DK0557385T3 - Topiske sammensætninger til transdermal afgivelse af prodrug-derivater af morfin - Google Patents

Topiske sammensætninger til transdermal afgivelse af prodrug-derivater af morfin

Info

Publication number
DK0557385T3
DK0557385T3 DK91920399T DK91920399T DK0557385T3 DK 0557385 T3 DK0557385 T3 DK 0557385T3 DK 91920399 T DK91920399 T DK 91920399T DK 91920399 T DK91920399 T DK 91920399T DK 0557385 T3 DK0557385 T3 DK 0557385T3
Authority
DK
Denmark
Prior art keywords
transdermal delivery
pct
morphine
topical compositions
prodrug derivatives
Prior art date
Application number
DK91920399T
Other languages
English (en)
Inventor
Hans Bundgaard
Lona Christrup
Joern Drustrup
Ann Fullerton
Martin Nicklasson
Original Assignee
Pharmacia & Upjohn Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia & Upjohn Ab filed Critical Pharmacia & Upjohn Ab
Application granted granted Critical
Publication of DK0557385T3 publication Critical patent/DK0557385T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
DK91920399T 1990-11-16 1991-11-11 Topiske sammensætninger til transdermal afgivelse af prodrug-derivater af morfin DK0557385T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9003665A SE9003665D0 (sv) 1990-11-16 1990-11-16 Morphine prodrugs
PCT/SE1991/000760 WO1992008459A1 (en) 1990-11-16 1991-11-11 Topical compositions for transdermal delivery of produg derivatives of morphine

Publications (1)

Publication Number Publication Date
DK0557385T3 true DK0557385T3 (da) 1999-04-26

Family

ID=20380936

Family Applications (1)

Application Number Title Priority Date Filing Date
DK91920399T DK0557385T3 (da) 1990-11-16 1991-11-11 Topiske sammensætninger til transdermal afgivelse af prodrug-derivater af morfin

Country Status (18)

Country Link
US (1) US5908846A (da)
EP (1) EP0557385B1 (da)
JP (1) JP3493434B2 (da)
AT (1) ATE168560T1 (da)
AU (1) AU655612B2 (da)
CA (1) CA2095223C (da)
DE (1) DE69129861T2 (da)
DK (1) DK0557385T3 (da)
ES (1) ES2121793T3 (da)
FI (1) FI932212A0 (da)
IE (1) IE913682A1 (da)
IL (1) IL99905A (da)
NO (1) NO931766L (da)
NZ (1) NZ240349A (da)
PT (1) PT99513B (da)
SE (1) SE9003665D0 (da)
WO (1) WO1992008459A1 (da)
ZA (1) ZA918512B (da)

