KR870004026A - 피페라지노 이소티아졸론의 제조방법 - Google Patents
피페라지노 이소티아졸론의 제조방법 Download PDFInfo
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- KR870004026A KR870004026A KR1019860008685A KR860008685A KR870004026A KR 870004026 A KR870004026 A KR 870004026A KR 1019860008685 A KR1019860008685 A KR 1019860008685A KR 860008685 A KR860008685 A KR 860008685A KR 870004026 A KR870004026 A KR 870004026A
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- South Korea
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
- C07D275/02—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings
- C07D275/03—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
- C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
- C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
- C07D275/06—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems with hetero atoms directly attached to the ring sulfur atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
- C07D513/14—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (1)
- (a) 일반식(A)의 사이클릭아민 또는 이의염을 일반식 R8-Y(여기서, R8는 하기에서 정의되는 일반식(B)의 그룹이다)의 화합물과 반응시켜 알킬화함으로써 일반식(B)의 치환된 알킬그룹을 도입하거나; (b) 일반식(A)의 사이클릭아민 또는 이의염을 일반식(C)의 알데하이드와 환원성 알킬화하거나; (C)일반식 (D)의 화합물 또는 이의염을 일반식(E1)의 화합물 또는 양이온 E2를 함유하는 화합물과 반응시키거나; (d) 일반식(F)의 화합물 또는 이의염을 (i) 일반식 (G),(H),(J),(K),(L1) 또는 (L2)의 화합물과 반응시켜 디엘스-알더반응(Diels-Alder reaction)시키거나 (ii) 에폭시화하거나 (iii)카벤을 삽입하거나 (iv) 질소 잔기를 삽입하여 일반식(N)의 아지리딘 또는 이의 염을 형성하거나; (e) 일반식(M)의 화합물 또는 이의 염을 적합한 질소 친핵제와 반응시켜 옥시란환을 개환한 다음, 생성된 중간체를 일반식(N)의 아지리딘 또는 이의 염으로 전환시키거나; (f) 일반식(F)의 화합물 또는 이의 염을 일반식 O=C=CR3R4(여기서, R3및 R4는 하기에서 정의되는 바와 같다)의 커텐과 반응시켜 일반식(P)의 화합물 또는 이의 염을 제조하거나; (g) 일반식(P)의 화합물 또는 이의 염을 환원시켜 일반식(Q)의 화합물 또는 이의 염을 제조하거나; (h)일반식(R)의 화합물 또는 이의 염으로부터 설핀산을 제거하거나; (j)일반식(I)에 따른 에틸렌성 불포화 화합물 또는 이의 염을 환원시켜 이의 포화 동족체를 형성하거나; (K)일반식(I)의 화합물에 산을 가하여 이의 산부가염으로 전환시키거나, 일반식(Ⅰ)의 화합물의 산부가염을 중화시켜 일반식(Ⅰ)의 화합물을 형성함을 특징으로 하여 일반식(Ⅰ)의 화합물 및 약제학적으로 허용되는 이의염을 제조하는 방법.상기식에서 R1및 R2는 각각 독립적으로 수소, 저급알킬, 아릴 또는 할로이거나, 이들은 함께 -CH2-, -CH2CH2-, -O-, -NH-,-CH=CH-S, =CH-S-CH=, -S-CH=CH-,를 나타내고, R3,R4,R5및 R6는 각각 독립적으로 수소, 저급알킬, 아릴 또는 할로이며, R7는 2-피리디닐, 2-피리미디닐, 2-피라지닐, 3-피리다지닐 또는 페닐이거나, 저급알킬, 트리플루오로메틸, 시아노, 니트로 또는 할로에 의해 치환된 2-피리디닐, 2-피리미디닐, 2-피라지닐, 3-피리다지닐 또는 페닐중의 하나 [단, R1및 R2가 함께 다음 일반식(Ⅳ)를 나타낼때, R7는 2-피리디닐, 2-피리미디닐 또는 치환된 피리미딘-2-일이 아니다.]이고,R9는 유기술포닐그룹, 예를 들어, 메틸술포닐이며, X는 저급 알킬렌, 비닐렌, O 또는 NH이고, Y는 이탈그룹, 예를 들어, 클로로 또는 브로모와 같은 할로원자이며; Z는 -(CH2)n- [여기서, n은 0내지 4이다],비닐렌, -O-, 또는이고;m은 2내지 5[단, 일반식(E2)에서 m은 2내지 4이다]이며; O는 1내지 3[단, 일반식(E2)에서 O는 2또는 3이다]이고; P는 1내지 4이며, 점선은 임의의 이중결합을 나타낸다.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US78831585A | 1985-10-17 | 1985-10-17 | |
US788315 | 1985-10-17 | ||
US06/893,507 US4732984A (en) | 1985-10-17 | 1986-08-05 | Piperazinoisothiazolones with psychotropic activity |
