DK0994890T3 - Benzimidazolderivater - Google Patents
BenzimidazolderivaterInfo
- Publication number
- DK0994890T3 DK0994890T3 DK98936306T DK98936306T DK0994890T3 DK 0994890 T3 DK0994890 T3 DK 0994890T3 DK 98936306 T DK98936306 T DK 98936306T DK 98936306 T DK98936306 T DK 98936306T DK 0994890 T3 DK0994890 T3 DK 0994890T3
- Authority
- DK
- Denmark
- Prior art keywords
- benzimidazole
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/30—Nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/052—Imidazole radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9711982.0A GB9711982D0 (en) | 1997-06-10 | 1997-06-10 | Benzimidazole derivatives |
GBGB9714552.8A GB9714552D0 (en) | 1997-07-11 | 1997-07-11 | Benzimidazole derivatives |
PCT/EP1998/003380 WO1998056761A2 (en) | 1997-06-10 | 1998-06-08 | Benzimidazole derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0994890T3 true DK0994890T3 (da) | 2003-12-01 |
Family
ID=26311687
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK98936306T DK0994890T3 (da) | 1997-06-10 | 1998-06-08 | Benzimidazolderivater |
Country Status (35)
Country | Link |
---|---|
US (1) | US6455507B1 (da) |
EP (1) | EP0994890B1 (da) |
JP (1) | JP4548866B2 (da) |
KR (1) | KR20010020465A (da) |
CN (1) | CN1265665A (da) |
AP (1) | AP1262A (da) |
AR (1) | AR012964A1 (da) |
AT (1) | ATE246700T1 (da) |
AU (1) | AU740792C (da) |
BR (1) | BR9810745A (da) |
CA (1) | CA2293470C (da) |
CO (1) | CO4970737A1 (da) |
DE (1) | DE69816992T2 (da) |
DK (1) | DK0994890T3 (da) |
EA (1) | EA002305B1 (da) |
EE (1) | EE9900564A (da) |
ES (1) | ES2205527T3 (da) |
HK (1) | HK1024921A1 (da) |
HR (1) | HRP980303B1 (da) |
HU (1) | HUP0002224A3 (da) |
ID (1) | ID24054A (da) |
IL (1) | IL133285A0 (da) |
IS (1) | IS5285A (da) |
MA (1) | MA26504A1 (da) |
MY (1) | MY132872A (da) |
NO (1) | NO314847B1 (da) |
NZ (1) | NZ501415A (da) |
OA (1) | OA11230A (da) |
PE (1) | PE84099A1 (da) |
PL (1) | PL337773A1 (da) |
PT (1) | PT994890E (da) |
SK (1) | SK171499A3 (da) |
TR (1) | TR199903053T2 (da) |
TW (1) | TW565566B (da) |
WO (1) | WO1998056761A2 (da) |
Families Citing this family (41)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR19990081940A (ko) | 1996-01-23 | 1999-11-15 | 그레이엄 브레레톤, 레슬리 에드워즈 | 항바이러스제로서 변형된 벤즈이미다졸 누클레오시드 |
US6455506B1 (en) | 1997-07-30 | 2002-09-24 | Smithkline Beecham Corporation | Lyxofuranosyl benzimidazoles as antiviral agents |
DE19741715A1 (de) * | 1997-09-22 | 1999-03-25 | Hoechst Ag | Pentopyranosyl-Nucleosid, seine Herstellung und Verwendung |
GB0008939D0 (en) * | 2000-04-11 | 2000-05-31 | Glaxo Group Ltd | Process for preparing substituted benzimidazole compounds |
MXJL03000027A (es) | 2001-03-12 | 2004-04-30 | Avanir Pharmaceuticals | Compuestos de benzimidazol para modular la ige e inhibir la proliferacion celular. |
AU2003270426A1 (en) | 2002-09-12 | 2004-04-30 | Avanir Pharmaceuticals | PHENYL-INDOLE COMPOUNDS FOR MODULATING IgE AND INHIBITING CELLULAR PROLIFERATION |
TWI276631B (en) | 2002-09-12 | 2007-03-21 | Avanir Pharmaceuticals | Phenyl-aza-benzimidazole compounds for modulating IgE and inhibiting cellular proliferation |
