DK1010688T3 - Substituerede 2-phenyl-1-(3,4-dihydroxy-5-nitrophenyl)-1-ethanoner, deres anvendelse til behandling af nogle centrale og perifere nervesystemlidelser og farmaceutiske præparater, der indeholder dem - Google Patents
Substituerede 2-phenyl-1-(3,4-dihydroxy-5-nitrophenyl)-1-ethanoner, deres anvendelse til behandling af nogle centrale og perifere nervesystemlidelser og farmaceutiske præparater, der indeholder demInfo
- Publication number
- DK1010688T3 DK1010688T3 DK99310223T DK99310223T DK1010688T3 DK 1010688 T3 DK1010688 T3 DK 1010688T3 DK 99310223 T DK99310223 T DK 99310223T DK 99310223 T DK99310223 T DK 99310223T DK 1010688 T3 DK1010688 T3 DK 1010688T3
- Authority
- DK
- Denmark
- Prior art keywords
- ethanones
- nitrophenyl
- dihydroxy
- phenyl
- substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
- C07D317/54—Radicals substituted by oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/39—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by esterified hydroxy groups
- C07C205/42—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by esterified hydroxy groups having nitro groups or esterified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
- C07C205/43—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by esterified hydroxy groups having nitro groups or esterified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton to carbon atoms of the same non-condensed six-membered aromatic ring or to carbon atoms of six-membered aromatic rings being part of the same condensed ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/45—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by at least one doubly—bound oxygen atom, not being part of a —CHO group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
- C07C205/57—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
- C07C205/59—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/56—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and doubly-bound oxygen atoms bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/63—Esters of sulfonic acids
- C07C309/72—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C309/73—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton to carbon atoms of non-condensed six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
- C07C45/29—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups
- C07C45/292—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups with chromium derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
- C07C45/46—Friedel-Crafts reactions
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/673—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by change of size of the carbon skeleton
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9827996A GB2344819A (en) | 1998-12-18 | 1998-12-18 | 2-Phenyl-1-(3,4-dihydroxy-5-nitrophenyl)-1-ethanones |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1010688T3 true DK1010688T3 (da) | 2003-08-04 |
Family
ID=10844561
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK99310223T DK1010688T3 (da) | 1998-12-18 | 1999-12-17 | Substituerede 2-phenyl-1-(3,4-dihydroxy-5-nitrophenyl)-1-ethanoner, deres anvendelse til behandling af nogle centrale og perifere nervesystemlidelser og farmaceutiske præparater, der indeholder dem |
Country Status (20)
Country | Link |
---|---|
US (1) | US6512136B1 (da) |
EP (1) | EP1010688B1 (da) |
CN (1) | CN1173926C (da) |
AR (1) | AR021893A1 (da) |
AT (1) | ATE236870T1 (da) |
AU (1) | AU754113B2 (da) |
BR (1) | BR9908084B1 (da) |
CA (1) | CA2292968C (da) |
CZ (1) | CZ297919B6 (da) |
DE (1) | DE69906671T2 (da) |
DK (1) | DK1010688T3 (da) |
ES (1) | ES2197583T3 (da) |
