DK0797575T3 - Imidazolderivater som proteinkinase-inhibitorer, især EGF-R-tyrosinkinase - Google Patents

Imidazolderivater som proteinkinase-inhibitorer, især EGF-R-tyrosinkinase

Info

Publication number
DK0797575T3
DK0797575T3 DK95941646T DK95941646T DK0797575T3 DK 0797575 T3 DK0797575 T3 DK 0797575T3 DK 95941646 T DK95941646 T DK 95941646T DK 95941646 T DK95941646 T DK 95941646T DK 0797575 T3 DK0797575 T3 DK 0797575T3
Authority
DK
Denmark
Prior art keywords
imidazole derivatives
protein kinase
tyrosine kinase
kinase inhibitors
especially egf
Prior art date
Application number
DK95941646T
Other languages
English (en)
Inventor
Charles Stanford Harmon
Markus Kamber
Anna Krasso
Wolfang Pirson
Pierre-Charles Wyss
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of DK0797575T3 publication Critical patent/DK0797575T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
DK95941646T 1994-12-13 1995-12-01 Imidazolderivater som proteinkinase-inhibitorer, især EGF-R-tyrosinkinase DK0797575T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH376894 1994-12-13
PCT/EP1995/004741 WO1996018626A1 (en) 1994-12-13 1995-12-01 Imidazole derivatives as protein kinase inhibitors in particular egf-r tyrosine kinase

Publications (1)

Publication Number Publication Date
DK0797575T3 true DK0797575T3 (da) 2004-02-16

Family

ID=4263074

Family Applications (1)

Application Number Title Priority Date Filing Date
DK95941646T DK0797575T3 (da) 1994-12-13 1995-12-01 Imidazolderivater som proteinkinase-inhibitorer, især EGF-R-tyrosinkinase

Country Status (16)

