DE69907675D1 - Ein substituiertes triazolo-pyridazin-derivat, davon hergestellte arzneimittel - Google Patents

Ein substituiertes triazolo-pyridazin-derivat, davon hergestellte arzneimittel

Info

Publication number
DE69907675D1
DE69907675D1 DE69907675T DE69907675T DE69907675D1 DE 69907675 D1 DE69907675 D1 DE 69907675D1 DE 69907675 T DE69907675 T DE 69907675T DE 69907675 T DE69907675 T DE 69907675T DE 69907675 D1 DE69907675 D1 DE 69907675D1
Authority
DE
Germany
Prior art keywords
pyridazine derivative
medicament manufactured
substituted triazolo
triazolo
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69907675T
Other languages
English (en)
Other versions
DE69907675T2 (de
Inventor
William Robert Carling
Pineiro Jose Luis Castro
Cameron John Cowden
Antony John Davies
Andrew Madin
James Francis Mccabe
Gareth Edward Stephen Pearce
Leslie Joseph Street
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Organon Pharma UK Ltd
Original Assignee
Merck Sharp and Dohme Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp and Dohme Ltd filed Critical Merck Sharp and Dohme Ltd
Application granted granted Critical
Publication of DE69907675D1 publication Critical patent/DE69907675D1/de
Publication of DE69907675T2 publication Critical patent/DE69907675T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurosurgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE69907675T 1998-06-24 1999-06-15 Ein substituiertes triazolo-pyridazin-derivat, davon hergestellte arzneimittel Expired - Lifetime DE69907675T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9813576 1998-06-24
GBGB9813576.7A GB9813576D0 (en) 1998-06-24 1998-06-24 Therapeutic agents
PCT/GB1999/001897 WO1999067245A1 (en) 1998-06-24 1999-06-15 A substituted triazolo-pyridazine derivative, pharmaceutical compositions made therefrom

Publications (2)

Publication Number Publication Date
DE69907675D1 true DE69907675D1 (de) 2003-06-12
DE69907675T2 DE69907675T2 (de) 2004-03-04

Family

ID=10834265

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69907675T Expired - Lifetime DE69907675T2 (de) 1998-06-24 1999-06-15 Ein substituiertes triazolo-pyridazin-derivat, davon hergestellte arzneimittel

Country Status (35)

Country Link
US (1) US6630471B1 (de)
EP (1) EP1090004B1 (de)
JP (1) JP4749545B2 (de)
KR (1) KR100604108B1 (de)
CN (1) CN1138779C (de)
AR (1) AR018925A1 (de)
AT (1) ATE239730T1 (de)
AU (1) AU757315B2 (de)
BG (1) BG64989B1 (de)
BR (1) BR9911563A (de)
CA (1) CA2335328C (de)
CO (1) CO5031239A1 (de)
CZ (1) CZ291409B6 (de)
DE (1) DE69907675T2 (de)
EA (1) EA003332B1 (de)
EE (1) EE200000767A (de)
ES (1) ES2196824T3 (de)
GB (1) GB9813576D0 (de)
GE (1) GEP20033143B (de)
HR (1) HRP20000879A2 (de)
HU (1) HUP0102894A3 (de)
ID (1) ID27771A (de)
IL (2) IL139775A0 (de)
IS (1) IS2258B (de)
MY (1) MY124341A (de)
NO (1) NO317992B1 (de)
NZ (1) NZ508290A (de)
PE (1) PE20000710A1 (de)
PL (1) PL204650B1 (de)
RS (1) RS49746B (de)
SK (1) SK285307B6 (de)
TR (1) TR200003789T2 (de)
TW (1) TWI222449B (de)
WO (1) WO1999067245A1 (de)
ZA (1) ZA200007485B (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2345443A (en) * 1999-01-08 2000-07-12 Merck Sharp & Dohme Use of triazolo-pyridazines for treating premenstrual syndrome
US20050042194A1 (en) 2000-05-11 2005-02-24 A.P. Pharma, Inc. Semi-solid delivery vehicle and pharmaceutical compositions
GB0111191D0 (en) * 2001-05-08 2001-06-27 Merck Sharp & Dohme Therapeutic agents
NZ541151A (en) 2002-12-18 2008-09-26 Vertex Pharma Triazolopyridazines as protein kinase inhibitors
WO2006061428A2 (en) * 2004-12-10 2006-06-15 Universität Zürich Gaba-a alpha 2 and alpha 3 receptor agonists for treating neuropathic, inflammatory and migraine associated pain
WO2011005520A1 (en) 2009-06-23 2011-01-13 Concert Pharmaceuticals, Inc. Deuterium-modified triazolo-pyridazine derivatives as gaba-a receptor modulators
WO2011011712A1 (en) * 2009-07-24 2011-01-27 Concert Pharmaceuticals, Inc. Substituted imidazotriazines
US8278460B2 (en) 2009-10-15 2012-10-02 Concert Pharmaceuticals, Inc. Substituted benzimidazoles
KR20120111739A (ko) 2009-12-31 2012-10-10 센트로 내셔널 드 인베스티가시오네스 온콜로지카스 (씨엔아이오) 키나제 억제제로서의 사용을 위한 삼환식 화합물
WO2012098387A1 (en) * 2011-01-18 2012-07-26 Centro Nacional De Investigaciones Oncológicas (Cnio) 6, 7-ring-fused triazolo [4, 3 - b] pyridazine derivatives as pim inhibitors
EA029834B1 (ru) 2011-09-27 2018-05-31 Жанфит ПРОИЗВОДНЫЕ 6-ЗАМЕЩЕННЫХ ТРИАЗОЛОПИРИДАЗИНОВ КАК АГОНИСТЫ Rev-Erb
CA3012791C (en) 2016-01-27 2024-01-23 Universitat Zurich Use of gabaa receptor modulators for treatment of itch
CA3096890A1 (en) * 2018-04-18 2019-10-24 Neurocycle Therapeutics, Inc. Gabaa positive allosteric modulator compounds, methods of making, and uses thereof
ES2935705T3 (es) 2018-09-13 2023-03-09 Saniona As Un ligando del receptor GABA A
HU231223B1 (hu) 2018-09-28 2022-01-28 Richter Gedeon Nyrt. GABAA A5 receptor modulátor hatású biciklusos vegyületek
US20240043418A1 (en) 2020-03-26 2024-02-08 Richter Gedeon Nyrt. 1,3-dihydro-2h-pyrrolo[3,4-c]pyridine derivatives as gabaa a5 receptor modulators