US7094764B2 (en) * | 2003-08-01 | 2006-08-22 | Janssen Pharmaceutica N.V. | Substituted benzimidazole-, Benztriazole-, and benzimidazolone-O-glucosides |
WO2005049582A1 (en) * | 2003-11-14 | 2005-06-02 | Auspex Pharmaceuticals, Inc. | Method of preparation of novel nucleoside analogs and uses |
CA2598690C (en) * | 2005-02-22 | 2011-11-15 | The Regents Of The University Of Michigan | Small molecule inhibitors of mdm2 and uses thereof |
DE102005019549A1 (de) * | 2005-04-25 | 2006-12-14 | Beiersdorf Ag | Kosmetische oder dermatologische Zubereitungen mit einem Gehalt an Diaminobenzimidazol |
WO2007070947A1 (en) * | 2005-12-22 | 2007-06-28 | Alchemia Ltd | Antibacterial agents |
US10238599B2 (en) | 2006-01-19 | 2019-03-26 | The Regents Of The University Of Michigan | Composition and method for treating congenital cytomegalovirus induced hearing loss |
US7951845B2 (en) | 2006-01-19 | 2011-05-31 | The Regents Of The University Of Michigan | Composition and method of treating hearing loss |
US8338397B2 (en) | 2006-01-19 | 2012-12-25 | The Regents Of The University Of Michigan | Composition and method of treating side effects from antibiotic treatment |
US9770433B2 (en) | 2006-01-19 | 2017-09-26 | The Regents Of The University Of Michigan | Composition and method for treating tinnitus |
US9889156B2 (en) | 2006-01-19 | 2018-02-13 | The Regents Of The University Of Michigan | Method for treating noise-induced hearing loss (NIHL) |
US8927528B2 (en) | 2006-01-19 | 2015-01-06 | The Regents Of The University Of Michigan | Composition for treating hearing loss |
US9919008B2 (en) | 2006-01-19 | 2018-03-20 | The Regents Of The University Of Michigan | Method for treating age-related hearing loss (ARHL) |
USRE46372E1 (en) | 2006-01-19 | 2017-04-25 | The Regents Of The Univerity Of Michigan | Method for treating hearing loss |
KR101654007B1 (ko) | 2007-08-15 | 2016-09-05 | 아이오니스 파마수티컬즈, 인코포레이티드 | 테트라하이드로피란 핵산 유사체 |
WO2009100045A1 (en) * | 2008-02-04 | 2009-08-13 | Translational Genomics Research Institute | Compounds, pharmaceutical compositions and methods of use of hydroxamic acid derivatives |
US8530640B2 (en) | 2008-02-07 | 2013-09-10 | Isis Pharmaceuticals, Inc. | Bicyclic cyclohexitol nucleic acid analogs |
WO2010036613A1 (en) | 2008-09-26 | 2010-04-01 | Merck Sharp & Dohme Corp. | Novel cyclic benzimidazole derivatives useful anti-diabetic agents |
MX2011004258A (es) | 2008-10-22 | 2011-06-01 | Merck Sharp & Dohme | Derivados de bencimidazol ciclicos novedosos utiles como agentes anti-diabeticos. |
AU2009309007A1 (en) | 2008-10-29 | 2010-05-06 | Merck Sharp & Dohme Corp. | Novel cyclic benzimidazole derivatives useful anti-diabetic agents |
CA2741672A1 (en) | 2008-10-31 | 2010-05-06 | Merck Sharp & Dohme Corp. | Novel cyclic benzimidazole derivatives useful anti-diabetic agents |
EP2393825A2 (en) | 2009-02-06 | 2011-12-14 | Isis Pharmaceuticals, Inc. | Oligomeric compounds and methods |
WO2010090969A1 (en) | 2009-02-06 | 2010-08-12 | Isis Pharmaceuticals, Inc. | Tetrahydropyran nucleic acid analogs |
