DE69941067D1 - Fluoreszierende Cyaninlabels mit einem Sulphamidobrückenglied - Google Patents
Fluoreszierende Cyaninlabels mit einem SulphamidobrückengliedInfo
- Publication number
- DE69941067D1 DE69941067D1 DE69941067T DE69941067T DE69941067D1 DE 69941067 D1 DE69941067 D1 DE 69941067D1 DE 69941067 T DE69941067 T DE 69941067T DE 69941067 T DE69941067 T DE 69941067T DE 69941067 D1 DE69941067 D1 DE 69941067D1
- Authority
- DE
- Germany
- Prior art keywords
- sub
- group
- indipendently
- alkylensulfonic
- alkylensulfonate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
- C09B23/02—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
- G01N33/532—Production of labelled immunochemicals
- G01N33/533—Production of labelled immunochemicals with fluorescent label
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Biochemistry (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Food Science & Technology (AREA)
- Pathology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- General Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Adhesives Or Adhesive Processes (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Thermal Transfer Or Thermal Recording In General (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP99112696A EP1065250B1 (de) | 1999-07-02 | 1999-07-02 | Fluorescierende Cyaninlabels mit einem Sulphamidobrückenglied |
Publications (1)
Publication Number | Publication Date |
---|---|
DE69941067D1 true DE69941067D1 (de) | 2009-08-13 |
Family
ID=8238492
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69922498T Expired - Lifetime DE69922498T2 (de) | 1999-07-02 | 1999-07-02 | Fluorescierende Cyaninlabels mit einem Sulphamidobrückenglied |
DE69941067T Expired - Lifetime DE69941067D1 (de) | 1999-07-02 | 1999-07-02 | Fluoreszierende Cyaninlabels mit einem Sulphamidobrückenglied |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69922498T Expired - Lifetime DE69922498T2 (de) | 1999-07-02 | 1999-07-02 | Fluorescierende Cyaninlabels mit einem Sulphamidobrückenglied |
Country Status (8)
Country | Link |
---|---|
US (1) | US6448008B1 (de) |
EP (2) | EP1065250B1 (de) |
AT (2) | ATE284433T1 (de) |
AU (1) | AU776841B2 (de) |
BR (1) | BR0005843A (de) |
CA (1) | CA2312099C (de) |
DE (2) | DE69922498T2 (de) |
ES (1) | ES2329572T3 (de) |
Families Citing this family (75)
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JP2001288197A (ja) * | 2000-04-10 | 2001-10-16 | Fuji Photo Film Co Ltd | 蛍光ヌクレオチド |
US7597878B2 (en) | 2000-09-19 | 2009-10-06 | Li-Cor, Inc. | Optical fluorescent imaging |
EP1770129B1 (de) | 2000-09-29 | 2012-07-25 | Life Technologies Corporation | Modifizierte Carbocyaninfarbstoffe und deren Konjugate |
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US8323903B2 (en) | 2001-10-12 | 2012-12-04 | Life Technologies Corporation | Antibody complexes and methods for immunolabeling |
US20050069962A1 (en) | 2001-10-12 | 2005-03-31 | Archer Robert M | Antibody complexes and methods for immunolabeling |
US20030124194A1 (en) | 2002-01-02 | 2003-07-03 | Gaw Debra A. | Amine functionalized superparamagnetic nanoparticles for the synthesis of bioconjugates and uses therefor |
WO2003079015A1 (en) * | 2002-03-11 | 2003-09-25 | Visen Medical, Inc. | Optical imaging probes |
DE60332339D1 (de) * | 2002-05-07 | 2010-06-10 | Univ New York State Res Found | "High througput" Methode, um Biomolekülanlieferung Formulierungen zu kennzeichnen |
US7172907B2 (en) * | 2003-03-21 | 2007-02-06 | Ge Healthcare Bio-Sciences Corp. | Cyanine dye labelling reagents with meso-substitution |
US20080102036A1 (en) * | 2003-06-04 | 2008-05-01 | Poss Kirtland G | Biocompatible Fluorescent Silicon Nanoparticles |
US7282339B2 (en) | 2003-09-17 | 2007-10-16 | Invitrogen Corporation | Competitive immunoassay |
