DK0591280T3 - Anvendelse af tetrahydrocarbazolderivater som 5HT1-receptoragonister - Google Patents

Anvendelse af tetrahydrocarbazolderivater som 5HT1-receptoragonister

Info

Publication number
DK0591280T3
DK0591280T3 DK92912379T DK92912379T DK0591280T3 DK 0591280 T3 DK0591280 T3 DK 0591280T3 DK 92912379 T DK92912379 T DK 92912379T DK 92912379 T DK92912379 T DK 92912379T DK 0591280 T3 DK0591280 T3 DK 0591280T3
Authority
DK
Denmark
Prior art keywords
receptor agonists
tetrahydrocarbazole derivatives
tetrahydrocarbazole
derivatives
agonists
Prior art date
Application number
DK92912379T
Other languages
Danish (da)
English (en)
Inventor
Francis David King
Laramie Mary Gaster
Alberto Julio Kaumann
Rodney Christopher Young
Original Assignee
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10697363&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0591280(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc
Application granted granted Critical
Publication of DK0591280T3 publication Critical patent/DK0591280T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56Ring systems containing three or more rings
    • C07D209/80[b, c]- or [b, d]-condensed
    • C07D209/82Carbazoles; Hydrogenated carbazoles
    • C07D209/88Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/06Antimigraine agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK92912379T 1991-06-26 1992-06-17 Anvendelse af tetrahydrocarbazolderivater som 5HT1-receptoragonister DK0591280T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB919113802A GB9113802D0 (en) 1991-06-26 1991-06-26 Medicaments
PCT/GB1992/001082 WO1993000086A1 (en) 1991-06-26 1992-06-17 Use of tetrahydrocarbazone derivatives as 5ht1 receptor agonists

Publications (1)

Publication Number Publication Date
DK0591280T3 true DK0591280T3 (da) 1999-02-15

Family

ID=10697363

Family Applications (1)

Application Number Title Priority Date Filing Date
DK92912379T DK0591280T3 (da) 1991-06-26 1992-06-17 Anvendelse af tetrahydrocarbazolderivater som 5HT1-receptoragonister

Country Status (35)

