DE69823229D1 - Zyklisch imid-substituierte pyridylalkan-, alken-, und alkin- carboxamid-derivate, verwendbar als zytostatische und immunosuppressive mittel - Google Patents

Zyklisch imid-substituierte pyridylalkan-, alken-, und alkin- carboxamid-derivate, verwendbar als zytostatische und immunosuppressive mittel

Info

Publication number
DE69823229D1
DE69823229D1 DE69823229T DE69823229T DE69823229D1 DE 69823229 D1 DE69823229 D1 DE 69823229D1 DE 69823229 T DE69823229 T DE 69823229T DE 69823229 T DE69823229 T DE 69823229T DE 69823229 D1 DE69823229 D1 DE 69823229D1
Authority
DE
Germany
Prior art keywords
cytostatic
immunosuppressive agents
alkin
alken
imid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69823229T
Other languages
English (en)
Other versions
DE69823229T2 (de
Inventor
Elfi Biedermann
Max Hasmann
Roland Loeser
Benno Rattel
Friedemann Reiter
Barbara Schein
Klaus Seibel
Klaus Vogt
Katja Wosikowski
Isabel Schemainda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Astellas Deutschland GmbH
Original Assignee
Klinge Pharma GmbH and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Klinge Pharma GmbH and Co filed Critical Klinge Pharma GmbH and Co
Priority to DE69823229T priority Critical patent/DE69823229T2/de
Publication of DE69823229D1 publication Critical patent/DE69823229D1/de
Application granted granted Critical
Publication of DE69823229T2 publication Critical patent/DE69823229T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE69823229T 1997-12-17 1998-12-16 Zyklisch imid-substituierte pyridylalkan-, alken-, und alkin- carboxamid-derivate, verwendbar als zytostatische und immunosuppressive mittel Expired - Lifetime DE69823229T2 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE69823229T DE69823229T2 (de) 1997-12-17 1998-12-16 Zyklisch imid-substituierte pyridylalkan-, alken-, und alkin- carboxamid-derivate, verwendbar als zytostatische und immunosuppressive mittel

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE19756212 1997-12-17
DE19756212A DE19756212A1 (de) 1997-12-17 1997-12-17 Neue, mit einem cyclischen Imid substituierte Pyridylalkan-, alken- und -alkincarbonsäureamide
PCT/EP1998/008267 WO1999031087A1 (en) 1997-12-17 1998-12-16 Cyclic imide-substituted pyridylalkane, alkene and alkine carboxamides useful as cytostatic and immunosuppressive agents
DE69823229T DE69823229T2 (de) 1997-12-17 1998-12-16 Zyklisch imid-substituierte pyridylalkan-, alken-, und alkin- carboxamid-derivate, verwendbar als zytostatische und immunosuppressive mittel

Publications (2)

Publication Number Publication Date
DE69823229D1 true DE69823229D1 (de) 2004-05-19
DE69823229T2 DE69823229T2 (de) 2005-03-10

Family

ID=7852321

Family Applications (2)

Application Number Title Priority Date Filing Date
DE19756212A Ceased DE19756212A1 (de) 1997-12-17 1997-12-17 Neue, mit einem cyclischen Imid substituierte Pyridylalkan-, alken- und -alkincarbonsäureamide
DE69823229T Expired - Lifetime DE69823229T2 (de) 1997-12-17 1998-12-16 Zyklisch imid-substituierte pyridylalkan-, alken-, und alkin- carboxamid-derivate, verwendbar als zytostatische und immunosuppressive mittel

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE19756212A Ceased DE19756212A1 (de) 1997-12-17 1997-12-17 Neue, mit einem cyclischen Imid substituierte Pyridylalkan-, alken- und -alkincarbonsäureamide

Country Status (11)

