DK0741710T3 - Chlorpyrimidin-mellemprodukter - Google Patents

Chlorpyrimidin-mellemprodukter

Info

Publication number: DK0741710T3
Authority: DK; Denmark
Prior art keywords: intermediates; processes; chloropyrimidine; chloropyrimidine intermediates; aminopurines
Prior art date: 1994-02-04

Application number

DK95907107T

Other languages

English (en)

Inventor

Susan Mary Daluge

Michael Tolar Martin

Michelle Joanne Ferry Fugett

Original Assignee

Wellcome Found

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-02-04

Filing date

1995-02-03

Publication date

2000-08-14

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10749873&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0741710(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1995-02-03 Application filed by Wellcome Found filed Critical Wellcome Found

2000-08-14 Application granted granted Critical

2000-08-14 Publication of DK0741710T3 publication Critical patent/DK0741710T3/da

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/50—Three nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/40—Heterocyclic compounds containing purine ring systems with halogen atoms or perhalogeno-alkyl radicals directly attached in position 2 or 6

DK95907107T 1994-02-04 1995-02-03 Chlorpyrimidin-mellemprodukter DK0741710T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB9402161A GB9402161D0 (en)	1994-02-04	1994-02-04	Chloropyrimidine intermediates
PCT/GB1995/000225 WO1995021161A1 (en)	1994-02-04	1995-02-03	Chloropyrimide intermediates

Publications (1)

Publication Number	Publication Date
DK0741710T3 true DK0741710T3 (da)	2000-08-14

Family

ID=10749873

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK95907107T DK0741710T3 (da)	1994-02-04	1995-02-03	Chlorpyrimidin-mellemprodukter

Country Status (28)

