DE69941067D1 - Fluoreszierende Cyaninlabels mit einem Sulphamidobrückenglied - Google Patents

Fluoreszierende Cyaninlabels mit einem Sulphamidobrückenglied

Info

Publication number
DE69941067D1
DE69941067D1 DE69941067T DE69941067T DE69941067D1 DE 69941067 D1 DE69941067 D1 DE 69941067D1 DE 69941067 T DE69941067 T DE 69941067T DE 69941067 T DE69941067 T DE 69941067T DE 69941067 D1 DE69941067 D1 DE 69941067D1
Authority
DE
Germany
Prior art keywords
sub
group
indipendently
alkylensulfonic
alkylensulfonate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69941067T
Other languages
English (en)
Inventor
Giuseppe Caputo
Ciana Leopoldo Della
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Visen Medical Inc
Original Assignee
Visen Medical Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Visen Medical Inc filed Critical Visen Medical Inc
Application granted granted Critical
Publication of DE69941067D1 publication Critical patent/DE69941067D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • CCHEMISTRY; METALLURGY
    • C09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09BORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/02Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531Production of immunochemical test materials
    • G01N33/532Production of labelled immunochemicals
    • G01N33/533Production of labelled immunochemicals with fluorescent label
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Adhesives Or Adhesive Processes (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Thermal Transfer Or Thermal Recording In General (AREA)
DE69941067T 1999-07-02 1999-07-02 Fluoreszierende Cyaninlabels mit einem Sulphamidobrückenglied Expired - Lifetime DE69941067D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP99112696A EP1065250B1 (de) 1999-07-02 1999-07-02 Fluorescierende Cyaninlabels mit einem Sulphamidobrückenglied

Publications (1)

Publication Number Publication Date
DE69941067D1 true DE69941067D1 (de) 2009-08-13

Family

ID=8238492

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69922498T Expired - Lifetime DE69922498T2 (de) 1999-07-02 1999-07-02 Fluorescierende Cyaninlabels mit einem Sulphamidobrückenglied
DE69941067T Expired - Lifetime DE69941067D1 (de) 1999-07-02 1999-07-02 Fluoreszierende Cyaninlabels mit einem Sulphamidobrückenglied

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE69922498T Expired - Lifetime DE69922498T2 (de) 1999-07-02 1999-07-02 Fluorescierende Cyaninlabels mit einem Sulphamidobrückenglied

Country Status (8)

Country Link
US (1) US6448008B1 (de)
EP (2) EP1065250B1 (de)
AT (2) ATE284433T1 (de)
AU (1) AU776841B2 (de)
BR (1) BR0005843A (de)
CA (1) CA2312099C (de)
DE (2) DE69922498T2 (de)
ES (1) ES2329572T3 (de)