Country Link
US (2) US5464864A (cs)
EP (1) EP0591280B1 (cs)
JP (1) JP3261502B2 (cs)
KR (1) KR100251571B1 (cs)
CN (1) CN1034072C (cs)
AP (1) AP344A (cs)
AT (1) ATE170746T1 (cs)
BR (2) BR9206237A (cs)
CA (1) CA2113726C (cs)
CZ (3) CZ282083B6 (cs)
DE (2) DE69226953T2 (cs)
DK (1) DK0591280T3 (cs)
FI (1) FI103967B1 (cs)
GB (1) GB9113802D0 (cs)
HK (1) HK1014669A1 (cs)
HU (1) HU218907B (cs)
IE (1) IE922062A1 (cs)
IL (4) IL117105A (cs)
LU (1) LU90939I2 (cs)
MA (1) MA22563A1 (cs)
MX (1) MX9203444A (cs)
NL (1) NL300103I2 (cs)
NO (2) NO304774B1 (cs)
NZ (1) NZ243288A (cs)
PL (3) PL171034B1 (cs)
PT (1) PT100620B (cs)
RU (1) RU2137474C1 (cs)
SA (1) SA92130141B1 (cs)
SG (1) SG47877A1 (cs)
SI (1) SI9200125B (cs)
SK (3) SK280906B6 (cs)
TW (1) TW214544B (cs)
UA (1) UA41254C2 (cs)
WO (1) WO1993000086A1 (cs)
ZA (1) ZA924658B (cs)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9211277D0 (en) 1992-05-28 1992-07-15 Glaxo Group Inc Pharmaceutical compositions
GB9226530D0 (en) * 1992-12-21 1993-02-17 Smithkline Beecham Plc Compounds
US5616603A (en) * 1995-05-26 1997-04-01 Smithkline Beecham Plc Enantiomers of carbazole derivatives as 5-HT1 -like agonists
GB9226566D0 (en) * 1992-12-21 1993-02-17 Smithkline Beecham Plc Compounds
US5618948A (en) * 1995-05-26 1997-04-08 Smithkline Beecham P.L.C. Process for preparing an enantiomer of a carbazole derivative
DE69610793T2 (de) * 1995-06-23 2001-05-03 Eli Lilly And Co., Indianapolis 6-Subsitituierte-1,2,3,4-tetrahydro-9H-Carbazole und 7-substituierte-1OH-Cyclohepta(7,6-B)-Indole
US5917054A (en) * 1995-07-18 1999-06-29 Smithkline Beecham P.L.C. Process for preparing enantiomers of carbazole derivatives as 5-HT1 -like agonists
US5708187A (en) * 1996-06-27 1998-01-13 Eli Lilly And Company 6-substituted-1,2,3,4-tetrahydro-9H-carbazoles and 7-substituted-10H-cyclohepta 7,6-B!indoles: New 5-HT1F agonists
US5891885A (en) * 1996-10-09 1999-04-06 Algos Pharmaceutical Corporation Method for treating migraine
GB9723061D0 (en) * 1997-10-31 1998-01-07 Vanguard Medica Ltd Medicaments
US7189753B1 (en) 1997-11-06 2007-03-13 Cady Roger K Preemptive prophylaxis of migraine
US6066092A (en) * 1997-11-06 2000-05-23 Cady; Roger K. Preemptive prophylaxis of migraine device and method
GB9808069D0 (en) * 1998-04-16 1998-06-17 Vanguard Medica Ltd Novel processes
GB9817911D0 (en) * 1998-08-17 1998-10-14 Vanguard Medica Ltd New use
US20030198669A1 (en) * 2001-07-05 2003-10-23 R.T. Alamo Ventures I, Llc Compositions and methods for rapid dissolving formulations of dihydroergotamine and caffeine for the treatment of migraine
US20030017175A1 (en) * 2001-07-05 2003-01-23 R.T. Alamo Ventures I, Inc. Sublingual administration of dihydroergotamine for the treatment of migraine
US6685951B2 (en) 2001-07-05 2004-02-03 R. T. Alamo Ventures I, Inc. Administration of dihydroergotamine as a sublingual spray or aerosol for the treatment of migraine
US7297711B2 (en) 2002-06-21 2007-11-20 Suven Life Sciences Limited Arylalkyl indoles having serotonin receptor affinity useful as therapeutic agents, process for their preparation and pharmaceutical compositions containing them
DE60317333T2 (de) 2002-06-21 2008-08-28 Suven Life Sciences Ltd. Tetracyklische arylsulfonylindole mit affinität zum serotonin rezeptor
JP4782425B2 (ja) 2002-11-28 2011-09-28 スベン ライフ サイエンシズ リミティド N−アリールスルホニル−3−アミノアルコキシインドール
WO2004048330A1 (en) 2002-11-28 2004-06-10 Suven Life Sciences Limited N-arylsulfonyl-3-substituted indoles having serotonin receptor affinity, process for their preparation and pharmaceutical composition containing them
EA009367B1 (ru) 2002-12-18 2007-12-28 Сувен Лайф Сайенсиз Лимитед ПРОИЗВОДНЫЕ 5-ТИА-5-ДИОКСО-4b-АЗАИНДЕНО[2,1-a]ИНДЕНА, ОБЛАДАЮЩИЕ АФФИННОСТЬЮ К РЕЦЕПТОРУ СЕРОТОНИНА
KR101411820B1 (ko) * 2006-08-07 2014-06-24 액테리온 파마슈티칼 리미티드 (3-아미노-1,2,3,4-테트라하이드로-9h-카르바졸-9-일)-아세트산 유도체
US8653066B2 (en) 2006-10-09 2014-02-18 Charleston Laboratories, Inc. Pharmaceutical compositions
PT2425820E (pt) 2007-02-11 2015-08-04 Map Pharmaceuticals Inc Método de administração terapêutica de dhe para permitir o rápido alívio das enxaquecas ao mesmo tempo que minimiza o perfil de efeitos secundários
US20090069399A1 (en) * 2007-09-12 2009-03-12 Protia, Llc Deuterium-enriched frovatriptan
US8124126B2 (en) 2008-01-09 2012-02-28 Charleston Laboratories, Inc. Pharmaceutical compositions
WO2010073253A1 (en) * 2008-12-22 2010-07-01 Natco Pharma Limited Method for preparing an optically active frovatriptan
EP3311667A1 (en) 2009-07-08 2018-04-25 Charleston Laboratories, Inc. Pharmaceutical compositions
US9204906B2 (en) 2009-10-22 2015-12-08 Nuvasive, Inc. Posterior cervical fusion system and techniques
US10098674B2 (en) 2009-10-22 2018-10-16 Nuvasive, Inc. System and method for posterior cervical fusion
EP2734634B1 (en) 2011-07-22 2019-08-21 The University of Chicago Igf-1 for use in the treatment of migraine
US9394314B2 (en) 2012-12-21 2016-07-19 Map Pharmaceuticals, Inc. 8′-hydroxy-dihydroergotamine compounds and compositions
EP2816030A1 (en) 2013-06-20 2014-12-24 Duke Chem, S. A. Process for the preparation of frovatriptan and its enantiomer
GB201312768D0 (en) * 2013-07-17 2013-08-28 Ge Healthcare Ltd Work-up procedure
WO2017152130A1 (en) 2016-03-04 2017-09-08 Charleston Laboratories, Inc. Pharmaceutical compositions
EP3766483A1 (en) 2019-07-19 2021-01-20 BioPharma Synergies, S. L. Orodispersible powder composition comprising a triptan