Country Link
US (1) US5959113A (da)
EP (1) EP0797575B1 (da)
JP (1) JPH10510281A (da)
CN (1) CN1145623C (da)
AR (1) AR003406A1 (da)
AT (1) ATE252094T1 (da)
AU (1) AU4301096A (da)
BR (1) BR9509998A (da)
CA (1) CA2207404C (da)
DE (1) DE69531956T2 (da)
DK (1) DK0797575T3 (da)
ES (1) ES2208698T3 (da)
FI (1) FI972492A0 (da)
PT (1) PT797575E (da)
TR (1) TR199501561A2 (da)
WO (1) WO1996018626A1 (da)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6083949A (en) * 1995-10-06 2000-07-04 Merck & Co., Inc. Substituted imidazoles having anti-cancer and cytokine inhibitory activity
AU728760B2 (en) * 1996-11-20 2001-01-18 Merck & Co., Inc. Triaryl substituted imidazoles, compositions containing such compounds and methods of use
WO1998022109A1 (en) * 1996-11-20 1998-05-28 Merck & Co., Inc. Triaryl substituted imidazoles as glucagon antagonists
US5880139A (en) * 1996-11-20 1999-03-09 Merck & Co., Inc. Triaryl substituted imidazoles as glucagon antagonists
US6022884A (en) 1997-11-07 2000-02-08 Amgen Inc. Substituted pyridine compounds and methods of use
AU4506399A (en) * 1998-06-05 1999-12-30 Novartis Ag Aryl pyridinyl thiazoles
AU4395399A (en) * 1998-07-02 2000-01-24 Sankyo Company Limited Five-membered heteroaryl compounds
JP3850596B2 (ja) 1999-02-25 2006-11-29 本州化学工業株式会社 新規な部分保護トリスフェノール類とその製造方法
WO2003024447A1 (en) * 2001-09-20 2003-03-27 Smithkline Beecham Corporation Inhibitors of glycogen synthase kinase-3
US6790852B2 (en) * 2002-04-18 2004-09-14 Hoffmann-La Roche Inc. 2-(2,6-dichlorophenyl)-diarylimidazoles
ES2497116T3 (es) 2002-08-19 2014-09-22 Lorus Therapeutics Inc. Imidazoles 2,4,5-trisustituidos y su uso como agentes antimicrobianos
CN100436450C (zh) * 2003-10-16 2008-11-26 霍夫曼-拉罗奇有限公司 三芳基咪唑
US7144889B2 (en) 2003-10-16 2006-12-05 Hoffman-La Roche Inc. Triarylimidazoles
US7169781B2 (en) * 2003-10-17 2007-01-30 Hoffmann-La Roche Inc. Imidazole derivatives and their use as pharmaceutical agents
AU2004289539C1 (en) 2003-11-14 2012-06-07 Lorus Therapeutics Inc. Aryl imidazoles and their use as anti-cancer agents
KR100905678B1 (ko) * 2005-02-18 2009-07-03 도쿠리쓰교세이호징 가가쿠 기주쓰 신코 기코 광학 활성 에폭시 화합물의 제조 방법, 및 상기 방법에사용하기 위한 착체 및 그의 제조 방법
US8148392B2 (en) 2005-05-25 2012-04-03 Lorus Therapeutics Inc. 2-indolyl imidazo [4,5-d] phenanthroline derivatives and their use in the treatment of cancer
JP5283872B2 (ja) * 2006-09-27 2013-09-04 シスメックス株式会社 腫瘍細胞に対する阻害剤の増殖抑制効果を評価する方法、及び腫瘍細胞の増殖を阻害する化合物をスクリーニングする方法
WO2008042216A2 (en) * 2006-09-28 2008-04-10 Follica, Inc. Methods, kits, and compositions for generating new hair follicles and growing hair
JP2016516082A (ja) 2013-03-20 2016-06-02 アプトース バイオサイエンシーズ， インコーポレイテッド ２−置換イミダゾ［４，５−ｄ］フェナントロリン誘導体及び癌の治療におけるそれらの使用
DK3052102T3 (da) 2013-10-04 2020-03-09 Aptose Biosciences Inc Sammensætninger til behandling af cancere
US9394236B2 (en) 2014-02-03 2016-07-19 Quadriga Biosciences, Inc. β-substituted γ-amino acids and analogs as chemotherapeutic agents
SG10201710436WA (en) 2014-02-03 2018-01-30 Quadriga Biosciences Inc Beta-substituted beta-amino acids and analogs as chemotherapeutic agents
ES2926931T3 (es) * 2014-02-07 2022-10-31 Agency Science Tech & Res Inhibidores de caseína quinasa 1 basados en azoles 2,4,5-tri-sustituidos como inductores de la cardiomiogénesis
TWI665178B (zh) 2015-08-03 2019-07-11 夸德里加生物科學公司 作為化療劑的β－取代的β－氨基酸和類似物及其應用
CN109212045A (zh) * 2017-07-04 2019-01-15 万全万特制药（厦门）有限公司 草酸艾司西酞普兰残留溶剂和杂质的分离测定方法
KR20200096914A (ko) 2017-10-30 2020-08-14 압토스 바이오사이언시스 인코포레이티드 암 치료용 아릴 이미다졸
CN114262298B (zh) * 2021-12-03 2023-09-26 郑州轻工业大学 2-溴-4-n,n-二甲氨基咪唑及其制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3707475A (en) * 1970-11-16 1972-12-26 Pfizer Antiinflammatory imidazoles
US3940486A (en) * 1971-05-10 1976-02-24 Ciba-Geigy Corporation Imidazole derivatives in the treatment of pain
CH561716A5 (da) * 1971-05-10 1975-05-15 Ciba Geigy Ag
MC2096A1 (fr) * 1989-02-23 1991-02-15 Hoffmann La Roche Pyrroles substitues
EP0624159B1 (en) * 1992-01-13 1998-11-25 Smithkline Beecham Corporation Pyridyl substituted imidazoles
MX9300141A (es) * 1992-01-13 1994-07-29 Smithkline Beecham Corp Compuestos de imidazol novedosos, procedimiento para su preparacion y composiciones farmaceuticas que lo contienen.
HUT71553A (en) * 1992-08-06 1995-12-28 Warner Lambert Co 2-thioindoles (selenoindoles) and related disulfides (selenides) which inhibit protein tyrosine kinases and which have antitumor properties
WO1995003297A1 (en) * 1993-07-21 1995-02-02 Smithkline Beecham Corporation Imidazoles for treating cytokine mediated disease
NZ274063A (en) * 1993-09-17 1997-11-24 Smithkline Beecham Corp Cytokine suppressive anti-inflammatory drug binding protein (csbp) and its use

Also Published As

Publication number Publication date
CN1175252A (zh) 1998-03-04
DE69531956T2 (de) 2004-07-29
FI972492A (fi) 1997-06-12
JPH10510281A (ja) 1998-10-06
CN1145623C (zh) 2004-04-14
AU4301096A (en) 1996-07-03
FI972492A0 (fi) 1997-06-12
EP0797575A1 (en) 1997-10-01
ES2208698T3 (es) 2004-06-16
CA2207404C (en) 2004-06-29
BR9509998A (pt) 1997-12-30
US5959113A (en) 1999-09-28
CA2207404A1 (en) 1996-06-20
WO1996018626A1 (en) 1996-06-20
DE69531956D1 (de) 2003-11-20
ATE252094T1 (de) 2003-11-15
AR003406A1 (es) 1998-08-05
PT797575E (pt) 2004-02-27
EP0797575B1 (en) 2003-10-15
MX9704263A (es) 1997-09-30
TR199501561A2 (tr) 1996-07-21

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