JP5214967B2 (ja) | 2004-08-13 | 2013-06-19 | エポック バイオサイエンシズ インコーポレーティッド | ホスホン酸蛍光色素および複合体 |
US8357801B2 (en) | 2005-05-24 | 2013-01-22 | Enzo Life Sciences, Inc. | Labeling of target molecules, identification of organelles and other applications, novel compositions, methods and kits |
US7737281B2 (en) * | 2005-05-24 | 2010-06-15 | Enzo Life Sciences, Inc. C/O Enzo Biochem, Inc. | Purine based fluorescent dyes |
US7569695B2 (en) * | 2005-05-24 | 2009-08-04 | Enzo Life Sciences, Inc. | Dyes for the detection or quantification of desirable target molecules |
WO2007028037A1 (en) * | 2005-09-02 | 2007-03-08 | Visen Medical, Inc. | Biocompatible n, n-disubstituted sulfonamide-containing fluorescent dye labels |
EP1934202B1 (de) | 2005-09-02 | 2019-01-09 | Visen Medical, Inc. | Nah-infrarot-fluorophore, die sich von nicotinsäure und picolinsäure ableiten |
EP1937676B1 (de) | 2005-09-02 | 2016-11-30 | Visen Medical, Inc. | Biologisch kompatible, fluoreszente mittel zur bilddarstellung |
PT1934607E (pt) | 2005-10-13 | 2013-11-13 | Fundacao D Anna Sommer Champalimaud E Dr Carlos Montez Champalimaud | Análise imuno-histoquímica in situ multiplex |
EP1968431B2 (de) | 2005-12-22 | 2022-06-01 | Visen Medical, Inc. | Kombiniertes röntgen- und optisches tomographie-bildgebungssystem |
EP1973575B1 (de) | 2005-12-22 | 2019-07-24 | Visen Medical, Inc. | Biokompatibele fluoreszierende metalloxide nanopartikel |
ITSV20060002A1 (it) * | 2006-01-19 | 2007-07-20 | Ferrania Technologies Spa | Colorante fluorescente di tipo cianinico |
EP1984724A4 (de) | 2006-01-24 | 2015-07-08 | Life Technologies Corp | Vorrichtung und verfahren zur quantifizierung von analyten |
US8114636B2 (en) | 2006-02-10 | 2012-02-14 | Life Technologies Corporation | Labeling and detection of nucleic acids |
EP2623986B1 (de) | 2006-02-10 | 2017-06-14 | Life Technologies Corporation | Markierung und Detektion von posttranslational modifizierten Proteinen |
US8562802B1 (en) | 2006-02-13 | 2013-10-22 | Life Technologies Corporation | Transilluminator base and scanner for imaging fluorescent gels, charging devices and portable electrophoresis systems |
SG171599A1 (en) | 2006-03-23 | 2011-06-29 | Absorber Ab | Blood group antigens of different types for diagnostic and therapeutic applications |
US8623639B2 (en) | 2006-04-20 | 2014-01-07 | Becton, Dickinson And Company | Thermostable proteins and methods of making and using thereof |
WO2008100817A2 (en) | 2007-02-09 | 2008-08-21 | Visen Medical, Inc. | Polycyclo dyes and use thereof |
US8906354B2 (en) | 2007-02-28 | 2014-12-09 | Bruker Biospin Corporation | Loaded latex optical molecular imaging probes containing lipophilic large stokes shift dyes |
US8017104B2 (en) | 2007-02-28 | 2011-09-13 | Carestream Health, Inc. | Large stoke shift dye used for optical imaging |
WO2008109832A2 (en) * | 2007-03-08 | 2008-09-12 | Visen Medical, Inc. | Viable near-infrared fluorochrome labeled cells and methods of making and using same |
WO2009055095A1 (en) | 2007-10-19 | 2009-04-30 | Visen Medical, Inc. | Imaging systems featuring waveguiding compensation |
EP3320923B1 (de) | 2008-01-18 | 2022-04-06 | Visen Medical, Inc. | Fluoreszierende bildgebungsmittel |
CN102026671B (zh) | 2008-03-14 | 2014-09-03 | Visen医药公司 | 整联蛋白靶向试剂及使用其的体内和体外成像方法 |
WO2009140541A2 (en) | 2008-05-16 | 2009-11-19 | Life Technologies Corporation | Dual labeling methods for measuring cellular proliferation |
US8864821B2 (en) | 2008-11-26 | 2014-10-21 | Visen Medical, Inc. | Methods and compositions for identifying subjects at risk of developing stent thrombosis |
WO2010138738A1 (en) | 2009-05-27 | 2010-12-02 | Lumicell Diagnostics, Inc. | Methods and systems for spatially identifying abnormal cells |