Country Link
US (1) US7192967B1 (de)
EP (1) EP1042315B1 (de)
JP (1) JP4527877B2 (de)
AT (1) ATE264321T1 (de)
AU (1) AU2414699A (de)
DE (2) DE19756212A1 (de)
DK (1) DK1042315T3 (de)
ES (1) ES2218881T3 (de)
PT (1) PT1042315E (de)
WO (1) WO1999031087A1 (de)
ZA (1) ZA9811231B (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1031564A1 (de) 1999-02-26 2000-08-30 Klinge Pharma GmbH Hemmer der Nicotinamidmonononukleotide-Bildung und deren Verwendung zur Krebstherapie
EP1348434A1 (de) * 2002-03-27 2003-10-01 Fujisawa Deutschland GmbH Verwendung von Pyridylamiden als Inhibitoren von Angiogenese
EP1768662A2 (de) 2004-06-24 2007-04-04 Novartis Vaccines and Diagnostics, Inc. Immunstimulatoren kleiner moleküle und assays für deren nachweis
EP2098231A1 (de) 2008-03-05 2009-09-09 Topotarget Switzerland SA Verwendung von NAD Synthesis Hemmern zur Behandlung von ischämischen Reperfusionsschäden
RU2011111728A (ru) 2008-08-29 2012-10-10 Топотаргет А/С (Dk) Новые производные мочевины и тиомочевины
WO2010066709A1 (en) * 2008-12-09 2010-06-17 Topotarget A/S Novel pyridinyl acrylamide derivatives
WO2011006988A1 (en) 2009-07-17 2011-01-20 Topotarget A/S Method for predicting the utility of administering nicotinic acid or a precursor or prodrug thereof to reduce the severity of side-effects of cancer treatment with nicotinamide phosphoribosyltransferase inhibitors
CA2809391A1 (en) 2010-09-03 2012-03-08 Genentech, Inc. 4-{[(pyridin-3-yl-methyl)aminocarbonyl]amino}benzene-sulfone derivatives as nampt inhibitors for therapy of diseases such as cancer
RU2617988C2 (ru) 2010-09-03 2017-05-02 ФОРМА ТиЭм, ЭлЭлСИ Новые соединения и композиции для ингибирования nampt
BR112013005108A2 (pt) 2010-09-03 2016-05-10 Forma Tm Llc compostos e composições de guanidina para a inibição de nampt
CA2834746A1 (en) 2011-05-04 2012-11-08 Forma Tm, Llc Novel compounds and compositions for the inhibition of nampt
RU2617643C2 (ru) 2011-05-09 2017-04-25 ФОРМА ТиЭм, ЭлЭлСИ Новые соединения и композиции для ингибирования nampt
JP6450323B2 (ja) 2013-01-07 2019-01-09 ユニバーシティ オブ サザン カリフォルニア デオキシウリジントリホスファターゼ阻害剤
GB201507937D0 (en) 2015-05-08 2015-06-24 Univ Hertfordshire Higher Education Corp Compounds for treatment of pancreatic cancer
WO2017006283A1 (en) 2015-07-08 2017-01-12 Cv6 Therapeutics (Ni) Limited Deoxyuridine triphosphatase inhibitors containing cyclopropano linkage
WO2017006270A1 (en) 2015-07-08 2017-01-12 University Of Southern California Deoxyuridine triphosphatase inhibitors
US10570100B2 (en) 2015-07-08 2020-02-25 University Of Southern California Deoxyuridine triphosphatase inhibitors containing amino sulfonyl linkage
AU2016290987C1 (en) 2015-07-08 2023-07-20 Cv6 Therapeutics (Ni) Limited Hydantoin containing deoxyuridine triphosphatase inhibitors
WO2018098208A1 (en) 2016-11-23 2018-05-31 Cv6 Therapeutics (Ni) Limited Nitrogen ring linked deoxyuridine triphosphatase inhibitors
WO2018098204A1 (en) 2016-11-23 2018-05-31 Cv6 Therapeutics (Ni) Limited 6-membered uracil isosteres
WO2018098209A1 (en) 2016-11-23 2018-05-31 Cv6 Therapeutics (Ni) Limited Amino sulfonyl compounds
US11247984B2 (en) 2017-01-05 2022-02-15 Cv6 Therapeutics (Ni) Limited Uracil containing compounds