Families Citing this family (75)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001288197A (ja) * 2000-04-10 2001-10-16 Fuji Photo Film Co Ltd 蛍光ヌクレオチド
US7597878B2 (en) 2000-09-19 2009-10-06 Li-Cor, Inc. Optical fluorescent imaging
EP1770129B1 (de) 2000-09-29 2012-07-25 Life Technologies Corporation Modifizierte Carbocyaninfarbstoffe und deren Konjugate
CA2423806C (en) 2000-09-29 2009-12-22 Molecular Probes, Inc. Modified carbocyanine dyes and their conjugates
US8323903B2 (en) 2001-10-12 2012-12-04 Life Technologies Corporation Antibody complexes and methods for immunolabeling
US20050069962A1 (en) 2001-10-12 2005-03-31 Archer Robert M Antibody complexes and methods for immunolabeling
US20030124194A1 (en) 2002-01-02 2003-07-03 Gaw Debra A. Amine functionalized superparamagnetic nanoparticles for the synthesis of bioconjugates and uses therefor
WO2003079015A1 (en) * 2002-03-11 2003-09-25 Visen Medical, Inc. Optical imaging probes
DE60332339D1 (de) * 2002-05-07 2010-06-10 Univ New York State Res Found "High througput" Methode, um Biomolekülanlieferung Formulierungen zu kennzeichnen
US7172907B2 (en) * 2003-03-21 2007-02-06 Ge Healthcare Bio-Sciences Corp. Cyanine dye labelling reagents with meso-substitution
US20080102036A1 (en) * 2003-06-04 2008-05-01 Poss Kirtland G Biocompatible Fluorescent Silicon Nanoparticles
US7282339B2 (en) 2003-09-17 2007-10-16 Invitrogen Corporation Competitive immunoassay
JP5214967B2 (ja) 2004-08-13 2013-06-19 エポック バイオサイエンシズ インコーポレーティッド ホスホン酸蛍光色素および複合体
US8357801B2 (en) 2005-05-24 2013-01-22 Enzo Life Sciences, Inc. Labeling of target molecules, identification of organelles and other applications, novel compositions, methods and kits
US7737281B2 (en) * 2005-05-24 2010-06-15 Enzo Life Sciences, Inc. C/O Enzo Biochem, Inc. Purine based fluorescent dyes
US7569695B2 (en) * 2005-05-24 2009-08-04 Enzo Life Sciences, Inc. Dyes for the detection or quantification of desirable target molecules
WO2007028037A1 (en) * 2005-09-02 2007-03-08 Visen Medical, Inc. Biocompatible n, n-disubstituted sulfonamide-containing fluorescent dye labels
EP1934202B1 (de) 2005-09-02 2019-01-09 Visen Medical, Inc. Nah-infrarot-fluorophore, die sich von nicotinsäure und picolinsäure ableiten
EP1937676B1 (de) 2005-09-02 2016-11-30 Visen Medical, Inc. Biologisch kompatible, fluoreszente mittel zur bilddarstellung
PT1934607E (pt) 2005-10-13 2013-11-13 Fundacao D Anna Sommer Champalimaud E Dr Carlos Montez Champalimaud Análise imuno-histoquímica in situ multiplex
EP1968431B2 (de) 2005-12-22 2022-06-01 Visen Medical, Inc. Kombiniertes röntgen- und optisches tomographie-bildgebungssystem
EP1973575B1 (de) 2005-12-22 2019-07-24 Visen Medical, Inc. Biokompatibele fluoreszierende metalloxide nanopartikel
ITSV20060002A1 (it) * 2006-01-19 2007-07-20 Ferrania Technologies Spa Colorante fluorescente di tipo cianinico
EP1984724A4 (de) 2006-01-24 2015-07-08 Life Technologies Corp Vorrichtung und verfahren zur quantifizierung von analyten
US8114636B2 (en) 2006-02-10 2012-02-14 Life Technologies Corporation Labeling and detection of nucleic acids
EP2623986B1 (de) 2006-02-10 2017-06-14 Life Technologies Corporation Markierung und Detektion von posttranslational modifizierten Proteinen
US8562802B1 (en) 2006-02-13 2013-10-22 Life Technologies Corporation Transilluminator base and scanner for imaging fluorescent gels, charging devices and portable electrophoresis systems
SG171599A1 (en) 2006-03-23 2011-06-29 Absorber Ab Blood group antigens of different types for diagnostic and therapeutic applications
US8623639B2 (en) 2006-04-20 2014-01-07 Becton, Dickinson And Company Thermostable proteins and methods of making and using thereof
WO2008100817A2 (en) 2007-02-09 2008-08-21 Visen Medical, Inc. Polycyclo dyes and use thereof
US8906354B2 (en) 2007-02-28 2014-12-09 Bruker Biospin Corporation Loaded latex optical molecular imaging probes containing lipophilic large stokes shift dyes
US8017104B2 (en) 2007-02-28 2011-09-13 Carestream Health, Inc. Large stoke shift dye used for optical imaging
WO2008109832A2 (en) * 2007-03-08 2008-09-12 Visen Medical, Inc. Viable near-infrared fluorochrome labeled cells and methods of making and using same
WO2009055095A1 (en) 2007-10-19 2009-04-30 Visen Medical, Inc. Imaging systems featuring waveguiding compensation
EP3320923B1 (de) 2008-01-18 2022-04-06 Visen Medical, Inc. Fluoreszierende bildgebungsmittel
CN102026671B (zh) 2008-03-14 2014-09-03 Visen医药公司 整联蛋白靶向试剂及使用其的体内和体外成像方法
WO2009140541A2 (en) 2008-05-16 2009-11-19 Life Technologies Corporation Dual labeling methods for measuring cellular proliferation
US8864821B2 (en) 2008-11-26 2014-10-21 Visen Medical, Inc. Methods and compositions for identifying subjects at risk of developing stent thrombosis
WO2010138738A1 (en) 2009-05-27 2010-12-02 Lumicell Diagnostics, Inc. Methods and systems for spatially identifying abnormal cells