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JPH07267862A (ja) * 1994-03-29 1995-10-17 Sekisui Chem Co Ltd 経皮吸収貼付剤
WO1996028451A1 (en) * 1995-03-14 1996-09-19 Euroceltique S.A. Morphine-3-esters
DE19508664C2 (de) * 1995-03-14 2001-08-23 Christian Mignat Verwendung von Morphin-3-estern, Morphin-3-ester als solche und Verfahren zu deren Herstellung
GB9519363D0 (en) 1995-09-22 1995-11-22 Euro Celtique Sa Pharmaceutical formulation
DE19602963A1 (de) * 1995-12-20 1997-07-31 Nycomed Arzneimittel Gmbh Neue Morphinderivate, Verfahren zu deren Herstellung und deren Verwendung
DE19923551A1 (de) * 1999-05-21 2000-11-30 Lohmann Therapie Syst Lts Pharmazeutisches Präparat mit dem Wirkstoff Diamorphin und seine Verwendung in einem Verfahren zur Behandlung der Opiatsucht
ATE526950T1 (de) 1999-10-29 2011-10-15 Euro Celtique Sa Hydrocodon-formulierungen mit gesteuerter freisetzung
US10179130B2 (en) 1999-10-29 2019-01-15 Purdue Pharma L.P. Controlled release hydrocodone formulations
US20020013331A1 (en) * 2000-06-26 2002-01-31 Williams Robert O. Methods and compositions for treating pain of the mucous membrane
CA2427815C (en) 2000-10-30 2007-07-10 Euro-Celtique S.A. Controlled release hydrocodone formulations
US6569449B1 (en) * 2000-11-13 2003-05-27 University Of Kentucky Research Foundation Transdermal delivery of opioid antagonist prodrugs
AUPR549901A0 (en) 2001-06-06 2001-07-12 Vital Health Sciences Pty Ltd Topical formulation containing tocopheryl phosphates
KR100612398B1 (ko) * 2000-11-14 2006-08-16 바이탈 헬스 사이언시즈 피티와이 리미티드 포스페이트 유도체의 착체
US20110104214A1 (en) 2004-04-15 2011-05-05 Purdue Pharma L.P. Once-a-day oxycodone formulations
CN1514729B (zh) * 2001-06-05 2012-09-05 控制释放***公司 缓释的止痛化合物
CN1547475B (zh) * 2001-07-27 2010-12-15 生命健康科学有限公司 含电子转移试剂的磷酸酯衍生物的皮肤制剂
WO2003049774A1 (en) * 2001-12-13 2003-06-19 Vital Health Sciences Pty Ltd Transdermal transport of compounds
AU2002950713A0 (en) 2002-08-09 2002-09-12 Vital Health Sciences Pty Ltd Carrier
ATE444296T1 (de) * 2002-10-25 2009-10-15 Euro Celtique Sa Analoga und prodrugs von buprenorphin
WO2004043396A2 (en) * 2002-11-09 2004-05-27 Nobex Corporation Modified carbamate-containing prodrugs and methods of synthesizing same
MXPA05007278A (es) * 2003-01-17 2005-09-30 Vital Health Sciences Pty Ltd Compuestos que tienen propiedades anti-proliferativas.
AU2003901815A0 (en) * 2003-04-15 2003-05-01 Vital Health Sciences Pty Ltd Phosphate derivatives
AU2004261181B2 (en) * 2003-07-25 2009-08-06 Euro-Celtique S.A. Preoperative treatment of post operative pain
ES2313299T3 (es) 2004-02-06 2009-03-01 Euro-Celtique S.A. Procedimientos para producir morfinonas 3 o protegidas y carboxilatos de morfinona dienol 3 o protegidos.
SI2351555T1 (sl) 2004-02-23 2017-01-31 Euro-Celtique S.A. Naprava za transdermalno dajanje opioida, varna pred zlorabo
JP4847437B2 (ja) * 2004-03-03 2011-12-28 バイタル ヘルス サイエンシズ プロプライアタリー リミティド アルカロイド製剤
ES2557475T3 (es) 2005-06-17 2016-01-26 Vital Health Sciences Pty Ltd. Un portador que comprende uno o más derivados di- y/o monofosfato de agentes de transferencia de electrones
KR20080085839A (ko) * 2005-12-23 2008-09-24 바이탈 헬스 사이언시즈 피티와이 리미티드 사이토킨 조절 특성을 가진 화합물
RU2428186C2 (ru) 2007-03-02 2011-09-10 Теика Фармасьютикал Ко., Лтд. Лекарственная композиция для чрескожной абсорбции, изделие, сохраняющее лекарственную композицию, и содержащий ее препарат для чрескожной абсорбции
US9511016B2 (en) * 2007-06-12 2016-12-06 Epicentrx, Inc. Topical composition for treating pain
US8354116B2 (en) * 2007-06-18 2013-01-15 Biochemics, Inc. Bifunctional synthetic molecules
US8784872B2 (en) 2007-11-19 2014-07-22 Comgenrx, Inc. Formulation for decreasing tobacco, alcohol, drug or food consumption
US20090130048A1 (en) * 2007-11-19 2009-05-21 Oronsky Bryan Todd Topical Composition for Treating Pain
WO2009158667A2 (en) * 2008-06-27 2009-12-30 Comgenrx, Inc. Povidone compositions for wound healing
US10849981B2 (en) 2009-07-02 2020-12-01 KemPham, Inc. Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of hydrocodone, prodrugs, methods of making and use thereof
US8871780B2 (en) 2009-07-02 2014-10-28 Kempharm, Inc. Phenylethanoic acid, phenylpropanoic acid and phenylpropenoic acid conjugates and prodrugs of hydrocodone, method of making and use thereof
UA102916C2 (uk) 2009-07-02 2013-08-27 Кемфарм, Інк. Композиція на основі кон'югату гідрокодону з бензойною кислотою, похідними бензойної кислоти або гетероарилкарбоновою кислотою, проліки, спосіб лікування від зловживань
WO2011094814A1 (en) 2010-02-05 2011-08-11 Phosphagenics Limited Carrier comprising non-neutralised tocopheryl phosphate
EP2552486B1 (en) 2010-03-30 2020-08-12 Phosphagenics Limited Transdermal delivery patch
US11607407B2 (en) 2010-04-13 2023-03-21 Relmada Therapeutics, Inc. Dermal pharmaceutical compositions of 1-methyl-2′,6′-pipecoloxylidide and method of use
TWI520732B (zh) 2011-01-18 2016-02-11 輝瑞有限公司 固體分子分散液
US9561243B2 (en) 2011-03-15 2017-02-07 Phosphagenics Limited Composition comprising non-neutralised tocol phosphate and a vitamin A compound
MX2017006520A (es) 2014-11-25 2017-08-09 Kempharm Inc * Acido benzoico, derivados de acido benzoico y conjugados de oxicodona de acido heteroaril carboxilico.
US10973761B2 (en) 2015-12-09 2021-04-13 Phosphagenics Limited Pharmaceutical formulation
CA3045702A1 (en) 2016-12-21 2018-06-28 Phosphagenics Limited Phosphorylation process of complex alcohols

