DK0841924T3 - Benzimidazolforbindelser - Google Patents

Benzimidazolforbindelser

Info

Publication number: DK0841924T3
Authority: DK; Denmark
Prior art keywords: benzimidazole
Prior art date: 1995-08-02

Application number

DK96925875T

Other languages

Danish (da)

English (en)

Inventor

Roger John Griffin

Alan Hilary Calvert

Nicola Jane Curtin

David Richard Newell

Bernard Thomas Golding

Original Assignee

Univ Newcastle Ventures Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-08-02

Filing date

1996-07-30

Publication date

2003-02-10

1995-08-02 Priority claimed from GBGB9515843.2A external-priority patent/GB9515843D0/en

1996-05-30 Priority claimed from GBGB9611245.3A external-priority patent/GB9611245D0/en

1996-07-30 Application filed by Univ Newcastle Ventures Ltd filed Critical Univ Newcastle Ventures Ltd

2003-02-10 Application granted granted Critical

2003-02-10 Publication of DK0841924T3 publication Critical patent/DK0841924T3/da

Links

HYZJCKYKOHLVJF-UHFFFAOYSA-N 1H-benzimidazole Chemical compound C1=CC=C2NC=NC2=C1 HYZJCKYKOHLVJF-UHFFFAOYSA-N 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/08—Radicals containing only hydrogen and carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/10—Radicals substituted by halogen atoms or nitro radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/12—Radicals substituted by oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/14—Radicals substituted by nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/16—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/18—Benzimidazoles; Hydrogenated benzimidazoles with aryl radicals directly attached in position 2

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Data Exchanges In Wide-Area Networks (AREA)

DK96925875T 1995-08-02 1996-07-30 Benzimidazolforbindelser DK0841924T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GBGB9515843.2A GB9515843D0 (en)	1995-08-02	1995-08-02	Benzimidazole compounds
GBGB9611245.3A GB9611245D0 (en)	1996-05-30	1996-05-30	Benzimidazole compounds
PCT/GB1996/001832 WO1997004771A1 (en)	1995-08-02	1996-07-30	Benzimidazole compounds

Publications (1)

Publication Number	Publication Date
DK0841924T3 true DK0841924T3 (da)	2003-02-10

Family

ID=26307504

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK96925875T DK0841924T3 (da)	1995-08-02	1996-07-30	Benzimidazolforbindelser

Country Status (26)

Country	Link
US (2)	US6100283A (pt)
EP (1)	EP0841924B1 (pt)
JP (1)	JPH11510154A (pt)
KR (1)	KR100447539B1 (pt)
CN (1)	CN1159007C (pt)
AP (1)	AP866A (pt)
AT (1)	ATE225173T1 (pt)
AU (1)	AU714873B2 (pt)
BR (1)	BR9610051A (pt)
CA (1)	CA2225465A1 (pt)
CZ (1)	CZ30398A3 (pt)
DE (1)	DE69624115T2 (pt)
DK (1)	DK0841924T3 (pt)
EA (1)	EA000999B1 (pt)
ES (1)	ES2183004T3 (pt)
HU (1)	HUP9901092A3 (pt)
IL (1)	IL123147A (pt)
MX (1)	MX9800927A (pt)
NO (1)	NO317033B1 (pt)
NZ (1)	NZ313713A (pt)
OA (1)	OA10661A (pt)
PL (1)	PL324869A1 (pt)
PT (1)	PT841924E (pt)
SK (1)	SK13598A3 (pt)
TR (1)	TR199800127T1 (pt)
WO (1)	WO1997004771A1 (pt)