US9155471B2 (en) 2009-05-27 2015-10-13 Lumicell, Inc'. Methods and systems for spatially identifying abnormal cells
US8401618B2 (en) 2009-08-28 2013-03-19 Visen Medical, Inc. Systems and methods for tomographic imaging in diffuse media using a hybrid inversion technique
WO2011026085A2 (en) 2009-08-31 2011-03-03 Promega Corporation Reactive cyanine compounds
JP5945226B2 (ja) 2009-09-22 2016-07-05 ビセン メディカル, インコーポレイテッド 拡散媒質の仮想屈折率整合のためのシステムおよび方法
CN101747655B (zh) * 2009-12-24 2013-04-03 渤海大学 含薁类结构水溶性菁染料及其合成方法
WO2012022734A2 (en) 2010-08-16 2012-02-23 Medimmune Limited Anti-icam-1 antibodies and methods of use
US9314304B2 (en) 2010-12-08 2016-04-19 Lumicell, Inc. Methods and system for image guided cell ablation with microscopic resolution
WO2012154885A2 (en) 2011-05-09 2012-11-15 Visen Medical, Inc. Carbonic anhydrase targeting agents and methods of using same
EP2831264B1 (de) 2012-03-30 2019-07-10 VisEn Medical, Inc. Bakterielle bildgebungsmittel und verfahren zur verwendung davon
JP6370785B2 (ja) 2012-08-15 2018-08-08 ビセン メディカル, インコーポレイテッド 前立腺がんイメージングのための前立腺特異的抗原薬剤およびその使用方法
EP2906106B1 (de) 2012-10-15 2023-06-14 VisEn Medical, Inc. Systeme, verfahren, und vorrichtung zur abbildung von diffusen medien mit modalitätsübergreifender gewichtung von fluoreszierenden und biolumineszierenden quellen
US20150246146A1 (en) 2012-10-25 2015-09-03 Life Technologies Corporation Methods and compositions for enzyme-mediated site-specific radiolabeling of glycoproteins
CN105164106B (zh) * 2013-03-08 2018-04-03 伊鲁米纳剑桥有限公司 多次甲基化合物和其作为荧光标记物的用途
JP6478971B2 (ja) 2013-03-14 2019-03-06 ルミセル, インコーポレーテッドLumicell, Inc. 医用撮像装置
AU2014228808C1 (en) 2013-03-15 2018-12-20 Visen Medical, Inc. 4,4-disubstituted cyclohexyl bridged heptamethine cyanine dyes and uses thereof
CA2901379C (en) 2013-03-15 2023-05-16 Visen Medical, Inc. Substituted silaxanthenium red to near-infrared fluorochromes for in vitro and in vivo imaging and detection
WO2015050959A1 (en) 2013-10-01 2015-04-09 Yale University Anti-kit antibodies and methods of use thereof
US10494419B2 (en) 2013-10-02 2019-12-03 Medimmune, Llc Neutralizing anti-influenza A antibodies and uses thereof
US10542918B2 (en) 2013-10-23 2020-01-28 Verily Life Sciences Llc Modulation of a response signal to distinguish between analyte and background signals
US9636034B2 (en) 2013-10-23 2017-05-02 Verily Life Sciences Llc Non-invasive analyte detection system with modulation source
JP5824729B2 (ja) * 2013-12-18 2015-11-25 東洋インキScホールディングス株式会社 カラーフィルタ用着色組成物、およびカラーフィルタ
EP3089653A1 (de) 2013-12-31 2016-11-09 Memorial Sloan Kettering Cancer Center Systeme, verfahren und vorrichtung für die mehrkanalbildgebung von fluoreszierenden quellen in echtzeit
BR112017012621A2 (pt) 2014-12-15 2018-01-02 Univ Cornell peptídeos cíclicos com seletividade de ligação nervosa melhorada, nanopartículas ligadas com os referidos peptídeos cíclicos, e o uso dos mesmos para a produção de imagens de tecido nervoso in vivo em tempo real
US9861710B1 (en) 2015-01-16 2018-01-09 Verily Life Sciences Llc Composite particles, methods, and in vivo diagnostic system
US10028659B2 (en) 2015-03-26 2018-07-24 Verily Life Sciences Llc Aptamer-based sensors, implantable devices and detection system
GB201516987D0 (en) 2015-09-25 2015-11-11 Illumina Cambridge Ltd Polymethine compounds and their use as fluorescent labels
JP2018538428A (ja) * 2015-12-01 2018-12-27 ディッシュマン ファーマスーティカルズ アンド ケミカルズ リミテッドDishman Pharmaceuticals and Chemicals Limited インドシアニングリーンの改善された製造方法
WO2017106525A1 (en) 2015-12-15 2017-06-22 Memorial Sloan Kettering Cancer Center Imaging systems and methods for tissue differentiation, e.g., for intraoperative visualization
WO2017181176A1 (en) 2016-04-15 2017-10-19 Lcahn School Of Medicine At Mount Sinai Tissue profiling using multiplexed immunohistochemical consecutive staining
RU2637310C1 (ru) * 2016-06-08 2017-12-04 Федеральное Государственное Бюджетное Учреждение Науки Институт Молекулярной Биологии Им. В.А. Энгельгардта Российской Академии Наук (Имб Ран) Флуоресцентно-меченые дезоксиуридинтрифосфаты
EP3496762A1 (de) 2016-08-11 2019-06-19 The U.S.A. as represented by the Secretary, Department of Health and Human Services Durch nahinfrarotlicht spaltbare konjugate und konjugatvorläufer
BR112019010947A2 (pt) 2016-11-30 2019-10-01 Univ Cornell nanopartículas ultrapequenas funcionalizadas por inibidores e métodos das mesmas
US20210108253A1 (en) 2017-03-30 2021-04-15 Life Technologies Corporation Quantification of ngs dna by adapter sequence
EP3773153A4 (de) 2018-03-30 2021-11-17 Perkinelmer Health Sciences Inc. Systeme und verfahren zur 3d-rekonstruktion anatomischer organe und einschlüsse mittels kurzwelliger infrarot (swir)-projektionstomografie
EP4175967A2 (de) 2020-07-02 2023-05-10 Life Technologies Corporation Trinukleotid-kappenanaloga, herstellung und verwendungen davon
EP4015004A1 (de) 2020-12-18 2022-06-22 Phi Pharma SA Proteoglykanspezifische verzweigte peptide

