DE69302945T2 - 29-Demethoxyrapamycin zur Induktion der Immunosuppression - Google Patents

29-Demethoxyrapamycin zur Induktion der Immunosuppression

Info

Publication number
DE69302945T2
DE69302945T2 DE69302945T DE69302945T DE69302945T2 DE 69302945 T2 DE69302945 T2 DE 69302945T2 DE 69302945 T DE69302945 T DE 69302945T DE 69302945 T DE69302945 T DE 69302945T DE 69302945 T2 DE69302945 T2 DE 69302945T2
Authority
DE
Germany
Prior art keywords
demethoxyrapamycin
immunosuppression
induction
rejection
mammal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69302945T
Other languages
English (en)
Other versions
DE69302945D1 (de
Inventor
Suren Nath Sehgal
Jay Joseph Armstrong
Chee Ping Eng
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth LLC
Original Assignee
American Home Products Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Home Products Corp filed Critical American Home Products Corp
Application granted granted Critical
Publication of DE69302945D1 publication Critical patent/DE69302945D1/de
Publication of DE69302945T2 publication Critical patent/DE69302945T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
DE69302945T 1992-03-27 1993-03-25 29-Demethoxyrapamycin zur Induktion der Immunosuppression Expired - Fee Related DE69302945T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US85892392A 1992-03-27 1992-03-27

Publications (2)

Publication Number Publication Date
DE69302945D1 DE69302945D1 (de) 1996-07-11
DE69302945T2 true DE69302945T2 (de) 1996-10-10

Family

ID=25329511

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69302945T Expired - Fee Related DE69302945T2 (de) 1992-03-27 1993-03-25 29-Demethoxyrapamycin zur Induktion der Immunosuppression

Country Status (9)

Country Link
EP (1) EP0562853B1 (de)
JP (1) JP3179235B2 (de)
AT (1) ATE138807T1 (de)
CA (1) CA2092729A1 (de)
DE (1) DE69302945T2 (de)
DK (1) DK0562853T3 (de)
ES (1) ES2089723T3 (de)
GR (1) GR3020310T3 (de)
MX (1) MX9301707A (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5527907A (en) * 1993-11-19 1996-06-18 Abbott Laboratories Macrolide immunomodulators
CA2175215C (en) * 1993-11-19 2008-06-03 Yat Sun Or Semisynthetic analogs of rapamycin (macrolides) being immunomodulators
ES2182112T3 (es) 1996-07-30 2003-03-01 Novartis Ag Composiciones farmaceuticas para el tratamiento del rechazo de transplantes y de estados autoinmunes o inflamatorios, que comprenden ciclosporina a y 40-o-(2-hidroxietil)-rapamicina.
JP2002535283A (ja) * 1999-01-22 2002-10-22 藤沢薬品工業株式会社 進行中の急性同種移植片拒絶反応を抑制する方法
US20100034867A1 (en) * 2005-04-29 2010-02-11 Atrium Medical Corporation Drug delivery coating for use with a medical device and methods of treating vascular injury
US9428845B1 (en) 2010-12-28 2016-08-30 Warp Drive Bio, Inc. Identifying new therapeutic agents
EP4289950A3 (de) 2015-01-09 2024-01-24 Revolution Medicines, Inc. Makrozyklische verbindungen mit beteiligung an einer kooperativen bindung und medizinische verwendungen davon
TW201629069A (zh) 2015-01-09 2016-08-16 霍普驅動生物科技股份有限公司 參與協同結合之化合物及其用途
US9989535B2 (en) 2015-10-01 2018-06-05 Warp Drive Bio, Inc. Methods and reagents for analyzing protein-protein interfaces
AU2017249412B2 (en) 2016-04-12 2022-07-07 Ginkgo Bioworks, Inc. Compositions and methods for the production of compounds
WO2018081592A2 (en) 2016-10-28 2018-05-03 Warp Drive Bio, Inc. Compositions and methods for the production of compounds
CN115873020A (zh) 2019-11-04 2023-03-31 锐新医药公司 Ras抑制剂
WO2021091982A1 (en) 2019-11-04 2021-05-14 Revolution Medicines, Inc. Ras inhibitors
CA3160142A1 (en) 2019-11-04 2021-05-14 Revolution Medicines, Inc. Ras inhibitors
PE20231207A1 (es) 2020-09-15 2023-08-17 Revolution Medicines Inc Derivados indolicos como inhibidores de ras en el tratamiento del cancer

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA737247B (en) 1972-09-29 1975-04-30 Ayerst Mckenna & Harrison Rapamycin and process of preparation
US4375464A (en) 1981-11-19 1983-03-01 Ayerst, Mckenna & Harrison Inc. Antibiotic AY24,668 and process of preparation
US4894366A (en) * 1984-12-03 1990-01-16 Fujisawa Pharmaceutical Company, Ltd. Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same
US5100899A (en) 1989-06-06 1992-03-31 Roy Calne Methods of inhibiting transplant rejection in mammals using rapamycin and derivatives and prodrugs thereof
US5023262A (en) * 1990-08-14 1991-06-11 American Home Products Corporation Hydrogenated rapamycin derivatives
GB9103430D0 (en) * 1991-02-19 1991-04-03 Smithkline Beecham Plc Novel compound
US5080899A (en) 1991-02-22 1992-01-14 American Home Products Corporation Method of treating pulmonary inflammation
US5078999A (en) 1991-02-22 1992-01-07 American Home Products Corporation Method of treating systemic lupus erythematosus
US5091389A (en) 1991-04-23 1992-02-25 Merck & Co., Inc. Lipophilic macrolide useful as an immunosuppressant

Also Published As

Publication number Publication date
JP3179235B2 (ja) 2001-06-25
DE69302945D1 (de) 1996-07-11
GR3020310T3 (en) 1996-09-30
MX9301707A (es) 1993-09-01
EP0562853B1 (de) 1996-06-05
EP0562853A1 (de) 1993-09-29
ES2089723T3 (es) 1996-10-01
DK0562853T3 (da) 1996-07-01
JPH0616674A (ja) 1994-01-25
ATE138807T1 (de) 1996-06-15
CA2092729A1 (en) 1993-09-28

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: WYETH (N.D.GES.D. STAATES DELAWARE), MADISON, N.J.

8339 Ceased/non-payment of the annual fee