DK0789580T3 - Nye præparatformer for cyclosporin til oral administration med simpel sammensætning og høj biotilgængelighed, og fremgangsmåder til deres fremstilling - Google Patents

Nye præparatformer for cyclosporin til oral administration med simpel sammensætning og høj biotilgængelighed, og fremgangsmåder til deres fremstilling

Info

Publication number
DK0789580T3
DK0789580T3 DK95925707T DK95925707T DK0789580T3 DK 0789580 T3 DK0789580 T3 DK 0789580T3 DK 95925707 T DK95925707 T DK 95925707T DK 95925707 T DK95925707 T DK 95925707T DK 0789580 T3 DK0789580 T3 DK 0789580T3
Authority
DK
Denmark
Prior art keywords
cyclosporin
weight
oral administration
high bioavailability
preparation
Prior art date
Application number
DK95925707T
Other languages
Danish (da)
English (en)
Inventor
Matthias Olbrich
Heinrich Poetter
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Application granted granted Critical
Publication of DK0789580T3 publication Critical patent/DK0789580T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Transplantation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Peptides Or Proteins (AREA)
DK95925707T 1994-11-03 1995-07-19 Nye præparatformer for cyclosporin til oral administration med simpel sammensætning og høj biotilgængelighed, og fremgangsmåder til deres fremstilling DK0789580T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4438861 1994-11-03
PCT/DE1995/000951 WO1996014079A1 (de) 1994-11-03 1995-07-19 Neue zubereitungsformen des cyclosporins zur oralen applikation mit einfacher zusammensetzung und hoher bioverfügbarkeit und verfahren zu deren herstellung

Publications (1)

Publication Number Publication Date
DK0789580T3 true DK0789580T3 (da) 2002-09-09

Family

ID=6532126

Family Applications (1)

Application Number Title Priority Date Filing Date
DK95925707T DK0789580T3 (da) 1994-11-03 1995-07-19 Nye præparatformer for cyclosporin til oral administration med simpel sammensætning og høj biotilgængelighed, og fremgangsmåder til deres fremstilling

Country Status (27)

Country Link
US (1) US6486124B2 (ru)
EP (1) EP0789580B1 (ru)
JP (1) JP3833248B2 (ru)
KR (1) KR970704464A (ru)
CN (1) CN1121238C (ru)
AT (1) ATE218359T1 (ru)
AU (1) AU715165B2 (ru)
BG (1) BG62955B1 (ru)
BR (1) BR9509550A (ru)
CA (1) CA2231404C (ru)
CZ (1) CZ287806B6 (ru)
DE (2) DE59510233D1 (ru)
DK (1) DK0789580T3 (ru)
EE (1) EE03425B1 (ru)
ES (1) ES2177652T3 (ru)
FI (1) FI118722B (ru)
HU (1) HUT77283A (ru)
LT (1) LT4306B (ru)
LV (1) LV11884B (ru)
NO (1) NO970741D0 (ru)
PL (1) PL183579B1 (ru)
PT (1) PT789580E (ru)
RU (1) RU2158601C2 (ru)
SK (1) SK164796A3 (ru)
TR (1) TR199501361A2 (ru)
TW (1) TW492876B (ru)
WO (1) WO1996014079A1 (ru)

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US20050059583A1 (en) * 2003-09-15 2005-03-17 Allergan, Inc. Methods of providing therapeutic effects using cyclosporin components
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US9839667B2 (en) 2005-10-14 2017-12-12 Allergan, Inc. Prevention and treatment of ocular side effects with a cyclosporin
US7745400B2 (en) * 2005-10-14 2010-06-29 Gregg Feinerman Prevention and treatment of ocular side effects with a cyclosporin
BR112014011770B1 (pt) * 2011-11-15 2022-11-08 Allergan, Inc Suspensões da forma 2 de ciclosporina a
US8796221B2 (en) * 2011-11-15 2014-08-05 Allergan, Inc. Cyclosporin A form 2 and method of making same

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Also Published As

Publication number Publication date
JP3833248B2 (ja) 2006-10-11
FI970634A (fi) 1997-02-14
EP0789580B1 (de) 2002-06-05
EE9700112A (et) 1997-12-15
CA2231404A1 (en) 1996-05-17
WO1996014079A1 (de) 1996-05-17
JPH10508306A (ja) 1998-08-18
AU715165B2 (en) 2000-01-20
EP0789580A1 (de) 1997-08-20
ATE218359T1 (de) 2002-06-15
DE19539860A1 (de) 1996-05-09
US20020025927A1 (en) 2002-02-28
RU2158601C2 (ru) 2000-11-10
TR199501361A2 (tr) 1996-06-21
BR9509550A (pt) 1997-09-16
PL183579B1 (pl) 2002-06-28
BG101117A (en) 1997-08-29
FI970634A0 (fi) 1997-02-14
US6486124B2 (en) 2002-11-26
BG62955B1 (bg) 2000-12-29
CZ287806B6 (en) 2001-02-14
AU2975195A (en) 1996-05-31
CN1121238C (zh) 2003-09-17
PT789580E (pt) 2002-09-30
LV11884A (lv) 1997-12-20
CN1162265A (zh) 1997-10-15
KR970704464A (ko) 1997-09-06
LV11884B (lv) 1998-03-20
EE03425B1 (et) 2001-06-15
CA2231404C (en) 2009-02-17
LT97002A (en) 1997-11-25
CZ361696A3 (en) 1997-07-16
HUT77283A (hu) 1998-03-30
FI118722B (fi) 2008-02-29
SK164796A3 (en) 1997-06-04
DE59510233D1 (de) 2002-07-11
NO970741L (no) 1997-02-18
PL318560A1 (en) 1997-06-23
LT4306B (lt) 1998-03-25
ES2177652T3 (es) 2002-12-16
TW492876B (en) 2002-07-01
NO970741D0 (no) 1997-02-18

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