DE69804659T2 - 21-hydro-6,19-oxidoprogesterone (21oh-60p) und deren verwendung als arzneimittel zur behandlung von glukokortikoidüberschuss - Google Patents

21-hydro-6,19-oxidoprogesterone (21oh-60p) und deren verwendung als arzneimittel zur behandlung von glukokortikoidüberschuss

Info

Publication number
DE69804659T2
DE69804659T2 DE69804659T DE69804659T DE69804659T2 DE 69804659 T2 DE69804659 T2 DE 69804659T2 DE 69804659 T DE69804659 T DE 69804659T DE 69804659 T DE69804659 T DE 69804659T DE 69804659 T2 DE69804659 T2 DE 69804659T2
Authority
DE
Germany
Prior art keywords
oxidoprogesterone
glucocortico
hydro
medicine
excess
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69804659T
Other languages
English (en)
Other versions
DE69804659D1 (de
Inventor
Gerardo Burton
Pedro Lantos
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Serono SA
Original Assignee
Applied Research Systems ARS Holding NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Applied Research Systems ARS Holding NV filed Critical Applied Research Systems ARS Holding NV
Application granted granted Critical
Publication of DE69804659D1 publication Critical patent/DE69804659D1/de
Publication of DE69804659T2 publication Critical patent/DE69804659T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A61P5/46—Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of glucocorticosteroids

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE69804659T 1997-09-23 1998-09-22 21-hydro-6,19-oxidoprogesterone (21oh-60p) und deren verwendung als arzneimittel zur behandlung von glukokortikoidüberschuss Expired - Fee Related DE69804659T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP97116526A EP0903146A1 (de) 1997-09-23 1997-09-23 21-Hydroy-6,19-oxidoprogesterone (21-0H-60P) als ANitoglucocortikoid
PCT/EP1998/006021 WO1999015181A1 (en) 1997-09-23 1998-09-22 21-hydroxy-6,19-oxidoprogesterone (21oh-6op) and its use as medicament for treating excess of glucocorticoids

Publications (2)

Publication Number Publication Date
DE69804659D1 DE69804659D1 (de) 2002-05-08
DE69804659T2 true DE69804659T2 (de) 2002-10-02

Family

ID=8227390

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69804659T Expired - Fee Related DE69804659T2 (de) 1997-09-23 1998-09-22 21-hydro-6,19-oxidoprogesterone (21oh-60p) und deren verwendung als arzneimittel zur behandlung von glukokortikoidüberschuss

Country Status (13)

