DE69926386D1 - Propofol-formulierung - Google Patents

Propofol-formulierung

Info

Publication number
DE69926386D1
DE69926386D1 DE69926386T DE69926386T DE69926386D1 DE 69926386 D1 DE69926386 D1 DE 69926386D1 DE 69926386 T DE69926386 T DE 69926386T DE 69926386 T DE69926386 T DE 69926386T DE 69926386 D1 DE69926386 D1 DE 69926386D1
Authority
DE
Germany
Prior art keywords
benzyl alcohol
propofol formulation
propofol
directed
pharmaceutical composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69926386T
Other languages
English (en)
Other versions
DE69926386T2 (de
Inventor
Thomas May
John Hofstetter
L Olson
K Menon
A Mikrut
S Ovenshire
John Rhodes
R Speicher
R Waterson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hospira Inc
Original Assignee
Hospira Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/178,347 external-priority patent/US6140373A/en
Application filed by Hospira Inc filed Critical Hospira Inc
Publication of DE69926386D1 publication Critical patent/DE69926386D1/de
Application granted granted Critical
Publication of DE69926386T2 publication Critical patent/DE69926386T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/186—Quaternary ammonium compounds, e.g. benzalkonium chloride or cetrimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Dermatology (AREA)
  • Anesthesiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
DE69926386T 1998-10-23 1999-10-19 Propofol-formulierung Expired - Lifetime DE69926386T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US09/178,347 US6140373A (en) 1998-10-23 1998-10-23 Propofol composition
US178347 1998-10-23
US354017 1999-07-15
US09/354,017 US6140374A (en) 1998-10-23 1999-07-15 Propofol composition
PCT/US1999/024347 WO2000024376A1 (en) 1998-10-23 1999-10-19 Propofol composition

Publications (2)

Publication Number Publication Date
DE69926386D1 true DE69926386D1 (de) 2005-09-01
DE69926386T2 DE69926386T2 (de) 2006-05-24

Family

ID=26874222

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69926386T Expired - Lifetime DE69926386T2 (de) 1998-10-23 1999-10-19 Propofol-formulierung

Country Status (9)

Country Link
US (1) US6140374A (de)
EP (1) EP1124537B1 (de)
JP (1) JP2002528405A (de)
AT (1) ATE300283T1 (de)
AU (1) AU768302B2 (de)
CA (1) CA2347925C (de)
DE (1) DE69926386T2 (de)
ES (1) ES2245133T3 (de)
WO (1) WO2000024376A1 (de)