Families Citing this family (74)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2776291B1 (fr) *	1998-03-18	2000-06-16	Pf Medicament	Nouveaux derives bis-benzamides, leur procede de fabrication, les compositions pharmaceutiques les contenant et leur utilisation comme medicament
US6911462B2 (en) *	1998-05-22	2005-06-28	Avanir Pharmaceuticals	Benzimidazole compounds for regulating IgE
US6919366B2 (en) *	1998-05-22	2005-07-19	Avanir Pharmaceuticals	Benzimidazole derivatives as modulators of IgE
UA65635C2 (uk)	1998-09-03	2004-04-15	Н-Гене Кутато Кфт.	НЕНАСИЧЕНІ ПОХІДНІ ГІДРОКСИМОВОЇ КИСЛОТИ, ЩО МАЮТЬ ВЛАСТИВОСТІ ІНГІБІТОРІВ NAD<sup>+</sup>-ADP-РИБОЗИЛТРАНСФЕРАЗИ
EP1391457B1 (de)	1998-11-03	2013-12-25	AbbVie Deutschland GmbH & Co KG	Substituierte 2-Phenylbenzimidazole und deren Verwendung als PARP Inhibitoren
IL143102A0 (en) *	1998-11-17	2002-04-21	Basf Ag	2-phenylbenzimidazoles and 2-phenylindoles, and production and use thereof
CZ300148B6 (cs)	1998-11-27	2009-02-25	Abbott Gmbh & Co. Kg	Derivát substituovaného benzimidazolu, zpusob jeho prípravy a jeho použití
DE19916460B4 (de) *	1999-04-12	2006-12-21	Abbott Gmbh & Co. Kg	Substituierte Benzimidazole, deren Herstellung und Anwendung
JP4093448B2 (ja) *	1999-01-11	2008-06-04	アグロン・ファーマシューティカルズ・インコーポレーテッド	ポリ（ａｄｐ−リボース）ポリメラーゼの三環系阻害剤
FR2788518B1 (fr) *	1999-01-14	2001-03-02	Centre Nat Rech Scient	Nouveaux carbamates actives stables, leur procede de preparation et leur utilisation pour la preparation d'urees
DE19918211A1 (de) *	1999-04-22	2000-10-26	Basf Ag	Cycloalkylsubstituierte Benzimidazole, deren Herstellung und Anwendung
DE19920936A1 (de) *	1999-05-07	2000-11-09	Basf Ag	Heterozyklisch substituierte Benzimidazole, deren Herstellung und Anwendung
ECSP003637A (es) *	1999-08-31	2002-03-25	Agouron Pharma	Inhibidores triciclicos de poli (adp-ribosa) polimerasas
WO2001021615A1 (en) *	1999-09-17	2001-03-29	Yamanouchi Pharmaceutical Co., Ltd.	Benzimidazole derivatives
DE19946289A1 (de) *	1999-09-28	2001-03-29	Basf Ag	Benzodiazepin-Derivate, deren Herstellung und Anwendung
US6759425B2 (en)	1999-10-21	2004-07-06	Avanir Pharmaceuticals	Benzimidazole compounds for modulating IgE and inhibiting cellular proliferation
IT1315267B1 (it) *	1999-12-23	2003-02-03	Novuspharma Spa	Derivati di 2-(1h-indol-3-il)-2-oxo-acetammidi ad attivita'antitumorale
AU2001240542A1 (en)	2000-02-01	2001-08-14	Basf Aktiengesellschaft	Heterocyclic compounds and their use as parp inhibitors
DE10021468A1 (de) *	2000-05-04	2001-11-08	Basf Ag	Verwendung von PARP-Inhibitoren in kosmetischen Zubereitungen
DE10022925A1 (de) *	2000-05-11	2001-11-15	Basf Ag	Substituierte Indole als PARP-Inhibitoren
RU2003127367A (ru) *	2001-03-12	2005-03-20	Аванир Фармасьютиклз (Us)	Бензимидазоловые соединения для модулирования ige и ингибирования клеточной пролиферации
US7072771B2 (en) *	2001-06-07	2006-07-04	University Of Kentucky Research Foundation	Selective PARP-1 targeting for designing chemo/radio sensitizing agents
WO2003020698A2 (en) *	2001-09-06	2003-03-13	Prochon Biotech Ltd.	Protein tyrosine kinase inhibitors