Country Link
US (1) US6303591B1 (de)
EP (2) EP0903146A1 (de)
AR (1) AR023008A1 (de)
AT (1) ATE215373T1 (de)
AU (1) AU738522B2 (de)
CA (1) CA2303817C (de)
DE (1) DE69804659T2 (de)
DK (1) DK1033990T3 (de)
ES (1) ES2172937T3 (de)
IL (1) IL135232A (de)
PT (1) PT1033990E (de)
WO (1) WO1999015181A1 (de)
ZA (1) ZA988674B (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GEP20053474B (en) 1999-04-30 2005-03-25 Pfizer Prod Inc Glucocorticoid Receptor Modulators
US7713989B2 (en) 2000-04-27 2010-05-11 Dow Robert L Glucocorticoid receptor modulators
JP2004509132A (ja) * 2000-09-18 2004-03-25 アプライド　リサーチ　システムズ　エーアールエス　ホールディング　ナームロゼ　フェンノートシャップ グルココルチコイド過剰の治療のための２１−ヒドロキシ−６，１９−オキシドプロゲステロン（２１ｏｈ−６ｏｐ）の硫黄アナログ
JP2004509131A (ja) * 2000-09-18 2004-03-25 アプライド　リサーチ　システムズ　エーアールエス　ホールディング　ナームロゼ　フェンノートシャップ ２１−ヒドロキシ−６，１９−オキシドプロゲステロン（２１ｏｈ−６ｏｐ）の製造方法
EP1201660B1 (de) 2000-10-30 2005-08-31 Pfizer Products Inc. Glucocorticoid Rezeptor Modulatoren
US8097606B2 (en) * 2003-07-23 2012-01-17 Corcept Therapeutics, Inc. Antiglucocorticoids for the treatment of catatonia
EP1886695A1 (de) * 2006-06-27 2008-02-13 Speedel Experimenta AG Pharmazeutische Kombinationen mit einem Aldosteron Synthasehemmer und Glucocorticoid Rezeptorantagonisten oder Cortisol Synthasehemmer oder Corticotropin Releasing Faktor Antagonisten
PL2054049T3 (pl) 2006-08-24 2016-11-30 Podstawione acyloanilidy i sposoby ich stosowania
WO2011150209A1 (en) 2010-05-26 2011-12-01 Corcept Therapeutics, Inc. Treatment of muscular dystrophy
US9744149B2 (en) 2012-07-13 2017-08-29 Gtx, Inc. Method of treating androgen receptor (AR)-positive breast cancers with selective androgen receptor modulator (SARMs)
US10258596B2 (en) 2012-07-13 2019-04-16 Gtx, Inc. Method of treating HER2-positive breast cancers with selective androgen receptor modulators (SARMS)
US9622992B2 (en) 2012-07-13 2017-04-18 Gtx, Inc. Method of treating androgen receptor (AR)-positive breast cancers with selective androgen receptor modulator (SARMs)
US10314807B2 (en) 2012-07-13 2019-06-11 Gtx, Inc. Method of treating HER2-positive breast cancers with selective androgen receptor modulators (SARMS)
KR102122941B1 (ko) 2012-07-13 2020-06-15 지티엑스, 인코포레이티드 선택적 안드로겐 수용체 조절자(sarms)를 이용한 안드로겐 수용체(ar) 양성 유방암의 치료 방법
US9969683B2 (en) 2012-07-13 2018-05-15 Gtx, Inc. Method of treating estrogen receptor (ER)-positive breast cancers with selective androgen receptor modulator (SARMS)
US10987334B2 (en) 2012-07-13 2021-04-27 University Of Tennessee Research Foundation Method of treating ER mutant expressing breast cancers with selective androgen receptor modulators (SARMs)
CA2977591A1 (en) 2015-03-02 2016-09-09 Corcept Therapeutics, Inc. Use of glucocorticoid receptor antagonist and somatostatin analogues to treat acth-secreting tumors
SG11201707525TA (en) 2015-03-30 2017-10-30 Corcept Therapeutics Inc Use of glucocorticoid receptor antagonists in combination with glucocorticoids to treat adrenal insufficiency
JP6768789B2 (ja) 2015-08-13 2020-10-14 コーセプト セラピューティクス， インコーポレイテッド Ａｃｔｈ依存性クッシング症候群を鑑別診断する方法
KR102197526B1 (ko) 2016-01-19 2020-12-31 코어셉트 쎄라퓨틱스 인코포레이티드 이소성 쿠싱 증후군의 감별 진단
EP3641780A4 (de) 2017-06-20 2021-02-24 Corcept Therapeutics, Inc. Verfahren zur behandlung von neuroepitheltumoren unter verwendung selektiver glucocorticoidrezeptormodulatoren
EP3902549A4 (de) * 2018-12-28 2022-09-14 Panda Consulting LLC Kurzwirkende selektive glucocorticoid-rezeptormodulatoren

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL118974A (en) * 1995-08-17 2001-09-13 Akzo Nobel Nv History 11 - (Transformed Phenyl) - Astra - 4, 9 - Diane, their preparation and pharmaceutical preparations containing them
PT1023074E (pt) * 1997-10-06 2006-12-29 Trustees Leland Stanford Junio Métodos para tratamento de psicose associada a disfunção relacionada com glucocorticóides

Also Published As

Publication number Publication date
WO1999015181A1 (en) 1999-04-01
AU738522B2 (en) 2001-09-20
IL135232A (en) 2005-05-17
IL135232A0 (en) 2001-05-20
CA2303817C (en) 2008-04-01
EP1033990A1 (de) 2000-09-13
ATE215373T1 (de) 2002-04-15
ZA988674B (en) 1999-06-28
EP0903146A1 (de) 1999-03-24
DK1033990T3 (da) 2002-07-08
US6303591B1 (en) 2001-10-16
AU1334199A (en) 1999-04-12
CA2303817A1 (en) 1999-04-01
ES2172937T3 (es) 2002-10-01
AR023008A1 (es) 2002-09-04
EP1033990B1 (de) 2002-04-03
PT1033990E (pt) 2002-07-31
DE69804659D1 (de) 2002-05-08

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: LABORATOIRES SERONO S.A., COINSINS, VAUD, CH

8339 Ceased/non-payment of the annual fee