DK0804481T3 - Somatostatin-derivater og deres radioaktivt mærkede produkter - Google Patents

Somatostatin-derivater og deres radioaktivt mærkede produkter

Info

Publication number
DK0804481T3
DK0804481T3 DK94925686T DK94925686T DK0804481T3 DK 0804481 T3 DK0804481 T3 DK 0804481T3 DK 94925686 T DK94925686 T DK 94925686T DK 94925686 T DK94925686 T DK 94925686T DK 0804481 T3 DK0804481 T3 DK 0804481T3
Authority
DK
Denmark
Prior art keywords
peptides
somatostatin
radiolabeled
radiodiagnostic
methods
Prior art date
Application number
DK94925686T
Other languages
Danish (da)
English (en)
Inventor
William Mcbride
Richard T Dean
Original Assignee
Diatide Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Diatide Inc filed Critical Diatide Inc
Application granted granted Critical
Publication of DK0804481T3 publication Critical patent/DK0804481T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/655Somatostatins
    • C07K14/6555Somatostatins at least 1 amino acid in D-form
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/08Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/083Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins the peptide being octreotide or a somatostatin-receptor-binding peptide
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/08Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00Preparations for use in therapy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00Preparations for testing in vivo
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Organic Chemistry (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Endocrinology (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK94925686T 1993-07-21 1994-07-21 Somatostatin-derivater og deres radioaktivt mærkede produkter DK0804481T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/095,760 US5620675A (en) 1992-06-23 1993-07-21 Radioactive peptides
PCT/US1994/008335 WO1995003330A1 (en) 1993-07-21 1994-07-21 Somatostatin derivatives and their radiolabelled products

Publications (1)

Publication Number Publication Date
DK0804481T3 true DK0804481T3 (da) 2003-07-28

Family

ID=22253472

Family Applications (1)

Application Number Title Priority Date Filing Date
DK94925686T DK0804481T3 (da) 1993-07-21 1994-07-21 Somatostatin-derivater og deres radioaktivt mærkede produkter

Country Status (11)

Country Link
US (2) US5620675A (de)
EP (1) EP0804481B1 (de)
JP (1) JP3601827B2 (de)
AT (1) ATE237637T1 (de)
AU (1) AU684823B2 (de)
CA (1) CA2167678C (de)
DE (1) DE69432530T2 (de)
DK (1) DK0804481T3 (de)
ES (1) ES2197169T3 (de)
WO (1) WO1995003330A1 (de)
ZA (1) ZA945367B (de)