DE10201240A1 (de) *	2002-01-15	2003-07-24	Bayer Ag	Substituierte Alkyluracile und ihre Verwendung
TW200304820A (en) *	2002-03-25	2003-10-16	Avanir Pharmaceuticals	Use of benzimidazole analogs in the treatment of cell proliferation
US20040034078A1 (en) *	2002-06-14	2004-02-19	Agouron Pharmaceuticals, Inc.	Benzimidazole inhibitors of poly(ADP-ribosyl) polymerase
AU2003270426A1 (en)	2002-09-12	2004-04-30	Avanir Pharmaceuticals	PHENYL-INDOLE COMPOUNDS FOR MODULATING IgE AND INHIBITING CELLULAR PROLIFERATION
TWI276631B (en) *	2002-09-12	2007-03-21	Avanir Pharmaceuticals	Phenyl-aza-benzimidazole compounds for modulating IgE and inhibiting cellular proliferation
WO2004065370A1 (en) *	2003-01-23	2004-08-05	Crystalgenomics, Inc.	Glycogen synthase kinase 3beta inhibitor, composition and process for the preparation thereof
ATE363905T1 (de) *	2003-04-17	2007-06-15	Janssen Pharmaceutica Nv	2-phenyl-benzimidazol und 2-phenyl-imidazo-4,5)- pyridin-derivate als checkpoint-kinase-cds1 (chk2)-hemmer zur behandlung von krebs
AU2004263190A1 (en) *	2003-08-08	2005-02-17	Avanir Pharmaceuticals	Selective pharmacologic inhibition of protein trafficking and related methods of treating human diseases
WO2006110683A1 (en)	2005-04-11	2006-10-19	Abbott Laboratories	2-substituted-1h-benzimidazole-4-carboxamides are parp inhibitors
TWI375673B (en)	2005-04-11	2012-11-01	Abbott Lab	1h-benzimidazole-4-carboxamides substituted with a quaternary carbon at the 2-position are potent parp inhibitors
NZ587586A (en)	2005-07-18	2012-04-27	Bipar Sciences Inc	Treatment of cancer
WO2007054814A1 (en)	2005-11-14	2007-05-18	Centre National De La Recherche Scientifique - Cnrs	Inhibitors of parp activity and uses thereof
EP1966157B1 (en)	2005-11-15	2010-03-24	Abbott Laboratories	Substituted 1h-benzimidazole-4-carboxamides are potent parp inhibitors
US20080293795A1 (en) *	2006-01-17	2008-11-27	Abbott Laboratories	Combination therapy with parp inhibitors
US20080146638A1 (en) *	2006-01-17	2008-06-19	Abbott Laboratories	Combination therapy with parp inhibitors
US20080280867A1 (en) *	2006-01-17	2008-11-13	Abbott Laboratories	Combination therapy with parp inhibitors
US20070265324A1 (en) *	2006-01-17	2007-11-15	Wolfgang Wernet	Combination Therapy with Parp Inhibitors
US20090029966A1 (en) *	2006-01-17	2009-01-29	Abbott Laboratories	Combination therapy with parp inhibitors
EP2007733B1 (en) *	2006-04-03	2016-05-25	MSD Italia S.r.l.	Amide substituted indazole and benzotriazole derivatives as poly(adp-ribose)polymerase (parp) inhibitors
ES2385849T3 (es)	2006-05-02	2012-08-01	Abbott Laboratories	Las 1H-bencimidazol-4-carboxamidas substituidas son potentes inhibidores de la PARP
US20080262062A1 (en) *	2006-11-20	2008-10-23	Bipar Sciences, Inc.	Method of treating diseases with parp inhibitors
EP2059802A4 (en) *	2006-09-05	2010-09-08	Bipar Sciences Inc	METHODS FOR DESIGNING PARP INHIBITORS AND USES THEREOF
WO2008030891A2 (en)	2006-09-05	2008-03-13	Bipar Sciences, Inc.	Inhibition of fatty acid synthesis by parp inhibitors and methods of treatment thereof
