DK1015433T3 - Substituerede 1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocin-10-oler, fremgangsmåder til fremstilling af disse og deres anvendelse som lægemidler - Google Patents

Substituerede 1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocin-10-oler, fremgangsmåder til fremstilling af disse og deres anvendelse som lægemidler

Info

Publication number: DK1015433T3
Authority: DK; Denmark
Prior art keywords: benzazocin; methano; ols; hexahydro; drugs
Prior art date: 1997-09-12

Application number

DK98950009T

Other languages

English (en)

Inventor

Matthias Grauert

Adrian Carter

Wolf-Dietrich Bechtel

Thomas Weiser

Rainer Palluk

Uwe Pschorn

Original Assignee

Boehringer Ingelheim Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-09-12

Filing date

1998-09-09

Publication date

2004-09-27

1998-09-09 Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma

2004-09-27 Application granted granted Critical

2004-09-27 Publication of DK1015433T3 publication Critical patent/DK1015433T3/da

Links

LKSFMIVSEZLAPD-UHFFFAOYSA-N 10-azatricyclo[7.3.1.02,7]trideca-2(7),3,5-trien-6-ol Chemical class C1C2CCNC1CC1=C2C=CC=C1O LKSFMIVSEZLAPD-UHFFFAOYSA-N 0.000 title 1
239000003814 drug Substances 0.000 title 1
229940079593 drug Drugs 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/22—Bridged ring systems
- C07D221/26—Benzomorphans
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

DK98950009T 1997-09-12 1998-09-09 Substituerede 1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocin-10-oler, fremgangsmåder til fremstilling af disse og deres anvendelse som lægemidler DK1015433T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE19740110A DE19740110A1 (de)	1997-09-12	1997-09-12	Substituierte 1,2,3,4,5,6-Hexahydro-2,6-methano-3-benzazocin-10-ole, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel

Publications (1)

Publication Number	Publication Date
DK1015433T3 true DK1015433T3 (da)	2004-09-27

Family

ID=7842134

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK98950009T DK1015433T3 (da)	1997-09-12	1998-09-09	Substituerede 1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocin-10-oler, fremgangsmåder til fremstilling af disse og deres anvendelse som lægemidler

Country Status (38)

Country	Link
US (1)	US6455538B1 (da)
EP (1)	EP1015433B1 (da)
JP (1)	JP3827528B2 (da)
KR (1)	KR100601008B1 (da)
CN (1)	CN1166640C (da)
AR (1)	AR017095A1 (da)
AT (1)	ATE267811T1 (da)
AU (1)	AU751036B2 (da)
BG (1)	BG64418B1 (da)
BR (1)	BR9812443A (da)
CA (1)	CA2302347C (da)
CO (1)	CO5011117A1 (da)
CZ (1)	CZ296909B6 (da)
DE (2)	DE19740110A1 (da)
DK (1)	DK1015433T3 (da)
EE (1)	EE04398B1 (da)
ES (1)	ES2222612T3 (da)
HR (1)	HRP980502B1 (da)
HU (1)	HUP0004588A3 (da)
ID (1)	ID24173A (da)
IL (1)	IL134572A (da)
MY (1)	MY120550A (da)
NO (1)	NO315650B1 (da)
NZ (1)	NZ503710A (da)
PE (1)	PE122899A1 (da)
PL (1)	PL198486B1 (da)
PT (1)	PT1015433E (da)
RS (1)	RS49888B (da)
RU (1)	RU2218334C2 (da)
SA (1)	SA98190765B1 (da)
SK (1)	SK284670B6 (da)
TR (1)	TR200000697T2 (da)
TW (1)	TW505645B (da)
UA (1)	UA61973C2 (da)
UY (2)	UY25175A1 (da)
WO (1)	WO1999014199A1 (da)
YU (1)	YU12000A (da)
ZA (1)	ZA988285B (da)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE19826365A1 (de) *	1998-06-12	1999-12-16	Gruenenthal Gmbh	Verwendung von Benzomorphanderivaten als Analgetikum
DE19957156A1 (de) *	1999-11-27	2001-05-31	Boehringer Ingelheim Pharma	Substituierte 1,2,3,4,5,6-Hexahydro-2,6-methano-3-benzazocine und ihre Verwendung als Arzneimittel
US6355652B1 (en)	1999-11-27	2002-03-12	Boehringer Ingelheim Pharma Kg	Substituted 1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocines and their use as pharmaceutical compositions
DE10204276A1 (de) *	2002-02-02	2003-08-07	Boehringer Ingelheim Pharma	N-Allyloxyethyl-1,2,3,4,5,6-Hexahydro-2,6-methano-3-benzazocine und ihre Verwendung als Arzneimittel
US6683089B2 (en)	2002-02-02	2004-01-27	Boehringer Ingelheim Pharma Gmbh & Co. Kg	N-allyoxyethyl-1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocine-10-ols
DE10223783A1 (de) *	2002-05-29	2003-12-11	Boehringer Ingelheim Pharma	Neue Formulierung zur parenteralen Applikation eines Na-Kanal-Blockers
US6828311B2 (en)	2002-05-29	2004-12-07	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Formulation for the parenteral application of a sodium channel blocker
US20040019075A1 (en) *	2002-05-29	2004-01-29	Boehringer Ingelheim Pharma Gmbh & Co. Kg	New formulation for the parenteral application of crobenetine
US20030235576A1 (en) *	2002-06-15	2003-12-25	Boehringer Ingelheim Pharma Gmbh & Co. Kg	New drug combinations for the treatment of ischaemic conditions
DE10226814A1 (de) *	2002-06-15	2004-01-08	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Neue Arzneimittelkombinationen zur Behandlung ischämischer Zustände
NZ567540A (en)	2005-12-22	2010-07-30	Newron Pharm Spa	2-Phenylethylamino derivatives as calcium and/or sodium channel modulators
DK2155663T3 (da)	2007-06-15	2018-01-22	Newron Pharm Spa	Substituerede 2-[2-(phenyl)ethylamino]alkanamidderivater og deres anvendelse som natrium- og/eller kalciumkanalmodulatorer
HUE030031T2 (en)	2011-06-27	2017-04-28	Newron Pharm Spa	Fluorinated arylalkylaminocarboxamide derivatives