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5443816A (en) * 1990-08-08 1995-08-22 Rhomed Incorporated Peptide-metal ion pharmaceutical preparation and method
US5985240A (en) * 1989-08-09 1999-11-16 Rhomed Incorporated Peptide radiopharmaceutical applications
US7238340B1 (en) * 1991-11-27 2007-07-03 Cis Bio International Monoamine, diamide, thiol-containing metal chelating agents
US5849261A (en) * 1991-02-08 1998-12-15 Diatide, Inc. Radiolabeled vasoactive intestinal peptides for diagnosis and therapy
US5443815A (en) * 1991-11-27 1995-08-22 Diatech, Inc. Technetium-99m labeled peptides for imaging
US5997844A (en) * 1991-02-08 1999-12-07 Diatide, Inc. Technetium-99m labeled peptides for imaging
US5965107A (en) * 1992-03-13 1999-10-12 Diatide, Inc. Technetium-99m labeled peptides for imaging
US5783170A (en) * 1991-11-27 1998-07-21 Diatide, Inc. Peptide-metal chelate conjugates
US5508020A (en) * 1992-06-05 1996-04-16 Diatech, Inc. Technetium-99M labeled peptides for imaging
US5716596A (en) * 1992-06-23 1998-02-10 Diatide, Inc. Radioactively labeled somatostatin-derived peptides for imaging and therapeutic uses
US6017512A (en) * 1992-06-23 2000-01-25 Diatide, Inc. Radiolabeled peptides
US5620675A (en) * 1992-06-23 1997-04-15 Diatech, Inc. Radioactive peptides
US5932189A (en) * 1994-07-29 1999-08-03 Diatech, Inc. Cyclic peptide somatostatin analogs
AU707040B2 (en) * 1993-06-23 1999-07-01 Cis Bio International Monoamine, diamide, thiol-containing metal chelating agents
DE69529988T2 (de) * 1994-05-02 2003-12-11 Diatide Inc Technetium-99m markierte bildformungsmittel
US5891418A (en) * 1995-06-07 1999-04-06 Rhomed Incorporated Peptide-metal ion pharmaceutical constructs and applications
CA2247430A1 (en) * 1996-02-27 1997-09-04 Mallinckrodt Medical, Inc. Use of labelled cck-b receptor ligands for the detection and localization of malignant human tumors
US6331285B1 (en) 1996-06-05 2001-12-18 Palatin Technologies, Inc. Structurally determined cyclic metallo-constructs and applications
US6355613B1 (en) 1996-07-31 2002-03-12 Peptor Limited Conformationally constrained backbone cyclized somatostatin analogs
FI965181A (fi) * 1996-12-20 1998-06-21 Map Medical Technologies Oy Polyalkoholi-peptidijohdannaiset
CA2320339A1 (en) * 1998-02-11 1999-08-19 Resolution Pharmaceuticals Inc. Angiogenesis targeting molecules
US6465613B1 (en) 1998-11-19 2002-10-15 Tulane University Hydrophilic somatostatin analogs
US6314314B1 (en) 1999-01-14 2001-11-06 Seth J. Karp Method for locating an internal bleeding site in a human body
US20020102208A1 (en) 1999-03-01 2002-08-01 Paul Chinn Radiolabeling kit and binding assay
MY133346A (en) * 1999-03-01 2007-11-30 Biogen Inc Kit for radiolabeling ligands with yttrium-90
US7067111B1 (en) * 1999-10-25 2006-06-27 Board Of Regents, University Of Texas System Ethylenedicysteine (EC)-drug conjugates, compositions and methods for tissue specific disease imaging
GB0018891D0 (en) 2000-08-01 2000-09-20 Novartis Ag Organic compounds
EP1286704B1 (de) 2000-06-02 2014-07-23 Board of Regents, The University of Texas System ETHYLENEDICYSTEINE (EC)-Glucose Analoge KONJUGATE
US7385025B2 (en) 2000-12-19 2008-06-10 Palatin Technologies, Inc. Metallopeptide compounds