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4283541A (en) 1980-05-27 1981-08-11 Usv Pharmaceutical Corporation Pyridylacyl-hydroxamates
NL8005133A (nl) 1980-09-12 1982-04-01 Duphar Int Res Fenylpiperazinederivaten met antiagressieve werking.
JPS57136518A (en) 1981-02-18 1982-08-23 Eisai Co Ltd Immunoregulator
US5326772A (en) 1984-09-28 1994-07-05 Byk Gulden Lomberg Chemische Fabrik Gmbh Diaryl compounds for their use
US4778796A (en) 1985-07-19 1988-10-18 Dainippon Pharmaceutical Co., Ltd. ω-(3-pyridyl)alkenamide derivatives and anti-allergenic pharmaceutical compositions containing same
DE3641822A1 (de) 1986-12-06 1988-06-16 Goedecke Ag Verwendung von dihydrophenylaminosaeurederivaten und diese enthaltende arzneimittel zur immunmodulation und cytostase
JPS63179869A (ja) 1987-01-20 1988-07-23 Dainippon Pharmaceut Co Ltd ピペリジン誘導体
JP2832979B2 (ja) 1988-02-15 1998-12-09 武田薬品工業株式会社 不飽和カルボン酸アミド誘導体
HU206181B (en) 1988-02-19 1992-09-28 Byk Gulden Lomberg Chem Fab Process for producing pharmaceutical compositions comprising optically pure r-(+)-niguldipin and its derivatives and suitable for treating tumoros diseases
EP0343307A1 (de) 1988-05-26 1989-11-29 Fabrica Espanola De Productos Quimicos Y Farmaceuticos, S.A. 4-Piperidinalkanamin-Derivate
IE903196A1 (en) 1989-09-05 1991-03-13 Searle & Co Substituted n-benzylpiperidine amides
FI97540C (fi) 1989-11-06 1997-01-10 Sanofi Sa Menetelmä terapeuttisesti käyttökelpoisten, aromaattisesti substituoitujen piperidiini- ja piperatsiinijohdannaisten valmistamiseksi
JPH05506027A (ja) * 1990-04-10 1993-09-02 ビイク　グルデン　ロンベルク　ヒエーミツシエ　フアブリーク　ゲゼルシヤフト　ミツト　ベシユレンクテル　ハフツング 新規ピリジンエステル
US5352684A (en) 1990-04-10 1994-10-04 Byk Gulden Lomberg Chemische Fabrik Gmbh Pyridines as medicaments
US5260323A (en) 1990-06-28 1993-11-09 Hoechst Aktiengesellschaft 2,4- and 2,5-substituted pyridine-N-oxides, processes for their preparation and their use
DE4020570A1 (de) 1990-06-28 1992-01-02 Hoechst Ag 2,4- und 2,5-substituierte pyridin-n-oxide, verfahren zu deren herstellung sowie deren verwendung
EP0471236B1 (de) 1990-07-30 1995-03-15 Takeda Chemical Industries, Ltd. Imidazopyridinderivate und ihre Verwendung
DE69131842T2 (de) 1990-10-05 2000-07-27 Ajinomoto Kk Piperidinderivate und ihre Verwendung als antiarrhythmische Wirkstoffe
FR2676053B1 (fr) 1991-05-03 1993-08-27 Sanofi Elf Nouveaux composes dialkylenepiperidino et leurs enantiomeres, procede pour leur preparation et compositions pharmaceutiques les contenant.
JPH05125048A (ja) * 1991-05-10 1993-05-21 Takeda Chem Ind Ltd ピリジン誘導体、その製造方法およびそれを含有する医薬製剤
ATE152102T1 (de) * 1991-05-10 1997-05-15 Takeda Chemical Industries Ltd Pyridinderivate, deren herstellung und anwendung
US5208247A (en) 1991-08-01 1993-05-04 American Cyanamid Company Pyridinium compounds which are useful as antagonists of platelet activating factor
EP0548883A1 (de) 1991-12-24 1993-06-30 Hoechst Aktiengesellschaft Substituierte Pyridin-N-oxide, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel
AU3171493A (en) 1991-12-31 1993-07-28 Fujisawa Pharmaceutical Co., Ltd. Oxadiazole derivatives having acetylcholinesterase-inhibitory and muscarinic agonist activity
FR2686084B1 (fr) 1992-01-10 1995-12-22 Bioprojet Soc Civ Nouveaux derives de l'imidazole, leur preparation et leurs applications therapeutiques.
GB9200535D0 (en) 1992-01-10 1992-02-26 Fujisawa Pharmaceutical Co New compound
US5612336A (en) 1992-07-13 1997-03-18 Merck, Sharp & Dohme Ltd. Heterocyclic amide derivatives as tachykinin antagonists
IL111235A (en) * 1993-10-15 2001-03-19 Schering Plough Corp Medicinal preparations for inhibiting protein G activity and for the treatment of malignant diseases, containing tricyclic compounds, some such new compounds and a process for the preparation of some of them
NZ274749A (en) * 1993-10-15 1998-05-27 Schering Corp Tricyclic carbamate derivatives useful for inhibition of g-protein function and for treating proliferative diseases, medicaments
ATE210653T1 (de) * 1993-10-15 2001-12-15 Schering Corp Tricyclische sulfonamide-derivate zur inhibierung der g-protein funktion und fur die bekandlung von proliferativen erkrantungen
CA2185448A1 (en) 1994-03-14 1995-09-21 James L. Mulshine Use of lipoxygenase inhibitors as anti-cancer therapeutic and intervention agents
IL117798A (en) * 1995-04-07 2001-11-25 Schering Plough Corp Tricyclic compounds useful for inhibiting the function of protein - G and for the treatment of malignant diseases, and pharmaceutical preparations containing them
US5712280A (en) * 1995-04-07 1998-01-27 Schering Corporation Tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
FR2738245B1 (fr) 1995-08-28 1997-11-21 Sanofi Sa Nouveaux derives de piperidine, procede pour leur obtention et compositions pharmaceutiques les contenant
DE19624668A1 (de) * 1996-06-20 1998-02-19 Klinge Co Chem Pharm Fab Verwendung von Pyridylalkan-, Pyridylalken- bzw. Pyridylalkinsäureamiden
DE19624704A1 (de) * 1996-06-20 1998-01-08 Klinge Co Chem Pharm Fab Neue Pyridylalkansäureamide
DE19624659A1 (de) * 1996-06-20 1998-01-08 Klinge Co Chem Pharm Fab Neue Pyridylalken- und Pyridylalkinsäureamide

