DK0778775T3 - Parenteral tirilazad-præparat med coopløsningsmiddel - Google Patents

Parenteral tirilazad-præparat med coopløsningsmiddel

Info

Publication number
DK0778775T3
DK0778775T3 DK95931566T DK95931566T DK0778775T3 DK 0778775 T3 DK0778775 T3 DK 0778775T3 DK 95931566 T DK95931566 T DK 95931566T DK 95931566 T DK95931566 T DK 95931566T DK 0778775 T3 DK0778775 T3 DK 0778775T3
Authority
DK
Denmark
Prior art keywords
pct
parenteral
tirilazad
solvent
preparation
Prior art date
Application number
DK95931566T
Other languages
English (en)
Inventor
Ching-Chiang Su
David S Baker
Susan M Machkovech
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Application granted granted Critical
Publication of DK0778775T3 publication Critical patent/DK0778775T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Cephalosporin Compounds (AREA)
DK95931566T 1994-09-01 1995-08-29 Parenteral tirilazad-præparat med coopløsningsmiddel DK0778775T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US29937094A 1994-09-01 1994-09-01
US38225695A 1995-02-01 1995-02-01
PCT/US1995/010730 WO1996006618A1 (en) 1994-09-01 1995-08-29 Cosolvent parenteral formulation of tirilazad

Publications (1)

Publication Number Publication Date
DK0778775T3 true DK0778775T3 (da) 1999-09-13

Family

ID=26971187

Family Applications (1)

Application Number Title Priority Date Filing Date
DK95931566T DK0778775T3 (da) 1994-09-01 1995-08-29 Parenteral tirilazad-præparat med coopløsningsmiddel

Country Status (23)

Country Link
US (1) US5858999A (da)
EP (1) EP0778775B1 (da)
JP (1) JPH10505063A (da)
KR (1) KR100359556B1 (da)
CN (1) CN1156962A (da)
AT (1) ATE175875T1 (da)
AU (1) AU696856B2 (da)
BR (1) BR9508655A (da)
CA (1) CA2196063A1 (da)
CZ (1) CZ283875B6 (da)
DE (1) DE69507493T2 (da)
DK (1) DK0778775T3 (da)
ES (1) ES2128761T3 (da)
FI (1) FI970858A0 (da)
GR (1) GR3029396T3 (da)
HU (1) HUT76808A (da)
MX (1) MX9701342A (da)
NO (1) NO311405B1 (da)
NZ (1) NZ292690A (da)
PL (1) PL181244B1 (da)
RU (1) RU2152789C2 (da)
SK (1) SK280278B6 (da)
WO (1) WO1996006618A1 (da)