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3642816A (en) * 1967-08-10 1972-02-15 Sterling Drug Inc 3-acetamido-1 2 3 4-tetrahydrocarbazole
US3959309A (en) * 1968-01-24 1976-05-25 Sterling Drug Inc. 3-Amido-1,2,3,4-tetrahydrocarbazoles
US4062864A (en) * 1968-01-24 1977-12-13 Sterling Drug Inc. 3-Hydroxy carbazole derivatives
US3592824A (en) * 1970-03-12 1971-07-13 Miles Lab 3-substituted amino-1,2,3,4-tetrahydrocarbazoles
US4172834A (en) * 1971-08-16 1979-10-30 Sterling Drug Inc. 3-Amino-tetrahydrocarbazoles
BE787537A (fr) * 1971-08-16 1973-02-14 Sterling Drug Inc Tetrahydrocarbazoles
US4257952A (en) * 1977-06-06 1981-03-24 Sterling Drug Inc. 3-Amino-tetrahydrocarbazoles
US4254134A (en) * 1978-03-17 1981-03-03 Endo Laboratories, Inc. Antidepressant 2-amino- and -2-(substituted amino)-cis-hexahydro-carbazoles
EP0115607A1 (de) * 1983-01-04 1984-08-15 MERCK PATENT GmbH Tetrahydrocarbazolderivate

Also Published As

Publication number Publication date
SA92130141B1 (ar) 2005-12-18
NO304774B1 (no) 1999-02-15
ATE170746T1 (de) 1998-09-15
JP3261502B2 (ja) 2002-03-04
NO934800L (no) 1993-12-23
EP0591280B1 (en) 1998-09-09
CZ150696A3 (en) 1997-06-11
AU652842B2 (en) 1994-09-08
MA22563A1 (fr) 1992-12-31
PL169392B1 (pl) 1996-07-31
UA41254C2 (uk) 2001-09-17
FI103967B (fi) 1999-10-29
SK131993A3 (en) 1994-06-08
AP9200403A0 (en) 1992-07-31
BR9206237A (pt) 1995-04-11
BR1100460A (pt) 2000-07-18
NO2005011I1 (no) 2005-05-18
CZ150596A3 (en) 1997-05-14
SI9200125A (en) 1992-12-31
CN1034072C (zh) 1997-02-19
HK1014669A1 (en) 1999-09-30
CA2113726A1 (en) 1993-01-07
DE10299042I2 (de) 2005-02-03
NZ243288A (en) 1994-09-27
WO1993000086A1 (en) 1993-01-07
AU1977592A (en) 1993-01-25
IE922062A1 (en) 1992-12-30
CZ282061B6 (cs) 1997-05-14
CZ282083B6 (cs) 1997-05-14
IL117104A (en) 1997-09-30
HU218907B (hu) 2000-12-28
PL171034B1 (en) 1997-02-28
CZ286193A3 (en) 1994-07-13
NL300103I2 (nl) 2003-02-03
IL117104A0 (en) 1996-06-18
PT100620B (pt) 1999-01-29
DE69226953T2 (de) 1999-05-12
PL169410B1 (pl) 1996-07-31
ZA924658B (en) 1993-12-24
NL300103I1 (nl) 2002-12-02
AP344A (en) 1994-07-05
LU90939I2 (fr) 2002-09-24
FI935842A (fi) 1993-12-23
IL102322A0 (en) 1993-01-14
SK280905B6 (sk) 2000-09-12
IL117105A (en) 1998-01-04
IL117105A0 (en) 1996-06-18
SI9200125B (en) 2001-12-31
RU2137474C1 (ru) 1999-09-20
SK280907B6 (sk) 2000-09-12
PT100620A (pt) 1993-09-30
DE10299042I1 (de) 2003-02-20
JPH06508827A (ja) 1994-10-06
SG47877A1 (en) 1998-04-17
CA2113726C (en) 2008-02-19
GB9113802D0 (en) 1991-08-14
CZ282327B6 (cs) 1997-06-11
IL102322A (en) 1997-09-30
US5637611A (en) 1997-06-10
FI935842A0 (fi) 1993-12-23
HUT68961A (en) 1995-08-28
FI103967B1 (fi) 1999-10-29
MX9203444A (es) 1993-12-01
NO2005011I2 (no) 2008-02-11
DE69226953D1 (de) 1998-10-15
NO934800D0 (no) 1993-12-23
SK280906B6 (sk) 2000-09-12
EP0591280A1 (en) 1994-04-13
KR100251571B1 (ko) 2000-07-01
US5464864A (en) 1995-11-07
TW214544B (cs) 1993-10-11
CN1069726A (zh) 1993-03-10

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