Families Citing this family (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6100302A (en) * 1999-04-05 2000-08-08 Baxter International Inc. Propofol formulation with enhanced microbial characteristics
GB0012597D0 (en) * 2000-05-25 2000-07-12 Astrazeneca Ab Formulation
MXPA02011531A (es) * 2000-05-25 2003-04-25 Astrazeneca Ab Beneficio de superviviencia.
AU6689601A (en) * 2000-06-16 2002-01-02 Rtp Pharma Inc Improved injectable dispersions of propofol
US6399087B1 (en) * 2000-12-20 2002-06-04 Amphastar Pharmaceuticals, Inc. Propofol formulation with enhanced microbial inhibition
US6815555B2 (en) 2001-09-26 2004-11-09 Theravance, Inc. Substituted phenol compounds useful for anesthesia and sedation
EP1509492B1 (de) * 2002-01-25 2011-08-31 Theravance, Inc. Sedative hypnotisch wirkende verbindungen mit kurzer wirkungsdauer zur anaesthesie und sedierung
WO2004082676A1 (en) * 2003-03-13 2004-09-30 Conforma Therapeutics Corporation Drug formulations having long and medium chain triglycerides
EP1492522A4 (de) * 2002-04-10 2009-01-14 Conforma Therapeutics Corp Ansamycin-formulierungen und verfahren zu ihrer herstellung und verwendung
EP1531687A4 (de) * 2002-06-18 2006-11-15 Martek Biosciences Corp STABILE EMULSIONEN VON LEN IN WûSSRIGEN L SUNGEN UND VERFAHREN ZU IHRER HERSTELLUNG
CA2494297C (en) * 2002-07-29 2011-10-18 Transform Pharmaceuticals, Inc. Aqueous 2,6-diisopropylphenol pharmaceutical compositions
US7550155B2 (en) * 2002-07-29 2009-06-23 Transform Pharmaceuticals Inc. Aqueous pharmaceutical compositions of 2,6-diisopropylphenol (propofol) and their uses
US20040220283A1 (en) * 2002-07-29 2004-11-04 Transform Pharmaceuticals, Inc. Aqueous 2,6-diisopropylphenol pharmaceutical compositions
JP2006504771A (ja) * 2002-10-29 2006-02-09 トランスフォーム・ファーマシューティカルズ・インコーポレイテッド システインを伴うプロポフォール
US20060148776A1 (en) * 2003-03-13 2006-07-06 Conforma Therapeutics Corporation Drug formulations having long and medium chain triglycerides
US7439268B2 (en) * 2003-07-18 2008-10-21 Idexx Laboratories Compositions containing prodrugs of florfenicol and methods of use
ATE444734T1 (de) * 2003-07-23 2009-10-15 Theravance Inc Pharmazeutische zusammensetzungen eines kurzwirkenden sedativen hypnosemittels
US8546453B2 (en) 2003-08-14 2013-10-01 Rensheng Zhang Propofol compositions and methods for reducing pain associated with propofol injection
US20050049210A1 (en) * 2003-08-27 2005-03-03 Idexx Laboratories, Inc. Methods for the controlled delivery of pharmacologically active compounds
EA200700440A1 (ru) * 2004-09-13 2008-02-28 Бхарат Сирумс Энд Вэксинс Лтд. Композиции стабильных эмульсий для внутривенного введения, имеющие защитную эффективность
US20060067953A1 (en) * 2004-09-29 2006-03-30 Conforma Therapeutics Corporation Oral pharmaceutical formulations and methods for producing and using same
US20070293586A1 (en) * 2005-02-03 2007-12-20 Suresh Dixit Novel propofol composition comprising ascorbic acid or pharmaceutically acceptable salts thereof
JP2008534609A (ja) 2005-03-30 2008-08-28 コンフォーマ・セラピューティクス・コーポレイション Ｈｓｐ９０阻害剤としてのアルキニルピロロピリミジンおよび関連類似体
BRPI0608661A2 (pt) * 2005-04-07 2010-01-19 Conforma Therapeutics Corp formulaÇço farmacÊutica, uso de formulaÇço farmacÊutica, e, mÉtodo de preparaÇço de uma formulaÇço farmacÊutica
US20090131538A1 (en) * 2005-05-27 2009-05-21 Taro Pharmaceuticals North America, Inc. c/o Taro Pharmaceuticals U.S.A., Inc. Novel propofol composition comprising a pharmaceutically acceptable salt of formaldehyde sulfoxylate
CN101304728A (zh) * 2005-08-05 2008-11-12 印度血清及疫苗有限公司 具有防腐功效的静脉内用丙泊酚乳剂组合物
CA2618799C (en) * 2005-08-12 2013-06-04 Bharat Serums & Vaccines Ltd. Aqueous anaesthetic compositions comprising propofol
TR200801336T1 (tr) * 2005-08-31 2008-08-21 Abraxis Bioscience, Inc. Kararlılığı artmış zayıf su çöznurluğune sahip ilaçların preparasyonuna yönelik kompozisyonlar ve yöntemler.
ES2719093T3 (es) 2005-08-31 2019-07-08 Abraxis Bioscience Llc Composiciones de fármacos poco solubles en agua con mayor estabilidad y métodos para su preparación
WO2007035963A2 (en) * 2005-09-23 2007-03-29 Conforma Therapeutics Corporation Anti-tumor methods using multi drug resistance independent synthetic hsp90 inhibitors
EP1954265A2 (de) * 2005-12-01 2008-08-13 Conforma Therapeutics Corporation Zusammensetzungen mit ansamycin
WO2008141097A2 (en) * 2007-05-09 2008-11-20 Pharmacofore, Inc. Stereoisomers propofol therapeutic compounds
EP2152651B1 (de) * 2007-05-09 2012-01-04 Pharmacofore, Inc. Therapeutische verbindungen
US7550625B2 (en) * 2007-10-19 2009-06-23 Idexx Laboratories Esters of florfenicol
WO2010082092A1 (en) 2009-01-13 2010-07-22 Claris Lifesciences Limited Propofol based anesthetic with preservative
ES2564502T3 (es) 2010-03-17 2016-03-23 Novaliq Gmbh Composición farmacéutica para el tratamiento de la presión intraocular aumentada
US8754125B2 (en) 2010-10-05 2014-06-17 The Medicines Company Antimicrobial preservation of propofol emulsions
EP2444063A1 (de) 2010-10-20 2012-04-25 Novaliq GmbH Flüssige pharmazeutische Zusammensetzungen zur Abgabe von Wirkstoffen
EP2462921A1 (de) 2010-11-11 2012-06-13 Novaliq GmbH Flüssige pharmazeutische Zusammensetzungen zur Behandlung einer Erkrankung der Hinterseite des Auges
EP3202421B1 (de) 2011-01-04 2018-03-28 Novaliq GmbH O/w-emulsionen mit semifluorierten alkanen
EP2714008B1 (de) 2011-05-25 2016-12-14 Novaliq GmbH Pharmazeutische zusammensetzung zur verabreichung an nägel
ES2962524T3 (es) 2011-05-25 2024-03-19 Dermaliq Therapeutics Inc Composición farmacéutica tópica a base de alcanos semifluorados
DK2806886T3 (en) 2012-01-23 2017-06-06 Novaliq Gmbh STABILIZED PROTEIN COMPOSITIONS BASED ON SEMIFLUORED ALKANES
EP3100722B1 (de) 2012-09-12 2024-03-20 Novaliq GmbH Semifluorierte alkane zur solubilisierung von meibum
DK2895144T3 (en) 2012-09-12 2017-03-06 Novaliq Gmbh SEMIFLUORED ALKAN COMPOSITIONS
CN105555311B (zh) 2013-07-23 2021-10-08 诺瓦利克有限责任公司 稳定的抗体组合物
DK3355990T3 (da) 2015-09-30 2019-09-16 Novaliq Gmbh Semifluorinerede forbindelser og disses sammensætninger
DE202016008739U1 (de) 2015-09-30 2019-04-29 Novaliq Gmbh Semifluorierte Verbindungen
PT3442480T (pt) 2016-06-23 2019-12-23 Novaliq Gmbh Método de administração tópica
MX2019003363A (es) 2016-09-22 2019-10-02 Novaliq Gmbh Composiciones farmaceuticas para usarse en la terapia de la blefaritis.
MX2019003364A (es) 2016-09-23 2019-10-02 Novaliq Gmbh Composiciones oftalmicas que comprenden ciclosporina.
ES2957559T3 (es) 2017-04-21 2024-01-22 Dermaliq Therapeutics Inc Composiciones de yodo
US11278503B2 (en) 2017-05-12 2022-03-22 Novaliq Gmbh Pharmaceutical compositions comprising semifluorinated alkanes for the treatment of contact lense-related conditions
US11723861B2 (en) 2017-09-27 2023-08-15 Novaliq Gmbh Ophthalmic compositions comprising latanoprost for use in the treatment of ocular diseases
WO2019068763A1 (en) 2017-10-04 2019-04-11 Novaliq Gmbh OPHTHALMIC COMPOSITIONS COMPRISING F6H8
KR20200128407A (ko) 2018-03-02 2020-11-12 노바리크 게엠베하 네비볼롤을 포함하는 약제학적 조성물
SG11202102820VA (en) 2018-10-12 2021-04-29 Novaliq Gmbh Ophthalmic composition for treatment of dry eye disease