CN101522609A (zh)	2006-09-05	2009-09-02	彼帕科学公司	癌症的治疗
MX2009007200A (es)	2007-01-10	2009-07-15	Angeletti P Ist Richerche Bio	Indazoles sustituidos con amida como inhibidores de poli(adp-ribosa)polimerasa (parp).
US8067613B2 (en)	2007-07-16	2011-11-29	Abbott Laboratories	Benzimidazole poly(ADP ribose)polymerase inhibitors
US20090062268A1 (en) *	2007-08-27	2009-03-05	Lead Therapeutics, Inc.	Novel inhibitors of poly(adp-ribose)polymerase (parp)
JP2011500684A (ja) *	2007-10-19	2011-01-06	バイパーサイエンシズ，インコーポレイティド	ベンゾピロン系ｐａｒｐ阻害剤を用いる癌の処置方法および組成物
CN101917982B (zh)	2007-11-12	2013-03-20	彼帕科学公司	使用4-碘-3-硝基苯甲酰胺与抗肿瘤剂组合治疗乳腺癌
US8436185B2 (en)	2008-01-08	2013-05-07	Merck Sharp & Dohme Corp.	Pharmaceutically acceptable salts of 2-{4-[(3S)-piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide
AU2009212401A1 (en) *	2008-02-04	2009-08-13	Bipar Sciences, Inc.	Methods of diagnosing and treating PARP-mediated diseases
WO2010083199A1 (en)	2009-01-19	2010-07-22	Abbott Laboratories	Benzthiazole inhibitors of poly(adp-ribose)polymerase
US20110218103A1 (en) *	2010-03-04	2011-09-08	Bayer Cropscience Ag	Fluoroalkyl-substituted 2-amidobenzimidazoles
CN102417483A (zh) *	2010-09-27	2012-04-18	中国药科大学	作为parp抑制剂的2-苯基-1h-苯并咪唑-4-甲酸酯衍生物
EP2561759A1 (en)	2011-08-26	2013-02-27	Bayer Cropscience AG	Fluoroalkyl-substituted 2-amidobenzimidazoles and their effect on plant growth
CN103130723B (zh) *	2011-11-30	2015-01-14	成都地奥制药集团有限公司	一种多聚(adp-核糖)聚合酶抑制剂
CN102627610B (zh) *	2012-04-11	2014-06-25	江苏先声药物研究有限公司	一类苯并咪唑类衍生物及其应用
EA201590482A1 (ru) *	2012-09-05	2015-07-30	Байер Кропсайенс Аг	Применение замещенных 2-амидобензимидазолов, 2-амидобензоксазолов и 2-амидобензотиазолов или их солей в качестве биологически активных веществ против абиотического стресса растений
CN104140426B (zh) *	2013-05-07	2017-02-01	上海汇伦生命科技有限公司	嘧啶并咪唑类化合物、其药物组合物及其制备方法和用途
CN104230896A (zh)	2013-06-17	2014-12-24	上海汇伦生命科技有限公司	苯并咪唑-2-哌嗪杂环类化合物、其药物组合物及其制备方法和用途
CN107556288A (zh) *	2016-07-01	2018-01-09	山东大学齐鲁医院	一种治疗转移性肿瘤的药物化合物
WO2018022851A1 (en)	2016-07-28	2018-02-01	Mitobridge, Inc.	Methods of treating acute kidney injury
KR20190107656A (ko)	2016-11-02	2019-09-20	이뮤노젠 아이엔씨	항체-약물 콘주게이트 및 parp 억제제로 병용 치료
CR20200334A (es)	2018-01-05	2021-03-09	Cybrexa 1 Inc	Compuestos, composiciones y métodos para tratar enfermedades que involucren tejidos con enfermedades ácidas o hipóxicas
US11874276B2 (en)	2018-04-05	2024-01-16	Dana-Farber Cancer Institute, Inc.	STING levels as a biomarker for cancer immunotherapy
KR20220052918A (ko)	2019-07-10	2022-04-28	싸이브렉사 2, 인크.	치료제로서의 사이토톡신의 펩티드 접합체
JP2022541747A (ja)	2019-07-10	2022-09-27	サイブレクサ３，インコーポレイテッド	治療薬としての微小管標的化剤のペプチドコンジュゲート
WO2021041532A1 (en)	2019-08-26	2021-03-04	Dana-Farber Cancer Institute, Inc.	Use of heparin to promote type 1 interferon signaling
CN111793034B (zh) *	2020-07-24	2021-11-19	华中科技大学	苯并咪唑盐衍生物与制备抗肿瘤药物的应用
EP4274905A1 (en)	2021-01-08	2023-11-15	Cybrexa 2, Inc.	Process for preparing a conjugate linking moiety
WO2022155172A1 (en)	2021-01-13	2022-07-21	Cybrexa 3, Inc.	Peptide conjugates of therapeutics