GB (1) | GB2344819A (da) |
HU (1) | HU226396B1 (da) |
PL (1) | PL193998B1 (da) |
PT (1) | PT1010688E (da) |
RU (1) | RU2232748C2 (da) |
SI (1) | SI1010688T1 (da) |
TR (1) | TR200003019T1 (da) |
WO (1) | WO2000037423A1 (da) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0015228D0 (en) * | 2000-06-21 | 2000-08-16 | Portela & Ca Sa | Substituted nitrated catechols, their use in the treatment of some central and peripheral nervous system disorders |
GB2377934B (en) * | 2001-07-25 | 2005-01-12 | Portela & Ca Sa | Method for the nitration of phenolic compounds |
FI20012242A0 (fi) * | 2001-11-19 | 2001-11-19 | Orion Corp | Uudet farmaseuttiset yhdisteet |
US20060105036A1 (en) | 2003-05-12 | 2006-05-18 | Stephen Peroutka | Threo-dops controlled release formulation |
US8158149B2 (en) * | 2004-05-12 | 2012-04-17 | Chelsea Therapeutics, Inc. | Threo-DOPS controlled release formulation |
WO2005025561A1 (en) * | 2003-09-04 | 2005-03-24 | Synergia Pharma, Inc. | Compositions and methods for orthostatic intolerance |
WO2006037061A2 (en) * | 2004-09-28 | 2006-04-06 | Farouk Karoum | Compositions and methods of using d-dopa to treat parkinson's disease |
MY148644A (en) * | 2005-07-18 | 2013-05-15 | Orion Corp | New pharmaceutical compounds |
SI1907382T1 (sl) | 2005-07-26 | 2015-10-30 | Bial-Portela & Ca S.A., | Nitrokateholni derivati kot inhibitorji COMT |
EP1764095A1 (en) * | 2005-09-20 | 2007-03-21 | Revotar Biopharmaceuticals AG | Novel nitrocatechol derivatives having selectin ligand activity |
US20090012177A1 (en) * | 2006-03-23 | 2009-01-08 | Rahim Shafa | Treatment of psychiatric disorders using entacapone, tolcapone and other COMT inhibitor or MB-COMT inhibitor drugs |
EP1845097A1 (en) | 2006-04-10 | 2007-10-17 | Portela & Ca., S.A. | Oxadiazole derivatives as COMT inhibitors |
ES2383768T3 (es) | 2006-06-28 | 2012-06-26 | Chelsea Therapeutics Inc. | Composiciones farmacéuticas que comprenden droxidopa |
LT2481410T (lt) * | 2007-01-31 | 2016-11-10 | Bial - Portela & Ca., S.A. | Nitrokatecholio dariniai kaip komt inhibitoriai vartojami konkrečiu dozavimo režimu |
JP2010520885A (ja) | 2007-03-09 | 2010-06-17 | チェルシー・セラピューティクス,インコーポレイテッド | 線維筋痛症の治療のためのドロキシドパ及びその医薬組成物 |
US8383681B2 (en) * | 2007-05-07 | 2013-02-26 | Chelsea Therapeutics, Inc. | Droxidopa and pharmaceutical composition thereof for the treatment of mood disorders, sleep disorders or attention deficit disorders |
EP2234608A2 (en) | 2007-12-11 | 2010-10-06 | Viamet Pharmaceuticals, Inc. | Metalloenzyme inhibitors using metal binding moieties in combination with targeting moieties |
AU2009217865A1 (en) * | 2008-02-28 | 2009-09-03 | Bial - Portela & Ca., S.A. | Pharmaceutical composition for poorly soluble drugs |
JP2011514380A (ja) | 2008-03-17 | 2011-05-06 | バイアル−ポルテラ アンド シーエー,エス.エー. | 5−[3−(2,5−ジクロロ−4,6−ジメチル−1−オキシ−ピリジン−3−イル)[1,2,4]オキサジアゾール−5−イル]−3−ニトロベンゼン−1,2−ジオールの結晶形 |
AU2010231961B2 (en) | 2009-04-01 | 2015-05-21 | Bial - Portela & Ca., S.A. | Pharmaceutical formulations comprising nitrocatechol derivatives and methods of making thereof |
BRPI1016132B8 (pt) * | 2009-04-01 | 2021-05-25 | Bial Portela & Ca Sa | composição, formulação farmacêutica, processo de obtenção de uma formulação farmacêutica estável |
TW201107303A (en) * | 2009-05-27 | 2011-03-01 | Sanofi Aventis | Process for the production of benzofurans |
EA026419B1 (ru) | 2010-03-04 | 2017-04-28 | Орион Корпорейшн | Применение леводопы, карбидопы и энтакапона для лечения болезни паркинсона |
US20140045900A1 (en) | 2011-02-11 | 2014-02-13 | Bial-Portela & Ca, S.A. | Administration regime for nitrocatechols |
JP5880913B2 (ja) | 2011-05-17 | 2016-03-09 | 三郎 佐古田 | パーキンソン病の体幹症状(姿勢反射異常)の治療剤 |