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2828039A1 (de) *	1978-06-26	1980-01-10	Boehringer Sohn Ingelheim	2-(2-alkoxyethyl)-2'-hydroxy-6,7-benzomorphane deren saeureadditionssalze diese enthaltende arzneimittel und verfahren zu deren herstellung
US4208523A (en)	1978-11-30	1980-06-17	Sterling Drug Inc.	11-Lower-alkyl-, 11-phenyl-lower-alkyl- and 11-cyclo-lower-alkyl-lower-alkyl-hexahydro-2,6-methano-3-benzazocines
US5607941A (en) *	1992-06-26	1997-03-04	Boehringer Ingelheim Kg	Useful for treating neurodegenerative diseases
DE4121821A1 (de)	1991-07-02	1993-01-14	Boehringer Ingelheim Kg	Neue benzomorphane und ihre verwendung als arzneimittel
DE19528472A1 (de)	1995-08-03	1997-02-06	Boehringer Ingelheim Kg	Neues Verfahren zur Herstellung von Norbenzomorphan einer Zwischenstufe bei Herstellung von pharmazeutisch wertvollen Benzomorphanderivaten, insbesondere von (-)-(1R,5S,S"R)-3'-Hydroxy-2-(2-methoxypropyl-)-5,9,9-trimethyl-6,7 benzomorphan