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1087561A (en) *	1963-02-16	1967-10-18	Fisons Pest Control Ltd	Fluorinated benzimidazoles and compositions containing them
DE3346575A1 (de) *	1983-12-23	1985-07-04	Dr. Karl Thomae Gmbh, 7950 Biberach	Neue benzimidazole, ihre herstellung und diese verbindungen enthaltende arzneimittel
DE3522230A1 (de) *	1985-06-21	1987-01-02	Thomae Gmbh Dr K	Neue 2-arylimidazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
GB8822483D0 (en) *	1988-09-24	1988-10-26	Medical Res Council	Developments relating to mas oncogene
GB8904174D0 (en) *	1989-02-23	1989-04-05	British Bio Technology	Compounds
IE70593B1 (en) *	1989-09-29	1996-12-11	Eisai Co Ltd	Biphenylmethane derivative the use of it and pharmacological compositions containing same
IL95975A (en) *	1989-10-24	1997-06-10	Takeda Chemical Industries Ltd	N-benzyl- 2-alkylbenzimidazole derivatives, their production and pharmaceutical compositions containing them
WO1992005784A1 (en) *	1990-10-02	1992-04-16	Warner-Lambert Company	4,5,6,7-tetrahydro-1h-imidazo[4,5-c]pyridine derivatives and analogues as angiotensin ii receptor antagonists
US5216003A (en) *	1992-01-02	1993-06-01	G. D. Searle & Co.	Diacid-containing benzimidazole compounds for treatment of neurotoxic injury
AU675484B2 (en) *	1993-03-24	1997-02-06	Neurosearch A/S	Benzimidazole compounds, their use and preparation
US5824696A (en) *	1993-09-01	1998-10-20	Smithkline Beecham Corporation	Medicaments
US5735973A (en) *	1993-12-20	1998-04-07	Tamura Kaken Corporation	Printed circuit board surface protective agent
US5821258A (en) *	1994-12-27	1998-10-13	Mitsui Chemicals, Inc.	Phenylbenzimidazole derivatives

