DK0934308T3 - 3-pyridyloxymethylheterocykliske etherforbindelser anvendelige til kontrollering af kemisk synaptisk transmission - Google Patents
3-pyridyloxymethylheterocykliske etherforbindelser anvendelige til kontrollering af kemisk synaptisk transmissionInfo
- Publication number
- DK0934308T3 DK0934308T3 DK97927830T DK97927830T DK0934308T3 DK 0934308 T3 DK0934308 T3 DK 0934308T3 DK 97927830 T DK97927830 T DK 97927830T DK 97927830 T DK97927830 T DK 97927830T DK 0934308 T3 DK0934308 T3 DK 0934308T3
- Authority
- DK
- Denmark
- Prior art keywords
- ether compounds
- synaptic transmission
- pyridyloxymethylheterocyclic
- compounds useful
- controlling chemical
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/660,044 US5629325A (en) | 1996-06-06 | 1996-06-06 | 3-pyridyloxymethyl heterocyclic ether compounds useful in controlling chemical synaptic transmission |
EP97927830A EP0934308B1 (fr) | 1996-06-06 | 1997-06-04 | Composes d'ethers 3-pyridyloxymethyle heterocycliques utilises dans la regulation de la transmission synaptique chimique |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0934308T3 true DK0934308T3 (da) | 2004-12-06 |
Family
ID=24647894
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK97927830T DK0934308T3 (da) | 1996-06-06 | 1997-06-04 | 3-pyridyloxymethylheterocykliske etherforbindelser anvendelige til kontrollering af kemisk synaptisk transmission |
Country Status (10)
Country | Link |
---|---|
US (2) | US5629325A (fr) |
EP (1) | EP0934308B1 (fr) |
JP (2) | JP4486712B2 (fr) |
AT (1) | ATE273296T1 (fr) |
CA (1) | CA2256022C (fr) |
DE (1) | DE69730229T2 (fr) |
DK (1) | DK0934308T3 (fr) |
ES (1) | ES2229364T3 (fr) |
PT (1) | PT934308E (fr) |
WO (1) | WO1997046554A1 (fr) |
Families Citing this family (73)
Publication number | Priority date | Publication date | Assignee | Title |
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US20020052497A1 (en) * | 2000-03-09 | 2002-05-02 | Targacept, Inc. | Compounds capable of activating cholinergic receptors |
US6979695B2 (en) * | 1996-04-23 | 2005-12-27 | Targacept, Inc. | Compounds capable of activating cholinergic receptors |
US5629325A (en) * | 1996-06-06 | 1997-05-13 | Abbott Laboratories | 3-pyridyloxymethyl heterocyclic ether compounds useful in controlling chemical synaptic transmission |
US6437138B1 (en) | 1996-06-06 | 2002-08-20 | Abbott Laboratories | 3-pyridyloxymethyl heterocyclic ether compounds useful in controlling chemical synaptic transmission |
DE69717148T2 (de) * | 1996-12-10 | 2003-10-02 | Abbott Laboratories, Abbott Park | 3-pyridylenantiomere und ihre verwendung als analgetika |
US6133253A (en) * | 1996-12-10 | 2000-10-17 | Abbott Laboratories | 3-Pyridyl enantiomers and their use as analgesics |
US5733912A (en) * | 1997-02-19 | 1998-03-31 | Abbott Laboratories | 7A-heterocycle substituted hexahydro-1H-pyrrolizine compounds useful in controlling chemical synaptic transmission |
CA2306477A1 (fr) * | 1997-11-05 | 1999-05-20 | Neurosearch A/S | Derives d'azacyclo-ether et leur utilisation en tant que modulateurs des recepteurs ach nicotiniques |
DK1047690T3 (da) * | 1997-12-19 | 2004-07-05 | Abbott Lab | Heterocykliske ether- og thioetherforbindelser, som er anvendelige til regulering af kemisk, synaptisk overförsel |