1997
- 1997-09-12 DE DE19740110A patent/DE19740110A1/de not_active Ceased
1998
- 1998-09-08 PE PE1998000847A patent/PE122899A1/es not_active Application Discontinuation
- 1998-09-09 HU HU0004588A patent/HUP0004588A3/hu unknown
- 1998-09-09 AT AT98950009T patent/ATE267811T1/de not_active IP Right Cessation
- 1998-09-09 EE EEP200000129A patent/EE04398B1/xx not_active IP Right Cessation
- 1998-09-09 KR KR1020007002562A patent/KR100601008B1/ko not_active IP Right Cessation
- 1998-09-09 UA UA2000042088A patent/UA61973C2/uk unknown
- 1998-09-09 ID IDW20000461A patent/ID24173A/id unknown
- 1998-09-09 PT PT98950009T patent/PT1015433E/pt unknown
- 1998-09-09 CN CNB988090155A patent/CN1166640C/zh not_active Expired - Fee Related
- 1998-09-09 BR BR9812443-9A patent/BR9812443A/pt not_active Application Discontinuation
- 1998-09-09 RS YUP-120/00A patent/RS49888B/sr unknown
- 1998-09-09 TR TR2000/00697T patent/TR200000697T2/xx unknown
- 1998-09-09 CA CA002302347A patent/CA2302347C/en not_active Expired - Fee Related
- 1998-09-09 SK SK334-2000A patent/SK284670B6/sk not_active IP Right Cessation
- 1998-09-09 PL PL339061A patent/PL198486B1/pl not_active IP Right Cessation
- 1998-09-09 AU AU96242/98A patent/AU751036B2/en not_active Ceased
- 1998-09-09 RU RU2000109358/04A patent/RU2218334C2/ru not_active IP Right Cessation
- 1998-09-09 JP JP2000511750A patent/JP3827528B2/ja not_active Expired - Fee Related
- 1998-09-09 ES ES98950009T patent/ES2222612T3/es not_active Expired - Lifetime
- 1998-09-09 EP EP98950009A patent/EP1015433B1/de not_active Expired - Lifetime
- 1998-09-09 IL IL13457298A patent/IL134572A/xx not_active IP Right Cessation
- 1998-09-09 UY UY25175A patent/UY25175A1/es not_active IP Right Cessation
- 1998-09-09 WO PCT/EP1998/005734 patent/WO1999014199A1/de active IP Right Grant
- 1998-09-09 NZ NZ503710A patent/NZ503710A/xx unknown
- 1998-09-09 DK DK98950009T patent/DK1015433T3/da active
- 1998-09-09 DE DE59811477T patent/DE59811477D1/de not_active Expired - Fee Related
- 1998-09-09 CZ CZ20000894A patent/CZ296909B6/cs not_active IP Right Cessation
- 1998-09-10 ZA ZA988285A patent/ZA988285B/xx unknown
- 1998-09-10 TW TW087115042A patent/TW505645B/zh active
- 1998-09-10 CO CO98052134A patent/CO5011117A1/es unknown
- 1998-09-10 MY MYPI98004142A patent/MY120550A/en unknown
- 1998-09-11 AR ARP980104530A patent/AR017095A1/es active Pending
- 1998-09-11 HR HR980502A patent/HRP980502B1/xx not_active IP Right Cessation
- 1998-11-16 SA SA98190765A patent/SA98190765B1/ar unknown
1999
- 1999-03-22 UY UY25439A patent/UY25439A1/es not_active IP Right Cessation
2000
- 2000-03-02 YU YU12000A patent/YU12000A/sh unknown
- 2000-03-09 BG BG104232A patent/BG64418B1/bg active Active
- 2000-03-10 NO NO20001288A patent/NO315650B1/no not_active IP Right Cessation
- 2000-03-10 US US09/523,473 patent/US6455538B1/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
ID24173A (id)	2000-07-13
EE200000129A (et)	2001-02-15
CN1166640C (zh)	2004-09-15
NO315650B1 (no)	2003-10-06
JP3827528B2 (ja)	2006-09-27
HUP0004588A3 (en)	2002-10-28
UA61973C2 (en)	2003-12-15
HRP980502A2 (en)	1999-06-30
ES2222612T3 (es)	2005-02-01
BR9812443A (pt)	2000-09-26
CO5011117A1 (es)	2001-02-28
PL198486B1 (pl)	2008-06-30
NO20001288D0 (no)	2000-03-10
CZ296909B6 (cs)	2006-07-12
UY25175A1 (es)	2000-12-29
CA2302347A1 (en)	1999-03-25
BG64418B1 (bg)	2005-01-31
SK3342000A3 (en)	2000-09-12
RS49888B (sr)	2008-08-07
CA2302347C (en)	2008-06-17
RU2218334C2 (ru)	2003-12-10
SK284670B6 (sk)	2005-08-04
AU9624298A (en)	1999-04-05
IL134572A0 (en)	2001-04-30
MY120550A (en)	2005-11-30
CN1269790A (zh)	2000-10-11
ATE267811T1 (de)	2004-06-15
KR100601008B1 (ko)	2006-07-19
AR017095A1 (es)	2001-08-22
TR200000697T2 (tr)	2001-01-22
JP2001516747A (ja)	2001-10-02
WO1999014199A1 (de)	1999-03-25
DE59811477D1 (de)	2004-07-01
HRP980502B1 (en)	2005-02-28
PE122899A1 (es)	1999-12-06
PT1015433E (pt)	2004-08-31
IL134572A (en)	2005-05-17
NO20001288L (no)	2000-03-13
SA98190765B1 (ar)	2006-06-10
PL339061A1 (en)	2000-12-04
TW505645B (en)	2002-10-11
EE04398B1 (et)	2004-12-15
DE19740110A1 (de)	1999-03-18
YU12000A (sh)	2002-11-15
BG104232A (en)	2000-10-31
CZ2000894A3 (cs)	2000-09-13
HUP0004588A2 (hu)	2001-07-30
KR20010023879A (ko)	2001-03-26
EP1015433A1 (de)	2000-07-05
UY25439A1 (es)	1999-11-17
US6455538B1 (en)	2002-09-24
NZ503710A (en)	2002-04-26
EP1015433B1 (de)	2004-05-26
AU751036B2 (en)	2002-08-08
ZA988285B (en)	1999-03-12

