DE69731835D1 - Verfahren zur herstellung von zwischenprodukten des florfenicols - Google Patents

Verfahren zur herstellung von zwischenprodukten des florfenicols

Info

Publication number
DE69731835D1
DE69731835D1 DE69731835T DE69731835T DE69731835D1 DE 69731835 D1 DE69731835 D1 DE 69731835D1 DE 69731835 T DE69731835 T DE 69731835T DE 69731835 T DE69731835 T DE 69731835T DE 69731835 D1 DE69731835 D1 DE 69731835D1
Authority
DE
Germany
Prior art keywords
florfenicols
intermediate products
producing intermediate
producing
products
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69731835T
Other languages
English (en)
Other versions
DE69731835T2 (de
DE69731835T3 (de
Inventor
C Towson
B Vashi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme Corp
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24808601&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69731835(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Schering Corp filed Critical Schering Corp
Publication of DE69731835D1 publication Critical patent/DE69731835D1/de
Publication of DE69731835T2 publication Critical patent/DE69731835T2/de
Application granted granted Critical
Publication of DE69731835T3 publication Critical patent/DE69731835T3/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/28—Nitrogen atoms not forming part of a nitro radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE69731835T 1996-08-19 1997-08-18 Verfahren zur herstellung von zwischenprodukten des florfenicols Expired - Lifetime DE69731835T3 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US699271 1996-08-19
US08/699,271 US5663361A (en) 1996-08-19 1996-08-19 Process for preparing intermediates to florfenicol
PCT/US1997/014205 WO1998007709A1 (en) 1996-08-19 1997-08-18 Process for preparing intermediates to florfenicol
EP97938263.7A EP0922040B2 (de) 1996-08-19 1997-08-18 Verfahren zur herstellung von zwischenprodukten des florfenicols

Publications (3)

Publication Number Publication Date
DE69731835D1 true DE69731835D1 (de) 2005-01-05
DE69731835T2 DE69731835T2 (de) 2005-07-21
DE69731835T3 DE69731835T3 (de) 2013-12-05

Family

ID=24808601

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69731835T Expired - Lifetime DE69731835T3 (de) 1996-08-19 1997-08-18 Verfahren zur herstellung von zwischenprodukten des florfenicols

Country Status (31)

