GB2206119B - A new cyclosporin derivative with modified "8-amino acid" - Google Patents

A new cyclosporin derivative with modified "8-amino acid"

Info

Publication number
GB2206119B
GB2206119B GB8814598A GB8814598A GB2206119B GB 2206119 B GB2206119 B GB 2206119B GB 8814598 A GB8814598 A GB 8814598A GB 8814598 A GB8814598 A GB 8814598A GB 2206119 B GB2206119 B GB 2206119B
Authority
GB
United Kingdom
Prior art keywords
modified
amino acid
cyclosporin derivative
new cyclosporin
new
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
GB8814598A
Other versions
GB2206119A (en
GB8814598D0 (en
Inventor
Arthur A Patchett
Raymond F White
Robert T Goegelman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of GB8814598D0 publication Critical patent/GB8814598D0/en
Publication of GB2206119A publication Critical patent/GB2206119A/en
Application granted granted Critical
Publication of GB2206119B publication Critical patent/GB2206119B/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
GB8814598A 1987-06-22 1988-06-20 A new cyclosporin derivative with modified "8-amino acid" Expired - Fee Related GB2206119B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US6467487A 1987-06-22 1987-06-22

Publications (3)

Publication Number Publication Date
GB8814598D0 GB8814598D0 (en) 1988-07-27
GB2206119A GB2206119A (en) 1988-12-29
GB2206119B true GB2206119B (en) 1990-10-31

Family

ID=22057543

Family Applications (1)

Application Number Title Priority Date Filing Date
GB8814598A Expired - Fee Related GB2206119B (en) 1987-06-22 1988-06-20 A new cyclosporin derivative with modified "8-amino acid"

Country Status (2)

Country Link
CA (1) CA1338319C (en)
GB (1) GB2206119B (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7696165B2 (en) 2006-03-28 2010-04-13 Albany Molecular Research, Inc. Use of cyclosporin alkyne analogues for preventing or treating viral-induced disorders
US7696166B2 (en) 2006-03-28 2010-04-13 Albany Molecular Research, Inc. Use of cyclosporin alkyne/alkene analogues for preventing or treating viral-induced disorders
US7732404B2 (en) 1999-12-30 2010-06-08 Dexcel Ltd Pro-nanodispersion for the delivery of cyclosporin

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3888357T2 (en) * 1987-06-22 1994-09-15 Merck & Co Inc Cyclosporin derivatives that carry a modified amino acid at position 8.
CH679119A5 (en) * 1988-05-13 1991-12-31 Sandoz Ag
US6007840A (en) * 1988-09-16 1999-12-28 Novartis Ag Pharmaceutical compositions comprising cyclosporins
KR0148748B1 (en) * 1988-09-16 1998-08-17 장 크라메르, 한스 루돌프 하우스 A multiphase cyclosporin composition
GB2227244A (en) * 1989-01-19 1990-07-25 Merck & Co Inc Immunosuppressive fluorinated cyclosporin analogs
GB8916901D0 (en) 1989-07-24 1989-09-06 Sandoz Ltd Improvements in or relating to organic compounds
US5122511A (en) * 1990-02-27 1992-06-16 Merck & Co., Inc. Immunosuppressive cyclosporin analogs with modified amino acids at position-8
US5214130A (en) * 1990-02-27 1993-05-25 Merck & Co., Inc. Synthesis of novel immunosuppressive cyclosporin analogs with modified amino acids at position-8
US6262022B1 (en) 1992-06-25 2001-07-17 Novartis Ag Pharmaceutical compositions containing cyclosporin as the active agent
EP0642332B1 (en) 1992-05-13 1997-01-15 Sandoz Ltd. Ophthalmic compositions containing a cyclosporin
ES2168271T3 (en) 1992-09-25 2002-06-16 Novartis Ag PHARMACEUTICAL COMPOSITIONS CONTAINING CYCLOSPORINS.
WO1994025606A2 (en) * 1993-04-23 1994-11-10 Sandoz Ltd. Recombinant alanine racemase and gapdh from tolypocladium
JP3833248B2 (en) 1994-11-03 2006-10-11 ノバルティス・アクチエンゲゼルシャフト Novel formulation of cyclosporine for oral administration with simple composition and high bioavailability and process for its production
DE19544507B4 (en) 1995-11-29 2007-11-15 Novartis Ag Cyclosporin containing preparations
KR20040004416A (en) 1997-01-30 2004-01-13 노파르티스 아게 Oil-Free Pharmaceutical Compositions Containing Cyclosporin A
PL210795B1 (en) 2001-10-19 2012-03-30 Isotechnika Inc The method of producing the ISATX247 enriched isomer (E), the method of producing the ISATX247 enriched mixture of the (Z) isomer, the method of stereoselective synthesis of the (E) ISATX247 isomer, the method of stereoselective synthesis of the (Z) isomer ISATX247 and the method of producing the mixture of ISATX247 isomers
US11311477B2 (en) 2006-03-07 2022-04-26 Sgn Nanopharma Inc. Ophthalmic preparations
US10137083B2 (en) 2006-03-07 2018-11-27 SGN Nanopharma Inc Ophthalmic preparations
WO2008069917A2 (en) 2006-11-20 2008-06-12 Scynexis, Inc. Novel cyclic peptides
BRPI1007476A2 (en) 2009-01-30 2016-02-16 Enanta Pharm Inc cyclosporine analogues to prevent or treat hepatitis C infection
US8481483B2 (en) 2009-02-19 2013-07-09 Enanta Pharmaceuticals, Inc. Cyclosporin analogues
US8685917B2 (en) 2009-07-09 2014-04-01 Enanta Pharmaceuticals, Inc. Cyclosporin analogues
US8349312B2 (en) 2009-07-09 2013-01-08 Enanta Pharmaceuticals, Inc. Proline substituted cyclosporin analogues
US8367053B2 (en) 2009-07-09 2013-02-05 Enanta Pharmaceuticals, Inc. Cyclosporin analogues
US8623814B2 (en) 2010-02-23 2014-01-07 Enanta Pharmaceuticals, Inc. Antiviral agents
WO2012145426A1 (en) 2011-04-18 2012-10-26 The Trustees Of Columbia University In The City Of New York Methods to treat cancer using cyclosporine and cyclosporine derivatives
WO2014085623A1 (en) 2012-11-28 2014-06-05 Enanta Pharmaceuticals, Inc. Novel [n-me-4-hydroxyleucine]-9-cyclosporin analogues
CA2921961A1 (en) 2013-08-26 2015-03-05 Enanta Pharmaceuticals, Inc. Cyclosporin analogues for preventing or treating hepatitis c
US9669095B2 (en) 2014-11-03 2017-06-06 Enanta Pharmaceuticals, Inc. Cyclosporin analogues for preventing or treating hepatitis C infection