JP6456143B2 (ja) | 2011-12-13 | 2019-01-23 | ノヴィファーマ,エス.アー. | カテコール−o−メチル転移酵素阻害剤を調製するための中間体として有用な化学的化合物 |
KR20140131335A (ko) | 2012-01-31 | 2014-11-12 | 룬드벡 엔에이 엘티디. | 드록시도파를 투여하는, 자세 안정성 개선 방법 |
TWI638802B (zh) | 2012-05-24 | 2018-10-21 | 芬蘭商奧利安公司 | 兒茶酚o-甲基轉移酶活性抑制化合物 |
WO2014147464A2 (en) * | 2013-03-20 | 2014-09-25 | Ra Chem Pharma Limited | Novel process for the preparation of tolcapone |
RU2017120184A (ru) | 2014-11-28 | 2018-12-28 | БИАЛ - ПОРТЕЛА ЭНД Ка, С.А. | Лекарства для замедления течения болезни паркинсона |
WO2019129121A1 (en) * | 2017-12-28 | 2019-07-04 | Rpxds Co., Ltd | Derivatives of phenylmethanone as fto inhibitors |
EP3972971A1 (en) * | 2019-05-21 | 2022-03-30 | H. Lundbeck A/S | New catecholamine prodrugs for use in the treatment of parkinson's diseases |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK175069B1 (da) * | 1986-03-11 | 2004-05-24 | Hoffmann La Roche | Pyrocatecholderivater |
YU213587A (en) | 1986-11-28 | 1989-06-30 | Orion Yhtymae Oy | Process for obtaining new pharmacologic active cateholic derivatives |
-
1998
- 1998-12-18 GB GB9827996A patent/GB2344819A/en not_active Withdrawn
-
1999
- 1999-12-17 AU AU18731/00A patent/AU754113B2/en not_active Ceased
- 1999-12-17 WO PCT/GB1999/004310 patent/WO2000037423A1/en active IP Right Grant
- 1999-12-17 HU HU0100786A patent/HU226396B1/hu not_active IP Right Cessation
- 1999-12-17 AT AT99310223T patent/ATE236870T1/de not_active IP Right Cessation
- 1999-12-17 TR TR2000/03019T patent/TR200003019T1/xx unknown
- 1999-12-17 CN CNB998050008A patent/CN1173926C/zh not_active Expired - Fee Related
- 1999-12-17 ES ES99310223T patent/ES2197583T3/es not_active Expired - Lifetime
- 1999-12-17 DK DK99310223T patent/DK1010688T3/da active
- 1999-12-17 BR BRPI9908084-2A patent/BR9908084B1/pt not_active IP Right Cessation
- 1999-12-17 SI SI9930313T patent/SI1010688T1/xx unknown
- 1999-12-17 CA CA002292968A patent/CA2292968C/en not_active Expired - Fee Related
- 1999-12-17 PT PT99310223T patent/PT1010688E/pt unknown
- 1999-12-17 AR ARP990106520A patent/AR021893A1/es active IP Right Grant
- 1999-12-17 DE DE69906671T patent/DE69906671T2/de not_active Expired - Lifetime
- 1999-12-17 CZ CZ20003018A patent/CZ297919B6/cs not_active IP Right Cessation
- 1999-12-17 PL PL99342542A patent/PL193998B1/pl not_active IP Right Cessation
- 1999-12-17 EP EP99310223A patent/EP1010688B1/en not_active Expired - Lifetime
- 1999-12-17 US US09/464,813 patent/US6512136B1/en not_active Expired - Fee Related
- 1999-12-17 RU RU2000123787/04A patent/RU2232748C2/ru not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
TR200003019T1 (tr) | 2001-02-21 |
HUP0100786A2 (hu) | 2001-08-28 |
ATE236870T1 (de) | 2003-04-15 |
CN1173926C (zh) | 2004-11-03 |
EP1010688B1 (en) | 2003-04-09 |
SI1010688T1 (en) | 2003-10-31 |
PL193998B1 (pl) | 2007-04-30 |
AU1873100A (en) | 2000-07-12 |
RU2232748C2 (ru) | 2004-07-20 |
ES2197583T3 (es) | 2004-01-01 |
CZ20003018A3 (cs) | 2000-12-13 |
PL342542A1 (en) | 2001-06-18 |
AR021893A1 (es) | 2002-08-07 |
BR9908084A (pt) | 2000-10-24 |
AU754113B2 (en) | 2002-11-07 |
CN1296471A (zh) | 2001-05-23 |
CA2292968C (en) | 2009-05-19 |
GB9827996D0 (en) | 1999-02-10 |
DE69906671T2 (de) | 2004-03-04 |
EP1010688A1 (en) | 2000-06-21 |
CA2292968A1 (en) | 2000-06-18 |
HU226396B1 (en) | 2008-11-28 |
US6512136B1 (en) | 2003-01-28 |
PT1010688E (pt) | 2003-08-29 |
DE69906671D1 (de) | 2003-05-15 |
WO2000037423A1 (en) | 2000-06-29 |
GB2344819A (en) | 2000-06-21 |
BR9908084B1 (pt) | 2009-12-01 |
CZ297919B6 (cs) | 2007-04-25 |
HUP0100786A3 (en) | 2002-12-28 |
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