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA002436B1 (ru) * 1996-07-25 2002-04-25 Мерк Шарп Энд Домэ Лимитед Замещенные производные триазоло-пиридазина в качестве лигандов рецепторов гамк

Also Published As

Publication number Publication date
GEP20033143B (en) 2003-12-25
ES2196824T3 (es) 2003-12-16
ID27771A (id) 2001-04-26
TWI222449B (en) 2004-10-21
YU77800A (sh) 2003-10-31
SK285307B6 (sk) 2006-10-05
BG105152A (en) 2001-10-31
KR20010053136A (ko) 2001-06-25
EA003332B1 (ru) 2003-04-24
KR100604108B1 (ko) 2006-07-26
NO317992B1 (no) 2005-01-17
CO5031239A1 (es) 2001-04-27
EP1090004A1 (de) 2001-04-11
CA2335328A1 (en) 1999-12-29
EP1090004B1 (de) 2003-05-07
NO20006576D0 (no) 2000-12-21
CN1138779C (zh) 2004-02-18
EE200000767A (et) 2002-06-17
HUP0102894A2 (hu) 2001-11-28
EA200100071A1 (ru) 2001-06-25
ATE239730T1 (de) 2003-05-15
WO1999067245A1 (en) 1999-12-29
NO20006576L (no) 2001-02-14
DE69907675T2 (de) 2004-03-04
NZ508290A (en) 2003-09-26
MY124341A (en) 2006-06-30
GB9813576D0 (en) 1998-08-19
CZ291409B6 (cs) 2003-03-12
CA2335328C (en) 2007-11-27
TR200003789T2 (tr) 2001-04-20
JP4749545B2 (ja) 2011-08-17
RS49746B (sr) 2008-04-04
HRP20000879A2 (en) 2001-06-30
HUP0102894A3 (en) 2003-03-28
PL204650B1 (pl) 2010-01-29
IL139775A (en) 2007-02-11
AU4630199A (en) 2000-01-10
US6630471B1 (en) 2003-10-07
BR9911563A (pt) 2001-03-20
PL345332A1 (en) 2001-12-17
IS5730A (is) 2000-11-24
IS2258B (is) 2007-06-15
CN1307579A (zh) 2001-08-08
BG64989B1 (bg) 2006-11-30
AR018925A1 (es) 2001-12-12
JP2002518501A (ja) 2002-06-25
AU757315B2 (en) 2003-02-13
IL139775A0 (en) 2002-02-10
CZ20004872A3 (cs) 2001-07-11
PE20000710A1 (es) 2000-08-14
ZA200007485B (en) 2002-01-07
SK19552000A3 (sk) 2001-08-06

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition