DK0562853T3 - 29-Demethoxyrapamycin til fremkaldelse af immunsuppression - Google Patents

29-Demethoxyrapamycin til fremkaldelse af immunsuppression

Info

Publication number
DK0562853T3
DK0562853T3 DK93302288.1T DK93302288T DK0562853T3 DK 0562853 T3 DK0562853 T3 DK 0562853T3 DK 93302288 T DK93302288 T DK 93302288T DK 0562853 T3 DK0562853 T3 DK 0562853T3
Authority
DK
Denmark
Prior art keywords
demethoxyrapamycin
induce immunosuppression
rejection
immunosuppression
induce
Prior art date
Application number
DK93302288.1T
Other languages
English (en)
Inventor
Suren Nath Sehgal
Jay Joseph Armstrong
Chee Ping Eng
Original Assignee
American Home Prod
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Home Prod filed Critical American Home Prod
Application granted granted Critical
Publication of DK0562853T3 publication Critical patent/DK0562853T3/da

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13Cyclosporins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Organic Chemistry (AREA)
  • Transplantation (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DK93302288.1T 1992-03-27 1993-03-25 29-Demethoxyrapamycin til fremkaldelse af immunsuppression DK0562853T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US85892392A 1992-03-27 1992-03-27

Publications (1)

Publication Number Publication Date
DK0562853T3 true DK0562853T3 (da) 1996-07-01

Family

ID=25329511

Family Applications (1)

Application Number Title Priority Date Filing Date
DK93302288.1T DK0562853T3 (da) 1992-03-27 1993-03-25 29-Demethoxyrapamycin til fremkaldelse af immunsuppression

Country Status (9)

Country Link
EP (1) EP0562853B1 (da)
JP (1) JP3179235B2 (da)
AT (1) ATE138807T1 (da)
CA (1) CA2092729A1 (da)
DE (1) DE69302945T2 (da)
DK (1) DK0562853T3 (da)
ES (1) ES2089723T3 (da)
GR (1) GR3020310T3 (da)
MX (1) MX9301707A (da)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2175215C (en) * 1993-11-19 2008-06-03 Yat Sun Or Semisynthetic analogs of rapamycin (macrolides) being immunomodulators
US5527907A (en) * 1993-11-19 1996-06-18 Abbott Laboratories Macrolide immunomodulators
EP1208847B8 (en) 1996-07-30 2007-02-14 Novartis AG Pharmaceutical compositions for the treatment of transplant rejection, as well as autoimmune or inflammatory conditions
EP1143993A4 (en) * 1999-01-22 2004-11-17 Fujisawa Pharmaceutical Co METHOD FOR SUPPRESSING A CONTINUOUS ACUTE ALLOGRAFT REPELLATION
US20100004738A1 (en) * 2005-04-29 2010-01-07 Atrium Medical Corporation Drug delivery coating for use with a medical device and methods of treating vascular injury
US9428845B1 (en) 2010-12-28 2016-08-30 Warp Drive Bio, Inc. Identifying new therapeutic agents
EP3247378B8 (en) 2015-01-09 2023-08-23 Revolution Medicines, Inc. Macrocyclic compounds that participate in cooperative binding and medical uses thereof
TW201629069A (zh) 2015-01-09 2016-08-16 霍普驅動生物科技股份有限公司 參與協同結合之化合物及其用途
CA3000822A1 (en) 2015-10-01 2017-04-06 Warp Drive Bio, Inc. Methods and reagents for analyzing protein-protein interfaces
EP3442599B1 (en) 2016-04-12 2022-03-30 Warp Drive Bio, Inc. Compositions and methods for the production of compounds
CA3042231A1 (en) 2016-10-28 2018-05-03 Ginkgo Bioworks, Inc. Compositions and methods for the production of compounds
KR20220109407A (ko) 2019-11-04 2022-08-04 레볼루션 메디슨즈, 인크. Ras 억제제
WO2021091967A1 (en) 2019-11-04 2021-05-14 Revolution Medicines, Inc. Ras inhibitors
AU2020379734A1 (en) 2019-11-04 2022-05-05 Revolution Medicines, Inc. Ras inhibitors
US11690915B2 (en) 2020-09-15 2023-07-04 Revolution Medicines, Inc. Ras inhibitors

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA737247B (en) 1972-09-29 1975-04-30 Ayerst Mckenna & Harrison Rapamycin and process of preparation
US4375464A (en) 1981-11-19 1983-03-01 Ayerst, Mckenna & Harrison Inc. Antibiotic AY24,668 and process of preparation
US4894366A (en) 1984-12-03 1990-01-16 Fujisawa Pharmaceutical Company, Ltd. Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same
US5100899A (en) 1989-06-06 1992-03-31 Roy Calne Methods of inhibiting transplant rejection in mammals using rapamycin and derivatives and prodrugs thereof
US5023262A (en) * 1990-08-14 1991-06-11 American Home Products Corporation Hydrogenated rapamycin derivatives
GB9103430D0 (en) * 1991-02-19 1991-04-03 Smithkline Beecham Plc Novel compound
US5080899A (en) 1991-02-22 1992-01-14 American Home Products Corporation Method of treating pulmonary inflammation
US5078999A (en) 1991-02-22 1992-01-07 American Home Products Corporation Method of treating systemic lupus erythematosus
US5091389A (en) 1991-04-23 1992-02-25 Merck & Co., Inc. Lipophilic macrolide useful as an immunosuppressant

Also Published As

Publication number Publication date
DE69302945T2 (de) 1996-10-10
DE69302945D1 (de) 1996-07-11
JPH0616674A (ja) 1994-01-25
GR3020310T3 (en) 1996-09-30
EP0562853B1 (en) 1996-06-05
ES2089723T3 (es) 1996-10-01
MX9301707A (es) 1993-09-01
ATE138807T1 (de) 1996-06-15
CA2092729A1 (en) 1993-09-28
JP3179235B2 (ja) 2001-06-25
EP0562853A1 (en) 1993-09-29

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