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1472793A (en) * 1974-03-28 1977-05-04 Ici Ltd Pharmaceutical compositions
US4798846A (en) * 1974-03-28 1989-01-17 Imperial Chemical Industries Plc Pharmaceutical compositions
IL78929A0 (en) * 1985-07-29 1986-09-30 Abbott Lab Microemulsion compositions for parenteral administration
US4866096A (en) * 1987-03-20 1989-09-12 Air Products And Chemicals, Inc. Stable fluorochemical aqueous emulsions
JPH05170742A (ja) * 1991-05-24 1993-07-09 Ishihara Sangyo Kaisha Ltd ジアミノトリフルオロメチルピリジン誘導体、それらの製造方法及びそれらを含有するホスホリパーゼ▲ａ２▼阻害剤
JP3005275B2 (ja) * 1990-10-18 2000-01-31 石原産業株式会社 キヌクリジン誘導体及びその製造方法
ES2107663T3 (es) * 1992-04-28 1997-12-01 Fresenius Ag Empleo de una emulsion que contiene acidos grasos omega-3 en la fabricacion de un medicamento a administrar por via parenteral para el tratamiento de las enfermedades inflamatorias.
JP2683783B2 (ja) * 1992-07-10 1997-12-03 雪印乳業株式会社 シェーグレン症候群治療剤
GB9405593D0 (en) * 1994-03-22 1994-05-11 Zeneca Ltd Pharmaceutical compositions
US5731355A (en) * 1994-03-22 1998-03-24 Zeneca Limited Pharmaceutical compositions of propofol and edetate
AU6708096A (en) * 1995-09-18 1997-04-09 Vesifact Ag Propofol nanodispersions
US5637625A (en) * 1996-03-19 1997-06-10 Research Triangle Pharmaceuticals Ltd. Propofol microdroplet formulations