JP2013520502A (ja) | 2010-02-25 | 2013-06-06 | メルク・シャープ・エンド・ドーム・コーポレイション | 有用な抗糖尿病薬である新規な環状ベンズイミダゾール誘導体 |
EP2601204B1 (en) | 2010-04-28 | 2016-09-07 | Ionis Pharmaceuticals, Inc. | Modified nucleosides and oligomeric compounds prepared therefrom |
US8546344B2 (en) | 2010-10-28 | 2013-10-01 | Viropharma Incorporated | Crystalline phases of 5,6-dichloro-2-(isopropylamino)-1-β-L-ribofuranosyl)-1H-benzimidazole |
WO2014134493A1 (en) * | 2013-03-01 | 2014-09-04 | Los Alamos National Security, Llc | Broad spectrum antibiotic compounds and use thereof |
DK3137476T3 (da) | 2014-04-28 | 2019-11-18 | Ionis Pharmaceuticals Inc | Linker-modificerede oligomerforbindelser |
US10077242B2 (en) * | 2014-12-01 | 2018-09-18 | Virginia Commonwealth University | Convergent approach to the total synthesis of telmisartan via a suzuki cross-coupling reaction |
RU2629670C2 (ru) * | 2016-08-04 | 2017-08-31 | Федеральное государственное бюджетное учреждение науки институт биоорганической химии им. академиков М.М. Шемякина и Ю.А. Овчинникова Российской академии наук (ИБХ РАН) | 2-Амино-5,6-дифтор-1-(бета-D-рибофуранозил)-бензимидазол, способ получения и противовирусная активность его в отношении вируса герпеса простого 1-го типа |
EP3907230A1 (en) | 2020-03-30 | 2021-11-10 | Biometrix Technology Inc. | Novel benzimidazole derivatives, preparation method thereof and use thereof as anti-cancer agent comprising the same |
KR102583547B1 (ko) | 2020-03-30 | 2023-10-06 | (주)바이오메트릭스 테크놀로지 | 신규한 벤지미다졸 유도체, 이의 제조방법 및 이의 항암제 용도 |
CN114096549A (zh) * | 2020-06-23 | 2022-02-25 | 博美利克斯技术公司 | 新型苯并咪唑衍生物、其制备方法及其作为抗癌剂或者抗病毒剂的用途 |
KR102449266B1 (ko) | 2020-06-23 | 2022-09-30 | (주)바이오메트릭스 테크놀로지 | 항암 활성 그리고 항바이러스 활성을 갖는 신규한 벤지미다졸-탄수화물 결합체 화합물(Benzimidazole carbohydrate conjugate compound) 및 이의 제조 방법 |
KR102342313B1 (ko) | 2021-08-27 | 2021-12-24 | (주)바이오메트릭스 테크놀로지 | 벤지미다졸-탄수화물 결합체 화합물을 포함하는 미셀, 이의 제조방법, 이의 항암제 또는 항바이러스제로서의 용도 |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR1491244A (fr) | 1966-03-09 | 1967-08-11 | Nouveaux benzimidazoles solubles | |
FR1476350A (fr) | 1966-04-18 | 1967-04-07 | Yale & Towne G M B H | Ferme-porte automatique à frein |
US3655901A (en) | 1970-07-30 | 1972-04-11 | Merck & Co Inc | Method of inhibiting the formation of phenylethanalamine-n-methyl transferase with 2-aminobenzimidazoles |
DE2130030A1 (de) | 1971-06-18 | 1972-12-21 | Bayer Ag | Fungizide und bakterizide Mittel |
ES482789A0 (es) | 1978-08-25 | 1980-12-01 | Thomae Gmbh Dr K | Procedimiento para la preparacion de nuevos bencimidazoles sustituidos en posicion 5 o 6 con un anillo de piridazinona |
DK405988A (da) | 1987-07-29 | 1989-01-30 | Hoffmann La Roche | Benzimidazolderivater |
IT1226100B (it) | 1988-07-07 | 1990-12-10 | Dompe Farmaceutici Spa | Derivati benzimidazolici farmacologicamente attivi. |
US5248672A (en) | 1990-11-01 | 1993-09-28 | The Regents Of The University Of Michigan | Polysubstituted benzimidazole nucleosides as antiviral agents |
ZA923641B (en) | 1991-05-21 | 1993-02-24 | Iaf Biochem Int | Processes for the diastereoselective synthesis of nucleosides |