Country	Link
US (8)	US6448403B1 (da)
EP (1)	EP0741710B1 (da)
JP (1)	JP3670012B2 (da)
KR (1)	KR100355983B1 (da)
CN (2)	CN1161343C (da)
AT (1)	ATE192742T1 (da)
AU (1)	AU690203B2 (da)
BR (1)	BR9506667A (da)
DE (1)	DE69516847T2 (da)
DK (1)	DK0741710T3 (da)
ES (1)	ES2148486T3 (da)
FI (1)	FI112477B (da)
GB (1)	GB9402161D0 (da)
GR (1)	GR3033850T3 (da)
HK (1)	HK1004087A1 (da)
HU (1)	HU223096B1 (da)
IL (1)	IL112539A (da)
MX (1)	MX9603091A (da)
MY (1)	MY113775A (da)
NO (1)	NO310819B1 (da)
NZ (1)	NZ278948A (da)
PL (1)	PL183885B1 (da)
PT (1)	PT741710E (da)
RU (1)	RU2140913C1 (da)
SG (1)	SG47918A1 (da)
TW (1)	TW390877B (da)
WO (1)	WO1995021161A1 (da)
ZA (1)	ZA95884B (da)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9402161D0 (en) *	1994-02-04	1994-03-30	Wellcome Found	Chloropyrimidine intermediates
CA2145928C (en) *	1994-04-27	2007-10-09	Gerhard Stucky	N-(2-amino-4,6-dichloropyrimidin-5-yl)formamide, and a process for its preparation
SK284810B6 (sk)	1997-05-13	2005-12-01	Lonza Ag	Spôsob výroby (1S,4R)- alebo (1R,4S)-4-(2-amino-6-chlór-9-H- purín-9-yl)-2-cyklopentén-1-metanolu
GB9721780D0 (en) *	1997-10-14	1997-12-10	Glaxo Group Ltd	Process for the synthesis of chloropurine intermediates
AU2702899A (en) *	1997-10-24	1999-05-17	Glaxo Group Limited	Process for preparing a chiral nucleoside analogue
AU5653498A (en) *	1997-11-12	1999-05-31	Glaxo Group Limited	Process for preparing a chiral nucleoside analogue
CZ298913B6 (cs) *	1997-11-27	2008-03-12	Lonza Ag	Zpusob výroby aminoalkoholu a jeho derivátu
ATE228508T1 (de) *	1998-12-21	2002-12-15	Lonza Ag	Verfahren zur herstellung von n-(amino-4,6- dihalogenpyrimidin)-formamiden
EP1423080A4 (en) *	2001-03-01	2009-06-03	Conforma Therapeutics Corp	PROCESS FOR TREATING PROLIFERATIVE GENETIC DISORDERS WITH HSP90 INHIBITORS
EP1440072A4 (en) *	2001-10-30	2005-02-02	Conforma Therapeutic Corp	PURINE ANALOGS HAVING HSP90 INHIBITORY ACTIVITY
US20070129334A1 (en) *	2001-10-30	2007-06-07	Conforma Therapeutics Corporation	Orally Active Purine-Based Inhibitors of Heat Shock Protein 90
US6780635B2 (en)	2001-12-27	2004-08-24	Council Of Scientific And Industrial Research	Process for the preparation of optically active azabicyclo heptanone derivatives
KR100573859B1 (ko) *	2002-07-15	2006-04-25	경동제약 주식회사	9-[4-아세톡시-3-(아세톡시메틸)부트-1-일]-2-아미노푸린의제조방법
US7138402B2 (en) *	2003-09-18	2006-11-21	Conforma Therapeutics Corporation	Pyrrolopyrimidines and related analogs as HSP90-inhibitors
US7560231B2 (en) *	2002-12-20	2009-07-14	Roche Molecular Systems, Inc.	Mannitol and glucitol derivatives
US20040266795A1 (en) *	2003-04-30	2004-12-30	Genny Shamai	Process for the preparation of famciclovir
WO2004103979A1 (ja) *	2003-05-26	2004-12-02	Sumitomo Chemical Company, Limited	Ｎ－（２－アミノ－４，６－ジクロロピリミジン－５－イル）ホルムアミドの製造方法
KR100573860B1 (ko) *	2003-06-13	2006-04-25	경동제약 주식회사	2-아미노-9-(2-치환에틸)푸린을 이용한 9-[4-아세톡시-3-(아세톡시메틸)부트-1-일]-2-아미노푸린의 제조방법
US6930093B2 (en) *	2003-07-10	2005-08-16	Valeant Research & Development	Use of ribofuranose derivatives against inflammatory bowel diseases
KR100573861B1 (ko) *	2003-07-18	2006-04-25	경동제약 주식회사	2-아미노-9-(2-할로게노에틸)푸린 및 그 중간체로서의 2-아미노-6,8-디클로로-9-(2-히드록시에틸)푸린의 제조방법
GB0320738D0 (en) *	2003-09-04	2003-10-08	Glaxo Group Ltd	Novel process
WO2005026167A1 (en) *	2003-09-04	2005-03-24	Teva Pharmaceutical Industries Ltd.	Process for preparing famciclovir
DE102004002055A1 (de) *	2004-01-15	2005-08-11	Degussa Ag	Verfahren zur Herstellung von 2-Amino-4,6-dichlor-5-formamidopyrimidin
AP2007003921A0 (en) *	2004-08-16	2007-02-28	Atugen Ag	Therapeutic uses of inhibitors of rtp801
JP2008534609A (ja) *	2005-03-30	2008-08-28	コンフォーマ・セラピューティクス・コーポレイション	Ｈｓｐ９０阻害剤としてのアルキニルピロロピリミジンおよび関連類似体
GB2426247A (en)	2005-05-20	2006-11-22	Arrow Int Ltd	Methods of preparing purine derivatives such as famciclovir
US20070105874A1 (en) *	2005-09-23	2007-05-10	Conforma Therapeutics Corporation	Anti-Tumor Methods Using Multi Drug Resistance Independent Synthetic HSP90 Inhibitors
EP1857458A1 (en) *	2006-05-05	2007-11-21	SOLMAG S.p.A.	Process for the preparation of abacavir
CN100465174C (zh) *	2006-06-13	2009-03-04	中国科学院上海有机化学研究所	制备光学纯阿巴卡韦的方法
WO2008072074A1 (en) *	2006-12-11	2008-06-19	Aurobindo Pharma Limited	An improved process for the preparation of purine derivative
EP1939196A1 (en) *	2006-12-21	2008-07-02	Esteve Quimica, S.A.	Process for the preparation of abacavir
WO2008155613A1 (en) *	2007-06-21	2008-12-24	Aurobindo Pharma Ltd	An improved process for preparing purine derivative
EP2085397A1 (en)	2008-01-21	2009-08-05	Esteve Quimica, S.A.	Crystalline form of abacavir
UA105556C2 (uk)	2010-01-27	2014-05-26	Віів Гелскер Компані	Комбінація сполук, що містить інгібітори віл інтегрази з іншими терапевтичними агентами
CZ305457B6 (cs)	2011-02-28	2015-09-30	Ústav organické chemie a biochemie, Akademie věd ČR v. v. i.	Pyrimidinové sloučeniny inhibující tvorbu oxidu dusnatého a prostaglandinu E2, způsob výroby a použití
WO2014133085A1 (ja)	2013-02-27	2014-09-04	国立大学法人京都大学	がんの予防または治療用医薬組成物
CN104672239A (zh) *	2013-11-26	2015-06-03	上海迪赛诺化学制药有限公司	一种采用一锅法制备阿巴卡韦式v中间体的工艺
CN109456329B (zh) *	2018-11-19	2021-03-09	迪嘉药业集团有限公司	一种泛昔洛韦的制备方法
CN113292507B (zh) *	2021-06-25	2022-07-19	潍坊奥通药业有限公司	一种2-氨基-6-氯鸟嘌呤及其中间体的制备方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3485225D1 (de)	1983-08-18	1991-12-05	Beecham Group Plc	Antivirale guanin-derivate.
EP0182024B1 (en)	1984-09-20	1991-04-03	Beecham Group Plc	Purine derivatives and their pharmaceutical use
US4965270A (en)	1987-05-30	1990-10-23	Beecham Group P.L.C.	Purine derivatives
GB8724765D0 (en)	1987-10-22	1987-11-25	Beecham Group Plc	Process
GB2243609B (en)	1988-01-20	1992-03-11	Univ Minnesota	Dideoxydidehydrocarbocyclic pyrimidines
US4916224A (en)	1988-01-20	1990-04-10	Regents Of The University Of Minnesota	Dideoxycarbocyclic nucleosides
US5631370A (en)	1988-01-20	1997-05-20	Regents Of The University Of Minnesota	Optically-active isomers of dideoxycarbocyclic nucleosides
GB8815265D0 (en)	1988-06-27	1988-08-03	Wellcome Found	Therapeutic nucleosides
GB8916698D0 (en)	1989-07-21	1989-09-06	Beecham Group Plc	Novel process
GB8918827D0 (en)	1989-08-17	1989-09-27	Beecham Group Plc	Novel compounds
MY104575A (en)	1989-12-22	1994-04-30	The Wellcome Foundation Ltd	Therapeutic nucleosides.
SK279618B6 (sk) *	1992-01-22	1999-01-11	Lonza A.G. (Dir.:Basel)	N-5-chránené 2,5-diamino-4,6-dichlórpyrimidíny a s
GB9402161D0 (en) *	1994-02-04	1994-03-30	Wellcome Found	Chloropyrimidine intermediates
CA2145928C (en) *	1994-04-27	2007-10-09	Gerhard Stucky	N-(2-amino-4,6-dichloropyrimidin-5-yl)formamide, and a process for its preparation

