DK0759786T3 - Somatostatinbindende peptidmetal-chelatkonjugater - Google Patents
Somatostatinbindende peptidmetal-chelatkonjugaterInfo
- Publication number
- DK0759786T3 DK0759786T3 DK95919827T DK95919827T DK0759786T3 DK 0759786 T3 DK0759786 T3 DK 0759786T3 DK 95919827 T DK95919827 T DK 95919827T DK 95919827 T DK95919827 T DK 95919827T DK 0759786 T3 DK0759786 T3 DK 0759786T3
- Authority
- DK
- Denmark
- Prior art keywords
- agents
- reagents
- methods
- imaging
- preparing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/008—Peptides; Proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/083—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins the peptide being octreotide or a somatostatin-receptor-binding peptide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/655—Somatostatins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/655—Somatostatins
- C07K14/6555—Somatostatins at least 1 amino acid in D-form
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/775—Apolipopeptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Optics & Photonics (AREA)
- Physics & Mathematics (AREA)
- Endocrinology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/241,625 US5783170A (en) | 1991-11-27 | 1994-05-12 | Peptide-metal chelate conjugates |
PCT/US1995/006034 WO1995031221A1 (en) | 1994-05-12 | 1995-05-12 | Somatostatin binding peptide-metal chelate conjugates |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0759786T3 true DK0759786T3 (da) | 2007-01-29 |
Family
ID=22911488
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK95919827T DK0759786T3 (da) | 1994-05-12 | 1995-05-12 | Somatostatinbindende peptidmetal-chelatkonjugater |
Country Status (12)
Country | Link |
---|---|
US (5) | US5783170A (da) |
EP (1) | EP0759786B1 (da) |
JP (1) | JP3918157B2 (da) |
CN (1) | CN1078480C (da) |
AT (1) | ATE340594T1 (da) |
AU (1) | AU708797B2 (da) |
DE (1) | DE69535242T2 (da) |
DK (1) | DK0759786T3 (da) |
ES (1) | ES2274517T3 (da) |
PT (1) | PT759786E (da) |
WO (1) | WO1995031221A1 (da) |
ZA (1) | ZA953878B (da) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5382654A (en) * | 1992-02-05 | 1995-01-17 | Mallinckrodt Medical, Inc. | Radiolabelled peptide compounds |
US5997844A (en) * | 1991-02-08 | 1999-12-07 | Diatide, Inc. | Technetium-99m labeled peptides for imaging |
US7238340B1 (en) * | 1991-11-27 | 2007-07-03 | Cis Bio International | Monoamine, diamide, thiol-containing metal chelating agents |
US5443815A (en) * | 1991-11-27 | 1995-08-22 | Diatech, Inc. | Technetium-99m labeled peptides for imaging |
US5965107A (en) * | 1992-03-13 | 1999-10-12 | Diatide, Inc. | Technetium-99m labeled peptides for imaging |
US5783170A (en) * | 1991-11-27 | 1998-07-21 | Diatide, Inc. | Peptide-metal chelate conjugates |
US6017512A (en) * | 1992-06-23 | 2000-01-25 | Diatide, Inc. | Radiolabeled peptides |
US6051206A (en) * | 1994-06-03 | 2000-04-18 | Diatide, Inc | Radiolabeled somatostatin-derived peptides for imaging and therapeutic uses |
US6713605B1 (en) * | 1996-04-10 | 2004-03-30 | Kansas State University Research Foundation | Synthetic peptides that inhibit leukocyte superoxide anion production and/or attract leukocytes |
US6685913B1 (en) | 1999-03-09 | 2004-02-03 | Thomas Jefferson University | Lipid soluble radioactive metal chelates for tumor therapy |