EP1283216A1 (de) * 2001-08-10 2003-02-12 Mallinckrodt Inc. Alle somatostatinrezeptorsubtypen-bindende Somatostatinanaloge und deren Verwendung
EP1435826A4 (de) 2001-09-21 2009-07-15 Univ Tulane Diagnostische oder therapeutische somatostatin- oder bombesin-analoge konjugate und ihre verwendung
WO2003061559A2 (en) * 2001-10-12 2003-07-31 University Of Vermont And State Agricultural College Binding peptides specific for the extracellular domain of erbb2 and uses therefor
AU2002359359A1 (en) * 2001-12-28 2003-07-24 Somatocor Pharmaceuticals, Inc. Imidazolidin-2,4-dione derivatives as non-peptide somatostatin receptor ligands
EP1487493B1 (de) * 2002-03-01 2010-01-20 The Administrators of The Tulane Educational Fund Konjugate von zytotoxischen mitteln und biologisch aktiven peptiden
EP1369134A1 (de) * 2002-06-05 2003-12-10 Bracco Imaging S.p.A. Mittel fur magnetisches Bildformungsverfahren
IL150384A0 (en) * 2002-06-24 2002-12-01 Peptor Ltd Radiolabelled somatostatin analogs backbone cyclized through metal complexation
US7709613B2 (en) * 2002-11-18 2010-05-04 Albert Einstein College Of Medicine Of Yeshiva University Rhenium-188 and rhenium-186 for treatment of tumors expressing a Na+/I− symporter
CA2518406A1 (en) * 2003-03-10 2004-09-23 Biogen Idec Ma Inc. Thiol-mediated drug attachment to targeting peptides
WO2005018682A2 (en) 2003-08-20 2005-03-03 The Regents Of The University Of California Somatostatin analogs with inhibitory activity to growth hormone release
US9050378B2 (en) * 2003-12-10 2015-06-09 Board Of Regents, The University Of Texas System N2S2 chelate-targeting ligand conjugates
WO2005123144A2 (en) * 2004-01-20 2005-12-29 Board Of Regents, The University Of Texas System System and method for an automated synthesis of gallium-68 generator-based radiopharmaceutical agents
US20060024229A1 (en) * 2004-07-29 2006-02-02 Seth Karp Method and product for locating an internal bleeding site
GB0421308D0 (en) * 2004-09-24 2004-10-27 Amersham Plc Enzyme inhibitor imaging agents
FR2876033B1 (fr) * 2004-10-01 2008-12-05 Inst Nat Sante Rech Med Utilisation de ligands de vcam-1 pour la detection et/ou le traitement de maladies cardiovasculaires
US7833513B2 (en) 2004-12-03 2010-11-16 Rhode Island Hospital Treatment of Alzheimer's Disease
US8758723B2 (en) 2006-04-19 2014-06-24 The Board Of Regents Of The University Of Texas System Compositions and methods for cellular imaging and therapy
ES2399147T3 (es) 2006-09-08 2013-03-26 Rhode Island Hospital Tratamiento, prevención y reversión de una enfermedad hepática alcohólica
JP2010502719A (ja) 2006-09-08 2010-01-28 ロード アイランド ホスピタル アルコール誘発性脳疾患の治療、予防および回復
US10925977B2 (en) 2006-10-05 2021-02-23 Ceil>Point, LLC Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
US20080167544A1 (en) * 2006-12-01 2008-07-10 Cold Spring Diagnostics, Inc. Compositions And Methods For Locating An Internal Bleeding Site
WO2012159107A1 (en) 2011-05-19 2012-11-22 Rhode Island Hospital Inhibition of renal fibrosis
EP4321165A2 (de) 2013-12-27 2024-02-14 National University Corporation Tokyo Medical and Dental University Verfahren zur diagnose von morbus alzheimer und frontotemporaler lobardegeneration, diagnosemittel, therapeutikum und screening-verfahren für diese mittel

