DK0672063T3 - Mindste genkendelsesenhed af et PEM mucintandemgentagelsesspecifikt monoklonalt antistof - Google Patents

Mindste genkendelsesenhed af et PEM mucintandemgentagelsesspecifikt monoklonalt antistof

Info

Publication number
DK0672063T3
DK0672063T3 DK92908820.1T DK92908820T DK0672063T3 DK 0672063 T3 DK0672063 T3 DK 0672063T3 DK 92908820 T DK92908820 T DK 92908820T DK 0672063 T3 DK0672063 T3 DK 0672063T3
Authority
DK
Denmark
Prior art keywords
pct
monoclonal antibody
recognition unit
specific monoclonal
tandem repeat
Prior art date
Application number
DK92908820.1T
Other languages
English (en)
Inventor
Nigel Stephen A Courtenay-Luck
Original Assignee
Cancer Therapeutics Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cancer Therapeutics Limited filed Critical Cancer Therapeutics Limited
Application granted granted Critical
Publication of DK0672063T3 publication Critical patent/DK0672063T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4727—Mucins, e.g. human intestinal mucin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1021—Tetrapeptides with the first amino acid being acidic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK92908820.1T 1991-04-23 1992-04-23 Mindste genkendelsesenhed af et PEM mucintandemgentagelsesspecifikt monoklonalt antistof DK0672063T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB919108652A GB9108652D0 (en) 1991-04-23 1991-04-23 Immunoreactive compounds

Publications (1)

Publication Number Publication Date
DK0672063T3 true DK0672063T3 (da) 1998-05-18

Family

ID=10693760

Family Applications (1)

Application Number Title Priority Date Filing Date
DK92908820.1T DK0672063T3 (da) 1991-04-23 1992-04-23 Mindste genkendelsesenhed af et PEM mucintandemgentagelsesspecifikt monoklonalt antistof

Country Status (10)

Country Link
US (4) US5591593A (da)
EP (1) EP0672063B1 (da)
JP (1) JP3280966B2 (da)
AT (1) ATE159727T1 (da)
DE (1) DE69222956T2 (da)
DK (1) DK0672063T3 (da)
ES (1) ES2111066T3 (da)
GB (2) GB9108652D0 (da)
GR (1) GR3025982T3 (da)
WO (1) WO1992018534A1 (da)

Families Citing this family (34)