US893507 | 1986-08-05 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR870004026A true KR870004026A (ko) | 1987-05-07 |
KR900000371B1 KR900000371B1 (ko) | 1990-01-25 |
Family
ID=27120784
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019860008685A KR900000371B1 (ko) | 1985-10-17 | 1986-10-16 | 피페라지노이소티아졸론 및 이의 제조방법 |
Country Status (12)
Country | Link |
---|---|
US (1) | US4732984A (ko) |
EP (1) | EP0220051B1 (ko) |
KR (1) | KR900000371B1 (ko) |
AU (1) | AU603776B2 (ko) |
CA (1) | CA1272197A (ko) |
DE (1) | DE3679767D1 (ko) |
DK (1) | DK495586A (ko) |
ES (1) | ES2039200T3 (ko) |
GB (1) | GB2181730B (ko) |
GR (1) | GR3002635T3 (ko) |
HU (1) | HU206344B (ko) |
PT (1) | PT83548B (ko) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3321969A1 (de) * | 1983-06-18 | 1984-12-20 | Troponwerke GmbH & Co KG, 5000 Köln | 2-pyrimidinyl-1-piperazin-derivate, verfahren zu ihrer herstellung und diese enthaltende arzneimittel |
US4797488A (en) * | 1987-04-03 | 1989-01-10 | American Home Products Corporation | Psychotropic polycyclic imides |
US4804751A (en) * | 1987-06-30 | 1989-02-14 | American Home Products Corporation | Polycyclic hydrocarbon succinimides with psychotropic activity |
ATA39088A (de) | 1988-02-18 | 1990-06-15 | Binder Dieter Dr | Basisch substituierte thienoisothiazol-3(2h)-on-1,1-dioxide und ihre pharmazeutisch vertraeglichen salze, verfahren zu ihrer herstellung und ihre verwendung |
WO1990002552A1 (en) * | 1988-09-16 | 1990-03-22 | Pfizer Inc. | Antipsychotic 4-[4-(3-benzisothiazolyl)-1-piperazinyl]butyl bridged bicyclic imides |
US5053508A (en) * | 1990-03-09 | 1991-10-01 | American Home Products Corporation | Fused heterotricyclic imides with psychotropic activity and intermedrates thereof |
DK0482696T3 (da) * | 1990-10-23 | 1996-05-20 | Akzo Nobel Nv | 4-(4- eller 6-(trifluormethyl-2-pyridinyl))-1-piperazinylalkyl-substituerede lactamer |
US5484788A (en) * | 1993-03-26 | 1996-01-16 | Beth Israel Hospital Association | Buspirone as a systemic immunosuppressant |
US5631017A (en) * | 1993-03-26 | 1997-05-20 | Beth Israel Deaconess Medical Center, Inc. | Topical application of buspirone for treatment of pathological conditions associated with immune responses |
US5459143A (en) * | 1993-12-09 | 1995-10-17 | Bayer Aktiengesellschaft | N,N-disubstituted piperazines |
US5409932A (en) * | 1993-12-09 | 1995-04-25 | Bayer Ag | Piperazine-substituted pyrroloanthracenes |
US5637314A (en) * | 1995-06-07 | 1997-06-10 | Beth Israel Deaconess Medical Center, Inc. | Topical and systemic application of buspirone or derivatives thereof for treating atopic dermatitis |
US7468439B2 (en) | 2006-09-06 | 2008-12-23 | Bristol-Myers Squibb Company | Alkylene bridged sultam compounds useful as modulators of nuclear hormone receptor function |