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Publication number Priority date Publication date Assignee Title
US4626539A (en) * 1984-08-10 1986-12-02 E. I. Dupont De Nemours And Company Trandermal delivery of opioids
US4673679A (en) * 1986-05-14 1987-06-16 E. I. Du Pont De Nemours And Company Use of prodrugs of 3-hydroxymorphinans to prevent bitter taste upon buccal, nasal or sublingual administration
US4908389A (en) * 1986-08-27 1990-03-13 Warner-Lambert Company Penetration enhancement system
US4940586A (en) * 1987-02-26 1990-07-10 Alza Corporation Skin permeation enhancer compositions using sucrose esters
US4879297A (en) * 1987-06-01 1989-11-07 Warner-Lambert Company Fatty acids and their small chain esters as penetration enhancers in aqueous systems
US4891377A (en) * 1988-12-02 1990-01-02 Board Of Regents Acting For And On Behalf Of University Of Michigan Transdermal delivery of the narcotic analgesics etorphine and analogs
ATE143603T1 (de) * 1990-03-30 1996-10-15 Yasunori Morimoto Transdermal absorbierbares mittel mit morphin hydrochlorid
US5069909A (en) * 1990-06-20 1991-12-03 Cygnus Therapeutic Systems Transdermal administration of buprenorphine

Also Published As

Publication number Publication date
NO931766D0 (no) 1993-05-14
WO1992008459A1 (en) 1992-05-29
AU8938191A (en) 1992-06-11
ATE168560T1 (de) 1998-08-15
JPH06502422A (ja) 1994-03-17
CA2095223A1 (en) 1992-05-17
NO931766L (no) 1993-05-14
IE913682A1 (en) 1992-05-20
NZ240349A (en) 1993-07-27
ES2121793T3 (es) 1998-12-16
DE69129861T2 (de) 1999-04-01
FI932212A (fi) 1993-05-14
EP0557385A1 (en) 1993-09-01
FI932212A0 (fi) 1993-05-14
ZA918512B (en) 1992-08-26
US5908846A (en) 1999-06-01
EP0557385B1 (en) 1998-07-22
JP3493434B2 (ja) 2004-02-03
DE69129861D1 (de) 1998-08-27
CA2095223C (en) 2002-12-17
PT99513B (pt) 1999-04-30
IL99905A0 (en) 1992-08-18
IL99905A (en) 1995-06-29
PT99513A (pt) 1992-09-30
AU655612B2 (en) 1995-01-05
SE9003665D0 (sv) 1990-11-16

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