US6358491B1 (en) * | 1999-08-27 | 2002-03-19 | Berlex Laboratories, Inc. | Somatostatin analogs |
US6579967B1 (en) | 1999-12-14 | 2003-06-17 | The Salk Institute For Biological Studies | Receptor-selective somatostatin analogs |
US7019109B2 (en) * | 2001-03-16 | 2006-03-28 | The Salk Institute For Bilogical Studies | SSTR1-selective analogs |
US20020187099A1 (en) * | 2001-05-16 | 2002-12-12 | Rajesh Manchanda | Stabilization of radionuclide-containing compositions |
AU2003259172A1 (en) * | 2002-07-24 | 2004-02-09 | The Salk Institute For Biological Studies | Receptor (sstr4)- selective somatostatin analogs |
DK1599609T3 (da) * | 2003-02-13 | 2010-03-29 | Univ California | Fremgangsmåder og sammensætninger til detektering og analyse af polynukleotid-bindende proteins vekselvirkninger ved brug af lys samlende multichromophorer |
WO2004081031A2 (en) * | 2003-03-10 | 2004-09-23 | Biogen Idec Inc. | Thiol-mediated drug attachment to targeting peptides |
WO2004106939A2 (en) * | 2003-06-03 | 2004-12-09 | Paul Scherrer Institut | Method for the linkage of bifunctional chelating agents and (radioactive) transition metal complexes to proteins and peptides |
US8540968B2 (en) * | 2004-03-02 | 2013-09-24 | Cellectar, Inc. | Phospholipid ether analogs as agents for detecting and locating cancer, and methods thereof |
DE602005015687D1 (de) | 2004-03-02 | 2009-09-10 | Cellectar Inc | Phospholipid-analoga für die behandlung von krebs |
EP1717247A1 (en) * | 2005-04-28 | 2006-11-02 | Schering AG | Cyclic peptides binding to the somatostatin receptor |
WO2006114324A1 (en) * | 2005-04-28 | 2006-11-02 | Schering Ag | Compounds comprising cyclized somatostatin receptor binding peptides |
US7842280B2 (en) * | 2006-09-06 | 2010-11-30 | Case Western Reserve University | Flexibly labeling peptides |
WO2008143958A1 (en) * | 2007-05-18 | 2008-11-27 | The Brigham And Women's Hospital, Inc. | Use of somatostatin analogs in myocardial perfusion imaging |
US20100204449A1 (en) * | 2007-09-04 | 2010-08-12 | Zheng Xin Dong | Methods and intermediates for chemical synthesis of polypeptides and proteins |
WO2009148619A2 (en) | 2008-06-06 | 2009-12-10 | Providence Medical Technology, Inc. | Facet joint implants and delivery tools |
US8361152B2 (en) | 2008-06-06 | 2013-01-29 | Providence Medical Technology, Inc. | Facet joint implants and delivery tools |
DK3708192T3 (da) | 2009-06-12 | 2023-11-06 | Cellectar Inc | Etherphospholipidforbindelser til behandling af cancer og billeddannelse og detektering af cancerstamceller |
EP2475400A2 (en) * | 2009-09-11 | 2012-07-18 | Cellectar, Inc. | Non-radioactive phospholipid compounds, compositions, and methods of use |
US20120065092A1 (en) * | 2010-09-14 | 2012-03-15 | Wai Hobert | Fusion analyte cytometric bead assay, and systems and kits for performing the same |
WO2013036616A1 (en) * | 2011-09-07 | 2013-03-14 | Dow Global Technologies Llc | Wellbore servicing fluid having hydrophobically modified polymers |
US20160040212A1 (en) * | 2013-03-15 | 2016-02-11 | The Broad Institute, Inc. | Methods for the Detection of DNA-RNA Proximity in Vivo |
CN110256310A (zh) * | 2019-07-01 | 2019-09-20 | 吉尔生化(上海)有限公司 | 一种n-芴甲氧羰基-s-(4-甲氧基三苯甲基)-l-高半胱氨酸的制备方法 |