1996
- 1996-07-30 NZ NZ313713A patent/NZ313713A/en unknown
- 1996-07-30 CA CA002225465A patent/CA2225465A1/en not_active Abandoned
- 1996-07-30 PL PL96324869A patent/PL324869A1/xx unknown
- 1996-07-30 BR BR9610051-6A patent/BR9610051A/pt not_active Application Discontinuation
- 1996-07-30 JP JP9507360A patent/JPH11510154A/ja not_active Ceased
- 1996-07-30 AP APAP/P/1998/001183A patent/AP866A/en active
- 1996-07-30 TR TR1998/00127T patent/TR199800127T1/xx unknown
- 1996-07-30 IL IL12314796A patent/IL123147A/en not_active IP Right Cessation
- 1996-07-30 EP EP96925875A patent/EP0841924B1/en not_active Expired - Lifetime
- 1996-07-30 CZ CZ98303A patent/CZ30398A3/cs unknown
- 1996-07-30 WO PCT/GB1996/001832 patent/WO1997004771A1/en not_active Application Discontinuation
- 1996-07-30 DE DE69624115T patent/DE69624115T2/de not_active Expired - Fee Related
- 1996-07-30 AT AT96925875T patent/ATE225173T1/de not_active IP Right Cessation
- 1996-07-30 ES ES96925875T patent/ES2183004T3/es not_active Expired - Lifetime
- 1996-07-30 PT PT96925875T patent/PT841924E/pt unknown
- 1996-07-30 KR KR10-1998-0700752A patent/KR100447539B1/ko not_active IP Right Cessation
- 1996-07-30 AU AU66240/96A patent/AU714873B2/en not_active Ceased
- 1996-07-30 DK DK96925875T patent/DK0841924T3/da active
- 1996-07-30 EA EA199800184A patent/EA000999B1/ru not_active IP Right Cessation
- 1996-07-30 SK SK135-98A patent/SK13598A3/sk unknown
- 1996-07-30 HU HU9901092A patent/HUP9901092A3/hu not_active Application Discontinuation
- 1996-07-31 CN CNB961968818A patent/CN1159007C/zh not_active Expired - Fee Related
1998
- 1998-01-30 NO NO19980414A patent/NO317033B1/no not_active IP Right Cessation
- 1998-01-30 OA OA9800017A patent/OA10661A/en unknown
- 1998-02-02 MX MX9800927A patent/MX9800927A/es not_active IP Right Cessation
- 1998-02-02 US US09/017,314 patent/US6100283A/en not_active Expired - Fee Related
2000
- 2000-06-16 US US09/594,776 patent/US6310082B1/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
AP9801183A0 (en)	1998-01-31
IL123147A0 (en)	1998-09-24
CN1159007C (zh)	2004-07-28
DE69624115T2 (de)	2003-06-18
US6100283A (en)	2000-08-08
PL324869A1 (en)	1998-06-22
CN1195985A (zh)	1998-10-14
ES2183004T3 (es)	2003-03-16
TR199800127T1 (xx)	1998-04-21
CZ30398A3 (cs)	1998-06-17
EA000999B1 (ru)	2000-08-28
US6310082B1 (en)	2001-10-30
AU714873B2 (en)	2000-01-13
AU6624096A (en)	1997-02-26
IL123147A (en)	2004-02-19
ATE225173T1 (de)	2002-10-15
DE69624115D1 (de)	2002-11-07
NZ313713A (en)	2001-03-30
NO980414L (no)	1998-04-02
CA2225465A1 (en)	1997-02-13
HUP9901092A2 (hu)	1999-07-28
HUP9901092A3 (en)	2001-11-28
NO317033B1 (no)	2004-07-26
AP866A (en)	2000-08-17
PT841924E (pt)	2003-02-28
BR9610051A (pt)	1999-12-21
NO980414D0 (no)	1998-01-30
KR100447539B1 (ko)	2004-11-10
EP0841924B1 (en)	2002-10-02
WO1997004771A1 (en)	1997-02-13
EA199800184A1 (ru)	1998-10-29
JPH11510154A (ja)	1999-09-07
OA10661A (en)	2002-11-25
MX9800927A (es)	1998-10-31
SK13598A3 (en)	1998-06-03
EP0841924A1 (en)	1998-05-20
KR19990036086A (ko)	1999-05-25

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DK0841924T3 (da)	2003-02-10	Benzimidazolforbindelser
DK0994890T3 (da)	2003-12-01	Benzimidazolderivater
DE69609678D1 (de)	2000-09-14	Synchronisiervorrichtung-Kupplung-Anordnung
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DE69622196T2 (de)	2002-10-31	Motorträgeranordnung
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NO965549D0 (no)	1996-12-23	Omstillingsverktöy
DK0760210T3 (da)	2002-04-15	Nultids-klemmeindretning
DE69600080D1 (de)	1997-11-27	Verbindungsanordnung
DE59609500D1 (de)	2002-09-05	Benzimidazol-isoindoleninfarbstoffe
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FI1900U1 (fi)	1995-05-09	Spejningsbraeda foer katter i hoeghus
FI955358A0 (fi)	1995-11-07	Aotkomstfoerfarande foer tvaovaegskommunikation i kabeltelevisionssystem
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