos de indol
US9024055B2 (en) 2011-09-22 2015-05-05 Acorda Therapeutics, Inc. Acetaminophen conjugates, compositions and methods of use thereof
CN102516258B (zh) * 2011-11-11 2014-06-25 正大天晴药业集团股份有限公司 水溶性维生素e衍生物修饰的脂溶性抗癌药物化合物和制剂、该化合物的制备方法及应用
CN102382133B (zh) * 2011-12-02 2016-03-23 陕西合成药业股份有限公司 一种磷丙泊酚钠的制备及纯化方法
UY34897A (es) 2012-07-09 2014-01-31 Onyx Therapeutics Inc Profarmacos de inhibidores peptidicos de expoxi cetona proteasa
US9580459B2 (en) * 2013-04-26 2017-02-28 Metselex, Inc. Water-soluble ursodeoxycholic acid prodrugs
US9708467B2 (en) 2013-10-01 2017-07-18 Zimmer, Inc. Polymer compositions comprising one or more protected antioxidants
WO2015117024A1 (en) * 2014-01-31 2015-08-06 Mayo Foundation For Medical Education And Research Novel therapeutics for the treatment of glaucoma
ES2900838T3 (es) 2014-02-21 2022-03-18 Shanghai Micurx Pharmaceutical Co Ltd Profármacos de O-carbonil fosforamidato solubles en agua para administración terapéutica
WO2015138137A1 (en) 2014-03-12 2015-09-17 Zimmer, Inc. Melt-stabilized ultra high molecular weight polyethylene and method of making the same
TWI755257B (zh) 2014-10-21 2022-02-11 美商艾伯維有限公司 卡比多巴及左旋多巴之前藥及使用方法
CA2969751C (en) 2014-12-03 2020-09-22 Zimmer, Inc. Antioxidant-infused ultra high molecular weight polyethylene
CN106674269A (zh) * 2015-11-11 2017-05-17 陕西合成药业股份有限公司 一种磷丙泊酚钠四水合物及晶型及其制备方法和用途
CN106674268A (zh) * 2015-11-11 2017-05-17 陕西合成药业股份有限公司 一种磷丙泊酚钠三水合物及晶型及其制备方法和用途
CN106674270A (zh) * 2015-11-11 2017-05-17 陕西合成药业股份有限公司 一种磷丙泊酚钠无水合物及晶型及其制备方法和用途
US10973761B2 (en) 2015-12-09 2021-04-13 Phosphagenics Limited Pharmaceutical formulation
WO2017147146A1 (en) * 2016-02-23 2017-08-31 Concentric Analgesics, Inc. Prodrugs of phenolic trpv1 agonists
US20190224220A1 (en) * 2016-04-20 2019-07-25 Abbvie Inc. Carbidopa and L-Dopa Prodrugs and Methods of Use
WO2017205632A1 (en) * 2016-05-27 2017-11-30 The Johns Hopkins University Buccal, sublingual and intranasal delivery of fospropofol
US11929552B2 (en) 2016-07-21 2024-03-12 Astronics Aerosat Corporation Multi-channel communications antenna
KR102647670B1 (ko) 2016-12-21 2024-03-15 아베초 바이오테크놀로지 리미티드 방법
US10992052B2 (en) 2017-08-28 2021-04-27 Astronics Aerosat Corporation Dielectric lens for antenna system
US10174138B1 (en) * 2018-01-25 2019-01-08 University Of Massachusetts Method for forming highly reactive olefin functional polymers
CN109456360B (zh) * 2018-12-17 2021-05-14 河南中医药大学 一种磷丙泊酚钠的制备方法
WO2020156189A1 (zh) * 2019-01-30 2020-08-06 四川科伦博泰生物医药股份有限公司 喜树碱衍生物及其水溶性前药、包含其的药物组合物及其制备方法和用途
US11547714B2 (en) 2020-02-05 2023-01-10 Epalex Corporation Fospropofol salts, methods and compositions
US11439653B1 (en) 2021-03-30 2022-09-13 Epalex Corporation Fospropofol formulations
US11628178B2 (en) 2019-03-26 2023-04-18 Epalex Corporation Fospropofol methods and compositions
US11478490B1 (en) 2021-03-30 2022-10-25 Epalex Corporation Fospropofol formulations
CN113666958A (zh) * 2020-05-13 2021-11-19 成都百裕制药股份有限公司 ***素衍生物及其制备方法和在医药上的应用
CN117279664A (zh) 2021-04-10 2023-12-22 普方生物制药美国公司 Folr1结合剂、其偶联物及其使用方法
EP4326768A1 (en) 2021-04-23 2024-02-28 Profoundbio Us Co. Anti-cd70 antibodies, conjugates thereof and methods of using the same
TW202320857A (zh) 2021-07-06 2023-06-01 美商普方生物製藥美國公司 連接子、藥物連接子及其結合物及其使用方法