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US5443815A (en) * 1991-11-27 1995-08-22 Diatech, Inc. Technetium-99m labeled peptides for imaging
GB9108652D0 (en) * 1991-04-23 1991-06-12 Antisoma Ltd Immunoreactive compounds
AU684348B2 (en) * 1994-06-07 1997-12-11 Nihon Medi-Physics Co., Ltd. Tumor affinity peptide, and radioactive diagnostic agent and adioactive therapeutic agent containing the peptide
CA2165228A1 (en) * 1994-12-27 1996-06-28 Yoshitoshi Itaya Metal chelate forming peptides and use thereof
GR1002903B (el) * 1995-11-21 1998-05-12 Antisoma Limited Πεπτιδιο συγγενες με ογκο και ραδιενεργος διαγνωστικος παραγοντας και ραδιενεργος θεραπευτικος παραγοντας που περιεχει το πεπτιδιο.
WO1997043416A1 (en) * 1996-05-10 1997-11-20 Biogen, Inc. Common gamma chain blocking agents
US8038994B2 (en) * 1996-05-15 2011-10-18 Quest Pharmatech Inc. Combination therapy for treating disease
SI0910407T1 (en) * 1996-05-15 2003-10-31 Altarex Corp. Method and composition for reconforming multi-epitopic antigens to initiate an immune response
US7318921B2 (en) * 1996-05-15 2008-01-15 Altarex Medical Corp. Therapeutic compositions that alter the immune response
US20060159688A1 (en) * 1996-05-15 2006-07-20 Ragupathy Madiyalakan Method for diagnosing efficacy of xenotypic antibody therapy
US7361346B1 (en) * 1996-05-15 2008-04-22 Altarex Corp. Therapeutic compositions that produce an immune response
US5952294A (en) * 1996-07-31 1999-09-14 University Of Pittsburgh Of The Commonwealth System Of Higher Education Peptidyl prodrugs and methods of making and using the same
ATE337329T1 (de) * 1997-08-28 2006-09-15 Biomira Inc Zufälligverteilt erzeugte kombinatorische peptidbibliotheken
WO2000077031A2 (en) * 1999-06-15 2000-12-21 University Health Network Muc1 ligands
WO2003002908A1 (en) * 2000-06-26 2003-01-09 Reveo, Inc. Backlight for a liquid crystal display having high light-recycling efficiency
MXPA03003401A (es) * 2000-10-16 2004-06-30 Neopharm Inc Formulacion liposomica de mitoxantrona.
US20040143101A1 (en) * 2001-04-02 2004-07-22 Soltis Daniel A. Immunoglobulin construct containing anti-mucin variable domain sequences for eliciting an anti-idiotype anti-tumor response
US20050069549A1 (en) 2002-01-14 2005-03-31 William Herman Targeted ligands
WO2003086041A2 (en) * 2002-04-11 2003-10-23 Altarex Medical Corporation Binding agents and their use in targeting tumor cells
EP2486941B1 (en) 2006-10-02 2017-03-15 E. R. Squibb & Sons, L.L.C. Human antibodies that bind CXCR4 and uses thereof
US7906120B2 (en) 2006-11-21 2011-03-15 Abbott Laboratories Neutralizing monoclonal antibodies against the Nogo-66 receptor (NgR)
KR101552735B1 (ko) 2006-12-01 2015-09-14 메다렉스, 엘.엘.시. 씨디22에 결합하는 인간 항체 및 이의 용도
CL2007003622A1 (es) 2006-12-13 2009-08-07 Medarex Inc Anticuerpo monoclonal humano anti-cd19; composicion que lo comprende; y metodo de inhibicion del crecimiento de celulas tumorales.
WO2008074004A2 (en) 2006-12-14 2008-06-19 Medarex, Inc. Human antibodies that bind cd70 and uses thereof
AR072999A1 (es) 2008-08-11 2010-10-06 Medarex Inc Anticuerpos humanos que se unen al gen 3 de activacion linfocitaria (lag-3) y los usos de estos
JP6087289B2 (ja) * 2010-12-14 2017-03-01 レセプタ バイオファーマ エス．エー． Ｎａｐｉ２ｂ輸送体に対するヒト化モノクローナル抗体の相補性決定領域に由来する抗腫瘍ペプチド
EP3252076B1 (en) 2011-01-14 2019-09-04 The Regents Of The University Of California Diagnostic use of antibodies against ror-1 protein
UY34887A (es) 2012-07-02 2013-12-31 Bristol Myers Squibb Company Una Corporacion Del Estado De Delaware Optimización de anticuerpos que se fijan al gen de activación de linfocitos 3 (lag-3) y sus usos
CN107550864B (zh) * 2017-08-23 2020-12-18 科笛生物医药(上海)有限公司 Eppt多肽-聚乙二醇-磷脂复合膜材料、其制备方法及主动靶向脂质体递药***和应用
BR112021001201A2 (pt) 2018-07-25 2021-04-27 Innovent Biologics (Suzhou) Co., Ltd. anticorpo anti-tigit e uso do mesmo
CN109762067B (zh) 2019-01-17 2020-02-28 北京天广实生物技术股份有限公司 结合人Claudin 18.2的抗体及其用途
TW202140564A (zh) 2020-02-27 2021-11-01 大陸商正大天晴藥業集團股份有限公司 結合ｉｌ４ｒ的抗體及其用途
CN115461370A (zh) 2020-05-12 2022-12-09 正大天晴药业集团股份有限公司 St2抗原结合蛋白
CN118159286A (zh) 2021-11-25 2024-06-07 正大天晴药业集团股份有限公司 抗Siglec-15抗体及其应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT84182B (pt) * 1986-01-22 1989-09-14 Pasteur Institut Novo retrovirus susceptivel de provocar o sida, meios e processos para a sua deteccao "in vitro"
GB8607679D0 (en) * 1986-03-27 1986-04-30 Winter G P Recombinant dna product
US5077220A (en) * 1988-08-26 1991-12-31 John Muir Cancer & Aging Institute Monoclonal antibody specific to a novel glycoprotein antigen on human carcinoma cells
WO1990005142A1 (en) * 1988-11-10 1990-05-17 Imperial Cancer Research Technology Ltd. Polypeptides
JPH02273195A (ja) * 1988-11-17 1990-11-07 Univ Melbourne ヒト多型性上皮ムチンと反応するモノクローナル抗体
JP2750220B2 (ja) * 1989-07-21 1998-05-13 ワシントン ユニバーシティ 組換え産生したヒト細胞膜補助因子タンパク（ｍｃｐ）
CA1341094C (en) * 1989-09-25 2000-09-05 Ronald G. Worton Diagnosis for malignant hyperthermia
WO1992010518A1 (en) * 1990-12-07 1992-06-25 Yale University Purified slit protein and sequence elements thereof
GB9108652D0 (en) * 1991-04-23 1991-06-12 Antisoma Ltd Immunoreactive compounds

Also Published As

Publication number Publication date
GB9108652D0 (en) 1991-06-12
US5833943A (en) 1998-11-10
ES2111066T3 (es) 1998-03-01
EP0672063B1 (en) 1997-10-29
EP0672063A1 (en) 1995-09-20
GR3025982T3 (en) 1998-04-30
ATE159727T1 (de) 1997-11-15
GB9319300D0 (en) 1993-12-22
JPH06506927A (ja) 1994-08-04
DE69222956D1 (de) 1997-12-04
US6107469A (en) 2000-08-22
DE69222956T2 (de) 1998-04-09
GB2270078B (en) 1995-07-12
GB2270078A (en) 1994-03-02
US5591593A (en) 1997-01-07
JP3280966B2 (ja) 2002-05-13
WO1992018534A1 (en) 1992-10-29
US6174691B1 (en) 2001-01-16

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