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1287000A (fr) * 1961-03-07 1962-03-09 Gevaert Photo Prod Nv Procédé pour la sensibilisation d'émulsions photographiques
US5808044A (en) 1993-01-22 1998-09-15 Pharmacia Biotech Inc. Indocarbocyanine and benzindocarbocyanine phosphoramidites
US5556959A (en) * 1993-01-22 1996-09-17 Pharmacia P-L Biochemicals Inc. Indocarbocyanine-linked phosphoramidites
US5714386A (en) * 1996-01-11 1998-02-03 Board Of Trustees Of The Leland Stanford Junior University Cy7-allophycocyanin conjugates for use in multiplex fluorescence detection assays

Also Published As

Publication number Publication date
DE69922498T2 (de) 2005-12-08
ATE284433T1 (de) 2004-12-15
BR0005843A (pt) 2002-01-02
EP1065250A1 (de) 2001-01-03
US6448008B1 (en) 2002-09-10
CA2312099C (en) 2009-05-12
EP1491591B1 (de) 2009-07-01
ES2329572T3 (es) 2009-11-27
EP1491591A1 (de) 2004-12-29
EP1065250B1 (de) 2004-12-08
ATE435262T1 (de) 2009-07-15
AU4258100A (en) 2001-01-11
CA2312099A1 (en) 2001-01-02
AU776841B2 (en) 2004-09-23
DE69922498D1 (de) 2005-01-13

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