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2829151A (en) 1952-11-03 1958-04-01 Dow Chemical Co Chlorotoloxy-ethyl phosphates
US3271314A (en) 1958-12-04 1966-09-06 Ethyl Corp 2, 6-diisopropylphenol
GB1146173A (en) 1966-06-18 1969-03-19 Geigy Uk Ltd Production of triaryl phosphates
US3723578A (en) 1970-10-13 1973-03-27 Gaf Corp Phosphate esters of ethers of thiol substituted phenols
US4171272A (en) 1977-12-02 1979-10-16 Fmc Corporation Turbine lubricant
FR2601259B1 (fr) 1986-07-11 1990-06-22 Rhone Poulenc Chimie Nouvelles compositions tensio-actives a base d'esters phosphoriques leur procede de preparation et leur application a la formulation de matieres actives.
US5053512A (en) 1987-04-14 1991-10-01 Research Triangle Institute Total synthesis of 20(S) and 20(R)-camptothecin and compthothecin derivatives
US5364858A (en) 1987-03-31 1994-11-15 Research Triangle Institute Camptothecin analogs as potent inhibitors of topoisomerase I
US5244903A (en) 1987-03-31 1993-09-14 Research Triangle Institute Camptothecin analogs as potent inhibitors of topoisomerase I
US5106742A (en) 1987-03-31 1992-04-21 Wall Monroe E Camptothecin analogs as potent inhibitors of topoisomerase I
US4894456A (en) 1987-03-31 1990-01-16 Research Triangle Institute Synthesis of camptothecin and analogs thereof
US5122526A (en) 1987-03-31 1992-06-16 Research Triangle Institute Camptothecin and analogs thereof and pharmaceutical compositions and method using them
US4981968A (en) 1987-03-31 1991-01-01 Research Triangle Institute Synthesis of camptothecin and analogs thereof
US5122606A (en) 1987-04-14 1992-06-16 Research Triangle Institute 10,11-methylenedioxy camptothecins
US5180722A (en) 1987-04-14 1993-01-19 Research Triangle Institute 10,11-methylenedioxy-20(RS)-camptothecin and 10,11-methylenedioxy-20(S)-camptothecin analogs
US5049668A (en) 1989-09-15 1991-09-17 Research Triangle Institute 10,11-methylenedioxy-20(RS)-camptothecin analogs
MY103951A (en) 1988-01-12 1993-10-30 Kao Corp Detergent composition
CA2014539C (en) 1989-04-17 2000-07-25 Shinichiro Umeda Water borne metallic coating composition
US5091211A (en) 1989-08-17 1992-02-25 Lord Corporation Coating method utilizing phosphoric acid esters
JPH03209414A (ja) 1990-01-12 1991-09-12 Nikon Corp 焦点調節装置
EP0553074B1 (en) 1990-10-17 1996-06-05 Tomen Corporation Method and composition for enhancing uptake and transport of bioactive agents in plants
US5646176A (en) 1992-12-24 1997-07-08 Bristol-Myers Squibb Company Phosphonooxymethyl ethers of taxane derivatives
CA2111527C (en) 1992-12-24 2000-07-18 Jerzy Golik Phosphonooxymethyl ethers of taxane derivatives
CA2129288C (en) 1993-08-17 2000-05-16 Jerzy Golik Phosphonooxymethyl esters of taxane derivatives
US5731356A (en) * 1994-03-22 1998-03-24 Zeneca Limited Pharmaceutical compositions of propofol and edetate
US5786344A (en) * 1994-07-05 1998-07-28 Arch Development Corporation Camptothecin drug combinations and methods with reduced side effects
US5646159A (en) 1994-07-20 1997-07-08 Research Triangle Institute Water-soluble esters of camptothecin compounds
IT1270093B (it) 1994-09-28 1997-04-28 Zambon Spa Processo per la purificazione di 2,6-diisopropilfenolo
TW354293B (en) 1995-06-06 1999-03-11 Bristol Myers Squibb Co Prodrugs of paclitaxel derivatives
US5804682A (en) 1995-11-29 1998-09-08 Henkel Corporation Aqueous dispersions of polyamides
US5637625A (en) 1996-03-19 1997-06-10 Research Triangle Pharmaceuticals Ltd. Propofol microdroplet formulations
US5746973A (en) 1996-07-10 1998-05-05 Naraghi; Ali Method for reducing odorant depletion
PT1056754E (pt) * 1998-01-29 2004-03-31 Bristol Myers Squibb Co Derivados fosfatados de 1,3,4-oxadiazolona de diarilo
US6204257B1 (en) * 1998-08-07 2001-03-20 Universtiy Of Kansas Water soluble prodrugs of hindered alcohols