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US6254564B1 (en) 1998-09-10 2001-07-03 Percardia, Inc. Left ventricular conduit with blood vessel graft
US6017948A (en) * 1998-10-30 2000-01-25 Supergen, Inc. Water-miscible pharmaceutical compositions
DE69922252T2 (de) * 1999-01-28 2005-12-01 Patel, Dinesh Shantilal Parenterale lösungen enthaltend propofol (2,6-diisopropylphenol) und 2.5-di-0-methyl-1.4;3.6-dianhydro-d-glucitol als lösungsmittel
DE10010073B4 (de) 2000-02-28 2005-12-22 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Verankerung für implantierbare Herzklappenprothesen
DE10010074B4 (de) 2000-02-28 2005-04-14 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Vorrichtung zur Befestigung und Verankerung von Herzklappenprothesen
FR2828263B1 (fr) 2001-08-03 2007-05-11 Philipp Bonhoeffer Dispositif d'implantation d'un implant et procede d'implantation du dispositif
US20040053895A1 (en) * 2002-09-18 2004-03-18 Bone Care International, Inc. Multi-use vessels for vitamin D formulations
US20040058895A1 (en) * 2002-09-18 2004-03-25 Bone Care International, Inc. Multi-use vessels for vitamin D formulations
US7148211B2 (en) * 2002-09-18 2006-12-12 Genzyme Corporation Formulation for lipophilic agents
AU2004304716B2 (en) * 2003-12-18 2010-05-27 Biomas Ltd. Tellurium derivatives for prevention and treatment of neurodegenerative processes
CA2580642C (en) 2004-09-17 2014-09-02 Biomas, Ltd. Novel tellurium compounds and their use as immunomodulators
EP2471536A1 (en) * 2004-09-29 2012-07-04 Harbor BioSciences, Inc. Steroid analogs and characterization and treatment methods
DE102005003632A1 (de) 2005-01-20 2006-08-17 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Katheter für die transvaskuläre Implantation von Herzklappenprothesen
DE102005051849B4 (de) 2005-10-28 2010-01-21 JenaValve Technology Inc., Wilmington Vorrichtung zur Implantation und Befestigung von Herzklappenprothesen
DE102005052628B4 (de) 2005-11-04 2014-06-05 Jenavalve Technology Inc. Selbstexpandierendes, flexibles Drahtgeflecht mit integrierter Klappenprothese für den transvaskulären Herzklappenersatz und ein System mit einer solchen Vorrichtung und einem Einführkatheter
US20070213813A1 (en) 2005-12-22 2007-09-13 Symetis Sa Stent-valves for valve replacement and associated methods and systems for surgery
US7896915B2 (en) 2007-04-13 2011-03-01 Jenavalve Technology, Inc. Medical device for treating a heart valve insufficiency
US9138315B2 (en) 2007-04-13 2015-09-22 Jenavalve Technology Gmbh Medical device for treating a heart valve insufficiency or stenosis
CN101720211B (zh) 2007-05-15 2013-06-05 耶拿阀门科技公司 用于操纵导管尖端的手柄、导管***和用于***自扩式心脏瓣膜支架的医疗******
US8317858B2 (en) 2008-02-26 2012-11-27 Jenavalve Technology, Inc. Stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient
US9044318B2 (en) 2008-02-26 2015-06-02 Jenavalve Technology Gmbh Stent for the positioning and anchoring of a valvular prosthesis
US9168130B2 (en) 2008-02-26 2015-10-27 Jenavalve Technology Gmbh Stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient
BR112012021347A2 (pt) 2008-02-26 2019-09-24 Jenavalve Tecnology Inc stent para posicionamento e ancoragem de uma prótese valvular em um local de implantação no coração de um paciente
US8465540B2 (en) 2008-02-26 2013-06-18 Jenavalve Technology, Inc. Stent for the positioning and anchoring of a valvular prosthesis
US8398704B2 (en) 2008-02-26 2013-03-19 Jenavalve Technology, Inc. Stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient
HUE046243T2 (hu) 2008-05-28 2020-02-28 Reveragen Biopharma Inc Nem-hormonális NF-KB szteroid modulátorok betegség kezelésére
US8468667B2 (en) 2009-05-15 2013-06-25 Jenavalve Technology, Inc. Device for compressing a stent
EP2556083A4 (en) 2010-04-05 2013-12-04 Validus Biopharma Inc NONHORMONAL STEROID MODULATORS OF NF-KAPPA-B FOR DISEASE TREATMENT
US11278406B2 (en) 2010-05-20 2022-03-22 Jenavalve Technology, Inc. Catheter system for introducing an expandable heart valve stent into the body of a patient, insertion system with a catheter system and medical device for treatment of a heart valve defect
US10856978B2 (en) 2010-05-20 2020-12-08 Jenavalve Technology, Inc. Catheter system
US9744031B2 (en) 2010-05-25 2017-08-29 Jenavalve Technology, Inc. Prosthetic heart valve and endoprosthesis comprising a prosthetic heart valve and a stent
JP6005168B2 (ja) 2011-10-21 2016-10-12 イエナバルブ テクノロジー インク 患者の身体への拡張型心臓弁ステント導入用カテーテルシステム、カテーテルシステムを備えた挿入システムおよび心臓弁欠陥治療用医療機器
JP6227632B2 (ja) 2012-05-16 2017-11-08 イェーナヴァルヴ テクノロジー ゲゼルシャフト ミット ベシュレンクテル ハフツング 拡張可能心臓代用弁を導入するためのカテーテル送達システムおよび心臓弁欠陥の治療のための医療デバイス
CN103861090B (zh) * 2012-12-18 2017-06-13 美迪思生物科技(北京)有限公司 含蛋白或多肽的疏水溶液、其制备方法及用途
JP6563394B2 (ja) 2013-08-30 2019-08-21 イェーナヴァルヴ テクノロジー インコーポレイテッド 人工弁のための径方向に折り畳み自在のフレーム及び当該フレームを製造するための方法
CN107530168B (zh) 2015-05-01 2020-06-09 耶拿阀门科技股份有限公司 在心脏瓣膜替换中具有降低的起搏器比例的装置和方法
WO2017004205A1 (en) 2015-06-29 2017-01-05 Reveragen Biopharma, Inc. NON-HORMONAL STEROID MODULATORS OF NF-κB FOR TREATMENT OF DISEASE
EP3454795B1 (en) 2016-05-13 2023-01-11 JenaValve Technology, Inc. Heart valve prosthesis delivery system for delivery of heart valve prosthesis with introducer sheath and loading system
EP3573579B1 (en) 2017-01-27 2023-12-20 JenaValve Technology, Inc. Heart valve mimicry
US11382922B2 (en) 2019-03-07 2022-07-12 Reveragen Biopharma, Inc. Aqueous oral pharmaceutical suspension compositions