Family Cites Families (71)
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US4444690A (en) * | 1982-02-25 | 1984-04-24 | University Patents, Inc. | Technetium chelates |
US4472509A (en) * | 1982-06-07 | 1984-09-18 | Gansow Otto A | Metal chelate conjugated monoclonal antibodies |
US4668503A (en) * | 1982-07-26 | 1987-05-26 | Trustees Of University Of Massachusetts | Process for labeling amines with 99m Tc |
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US4485101A (en) * | 1983-10-11 | 1984-11-27 | Administrators Of The Tulane Educational Fund | Peptides |
JPS61501321A (ja) * | 1984-01-23 | 1986-07-03 | インスティテュト・フォ−・エネジテクニク | たんぱく様物質標識用テクネチウム99m組成物およびその使用方法 |
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US5279811A (en) * | 1987-02-18 | 1994-01-18 | The Du Pont Merck Pharmaceutical Company | Ester-substituted diaminedithiols and radiolabeled complexes thereof |
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EP0413766A4 (en) * | 1988-05-02 | 1991-11-21 | New England Deaconess Hospital Corporation | Synthetic peptides for arterial imaging |
US5218128A (en) * | 1988-06-15 | 1993-06-08 | Centocor, Inc. | Bifunctional coupling agents and radionuclide labeled compositions prepared therefrom |
US5180816A (en) * | 1988-08-24 | 1993-01-19 | Centocor | One vial method for labeling protein/linker conjugates with technetium-99M |
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US5196515A (en) * | 1989-03-17 | 1993-03-23 | The Johns Hopkins University | Thiolactone bifunctional chelating agents for diagnostic and therapeutic products |
US5095111A (en) * | 1989-03-17 | 1992-03-10 | The John Hopkins University | Thiolactone bifunctional chelating agents for diagnostic and therapeutic products |
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DE69023394T2 (de) * | 1989-06-16 | 1996-07-04 | Merck Frosst Canada Inc | Chelat-Derivate von atrialnatriurethischem Faktor (ANF). |
GB8914020D0 (en) * | 1989-06-19 | 1989-08-09 | Antisoma Ltd | Synthetic peptides for use in thrombus detection |
ES2070329T3 (es) * | 1989-07-20 | 1995-06-01 | Sandoz Ltd | Derivados de polipeptidos. |
FR2650672A1 (fr) * | 1989-08-02 | 1991-02-08 | Medgenix Group Sa | Procede de marquage de proteines ou polypeptides au technetium-99m, conjugue obtenu, utilisation a titre d'agent d'imagerie, kit de reconstitution desdits conjugues |
US5112953A (en) * | 1989-12-29 | 1992-05-12 | Neorx Corporation | Radiolabeled proteins for diagnostic or therapeutic use |
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DK0450480T3 (da) * | 1990-04-06 | 1995-08-14 | Univ Tulane | Somatostatinaloger |
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US5382654A (en) * | 1992-02-05 | 1995-01-17 | Mallinckrodt Medical, Inc. | Radiolabelled peptide compounds |
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US7238340B1 (en) * | 1991-11-27 | 2007-07-03 | Cis Bio International | Monoamine, diamide, thiol-containing metal chelating agents |
US5997844A (en) * | 1991-02-08 | 1999-12-07 | Diatide, Inc. | Technetium-99m labeled peptides for imaging |
DE69229436T2 (de) * | 1991-02-08 | 1999-11-25 | Biomeasure, Inc. | Verwendung von somatostatinanalogen zur behandlung von melanomen |
US5443815A (en) * | 1991-11-27 | 1995-08-22 | Diatech, Inc. | Technetium-99m labeled peptides for imaging |
