DK0729933T3 - Tricykliske forbindelser, deres fremstilling, deres anvendelse ved fremstillingen af colchicin og thiocolchicin, som er opt - Google Patents

Tricykliske forbindelser, deres fremstilling, deres anvendelse ved fremstillingen af colchicin og thiocolchicin, som er opt

Info

Publication number
DK0729933T3
DK0729933T3 DK96400417T DK96400417T DK0729933T3 DK 0729933 T3 DK0729933 T3 DK 0729933T3 DK 96400417 T DK96400417 T DK 96400417T DK 96400417 T DK96400417 T DK 96400417T DK 0729933 T3 DK0729933 T3 DK 0729933T3
Authority
DK
Denmark
Prior art keywords
preparation
alkyl
thiocolchicine
colchicine
optic
Prior art date
Application number
DK96400417T
Other languages
English (en)
Inventor
Francis Brion
Bernadette Chappert
Christian Diolez
Christian Marie
Alain Mazurie
Michel Middendorp
Didier Pronine
Edmond Toromanoff
Original Assignee
Hoechst Marion Roussel Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Marion Roussel Inc filed Critical Hoechst Marion Roussel Inc
Application granted granted Critical
Publication of DK0729933T3 publication Critical patent/DK0729933T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/527—Unsaturated compounds containing keto groups bound to rings other than six-membered aromatic rings
    • C07C49/543—Unsaturated compounds containing keto groups bound to rings other than six-membered aromatic rings to a six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/72—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/73—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton to carbon atoms of non-condensed six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/56—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
    • C07C49/747—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/753—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups
    • C07C49/755—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups a keto group being part of a condensed ring system with two or three rings, at least one ring being a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/30—Ortho- or ortho- and peri-condensed systems containing three rings containing seven-membered rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
DK96400417T 1995-03-03 1996-02-28 Tricykliske forbindelser, deres fremstilling, deres anvendelse ved fremstillingen af colchicin og thiocolchicin, som er opt DK0729933T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9502480A FR2731217B1 (fr) 1995-03-03 1995-03-03 Nouveaux derives tricycliques, leur preparation, leur application a la preparation de la colchicine et de la thiocolchicine optiquement actives ou racemiques et d'analogues ou derives et intermediaires

Publications (1)

Publication Number Publication Date
DK0729933T3 true DK0729933T3 (da) 2000-07-17

Family

ID=9476700

Family Applications (1)

Application Number Title Priority Date Filing Date
DK96400417T DK0729933T3 (da) 1995-03-03 1996-02-28 Tricykliske forbindelser, deres fremstilling, deres anvendelse ved fremstillingen af colchicin og thiocolchicin, som er opt

Country Status (18)

Country Link
US (3) US5705704A (da)
EP (1) EP0729933B1 (da)
JP (1) JP3831445B2 (da)
KR (2) KR100415038B1 (da)
CN (2) CN1067044C (da)
AT (1) ATE189203T1 (da)
AU (1) AU717153B2 (da)
CA (1) CA2170806C (da)
DE (1) DE69606337T2 (da)
DK (1) DK0729933T3 (da)
EA (1) EA000093B1 (da)
ES (1) ES2141445T3 (da)
FR (1) FR2731217B1 (da)
GR (1) GR3033123T3 (da)
HU (1) HUP9600517A3 (da)
MX (1) MX9600816A (da)
PT (1) PT729933E (da)
ZA (1) ZA961694B (da)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU728852B2 (en) * 1996-03-20 2001-01-18 Genentech Inc. Tricyclic compounds having an activity vis-a-vis integrins in particular vis-a-vis alphavbeta3 integrins, their preparation process and inttermediates of this process, their use as medicaments and the pharmaceutical compositions containing them
FR2746394B1 (fr) 1996-03-20 1998-05-29 Roussel Uclaf Nouveaux composes tricycliques, leur procede de preparation, et les intermediaires de ce procede, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant
US6459001B1 (en) * 1997-03-20 2002-10-01 Aventis Pharma S.A. Tricyclic compounds, their preparation process and the intermediates of this process, their use as medicaments and the pharmaceutical compositions containing them
FR2768734B1 (fr) * 1997-09-24 2000-01-28 Roussel Uclaf Nouveaux composes tricycliques, leur procede de preparation et les intermediaires de ce procede, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant
FR2768736B1 (fr) * 1997-09-24 2000-05-26 Roussel Uclaf Nouveaux composes tricycliques, leur procede de preparation et les intermediaires de ce procede, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant
CN1391553A (zh) 1999-11-18 2003-01-15 味之素株式会社 高甜度甜味剂用的新型中间体以及它的制造方法
IT1318436B1 (it) * 2000-03-31 2003-08-25 Enichem Spa Ciclopentadieni sostituiti policiclici e metodo per la loropreparazione.
US7210997B2 (en) * 2001-09-28 2007-05-01 Igt Gaming device having a mechanical award indicator
WO2011022805A1 (en) * 2009-08-26 2011-03-03 Alberta Health Services Novel colchicine derivatives, methods and uses thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5426224A (en) * 1993-03-18 1995-06-20 The University Of North Carolina At Chapel Hill Mammalian DNA topoisomerase II inhibitor and method

Also Published As

Publication number Publication date
CA2170806C (fr) 2009-12-01
HU9600517D0 (en) 1996-04-29
FR2731217A1 (fr) 1996-09-06
DE69606337T2 (de) 2000-08-10
HUP9600517A3 (en) 1998-07-28
CN1067044C (zh) 2001-06-13
EP0729933B1 (fr) 2000-01-26
US6268520B1 (en) 2001-07-31
CN1310171A (zh) 2001-08-29
KR100415038B1 (ko) 2004-04-13
PT729933E (pt) 2000-05-31
ATE189203T1 (de) 2000-02-15
AU717153B2 (en) 2000-03-16
AU4585096A (en) 1996-09-12
DE69606337D1 (de) 2000-03-02
HUP9600517A2 (en) 1997-01-28
JP3831445B2 (ja) 2006-10-11
ES2141445T3 (es) 2000-03-16
KR100414622B1 (ko) 2004-01-13
EA000093B1 (ru) 1998-06-25
EA199600007A2 (ru) 1996-10-01
US5705704A (en) 1998-01-06
ZA961694B (en) 1997-03-03
EA199600007A3 (ru) 1996-12-30
GR3033123T3 (en) 2000-08-31
CN1143622A (zh) 1997-02-26
CA2170806A1 (fr) 1996-09-04
FR2731217B1 (fr) 1997-06-13
US5959146A (en) 1999-09-28
KR960034153A (ko) 1996-10-22
MX9600816A (es) 1997-02-28
EP0729933A1 (fr) 1996-09-04
JPH0967326A (ja) 1997-03-11

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