US9155471B2 (en) | 2009-05-27 | 2015-10-13 | Lumicell, Inc'. | Methods and systems for spatially identifying abnormal cells |
US8401618B2 (en) | 2009-08-28 | 2013-03-19 | Visen Medical, Inc. | Systems and methods for tomographic imaging in diffuse media using a hybrid inversion technique |
WO2011026085A2 (en) | 2009-08-31 | 2011-03-03 | Promega Corporation | Reactive cyanine compounds |
JP5945226B2 (ja) | 2009-09-22 | 2016-07-05 | ビセン メディカル, インコーポレイテッド | 拡散媒質の仮想屈折率整合のためのシステムおよび方法 |
CN101747655B (zh) * | 2009-12-24 | 2013-04-03 | 渤海大学 | 含薁类结构水溶性菁染料及其合成方法 |
WO2012022734A2 (en) | 2010-08-16 | 2012-02-23 | Medimmune Limited | Anti-icam-1 antibodies and methods of use |
US9314304B2 (en) | 2010-12-08 | 2016-04-19 | Lumicell, Inc. | Methods and system for image guided cell ablation with microscopic resolution |
WO2012154885A2 (en) | 2011-05-09 | 2012-11-15 | Visen Medical, Inc. | Carbonic anhydrase targeting agents and methods of using same |
EP2831264B1 (de) | 2012-03-30 | 2019-07-10 | VisEn Medical, Inc. | Bakterielle bildgebungsmittel und verfahren zur verwendung davon |
JP6370785B2 (ja) | 2012-08-15 | 2018-08-08 | ビセン メディカル, インコーポレイテッド | 前立腺がんイメージングのための前立腺特異的抗原薬剤およびその使用方法 |
EP2906106B1 (de) | 2012-10-15 | 2023-06-14 | VisEn Medical, Inc. | Systeme, verfahren, und vorrichtung zur abbildung von diffusen medien mit modalitätsübergreifender gewichtung von fluoreszierenden und biolumineszierenden quellen |
US20150246146A1 (en) | 2012-10-25 | 2015-09-03 | Life Technologies Corporation | Methods and compositions for enzyme-mediated site-specific radiolabeling of glycoproteins |
CN105164106B (zh) * | 2013-03-08 | 2018-04-03 | 伊鲁米纳剑桥有限公司 | 多次甲基化合物和其作为荧光标记物的用途 |
JP6478971B2 (ja) | 2013-03-14 | 2019-03-06 | ルミセル, インコーポレーテッドLumicell, Inc. | 医用撮像装置 |
AU2014228808C1 (en) | 2013-03-15 | 2018-12-20 | Visen Medical, Inc. | 4,4-disubstituted cyclohexyl bridged heptamethine cyanine dyes and uses thereof |
CA2901379C (en) | 2013-03-15 | 2023-05-16 | Visen Medical, Inc. | Substituted silaxanthenium red to near-infrared fluorochromes for in vitro and in vivo imaging and detection |
WO2015050959A1 (en) | 2013-10-01 | 2015-04-09 | Yale University | Anti-kit antibodies and methods of use thereof |
US10494419B2 (en) | 2013-10-02 | 2019-12-03 | Medimmune, Llc | Neutralizing anti-influenza A antibodies and uses thereof |
US10542918B2 (en) | 2013-10-23 | 2020-01-28 | Verily Life Sciences Llc | Modulation of a response signal to distinguish between analyte and background signals |
US9636034B2 (en) | 2013-10-23 | 2017-05-02 | Verily Life Sciences Llc | Non-invasive analyte detection system with modulation source |
JP5824729B2 (ja) * | 2013-12-18 | 2015-11-25 | 東洋インキScホールディングス株式会社 | カラーフィルタ用着色組成物、およびカラーフィルタ |
EP3089653A1 (de) | 2013-12-31 | 2016-11-09 | Memorial Sloan Kettering Cancer Center | Systeme, verfahren und vorrichtung für die mehrkanalbildgebung von fluoreszierenden quellen in echtzeit |
BR112017012621A2 (pt) | 2014-12-15 | 2018-01-02 | Univ Cornell | peptídeos cíclicos com seletividade de ligação nervosa melhorada, nanopartículas ligadas com os referidos peptídeos cíclicos, e o uso dos mesmos para a produção de imagens de tecido nervoso in vivo em tempo real |
US9861710B1 (en) | 2015-01-16 | 2018-01-09 | Verily Life Sciences Llc | Composite particles, methods, and in vivo diagnostic system |
US10028659B2 (en) | 2015-03-26 | 2018-07-24 | Verily Life Sciences Llc | Aptamer-based sensors, implantable devices and detection system |
GB201516987D0 (en) | 2015-09-25 | 2015-11-11 | Illumina Cambridge Ltd | Polymethine compounds and their use as fluorescent labels |
JP2018538428A (ja) * | 2015-12-01 | 2018-12-27 | ディッシュマン ファーマスーティカルズ アンド ケミカルズ リミテッドDishman Pharmaceuticals and Chemicals Limited | インドシアニングリーンの改善された製造方法 |