CA2102633A1 (en) * | 1991-06-03 | 1992-12-04 | Peter H. Cox | Radiolabelled somatostatin derivatives, their preparation and use |
US5225180A (en) * | 1991-09-10 | 1993-07-06 | Diatech, Inc. | Technetium-99m labeled somatostatin-derived peptides for imaging |
US5783170A (en) * | 1991-11-27 | 1998-07-21 | Diatide, Inc. | Peptide-metal chelate conjugates |
EP0629133B1 (en) * | 1992-01-03 | 2000-11-29 | Rhomed, Incorporated | Peptide-metal ion pharmaceutical applications |
CA2129033A1 (en) * | 1992-02-05 | 1993-08-19 | Leon Lyle | Radiolabelled peptide compounds |
US5326856A (en) * | 1992-04-09 | 1994-07-05 | Cytogen Corporation | Bifunctional isothiocyanate derived thiocarbonyls as ligands for metal binding |
US5508020A (en) * | 1992-06-05 | 1996-04-16 | Diatech, Inc. | Technetium-99M labeled peptides for imaging |
US5716596A (en) * | 1992-06-23 | 1998-02-10 | Diatide, Inc. | Radioactively labeled somatostatin-derived peptides for imaging and therapeutic uses |
US5620675A (en) * | 1992-06-23 | 1997-04-15 | Diatech, Inc. | Radioactive peptides |
DE69434832D1 (de) * | 1993-06-23 | 2006-10-05 | Diatide Inc | Radioaktiv-markierte Peptidderivate des Somatostatins zur bildformenden und therapeutischen Verwendung |
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-
1994
- 1994-05-12 US US08/241,625 patent/US5783170A/en not_active Expired - Fee Related
-
1995
- 1995-05-12 AT AT95919827T patent/ATE340594T1/de not_active IP Right Cessation
- 1995-05-12 ES ES95919827T patent/ES2274517T3/es not_active Expired - Lifetime
- 1995-05-12 CN CN95193841A patent/CN1078480C/zh not_active Expired - Fee Related
- 1995-05-12 EP EP95919827A patent/EP0759786B1/en not_active Expired - Lifetime
- 1995-05-12 AU AU25500/95A patent/AU708797B2/en not_active Ceased
- 1995-05-12 DE DE69535242T patent/DE69535242T2/de not_active Expired - Fee Related
- 1995-05-12 WO PCT/US1995/006034 patent/WO1995031221A1/en active IP Right Grant
- 1995-05-12 ZA ZA953878A patent/ZA953878B/xx unknown
- 1995-05-12 JP JP52982195A patent/JP3918157B2/ja not_active Expired - Fee Related
- 1995-05-12 PT PT95919827T patent/PT759786E/pt unknown
- 1995-05-12 DK DK95919827T patent/DK0759786T3/da active
-
1998
- 1998-03-13 US US09/042,224 patent/US5972308A/en not_active Expired - Fee Related
- 1998-03-13 US US09/039,062 patent/US5965108A/en not_active Expired - Fee Related
- 1998-03-13 US US09/042,315 patent/US5985241A/en not_active Expired - Fee Related
- 1998-03-13 US US09/039,116 patent/US5981477A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US5972308A (en) | 1999-10-26 |
PT759786E (pt) | 2007-01-31 |
AU708797B2 (en) | 1999-08-12 |
AU2550095A (en) | 1995-12-05 |
DE69535242D1 (de) | 2006-11-09 |
US5965108A (en) | 1999-10-12 |
EP0759786B1 (en) | 2006-09-27 |
EP0759786A1 (en) | 1997-03-05 |
US5981477A (en) | 1999-11-09 |
CN1155248A (zh) | 1997-07-23 |
JPH10500411A (ja) | 1998-01-13 |
CN1078480C (zh) | 2002-01-30 |
ATE340594T1 (de) | 2006-10-15 |
US5985241A (en) | 1999-11-16 |
JP3918157B2 (ja) | 2007-05-23 |
ZA953878B (en) | 1996-01-18 |
US5783170A (en) | 1998-07-21 |
WO1995031221A1 (en) | 1995-11-23 |
DE69535242T2 (de) | 2007-05-16 |
ES2274517T3 (es) | 2007-05-16 |
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