1994
- 1994-02-04 GB GB9402161A patent/GB9402161D0/en active Pending
1995
- 1995-02-03 NZ NZ278948A patent/NZ278948A/en not_active IP Right Cessation
- 1995-02-03 SG SG1996005343A patent/SG47918A1/en unknown
- 1995-02-03 EP EP95907107A patent/EP0741710B1/en not_active Expired - Lifetime
- 1995-02-03 AT AT95907107T patent/ATE192742T1/de active
- 1995-02-03 BR BR9506667A patent/BR9506667A/pt not_active IP Right Cessation
- 1995-02-03 RU RU96118435A patent/RU2140913C1/ru active
- 1995-02-03 PT PT95907107T patent/PT741710E/pt unknown
- 1995-02-03 ES ES95907107T patent/ES2148486T3/es not_active Expired - Lifetime
- 1995-02-03 AU AU15438/95A patent/AU690203B2/en not_active Expired
- 1995-02-03 KR KR1019960704228A patent/KR100355983B1/ko not_active IP Right Cessation
- 1995-02-03 JP JP52046795A patent/JP3670012B2/ja not_active Expired - Lifetime
- 1995-02-03 IL IL11253995A patent/IL112539A/xx not_active IP Right Cessation
- 1995-02-03 DK DK95907107T patent/DK0741710T3/da active
- 1995-02-03 DE DE69516847T patent/DE69516847T2/de not_active Expired - Lifetime
- 1995-02-03 MY MYPI95000246A patent/MY113775A/en unknown
- 1995-02-03 WO PCT/GB1995/000225 patent/WO1995021161A1/en active IP Right Grant
- 1995-02-03 CN CNB021023441A patent/CN1161343C/zh not_active Expired - Lifetime
- 1995-02-03 PL PL95315713A patent/PL183885B1/pl unknown
- 1995-02-03 CN CN95191478A patent/CN1105109C/zh not_active Expired - Lifetime
- 1995-02-03 US US08/682,743 patent/US6448403B1/en not_active Expired - Lifetime
- 1995-02-03 ZA ZA95884A patent/ZA95884B/xx unknown
- 1995-02-03 HU HU9602114A patent/HU223096B1/hu active IP Right Grant
- 1995-03-14 TW TW084102412A patent/TW390877B/zh not_active IP Right Cessation
1996
- 1996-07-30 MX MX9603091A patent/MX9603091A/es unknown
- 1996-08-02 NO NO19963239A patent/NO310819B1/no not_active IP Right Cessation
- 1996-08-02 FI FI963070A patent/FI112477B/fi not_active IP Right Cessation
1997
- 1997-10-24 US US08/957,605 patent/US5917042A/en not_active Expired - Lifetime
- 1997-10-24 US US08/957,606 patent/US6555687B1/en not_active Expired - Lifetime
- 1997-10-24 US US08/957,043 patent/US5917041A/en not_active Expired - Lifetime
- 1997-10-24 US US08/957,603 patent/US6087501A/en not_active Expired - Lifetime
1998
- 1998-04-21 HK HK98103336A patent/HK1004087A1/xx not_active IP Right Cessation
1999
- 1999-10-15 US US09/419,416 patent/US6552193B1/en not_active Expired - Lifetime
2000
- 2000-06-30 GR GR20000401551T patent/GR3033850T3/el unknown
2002
- 2002-06-27 US US10/184,482 patent/US6870053B2/en not_active Expired - Fee Related
2003
- 2003-03-18 US US10/389,815 patent/US20030187263A1/en not_active Abandoned