WO2017106525A1 (en) | 2015-12-15 | 2017-06-22 | Memorial Sloan Kettering Cancer Center | Imaging systems and methods for tissue differentiation, e.g., for intraoperative visualization |
WO2017181176A1 (en) | 2016-04-15 | 2017-10-19 | Lcahn School Of Medicine At Mount Sinai | Tissue profiling using multiplexed immunohistochemical consecutive staining |
RU2637310C1 (ru) * | 2016-06-08 | 2017-12-04 | Федеральное Государственное Бюджетное Учреждение Науки Институт Молекулярной Биологии Им. В.А. Энгельгардта Российской Академии Наук (Имб Ран) | Флуоресцентно-меченые дезоксиуридинтрифосфаты |
EP3496762A1 (de) | 2016-08-11 | 2019-06-19 | The U.S.A. as represented by the Secretary, Department of Health and Human Services | Durch nahinfrarotlicht spaltbare konjugate und konjugatvorläufer |
BR112019010947A2 (pt) | 2016-11-30 | 2019-10-01 | Univ Cornell | nanopartículas ultrapequenas funcionalizadas por inibidores e métodos das mesmas |
US20210108253A1 (en) | 2017-03-30 | 2021-04-15 | Life Technologies Corporation | Quantification of ngs dna by adapter sequence |
EP3773153A4 (de) | 2018-03-30 | 2021-11-17 | Perkinelmer Health Sciences Inc. | Systeme und verfahren zur 3d-rekonstruktion anatomischer organe und einschlüsse mittels kurzwelliger infrarot (swir)-projektionstomografie |
EP4175967A2 (de) | 2020-07-02 | 2023-05-10 | Life Technologies Corporation | Trinukleotid-kappenanaloga, herstellung und verwendungen davon |
EP4015004A1 (de) | 2020-12-18 | 2022-06-22 | Phi Pharma SA | Proteoglykanspezifische verzweigte peptide |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR1287000A (fr) * | 1961-03-07 | 1962-03-09 | Gevaert Photo Prod Nv | Procédé pour la sensibilisation d'émulsions photographiques |
US5808044A (en) | 1993-01-22 | 1998-09-15 | Pharmacia Biotech Inc. | Indocarbocyanine and benzindocarbocyanine phosphoramidites |
US5556959A (en) * | 1993-01-22 | 1996-09-17 | Pharmacia P-L Biochemicals Inc. | Indocarbocyanine-linked phosphoramidites |
US5714386A (en) * | 1996-01-11 | 1998-02-03 | Board Of Trustees Of The Leland Stanford Junior University | Cy7-allophycocyanin conjugates for use in multiplex fluorescence detection assays |
-
1999
- 1999-07-02 EP EP99112696A patent/EP1065250B1/de not_active Expired - Lifetime
- 1999-07-02 AT AT99112696T patent/ATE284433T1/de not_active IP Right Cessation
- 1999-07-02 DE DE69922498T patent/DE69922498T2/de not_active Expired - Lifetime
- 1999-07-02 ES ES04023147T patent/ES2329572T3/es not_active Expired - Lifetime
- 1999-07-02 AT AT04023147T patent/ATE435262T1/de not_active IP Right Cessation
- 1999-07-02 EP EP04023147A patent/EP1491591B1/de not_active Expired - Lifetime
- 1999-07-02 DE DE69941067T patent/DE69941067D1/de not_active Expired - Lifetime
-
2000
- 2000-06-21 AU AU42581/00A patent/AU776841B2/en not_active Expired
- 2000-06-22 CA CA002312099A patent/CA2312099C/en not_active Expired - Lifetime
- 2000-06-30 US US09/609,035 patent/US6448008B1/en not_active Expired - Lifetime
- 2000-07-03 BR BR0005843-2A patent/BR0005843A/pt not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
DE69922498T2 (de) | 2005-12-08 |
ATE284433T1 (de) | 2004-12-15 |
BR0005843A (pt) | 2002-01-02 |
EP1065250A1 (de) | 2001-01-03 |
US6448008B1 (en) | 2002-09-10 |
CA2312099C (en) | 2009-05-12 |
EP1491591B1 (de) | 2009-07-01 |
ES2329572T3 (es) | 2009-11-27 |
EP1491591A1 (de) | 2004-12-29 |
EP1065250B1 (de) | 2004-12-08 |
ATE435262T1 (de) | 2009-07-15 |
AU4258100A (en) | 2001-01-11 |
CA2312099A1 (en) | 2001-01-02 |
AU776841B2 (en) | 2004-09-23 |
DE69922498D1 (de) | 2005-01-13 |
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Legal Events
Date | Code | Title | Description |
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8364 | No opposition during term of opposition |