CN101186612B (zh) * | 2006-11-15 | 2012-10-03 | 天津和美生物技术有限公司 | 可抑制细胞释放肿瘤坏死因子的吡咯啉衍生物及其制备和应用 |
WO2009059077A1 (en) | 2007-11-01 | 2009-05-07 | Bristol-Myers Squibb Company | Fused heterocyclic compounds useful as modulators of nuclear hormone receptor function |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1147947B (de) * | 1961-07-25 | 1963-05-02 | Knoll Ag | Verfahren zur Herstellung neuer 1, 2-Benzisothiazolone |
NZ182325A (en) * | 1975-11-18 | 1979-03-16 | Beecham Group Ltd | 2-substituted-1,2-benzisothiazol-3-ones |
US4110449A (en) * | 1977-05-23 | 1978-08-29 | E. R. Squibb & Sons, Inc. | 2-substituted benzisothiazol-3-ones |
AT364852B (de) * | 1977-11-05 | 1981-11-25 | Thomae Gmbh Dr K | Verfahren zur herstellung von kondensierten isothiazol-3(2h)-on-1,1-dioxiden und von deren salzen |
US4337250A (en) * | 1979-07-30 | 1982-06-29 | Pfizer Inc. | Hexahydro-trans- and tetrahydropyridoindole neuroleptic agents |
JPS5976059A (ja) * | 1982-10-21 | 1984-04-28 | Sumitomo Chem Co Ltd | 環状イミド誘導体及びその酸付加塩 |
DE3321969A1 (de) * | 1983-06-18 | 1984-12-20 | Troponwerke GmbH & Co KG, 5000 Köln | 2-pyrimidinyl-1-piperazin-derivate, verfahren zu ihrer herstellung und diese enthaltende arzneimittel |
-
1986
- 1986-08-05 US US06/893,507 patent/US4732984A/en not_active Expired - Lifetime
- 1986-10-09 AU AU63642/86A patent/AU603776B2/en not_active Ceased
- 1986-10-09 CA CA000520188A patent/CA1272197A/en not_active Expired - Fee Related
- 1986-10-14 EP EP86307952A patent/EP0220051B1/en not_active Expired - Lifetime
- 1986-10-14 GB GB8624575A patent/GB2181730B/en not_active Expired
- 1986-10-14 ES ES198686307952T patent/ES2039200T3/es not_active Expired - Lifetime
- 1986-10-14 DE DE8686307952T patent/DE3679767D1/de not_active Expired - Fee Related
- 1986-10-15 PT PT83548A patent/PT83548B/pt not_active IP Right Cessation
- 1986-10-16 KR KR1019860008685A patent/KR900000371B1/ko not_active IP Right Cessation
- 1986-10-16 HU HU864316A patent/HU206344B/hu not_active IP Right Cessation
- 1986-10-16 DK DK495586A patent/DK495586A/da not_active Application Discontinuation
-
1991
- 1991-08-30 GR GR91401253T patent/GR3002635T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
HU206344B (en) | 1992-10-28 |
GB2181730B (en) | 1989-09-13 |
GR3002635T3 (en) | 1993-01-25 |
EP0220051A1 (en) | 1987-04-29 |
PT83548B (pt) | 1988-10-14 |
AU603776B2 (en) | 1990-11-29 |
KR900000371B1 (ko) | 1990-01-25 |
GB2181730A (en) | 1987-04-29 |
DE3679767D1 (en) | 1991-07-18 |
PT83548A (en) | 1986-11-01 |
DK495586D0 (da) | 1986-10-16 |
AU6364286A (en) | 1987-04-30 |
GB8624575D0 (en) | 1986-11-19 |
DK495586A (da) | 1987-04-18 |
US4732984A (en) | 1988-03-22 |
ES2039200T3 (es) | 1993-09-16 |
HUT45997A (en) | 1988-09-28 |
CA1272197A (en) | 1990-07-31 |
EP0220051B1 (en) | 1991-06-12 |
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