AU2880699A (en) | 1998-04-02 | 1999-10-25 | R.J. Reynolds Tobacco Company | Pharmaceutical compositions and methods for use |
US6723838B1 (en) | 1998-04-22 | 2004-04-20 | Johns Hopkins University | Signal transducing synaptic molecules and uses thereof |
JP2002516904A (ja) | 1998-06-03 | 2002-06-11 | ジーピーアイ ニル ホールディングス インコーポレイテッド | N−複素環式カルボン酸またはカルボン酸等配電子体のn−結合スルホンアミド |
US6331537B1 (en) | 1998-06-03 | 2001-12-18 | Gpi Nil Holdings, Inc. | Carboxylic acids and carboxylic acid isosteres of N-heterocyclic compounds |
US6232316B1 (en) | 1998-06-16 | 2001-05-15 | Targacept, Inc. | Methods for treatment of CNS disorders |
US20050131034A1 (en) * | 1998-06-16 | 2005-06-16 | Caldwell William S. | Compounds capable of activating cholinergic receptors |
US7790757B2 (en) * | 1998-06-16 | 2010-09-07 | Targacept, Inc. | Compounds capable of activating cholinergic receptors |
DE69919537T2 (de) * | 1998-06-16 | 2005-09-08 | Targacept, Inc. | Arylsubstituierte olefinische amine und ihre verwendung als cholinergische rezeptoragonisten |
ATE273298T1 (de) * | 1998-08-25 | 2004-08-15 | Ortho Mcneil Pharm Inc | Pyridyl-ether und -thioether als nikotin- acetylcholin-rezeptorliganden und ihre therapeutische anwendung |
WO2000046193A2 (fr) * | 1999-02-03 | 2000-08-10 | Schering Aktiengesellschaft | Derives d'ether |
US6284779B1 (en) | 1999-02-03 | 2001-09-04 | Schering Aktiiengesellschaft | Heteroaromatic compounds |
US6833370B1 (en) * | 1999-05-21 | 2004-12-21 | Abbott Laboratories | Heterocycle substituted aminoazacycles useful as central nervous system agents |
US20010031771A1 (en) | 1999-05-24 | 2001-10-18 | Gary Maurice Dull | Pharmaceutical compositions and methods for use |
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WO2001019817A2 (fr) * | 1999-09-14 | 2001-03-22 | Abbott Laboratories | Composes d'ether 3-pyrrolidinyloxy-3'-pyridyle utilises comme regulateurs de la transmission synaptique chimique |
US6417189B1 (en) | 1999-11-12 | 2002-07-09 | Gpi Nil Holdings, Inc. | AZA compounds, pharmaceutical compositions and methods of use |
US7253169B2 (en) | 1999-11-12 | 2007-08-07 | Gliamed, Inc. | Aza compounds, pharmaceutical compositions and methods of use |
ATE319712T1 (de) | 1999-12-21 | 2006-03-15 | Mgi Gp Inc | Hydantoin derivate, pharmazeutische zusammensetzungen und verfahren zu ihrer verwendung |
US6277855B1 (en) | 2000-04-21 | 2001-08-21 | Inspire Pharmaceuticals, Inc. | Method of treating dry eye disease with nicotinic acetylcholine receptor agonists |
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US8124625B2 (en) * | 2001-09-14 | 2012-02-28 | Shionogi & Co., Ltd. | Method of enhancing the expression of apolipoprotein AI using olefin derivatives |
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US20030187026A1 (en) * | 2001-12-13 | 2003-10-02 | Qun Li | Kinase inhibitors |
CA2470214A1 (fr) * | 2001-12-13 | 2003-06-26 | Abbott Laboratories | Inhibiteurs de kinase |
US20030162770A1 (en) | 2002-02-22 | 2003-08-28 | Davis Bonnie M. | Use of modulators of nicotinic receptors for treatment of cognitive dysfunction |
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WO2005000806A2 (fr) * | 2003-06-10 | 2005-01-06 | Georgetown University | Ligands pour les recepteurs de l'acetylcholine nicotinique, et procedes de production et d'utilisation de ces ligands |