Also Published As

Publication number Publication date
AU5339499A (en) 2000-02-28
WO2000008033A1 (en) 2000-02-17
ATE319723T1 (de) 2006-03-15
CN1680402A (zh) 2005-10-12
HUP0200317A3 (en) 2004-07-28
DE69930269T2 (de) 2006-12-07
US20030176324A1 (en) 2003-09-18
HU229401B1 (en) 2013-12-30
CA2339834A1 (en) 2000-02-17
BR9912853A (pt) 2001-10-30
NO20010659L (no) 2001-04-06
EP1683803A1 (en) 2006-07-26
CY1105043T1 (el) 2010-03-03
CN1198834C (zh) 2005-04-27
US6451776B2 (en) 2002-09-17
NO330357B1 (no) 2011-04-04
KR20010079627A (ko) 2001-08-22
MXPA01001431A (es) 2002-11-29
AU769755B2 (en) 2004-02-05
IL141316A0 (en) 2002-03-10
JP2002522443A (ja) 2002-07-23
PL198141B1 (pl) 2008-05-30
ZA200101039B (en) 2002-02-05
CN1357000A (zh) 2002-07-03
DE69930269D1 (de) 2006-05-04
RU2235727C2 (ru) 2004-09-10
HK1047939B (zh) 2005-11-18
HUP0200317A2 (en) 2002-06-29
CA2339834C (en) 2011-01-25
JP4554081B2 (ja) 2010-09-29
CZ304020B6 (cs) 2013-08-28
US6204257B1 (en) 2001-03-20
US6872838B2 (en) 2005-03-29
EP1102776A1 (en) 2001-05-30
ES2268876T3 (es) 2007-03-16
HK1047939A1 (en) 2003-03-14
US20010025035A1 (en) 2001-09-27
PT1102776E (pt) 2007-02-28
NO20010659D0 (no) 2001-02-07
IL141316A (en) 2004-06-20
KR100662799B1 (ko) 2007-01-02
CZ2001479A3 (cs) 2001-09-12
PL347211A1 (en) 2002-03-25
UA73479C2 (uk) 2005-08-15
US7244718B2 (en) 2007-07-17
TR200100772T2 (tr) 2001-12-21
US20050090431A1 (en) 2005-04-28
EP1102776B1 (en) 2006-03-08
NZ509795A (en) 2003-10-31

Similar Documents

Publication Publication Date Title
DK1102776T3 (da) Vandoplöselige prodrugs af hindrede phenoler
IL124593A0 (en) Substituted aryl or heteroarylamides having retinoid-like biological activity
FI903331A0 (fi) Substituerade kinazolinoner, vilka aer anvaendbara som angiotensin-ii-antagonister.
BR9205854A (pt) Composiçoes de mistura curavel por UV e processos.
DK1100789T3 (da) Substituerede benzoylcyclohexandioner
PT1189970E (pt) Aditivo carboxi-funcional para a condensacao de poliamidas
CA2136509A1 (en) Benzophenone Derivative, and Ultraviolet Light Absorbent and an Endermic Liniment
GT199900011A (es) Nuevos derivados del acido dihidroxihexanoico
DE69926379D1 (de) Verfahren zur herstellung von 2-(2,4-dihydroxyphenyl) or 2-(2,4-dialkoxyphenyl) -4,6-bisaryl-1,3,5-triazine
BR9502522A (pt) Composiçao concentrada em suspensao
DE69730796D1 (de) Naphthylverbindungen, Zusammensetzungen und Verfahren
DK0785949T3 (da) Fremgangsmåde til oprensning af keratinocytvækstfaktorer
BR9714049A (pt) Imidazopiridazinas
ES2154692T3 (es) Dihidrofarnesal.
UY24596A1 (es) Nuevos derivados sintéticos del catecol
DK0915858T3 (da) Mellemprodukter til fremstilling af 2-imidazolin-5-oner
DK1151130T3 (da) Coenzym, der er nyttigt til syntese af L-carnitin
BR9902051A (pt) Oxidação seletiva e a preparação de compostos aromáticos contendo grupos hidroxila.
DE69724548D1 (de) Substituierte 2,3-Aryl-Benzothiophene und ihre östrogene Aktivität
HN1999000027A (es) Nuevas composiciones herbicidas
GB9025890D0 (en) Pharmaceutical compounds
ES2192317T3 (es) Composicion a base de agua de mar diluida destinada al lavado de las fosas nasales.
BR9907697A (pt) Carbonatos de serina
DK0963998T3 (da) Azasteroidforbindelse til behandling eller prævention af prostatacancer
ATE100996T1 (de) Blattglanzmittel.