EP0521463A3 (en) | 1991-07-04 | 1993-04-14 | Hoechst Aktiengesellschaft | Substituted cyclic cycloalkyltriols, process, intermediates for their preparation and their use as antiviral and antiparasitic agents |
GB9205071D0 (en) | 1992-03-09 | 1992-04-22 | Wellcome Found | Therapeutic nucleosides |
WO1994008456A1 (en) | 1992-10-21 | 1994-04-28 | The Regents Of The University Of Michigan | Polysubstituted benzimidazoles as antiviral agents |
US5399580A (en) | 1993-03-08 | 1995-03-21 | Burroughs Wellcome Co. | Therapeutic nucleosides-uses |
GB9413724D0 (en) | 1994-07-07 | 1994-08-24 | Wellcome Found | Therapeutic nucleosides |
-
1998
- 1998-06-08 WO PCT/EP1998/003380 patent/WO1998056761A2/en not_active Application Discontinuation
- 1998-06-08 SK SK1714-99A patent/SK171499A3/sk unknown
- 1998-06-08 HU HU0002224A patent/HUP0002224A3/hu unknown
- 1998-06-08 DE DE69816992T patent/DE69816992T2/de not_active Expired - Lifetime
- 1998-06-08 AU AU85360/98A patent/AU740792C/en not_active Ceased
- 1998-06-08 JP JP50153899A patent/JP4548866B2/ja not_active Expired - Lifetime
- 1998-06-08 DK DK98936306T patent/DK0994890T3/da active
- 1998-06-08 CA CA002293470A patent/CA2293470C/en not_active Expired - Lifetime
- 1998-06-08 PT PT98936306T patent/PT994890E/pt unknown
- 1998-06-08 EP EP98936306A patent/EP0994890B1/en not_active Expired - Lifetime
- 1998-06-08 IL IL13328598A patent/IL133285A0/xx unknown
- 1998-06-08 MA MA25102A patent/MA26504A1/fr unknown
- 1998-06-08 NZ NZ501415A patent/NZ501415A/en unknown
- 1998-06-08 PL PL98337773A patent/PL337773A1/xx unknown
- 1998-06-08 ES ES98936306T patent/ES2205527T3/es not_active Expired - Lifetime
- 1998-06-08 KR KR1019997011599A patent/KR20010020465A/ko not_active Application Discontinuation
- 1998-06-08 AP APAP/P/1999/001707A patent/AP1262A/en active
- 1998-06-08 BR BR9810745-3A patent/BR9810745A/pt not_active IP Right Cessation
- 1998-06-08 EE EEP199900564A patent/EE9900564A/xx unknown
- 1998-06-08 US US09/424,934 patent/US6455507B1/en not_active Expired - Lifetime
- 1998-06-08 TR TR1999/03053T patent/TR199903053T2/xx unknown
- 1998-06-08 EA EA199901031A patent/EA002305B1/ru not_active IP Right Cessation
- 1998-06-08 CN CN98807910A patent/CN1265665A/zh active Pending
- 1998-06-08 ID IDW20000038A patent/ID24054A/id unknown
- 1998-06-08 AT AT98936306T patent/ATE246700T1/de not_active IP Right Cessation
- 1998-06-09 HR HR980303A patent/HRP980303B1/xx not_active IP Right Cessation
- 1998-06-09 MY MYPI98002560A patent/MY132872A/en unknown
- 1998-06-09 TW TW087109162A patent/TW565566B/zh not_active IP Right Cessation
- 1998-06-09 PE PE1998000488A patent/PE84099A1/es not_active Application Discontinuation
- 1998-06-09 CO CO98032828A patent/CO4970737A1/es unknown
- 1998-06-10 AR ARP980102756A patent/AR012964A1/es not_active Application Discontinuation
-
1999
- 1999-12-06 IS IS5285A patent/IS5285A/is unknown
- 1999-12-09 OA OA9900275A patent/OA11230A/en unknown
- 1999-12-09 NO NO19996086A patent/NO314847B1/no not_active IP Right Cessation
-
2000
- 2000-05-18 HK HK00102973A patent/HK1024921A1/xx not_active IP Right Cessation
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