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0194972A2 (en) * 1985-03-11 1986-09-17 Sandoz Ag Novel cyclosporins

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0194972A2 (en) * 1985-03-11 1986-09-17 Sandoz Ag Novel cyclosporins

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7732404B2 (en) 1999-12-30 2010-06-08 Dexcel Ltd Pro-nanodispersion for the delivery of cyclosporin
US7696165B2 (en) 2006-03-28 2010-04-13 Albany Molecular Research, Inc. Use of cyclosporin alkyne analogues for preventing or treating viral-induced disorders
US7696166B2 (en) 2006-03-28 2010-04-13 Albany Molecular Research, Inc. Use of cyclosporin alkyne/alkene analogues for preventing or treating viral-induced disorders

Also Published As

Publication number Publication date
CA1338319C (en) 1996-05-07
GB2206119A (en) 1988-12-29
GB8814598D0 (en) 1988-07-27

Similar Documents

Publication Publication Date Title
GB2206119B (en) A new cyclosporin derivative with modified "8-amino acid"
GB8812273D0 (en) New cyclosporin analogs with modified"c-9-amino]"acids
EP0292959A3 (en) Superconducting member superconducting member
GB2203149B (en) New ribofuranuronic acid derivatives
GB2213183B (en) Fish-plates
GB8702807D0 (en) Spare parts retrieval
GB8713195D0 (en) Superconductors
PH23637A (en) 2,1-benzonthiazepine-2,2-dioxide-5-carboxylic acid derivatives
CS867987A1 (en) Zpusob pripravy 1 isokyanato 4 ehlorbenzenu
JPS6413096A (en) 1-aminoethylphosphinic acid derivative
CS545187A1 (en) 2 (2 (fenylthio)benzyl) 2 imidazolin a jeho oxalat
CS773487A1 (en) 13 acetyltergurid a zpusob jeho vyroby
CS773287A1 (en) 1 tosylderivaty ergolinu a zpusob jejich vyroby
CS705187A1 (en) 6 purinylthio acyldipeptidy a zpusob jejich vyroby
CS415387A1 (en) Zpusob stabilizace linearniho polyetylenu a jeho kopolymeru s propylenem a 1 butenem pevnymi stabilizatory a zarizeni k provadeni tohoto zpusobu
GB8712647D0 (en) 2'-phenoxyalkanesulfonanilide derivatives
AU101292S (en) 8 october 1987
CS306087A1 (en) Zpusob enzymove vyroby 6 aminopenicilanove kyseliny z fenoxymethylpenicilinu stabilizovanymi bunkami kvasinek
CA57949S (en) Support boucle-d'oreille
CS437987A1 (en) 7 methyl 1 oktin a zpusob jeho pripravy
GB2211716B (en) A harvester
CS26787A1 (en) Sposob pripravy vysokocisteho 2 propanolu
CS92687A1 (en) 2alkyltio 6 formamidobenzotiazoly
CS266487A1 (en) Zpusob pripravy 4 jodanilinu
CS26687A1 (en) Sposob pripravy vysokocisteho 2 propanolu

Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee

Effective date: 20020620