Family Cites Families (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7607987A (nl) 1975-08-08 1977-02-10 Merck & Co Inc Werkwijze voor het bereiden van peptiden.
CA1083143A (en) 1976-01-02 1980-08-05 Nedumparambil A. Abraham Carba derivatives of somatostatin and process therefor
CA1107273A (en) 1978-05-19 1981-08-18 Chester A. Meyers Somatostatin analogs having a substituted tryptophyl residue in position eight
NZ195303A (en) 1979-10-31 1984-10-19 Merck & Co Inc Cyclic hexapeptide somatostatin analogues,and pharmaceutical compositions
US4235886A (en) * 1979-10-31 1980-11-25 Merck & Co., Inc. Cyclic hexapeptide somatostatin analogs
US4444690A (en) * 1982-02-25 1984-04-24 University Patents, Inc. Technetium chelates
US4472509A (en) * 1982-06-07 1984-09-18 Gansow Otto A Metal chelate conjugated monoclonal antibodies
EP0113029B1 (de) * 1982-12-06 1989-04-19 Merck & Co. Inc. Dicyclische Hexapeptiden, deren Verfahren zur Herstellung und sie enthaltende pharmazeutische Zusammensetzungen
US4485101A (en) * 1983-10-11 1984-11-27 Administrators Of The Tulane Educational Fund Peptides
US4608251A (en) * 1984-11-09 1986-08-26 Pitman-Moore, Inc. LHRH analogues useful in stimulating anti-LHRH antibodies and vaccines containing such analogues
HUT42101A (en) * 1985-01-07 1987-06-29 Sandoz Ag Process for preparing stomatostatine derivatives and pharmaceutical compositions containing such compounds
US5077195A (en) * 1985-03-01 1991-12-31 Board Of Reagents, The University Of Texas System Polypeptides complementary to peptides or proteins having an amino acid sequence or nucleotide coding sequence at least partially known and methods of design therefor
US4650787A (en) 1985-04-25 1987-03-17 Schally Andrew Victor Biologically active octapeptides
US4725577A (en) 1985-04-25 1988-02-16 Administrators Of The Tulane Educational Fund Biologically active lysine containing octapeptides
US4611054A (en) * 1985-04-29 1986-09-09 Merck & Co., Inc. Cyclic hexapeptide somatostatin analogs
US4612366A (en) * 1985-06-17 1986-09-16 Merck & Co., Inc. Cyclic hexapeptide somatostatin analogs
US4904642A (en) * 1985-09-12 1990-02-27 The Administrators Of The Tulane Educational Fund Therapeutic somatostatin analogs
US4877868A (en) * 1986-03-12 1989-10-31 Neorx Corporation Radionuclide antibody coupling
US4853371A (en) * 1986-06-17 1989-08-01 The Administrators Of The Tulane Educational Fund Therapeutic somatostatin analogs
US4871717A (en) * 1987-01-07 1989-10-03 Administrators Of The Tulane Educational Fund Peptides
DE3850497T2 (de) 1987-04-02 1995-02-23 Centocor Inc Methode zur markierung von antikörpern mit einem metallion.
US5073541A (en) * 1987-11-18 1991-12-17 Administrators Of The Tulane Educational Fund Treatment of small cell lung cancer with somatostatin analogs
EP0381713B1 (de) 1988-04-29 1994-01-19 Mallinckrodt, Inc. Diaminedithiol-chelatierungsmittel für radioarzneimittel
US5084442A (en) * 1988-09-06 1992-01-28 Hoffmann-La Roche Inc. Cyclic growth hormone releasing factor analogs and method for the manufacture thereof
MY106120A (en) 1988-12-05 1995-03-31 Novartis Ag Peptide derivatives.
GB9111199D0 (en) * 1991-05-23 1991-07-17 Sandoz Ltd Improvements in or relating to organic compounds
US4971477A (en) 1988-12-22 1990-11-20 Total Containment, Inc. Secondary contained fluid supply system
US5196510A (en) * 1988-12-29 1993-03-23 Cytogen Corporation Molecular recognition units
CA2012115C (en) * 1989-03-15 2001-07-03 Biomeasure, Inc. Iodinated somatostatins
US5095111A (en) 1989-03-17 1992-03-10 The John Hopkins University Thiolactone bifunctional chelating agents for diagnostic and therapeutic products
JP2882679B2 (ja) * 1989-04-26 1999-04-12 ジ・アドミニストレーターズ・オブ・ザ・ツーレイン・エデュケイショナル・ファンド 線状ソマトスタチン類似体
ATE120374T1 (de) 1989-07-20 1995-04-15 Sandoz Ag Markierte polypeptidderivate.
US5443816A (en) 1990-08-08 1995-08-22 Rhomed Incorporated Peptide-metal ion pharmaceutical preparation and method
IL97459A0 (en) 1990-03-09 1992-06-21 Hybritech Inc Trifunctional antibody-like compounds as a combined diagnostic and therapeutic agent
TW212184B (de) * 1990-04-02 1993-09-01 Takeda Pharm Industry Co Ltd
US5178025A (en) 1990-08-31 1993-01-12 Innovative Medical Engineering, Inc. Tiltable lift seat devices
ES2141102T3 (es) 1991-02-08 2000-03-16 Diatide Inc Polipeptidos marcados con tecnecio-99m para la generacion de imagenes.
US5443815A (en) * 1991-11-27 1995-08-22 Diatech, Inc. Technetium-99m labeled peptides for imaging
US5552525A (en) 1991-02-08 1996-09-03 Diatech Inc. Technetium-99m labeled peptides for imaging inflammation
ATE181240T1 (de) 1991-02-08 1999-07-15 Biomeasure Inc Verwendung von somatostatinanalogen zur behandlung von melanomen
US5965107A (en) 1992-03-13 1999-10-12 Diatide, Inc. Technetium-99m labeled peptides for imaging
US5561220A (en) 1991-02-08 1996-10-01 Diatech, Inc. Technetium-99m labeled peptides for imaging inflammation
AU664855B2 (en) 1991-08-09 1995-12-07 Winfried Kolbeck Lanthionine bridged peptides
US5225180A (en) * 1991-09-10 1993-07-06 Diatech, Inc. Technetium-99m labeled somatostatin-derived peptides for imaging
DE69231586T2 (de) 1992-01-03 2001-07-19 Rhomed Inc Pharmazeutische anwendungen auf der basis von peptid-metall-ionen
CA2129033A1 (en) 1992-02-05 1993-08-19 Leon Lyle Radiolabelled peptide compounds
AU683015B2 (en) 1992-03-13 1997-10-30 Diatech, Inc. Technetium-99m labeled peptides for imaging inflammation
US5508020A (en) 1992-06-05 1996-04-16 Diatech, Inc. Technetium-99M labeled peptides for imaging
DK0641222T3 (da) 1992-05-21 2000-12-11 Diatide Inc Peptider mærket med technetium-99m til trombeafbildning
US5620675A (en) * 1992-06-23 1997-04-15 Diatech, Inc. Radioactive peptides
US5716596A (en) 1992-06-23 1998-02-10 Diatide, Inc. Radioactively labeled somatostatin-derived peptides for imaging and therapeutic uses
US5871711A (en) * 1992-06-23 1999-02-16 Diatide, Inc. Radioactively-labeled somatostatin-derived peptides for imaging and therapeutic uses
DE69332203T2 (de) 1992-10-02 2003-05-28 Diatide Inc Multimerische mehrzweckwirkstoffe gegen thrombose
DE69426673T2 (de) 1993-06-23 2001-09-20 Diatide Inc Radiomarkierte somatostatin derivate zur abbildung und zur therapeutischen verwendung