Also Published As

Publication number Publication date
US6140374A (en) 2000-10-31
AU768302B2 (en) 2003-12-04
ES2245133T3 (es) 2005-12-16
DE69926386T2 (de) 2006-05-24
ATE300283T1 (de) 2005-08-15
EP1124537A1 (de) 2001-08-22
EP1124537B1 (de) 2005-07-27
AU1210600A (en) 2000-05-15
WO2000024376A1 (en) 2000-05-04
JP2002528405A (ja) 2002-09-03
CA2347925C (en) 2009-03-17
CA2347925A1 (en) 2000-05-04

Similar Documents

Publication Publication Date Title
DE69926386D1 (de) Propofol-formulierung
PT1073470E (pt) Composicoes farmaceuticas contendo compostos com actividade capaz de melhorar a absorcao de ingredientes activos
AR020345A1 (es) Pirazol-carboxanilidas, procedimiento para su obtencion, composiciones, empleo de dichos compuestos y procedimiento para la lucha contra microorganismos indeseables, y procedimiento para la obtencion de dichas composiciones.
BR0112030A (pt) Novos compostos que possuem atividade antibacteriana, antifúngica ou antitumor
CY1107992T1 (el) Συνθεσεις πολυαμιδο-αμικου οξεος υδατικης βασεως
MXPA05001061A (es) Composiciones farmaceuticas, acuosas de 2,6-diisopropilfenol.
NO20026064D0 (no) Nye forbindelser
PT1263725E (pt) Novos compostos
BR0200782A (pt) Compostos para o tratamento da isquemia
WO2005072343A3 (en) Aqueous pharmaceutical compositions 2,6-diisopropylphenol (propofol) and their use
BRPI0113286B8 (pt) pirazóis substituídos e composição farmacêutica compreendendo os mesmos.
RS41104A (en) Sulphonamide derivatives, the preparation thereof and the application of same as medicaments
GT199800207A (es) Nuevos derivados de la eritromicina.
PA8541401A1 (es) Empleo de etoxilatos de alcoholes grasos como favorecedores de la penetracion
BR0210139A (pt) Composições farmacêuticas
RU95106674A (ru) Полиеновые соединения, фармацевтическая и косметическая композиция на их основе
BR0210028A (pt) Agentes antibacterianos
BR9713884A (pt) Benzamida heterociclicamente substituìda, usos da mesma e de cetobenzamidoaldeìdos desta, e, preparação medicamentosa.
SE0302139D0 (sv) Novel compounds
CY1109843T1 (el) Αναλογα της βιταμινης d
DE60301339D1 (de) Pyrazolopyrimidin- und pyrazolotriazinderivate und diese enthaltende pharmazeutische zubereitungen
BR9610527A (pt) Novos derivados de substâncias de ciclodepsipeptìdeo pf1022
BR0012610A (pt) Novo derivado de difenilpiperidina
CO5221025A1 (es) 4-trifluorometil-3-oxazolilpiridinas, procedimiento para su preparacion, agentes que las contienen y su uso como agente para la lucha contra organismos daninos
BR0312814A (pt) Levamisol / avermectinas ou similares em solvente de pirrolidona

Legal Events

Date Code Title Description
8364 No opposition during term of opposition