DK0533516T3 - Hidtil ukendte 1-(alkoxybenzyl)piperazinamidforbindelser, fremgangsmåder til fremstilling heraf og farmaceutiske midler, som indeholder dem - Google Patents
Hidtil ukendte 1-(alkoxybenzyl)piperazinamidforbindelser, fremgangsmåder til fremstilling heraf og farmaceutiske midler, som indeholder demInfo
- Publication number
- DK0533516T3 DK0533516T3 DK92402309.6T DK92402309T DK0533516T3 DK 0533516 T3 DK0533516 T3 DK 0533516T3 DK 92402309 T DK92402309 T DK 92402309T DK 0533516 T3 DK0533516 T3 DK 0533516T3
- Authority
- DK
- Denmark
- Prior art keywords
- compounds
- piperazinamide
- alkoxybenzyl
- processes
- preparation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
- C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
- C07D209/16—Tryptamines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
- C07D295/205—Radicals derived from carbonic acid
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Indole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9110431A FR2680508B1 (fr) | 1991-08-20 | 1991-08-20 | Nouveaux composes amidiques des 1-(alcoxybenzyl)piperazines, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent. |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0533516T3 true DK0533516T3 (da) | 1995-07-10 |
Family
ID=9416270
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK92402309.6T DK0533516T3 (da) | 1991-08-20 | 1992-08-20 | Hidtil ukendte 1-(alkoxybenzyl)piperazinamidforbindelser, fremgangsmåder til fremstilling heraf og farmaceutiske midler, som indeholder dem |
Country Status (13)
Country | Link |
---|---|
US (1) | US5340809A (es) |
EP (1) | EP0533516B1 (es) |
JP (1) | JPH0676397B2 (es) |
AT (1) | ATE118212T1 (es) |
AU (1) | AU648924B2 (es) |
CA (1) | CA2076443A1 (es) |
DE (1) | DE69201368T2 (es) |
DK (1) | DK0533516T3 (es) |
ES (1) | ES2071458T3 (es) |
FR (1) | FR2680508B1 (es) |
GR (1) | GR3015797T3 (es) |
NZ (1) | NZ244019A (es) |
ZA (1) | ZA926277B (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1245712B (it) * | 1991-04-09 | 1994-10-14 | Boehringer Mannheim Italia | Ammine eterocicliche utili terapia dell'asma e dell'infiammazione delle vie aeree |
EP1165082A4 (en) | 1999-03-03 | 2002-06-12 | Merck & Co Inc | PRENYLE PROTEIN TRANSFERASE INHIBITORS |
ES2279837T3 (es) * | 2000-11-20 | 2007-09-01 | Scios Inc. | Inhibidores de tipo piperidina/piperazina de la quinasa p38. |
US7115607B2 (en) * | 2001-07-25 | 2006-10-03 | Amgen Inc. | Substituted piperazinyl amides and methods of use |
ES2919779T3 (es) | 2017-06-20 | 2022-07-28 | Imbria Pharmaceuticals Inc | Derivado de 1-[(2,3,4-trimetoxifenil)metil]-piperazina, composiciones del mismo y métodos para aumentar la eficiencia del metabolismo cardíaco |
KR102042778B1 (ko) * | 2018-05-02 | 2019-11-08 | 이화여자대학교 산학협력단 | 신규 소듐채널 저해 화합물, 이의 제조방법, 및 이를 포함하는 소듐채널 관련 질환의 예방 또는 치료용 약학적 조성물 |
US11530184B2 (en) | 2020-06-30 | 2022-12-20 | Imbria Pharmaceuticals, Inc. | Crystal forms of 2-[4-[(2,3,4-trimethoxyphenyl)methyl]piperazin-1-yl]ethyl pyridine-3-carboxylate |
US11780811B2 (en) | 2020-06-30 | 2023-10-10 | Imbria Pharmaceuticals, Inc. | Methods of synthesizing 2-[4-[(2,3,4-trimethoxyphenyl)methyl]piperazin-1-yl]ethyl pyridine-3-carboxylate |
US11883396B2 (en) | 2021-05-03 | 2024-01-30 | Imbria Pharmaceuticals, Inc. | Methods of treating kidney conditions using modified forms of trimetazidine |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS57169478A (en) * | 1981-04-10 | 1982-10-19 | Nippon Chemiphar Co Ltd | Piperazine derivative |
FR2597100A1 (fr) * | 1986-01-21 | 1987-10-16 | Nippon Shinyaku Co Ltd | Derives du pyroglutamide |
JPH075545B2 (ja) * | 1988-08-04 | 1995-01-25 | 明治製菓株式会社 | ピロリジノン化合物及び脳機能障害改善剤 |
US4997836A (en) * | 1988-11-11 | 1991-03-05 | Takeda Chemical Industries, Ltd. | Trisubstituted piperazine compounds, their production and use |
EP0385043A1 (en) * | 1989-02-28 | 1990-09-05 | Fabrica Espanola De Productos Quimicos Y Farmaceuticos, S.A. (Faes) | New derivatives of 4-substituted piperazines |
FR2669029B1 (fr) * | 1990-11-14 | 1994-09-02 | Adir | Nouveaux derives de la n-benzoyl proline, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
-
1991
- 1991-08-20 FR FR9110431A patent/FR2680508B1/fr not_active Expired - Fee Related
-
1992
- 1992-08-13 US US07/929,993 patent/US5340809A/en not_active Expired - Fee Related
- 1992-08-19 CA CA002076443A patent/CA2076443A1/fr not_active Abandoned
- 1992-08-19 NZ NZ244019A patent/NZ244019A/en unknown
- 1992-08-19 AU AU21107/92A patent/AU648924B2/en not_active Ceased
- 1992-08-20 DK DK92402309.6T patent/DK0533516T3/da active
- 1992-08-20 AT AT92402309T patent/ATE118212T1/de not_active IP Right Cessation
- 1992-08-20 JP JP4221733A patent/JPH0676397B2/ja not_active Expired - Lifetime
- 1992-08-20 ZA ZA926277A patent/ZA926277B/xx unknown
- 1992-08-20 DE DE69201368T patent/DE69201368T2/de not_active Expired - Fee Related
- 1992-08-20 EP EP92402309A patent/EP0533516B1/fr not_active Expired - Lifetime
- 1992-08-20 ES ES92402309T patent/ES2071458T3/es not_active Expired - Lifetime
-
1995
- 1995-04-17 GR GR950400927T patent/GR3015797T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
EP0533516A3 (fr) | 1993-05-19 |
JPH05208967A (ja) | 1993-08-20 |
JPH0676397B2 (ja) | 1994-09-28 |
DE69201368T2 (de) | 1995-10-05 |
NZ244019A (en) | 1995-03-28 |
ATE118212T1 (de) | 1995-02-15 |
DE69201368D1 (de) | 1995-03-23 |
EP0533516A2 (fr) | 1993-03-24 |
US5340809A (en) | 1994-08-23 |
ES2071458T3 (es) | 1995-06-16 |
EP0533516B1 (fr) | 1995-02-08 |
ZA926277B (en) | 1993-03-03 |
GR3015797T3 (en) | 1995-07-31 |
FR2680508B1 (fr) | 1995-03-03 |
AU648924B2 (en) | 1994-05-05 |
FR2680508A1 (fr) | 1993-02-26 |
CA2076443A1 (fr) | 1993-02-21 |
AU2110792A (en) | 1993-02-25 |
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