Also Published As

Publication number Publication date
ZA945367B (en) 1995-04-05
JP3601827B2 (ja) 2004-12-15
WO1995003330A1 (en) 1995-02-02
ES2197169T3 (es) 2004-01-01
AU684823B2 (en) 1998-01-08
DE69432530D1 (de) 2003-05-22
CA2167678A1 (en) 1995-02-02
DE69432530T2 (de) 2004-04-08
EP0804481B1 (de) 2003-04-16
US6241965B1 (en) 2001-06-05
AU7550694A (en) 1995-02-20
EP0804481A1 (de) 1997-11-05
ATE237637T1 (de) 2003-05-15
CA2167678C (en) 2002-07-02
US5620675A (en) 1997-04-15
JPH09501419A (ja) 1997-02-10

Similar Documents

Publication Publication Date Title
DK0804481T3 (da) Somatostatin-derivater og deres radioaktivt mærkede produkter
DK0614379T3 (da) Technetium-99m-mærkede peptider til imagografi
DK0720621T3 (da) Radiomærkede somatostation-afledte peptider til billeddannende og terapeutiske anvendelser
MX9707426A (es) Peptidos marcados radioactivamente para diagnostico y terapia.
DK0649434T3 (da) Radioaktivt mærkede somatostatin-afledte peptider til billeddannende og terapeutiske anvendelser
ATE237365T1 (de) Technetium-99-markierte peptide zur visualisierung vom entzuendungen
ZA956254B (en) Peptides
CA2347670A1 (en) Radiolabeled somatostatin-derived peptides for imaging
US5993775A (en) Radioactively labeled peptides comprising a single thiol moiety