Also Published As

Publication number	Publication date
ATE192742T1 (de)	2000-05-15
FI112477B (fi)	2003-12-15
CN1105109C (zh)	2003-04-09
PT741710E (pt)	2000-09-29
EP0741710B1 (en)	2000-05-10
KR100355983B1 (ko)	2002-12-28
JPH09508412A (ja)	1997-08-26
NO963239L (no)	1996-10-02
RU2140913C1 (ru)	1999-11-10
FI963070A0 (fi)	1996-08-02
BR9506667A (pt)	1997-09-16
CN1139924A (zh)	1997-01-08
GR3033850T3 (en)	2000-10-31
NZ278948A (en)	1998-01-26
SG47918A1 (en)	1998-04-17
IL112539A0 (en)	1995-05-26
WO1995021161A1 (en)	1995-08-10
MX9603091A (es)	1998-01-31
US6870053B2 (en)	2005-03-22
HUT75300A (en)	1997-05-28
US5917041A (en)	1999-06-29
NO310819B1 (no)	2001-09-03
AU1543895A (en)	1995-08-21
US6087501A (en)	2000-07-11
MY113775A (en)	2002-05-31
CN1161343C (zh)	2004-08-11
US6552193B1 (en)	2003-04-22
FI963070A (fi)	1996-08-02
US6555687B1 (en)	2003-04-29
HU9602114D0 (en)	1996-09-30
DE69516847D1 (de)	2000-06-15
US20030187263A1 (en)	2003-10-02
NO963239D0 (no)	1996-08-02
GB9402161D0 (en)	1994-03-30
IL112539A (en)	2000-08-31
JP3670012B2 (ja)	2005-07-13
HU223096B1 (hu)	2004-03-29
ZA95884B (en)	1996-08-05
DE69516847T2 (de)	2000-10-26
US6448403B1 (en)	2002-09-10
PL183885B1 (pl)	2002-07-31
PL315713A1 (en)	1996-11-25
TW390877B (en)	2000-05-21
EP0741710A1 (en)	1996-11-13
AU690203B2 (en)	1998-04-23
CN1388123A (zh)	2003-01-01
HK1004087A1 (en)	1998-11-13
US5917042A (en)	1999-06-29
ES2148486T3 (es)	2000-10-16
US20020173649A1 (en)	2002-11-21

Publication	Publication Date	Title
DK0741710T3 (da)	2000-08-14	Chlorpyrimidin-mellemprodukter
TR200003513T2 (tr)	2001-06-21	Pirolo[2,3d]Pirimidin kompozisyonları ve kullanımları
ID23374A (id)	2000-04-20	Halogenopirimidin
DE69905170T2 (de)	2004-01-15	Thiazolopyrimidinderivate
ATE294152T1 (de)	2005-05-15	Substituierte tetrahydro-naphtaline und analoge verbindungen
ES2150021T3 (es)	2000-11-16	Derivados de acidos piridin- y pirazin-dicarboxilicos como reguladores de la proliferacion celular.
YU68602A (sh)	2006-03-03	Monoklonska antitela na humani ldl receptor, njihova produkcija i korišćenje
DE69521122T2 (de)	2002-03-07	2,3,4,5-tetrahydro-1h-3-benzazepin säure-additions-salze
DK1051404T3 (da)	2003-08-04	Substituerede phenyluraciler med herbicid virkning
AU6722498A (en)	1998-09-22	Disubstituted biphenyloxazolines
CO5150221A1 (es)	2002-04-29	Nuevas 3-fenoxi- y 3-fenilalquiloxi-2-fenil-propilaminas sustituidas
TR199800850T2 (xx)	1998-09-21	Kan� d�zenleyici bile�imler.
NO960849L (no)	1996-03-01	Difluorstaton-antivirale analoger
CA2182105A1 (en)	1995-08-10	Chloropyrimide intermediates
AR010620A4 (es)	2000-06-28	Jeringa autodescartable grima