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US9029557B2 (en) | 2004-12-07 | 2015-05-12 | The Regents Of The University Of California | Labeled A4B2 ligands and methods therefor |
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CN102112469B (zh) * | 2008-05-23 | 2014-09-10 | 乔治敦大学 | 神经元nAChR的安静减敏剂及其使用方法 |
AR072297A1 (es) * | 2008-06-27 | 2010-08-18 | Novartis Ag | Derivados de indol-2-il-piridin-3-ilo, composicion farmaceutica que los comprende y su uso en medicamentos para el tratamiento de enfermedades mediadas por la sintasa aldosterona. |
AU2009303545A1 (en) * | 2008-10-14 | 2010-04-22 | Psychogenics, Inc | Nicotinic acetylcholine receptor ligands and the uses thereof |
WO2010059393A1 (fr) | 2008-10-30 | 2010-05-27 | Janssen Pharmaceutica Nv | Modulateurs du récepteur de la sérotonine |
US20100125094A1 (en) * | 2008-11-17 | 2010-05-20 | Auspex Pharmaceuticals, Inc. | Pyrrolidinyl modulators of nicotinic acetylcholine receptors |
JP2012512834A (ja) | 2008-12-19 | 2012-06-07 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 炎症、喘息及びcopdの処置のためのccr2受容体アンタゴニストとしての環状ピリミジン−4−カルボキサミド |
EP2509982A1 (fr) | 2009-12-07 | 2012-10-17 | Targacept, Inc. | 3,6-diazabicyclo[3.1.1]heptanes comme ligands des récepteurs nicotiniques neuronaux à l'acétycholine |
PL3091012T3 (pl) | 2009-12-17 | 2018-08-31 | Centrexion Therapeutics Corporation | Antagoniści receptora CCR2 i ich zastosowanie |
US20130237550A1 (en) * | 2010-03-11 | 2013-09-12 | Targacept, Inc. | Arylvinylazacycloalkane compounds for constipation |
JP2013526507A (ja) | 2010-05-12 | 2013-06-24 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新規ccr2受容体アンタゴニスト、その製造方法及び薬物としてのその使用 |
US8946218B2 (en) | 2010-05-12 | 2015-02-03 | Boehringer Ingelheim International Gmbh | CCR2 receptor antagonists, method for producing the same, and use thereof as medicaments |
WO2011144501A1 (fr) | 2010-05-17 | 2011-11-24 | Boehringer Ingelheim International Gmbh | Antagonistes du récepteur ccr2 et leurs utilisations |
US9018212B2 (en) | 2010-05-25 | 2015-04-28 | Boehringer Ingelheim International Gmbh | Pyridazine carboxamides as CCR2 receptor antagonists |
JP5721242B2 (ja) * | 2010-06-01 | 2015-05-20 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新規ccr2アンタゴニスト |
WO2012031220A2 (fr) | 2010-09-03 | 2012-03-08 | University Of Florida Research Foundation, Inc. | Composés de nicotine et leurs analogues, procédés de synthèse pour fabriquer les composés et procédés d'utilisation |
EP2731941B1 (fr) | 2011-07-15 | 2019-05-08 | Boehringer Ingelheim International GmbH | Antagonistes ccr2, nouveaux et sélectifs |
EP2776423B1 (fr) | 2011-11-11 | 2020-05-06 | Georgetown University | Ligands nicotiniques substitués par un phényle, et leurs procédés d'utilisation |
US8889730B2 (en) | 2012-04-10 | 2014-11-18 | Pfizer Inc. | Indole and indazole compounds that activate AMPK |
EP2970177A1 (fr) | 2013-03-15 | 2016-01-20 | Pfizer Inc. | Composés indoliques activant l'ampk |
AU2016211330A1 (en) | 2015-01-28 | 2017-08-03 | Chrono Therapeutics Inc. | Drug delivery methods and systems |
JP6917910B2 (ja) | 2015-07-02 | 2021-08-11 | セントレクシオン セラピューティクス コーポレイション | (4−((3r,4r)−3−メトキシテトラヒドロ−ピラン−4−イルアミノ)ピペリジン−1−イル)(5−メチル−6−(((2r,6s)−6−(p−トリル)テトラヒドロ−2h−ピラン−2−イル)メチルアミノ)ピリミジン−4イル)メタノンクエン酸塩 |
EP3565617A1 (fr) | 2017-01-06 | 2019-11-13 | Chrono Therapeutics Inc. | Dispositifs et methodes d'administration transdermique de medicament |