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DK1112251T3 (da)	2003-09-01	Azetidinderivater, deres fremstilling og medikamenter indeholdende disse derivater
NO991815D0 (no)	1999-04-16	Oksadiazoler, fremgangsmÕter for deres fremstilling og deres anvendelse som medikamenter
NO990399L (no)	1999-03-29	Substituerte pyridiner og bifenyler som anti-hyperkolesteinemiske, anti-hyperlipoproteinemiske og anti-hyperglysemiske midler
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NO20000185D0 (no)	2000-01-14	Kondenserte 1,2,4-tiadiazinderivater, deres fremstilling og anvendelse
NO20012158D0 (no)	2001-05-02	Substituerte 2-fenylbenzimidazoler, fremgangsmåte til fremstilling og anvendelse derav
DK0927192T3 (da)	2004-09-13	Modificerede aminosyrer, lægemidler indeholdende disse forbindelser og fremgangsmåder til deres fremstilling
NO20001409L (no)	2000-05-16	Karboksamidotiazolderivater, fremgangsmÕte for fremstilling derav og farmasøytiske blandinger
NO961071D0 (no)	1996-03-15	Kjemiske forbindelser, deres fremstilling og anvendelse
DK1006110T3 (da)	2004-04-26	Derivater af acylpiperazinylpyrimidiner, fremstilling deraf og anvendelse som lægemidler
DK199900176U3 (da)	1999-08-13	Paroxetinsalte, farmaceutisk præparat indeholdende disse og anvendelser deraf
DK1019358T4 (da)	2008-01-14	3,3-diarylpropylaminer, deres anvendelse og fremstilling
NO20005146D0 (no)	2000-10-13	Tienylazolylalkoksyetanaminer, deres fremstilling og deres anvendelse som medikamenter
NO981522L (no)	1998-04-03	Aminosyrederivater, deres fremstilling og anvendelse som endotelinantagonister
DK1015433T3 (da)	2004-09-27	Substituerede 1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocin-10-oler, fremgangsmåder til fremstilling af disse og deres anvendelse som lægemidler
DK0903339T3 (da)	2002-04-08	Biphenylsulfonylcyanamid, fremgangsmåde til deres fremstilling og deres anvendelse som medikament
DK0795547T3 (da)	2000-09-18	(Aminoalkyl- og acylaminoalkyl-oxy)benzyloxyquinoliner, fremgangsmåde til deres fremstilling og deres anvendelse som bradyk
DK0838469T3 (da)	2002-03-18	10,13,15-trioxatricyclo(9.2.1 9.6)-pentadecanon-derivater, fremgangsmåde til deres fremstilling og lægemidler indeholdende disse forbindelser
NO960272D0 (no)	1996-01-23	Oksatiolaner, fremgangsmåte for deres fremstilling og farmasöytiske preparater som inneholder de samme
DK60593D0 (da)	1993-05-26	Kemiske forbindelser, deres fremstilling og anvendelse
DK1171444T3 (da)	2003-10-27	Pyridothienodiazepiner, fremgangsmåde til fremstilling af disse og farmaceutiske præparater indeholdende disse
DK1053224T3 (da)	2002-12-23	Biphenylfulfonylcyanamider, fremgangsmåde til fremstilling deraf og anvendelse deraf som lægemiddel
DK1157020T3 (da)	2003-01-27	Substituerede 1,2,3,4,5,6-hexahydro-2,6-methano-2-benzazocin-10-oler, fremgangsmåder til deres fremstilling og deres anvendelse som lægemiddel
NO308213B1 (no)	2000-08-14	Substituerte indanylidinacetylguanidiner, deres anvendelse og medikamenter inneholdende forbindelsene
DK0946579T3 (da)	2002-08-12	Nye forbindelser afledt af erythromcin, fremgangsmåde til deres fremstilling og deres anvendelse som lægemidler