Also Published As

Publication number Publication date
AU2414699A (en) 1999-07-05
US7192967B1 (en) 2007-03-20
WO1999031087A1 (en) 1999-06-24
ES2218881T3 (es) 2004-11-16
JP4527877B2 (ja) 2010-08-18
EP1042315B1 (de) 2004-04-14
ATE264321T1 (de) 2004-04-15
EP1042315A1 (de) 2000-10-11
DE19756212A1 (de) 1999-07-01
JP2002508367A (ja) 2002-03-19
ZA9811231B (en) 1999-06-08
PT1042315E (pt) 2004-08-31
DK1042315T3 (da) 2004-07-12
DE69823229T2 (de) 2005-03-10

Similar Documents

Publication Publication Date Title
DE69823229D1 (de) Zyklisch imid-substituierte pyridylalkan-, alken-, und alkin- carboxamid-derivate, verwendbar als zytostatische und immunosuppressive mittel
DK1060163T3 (da) Nye piperazinyl-substituerede pyridylalkan-, -alken og -alkyncarboxamider
ATE299495T1 (de) Aryl-substituierte pyridylalkan-, alken-, und alkin- carboxamidderivate, verwendbar als zytostatische und immunosuppressive mittel
DE69715888T2 (de) Pyridylalken- und pyridylalkin-säureamide als cytostatika und immunosuppressive arzneimittel
ATE223912T1 (de) Pyridylalkan-säureamide als cytostatika und immunosupressive arzneimittel
HUP9802857A2 (hu) Farnezil-transzferáz gátló hatású 4-merkapto-pirrolidin-származékok, eljárás előállításukra és a vegyületeket tartalmazó gyógyászati készítmények
MY133647A (en) Substituted quinoline-2-carboxamides, their preparation and their use as pharmaceuticals, and intermediates
DE60041973D1 (de) Substituierte piperidin-verbindungen als modulatoren der chemokine receptor aktivität
TR199800849T2 (xx) Siklikle heterosiklik N-ikame edilmi� alfa-iminohidroksamla karbon asitleri
DE69827651D1 (de) Verwendung von tempol zur behandlung von essentiellem hochdruck
HUP0004434A2 (hu) Adamantánszármazékok és ezeket tartalmazó gyógyászati készítmények
BR0212829A (pt) Derivados de 1,8-naftiridina e seu uso para tratar diabetes e distúrbios relacionados
ATE323692T1 (de) Piperidinylsubstituierte pyridylalkan-, -alken- und -alkincarbonsäuren als cytostatika und immunsuppressiva
DE69620165T2 (de) Piperazinone als inhibitoren von blutplattchenaggregation
BR9910899A (pt) Compostos de ácido sulfÈnico ou sulfonilamino n-(hetero-aralquil)-azaeterocicliamida
ATE188873T1 (de) Tris-platin-komplexe
TR200003797T2 (tr) Alfa-D-ksiloz'dan türetilen yeni terkipler, bunların hazırlanma yöntemleri ve tedavi maksatlı kullanımları.
TR199802665T2 (xx) Piperidin asetik asit t�revleri ve bunlar�n trombotik hastal�klar�n tedavisinde kullan�m�.
TR199901385T2 (xx) Piperidin t�revleri.
TH50173A (th) การใช้ 1-ไฮดรอกซี-2-ไพริโดนสำหรับการบำบัดการติดเชื้อที่ผิวหนัง
AR003444A1 (es) Nuevos compuestos de acetidinona, un procedimiento para la preparacion de los mismos y uso de los mismos para la manufactura de un medicamento ycomposicion farmaceutica que los contiene.
ATE221068T1 (de) Anellierte beta-carboline
NO924701L (no) Amid-bundete pyridyl-benzosyrederivater for behandling avleukotrien-relaterte sykdommer

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: ASTELLAS PHARMA GMBH, 81673 MUENCHEN, DE

8327 Change in the person/name/address of the patent owner

Owner name: ASTELLAS DEUTSCHLAND GMBH, 81673 MUENCHEN, DE