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AU573321B2 (en) * 1984-03-14 1988-06-02 Jerome Corbiere Process for solubilizing active principles and pharmaceuticalcompositions thus obtained
WO1987001706A2 (en) * 1985-09-12 1987-03-26 The Upjohn Company C20 through c26 amino steroids
US5175281A (en) * 1985-09-12 1992-12-29 The Upjohn Company Pharmaceutically active pyrimidinylpiperazinylsterioids
US4968675A (en) * 1988-10-28 1990-11-06 Upjohn Non-hemolytic lazaroid parenteral formulation
US5124154A (en) * 1990-06-12 1992-06-23 Insite Vision Incorporated Aminosteroids for ophthalmic use
WO1996003421A1 (en) * 1994-07-21 1996-02-08 Pharmacia & Upjohn Company Neurologically active aminosteroids
US5614515A (en) * 1994-11-17 1997-03-25 University Of Southern California Lazaroid-based compositions and method for preventing adhesion formation using the same

Also Published As

Publication number Publication date
BR9508655A (pt) 1997-08-12
ATE175875T1 (de) 1999-02-15
FI970858A (fi) 1997-02-28
EP0778775A1 (en) 1997-06-18
US5858999A (en) 1999-01-12
ES2128761T3 (es) 1999-05-16
DE69507493D1 (de) 1999-03-04
DE69507493T2 (de) 1999-06-10
NO970935D0 (no) 1997-02-28
AU696856B2 (en) 1998-09-17
HUT76808A (en) 1997-11-28
NO311405B1 (no) 2001-11-26
SK280278B6 (sk) 1999-10-08
PL181244B1 (pl) 2001-06-29
PL318901A1 (en) 1997-07-21
WO1996006618A1 (en) 1996-03-07
JPH10505063A (ja) 1998-05-19
EP0778775B1 (en) 1999-01-20
CN1156962A (zh) 1997-08-13
AU3493895A (en) 1996-03-22
NZ292690A (en) 1998-06-26
GR3029396T3 (en) 1999-05-28
SK26297A3 (en) 1997-09-10
CZ55997A3 (en) 1997-06-11
CA2196063A1 (en) 1996-03-07
RU2152789C2 (ru) 2000-07-20
KR100359556B1 (ko) 2002-12-18
MX9701342A (es) 1997-05-31
CZ283875B6 (cs) 1998-06-17
FI970858A0 (fi) 1997-02-28
NO970935L (no) 1997-04-11

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