US11596779B2 (en) | 2018-05-29 | 2023-03-07 | Morningside Venture Investments Limited | Drug delivery methods and systems |
WO2024146945A1 (fr) | 2023-01-07 | 2024-07-11 | Syngenta Crop Protection Ag | Nouveaux composés pesticides à base de carboxamide et de sulfonamide |
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US4592866A (en) * | 1982-09-30 | 1986-06-03 | A. H. Robins Company, Inc. | Fused aromatic oxazepinones, thiazepinones, diazepinones and sulfur analogs thereof |
ZA848275B (en) * | 1983-12-28 | 1985-08-28 | Degussa | New piridine-2-ethers or pyridine-2-thioethers having a nitrogen-containing cycloaliphatic ring |
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DE3641343A1 (de) * | 1986-12-03 | 1988-06-16 | Hoechst Ag | Carbamoylimidazol-derivate, verfahren zu ihrer herstellung und ihre verwendung als fungizide |
EP0287908A3 (fr) * | 1987-04-18 | 1989-12-27 | ASTA Medica Aktiengesellschaft | Composés cyclo-aliphatiques contenant de l'azote avec un reste d'acide aminé et une pyridine |
FI95572C (fi) * | 1987-06-22 | 1996-02-26 | Eisai Co Ltd | Menetelmä lääkeaineena käyttökelpoisen piperidiinijohdannaisten tai sen farmaseuttisen suolan valmistamiseksi |
DE3835291A1 (de) * | 1988-04-19 | 1989-11-02 | Bayer Ag | 1,3-disubstituierte pyrrolidine |
JPH0352887A (ja) * | 1989-07-20 | 1991-03-07 | Yoshitomi Pharmaceut Ind Ltd | ピリジン化合物 |
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IL107184A (en) * | 1992-10-09 | 1997-08-14 | Abbott Lab | Heterocyclic ether compounds that enhance cognitive function |
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US5629325A (en) * | 1996-06-06 | 1997-05-13 | Abbott Laboratories | 3-pyridyloxymethyl heterocyclic ether compounds useful in controlling chemical synaptic transmission |
-
1996
- 1996-06-06 US US08/660,044 patent/US5629325A/en not_active Expired - Lifetime
-
1997
- 1997-04-18 US US08/844,540 patent/US6127386A/en not_active Expired - Lifetime
- 1997-06-04 ES ES97927830T patent/ES2229364T3/es not_active Expired - Lifetime
- 1997-06-04 DK DK97927830T patent/DK0934308T3/da active
- 1997-06-04 WO PCT/US1997/009167 patent/WO1997046554A1/fr active IP Right Grant
- 1997-06-04 CA CA002256022A patent/CA2256022C/fr not_active Expired - Fee Related
- 1997-06-04 PT PT97927830T patent/PT934308E/pt unknown
- 1997-06-04 DE DE69730229T patent/DE69730229T2/de not_active Expired - Lifetime
- 1997-06-04 EP EP97927830A patent/EP0934308B1/fr not_active Expired - Lifetime
- 1997-06-04 JP JP50068698A patent/JP4486712B2/ja not_active Expired - Fee Related
- 1997-06-04 AT AT97927830T patent/ATE273296T1/de not_active IP Right Cessation
-
2009
- 2009-06-23 JP JP2009148236A patent/JP2009256360A/ja not_active Ceased
Also Published As
Publication number | Publication date |
---|---|
DE69730229T2 (de) | 2005-07-28 |
CA2256022C (fr) | 2008-07-29 |
ATE273296T1 (de) | 2004-08-15 |
ES2229364T3 (es) | 2005-04-16 |
DE69730229D1 (de) | 2004-09-16 |
EP0934308A1 (fr) | 1999-08-11 |
JP2009256360A (ja) | 2009-11-05 |
CA2256022A1 (fr) | 1997-12-11 |
EP0934308B1 (fr) | 2004-08-11 |
PT934308E (pt) | 2004-11-30 |
JP4486712B2 (ja) | 2010-06-23 |
US6127386A (en) | 2000-10-03 |
US5629325A (en) | 1997-05-13 |
WO1997046554A1 (fr) | 1997-12-11 |
JP2002515038A (ja) | 2002-05-21 |
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