Country Link
US (1) US5663361A (de)
EP (1) EP0922040B2 (de)
JP (1) JP3274868B2 (de)
KR (1) KR100286851B1 (de)
CN (1) CN1097583C (de)
AR (1) AR008298A1 (de)
AT (1) ATE283847T1 (de)
AU (1) AU714495B2 (de)
BR (1) BR9711318B1 (de)
CA (1) CA2264116C (de)
CO (1) CO4560550A1 (de)
CZ (1) CZ297915B6 (de)
DE (1) DE69731835T3 (de)
DK (1) DK0922040T3 (de)
ES (1) ES2234026T5 (de)
HK (1) HK1017890A1 (de)
HU (1) HU229610B1 (de)
ID (1) ID18047A (de)
IL (1) IL128574A (de)
MY (1) MY115679A (de)
NO (1) NO312962B1 (de)
NZ (1) NZ334111A (de)
PE (1) PE99798A1 (de)
PL (2) PL198553B1 (de)
PT (1) PT922040E (de)
SI (1) SI0922040T1 (de)
SK (1) SK286124B6 (de)
TR (2) TR199900354T2 (de)
TW (1) TW381075B (de)
WO (1) WO1998007709A1 (de)
ZA (1) ZA977406B (de)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1173933C (zh) * 2001-06-01 2004-11-03 中国科学院上海有机化学研究所 一种从l型取代苯丝氨酸酯制备d－（－）－苏式1－r－取代苯基－2－二氯乙酰氨基－3－氟－1－丙醇的方法
KR20040091698A (ko) * 2002-03-08 2004-10-28 쉐링-플라우 리미티드. 신규한 플로르페니콜형 항생제
CL2004001293A1 (es) * 2003-05-29 2005-05-06 Schering Plough Ltd Composicion farmaceutica que comprende compuestos antibacterianos como florfenicol, tiamfenicol, cloramfenicol en combinacion con al menos un portador seleccionado de triacetina, dimetilacetamida o una mezcla de ellas; y su uso en el tratamiento de u
US7439268B2 (en) * 2003-07-18 2008-10-21 Idexx Laboratories Compositions containing prodrugs of florfenicol and methods of use
US20050049210A1 (en) * 2003-08-27 2005-03-03 Idexx Laboratories, Inc. Methods for the controlled delivery of pharmacologically active compounds
US7126005B2 (en) * 2003-10-06 2006-10-24 Aurobindo Pharma Limited Process for preparing florfenicol
PE20060489A1 (es) 2004-08-13 2006-06-19 Schering Plough Ltd Formulacion farmaceutica que comprende un antibiotico, un triazol y un corticosteroide
NZ553777A (en) 2004-09-23 2010-11-26 Schering Plough Ltd Control of parasites in animals by the use of novel trifluoromethanesulfonanilide oxime ether derivatives
WO2006055565A2 (en) * 2004-11-19 2006-05-26 Schering-Plough Ltd. Control of parasites in animals by the use of parasiticidal 2-phenyl-3-(1h-pyrrol-2-yl) acrylonitrile derivatives
ES2315942T3 (es) * 2004-12-21 2009-04-01 Intervet International Bv Composicion veterinaria inyectable que contiene florfenicol.
WO2006135648A2 (en) * 2005-06-09 2006-12-21 Schering-Plough Ltd. Control of parasites in animals by n-[(phenyloxy)phenyl]-1,1,1-trifluoromethanesulfonamide and n-[(phenylsulfanyl)phenyl]-1,1,1-trifluoromethanesulfonamide derivatives
EP1928820B1 (de) * 2005-09-07 2014-01-29 Intervet International BV Verfahren zur herstellung von ester-oxazolidin-verbindungen und umwandlung derselben in florfenicol
US8119667B2 (en) * 2005-12-29 2012-02-21 Schering-Plough Animal Health Corporation Carbonates of fenicol antibiotics
US7518017B2 (en) 2006-02-17 2009-04-14 Idexx Laboratories Fenicol compounds and methods synthesizing 2-trifluoroacetamido-3-substituted propiophenone compounds
US20070238700A1 (en) * 2006-04-10 2007-10-11 Winzenberg Kevin N N-phenyl-1,1,1-trifluoromethanesulfonamide hydrazone derivative compounds and their usage in controlling parasites
WO2008076259A1 (en) * 2006-12-13 2008-06-26 Schering-Plough Ltd. Water-soluble prodrugs of florfenicol and its analogs
US8044230B2 (en) * 2006-12-13 2011-10-25 Intervet Inc. Water-soluble prodrugs of chloramphenicol, thiamphenicol, and analogs thereof
PE20090234A1 (es) * 2007-04-27 2009-04-02 Schering Plough Ltd Composiciones farmaceuticas que comprenden florfenicol y ciclodextrinas
CN101784534A (zh) * 2007-05-30 2010-07-21 先灵-普劳有限公司 制备可用作氟苯尼考中间体的*唑啉保护的氨基二醇化合物的方法
TWI430995B (zh) 2007-06-26 2014-03-21 Du Pont 萘異唑啉無脊椎有害動物控制劑
CN105640952A (zh) 2007-06-27 2016-06-08 杜邦公司 动物虫害控制方法
RU2010106607A (ru) * 2007-07-25 2011-08-27 Интервет Интернэшнл Б.В. (Nl) Способ получения оксазолидин- и оксазолидинонаминодиолов
US7550625B2 (en) * 2007-10-19 2009-06-23 Idexx Laboratories Esters of florfenicol
PL2217207T3 (pl) * 2007-11-09 2019-05-31 Intervet Int Bv Preparat o szybkim uwalnianiu w postaci stałej, jego przygotowanie i zastosowanie
TWI401023B (zh) 2008-02-06 2013-07-11 Du Pont 中離子農藥
JP2011529895A (ja) * 2008-07-30 2011-12-15 インターベツト・インターナシヨナル・ベー・ベー フロルフェニコール中間体として有用なオキサゾリン保護アミノジオール化合物を調製する方法
CN102574815A (zh) 2009-08-05 2012-07-11 杜邦公司 介离子杀虫剂
UA110924C2 (uk) 2009-08-05 2016-03-10 Е. І. Дю Пон Де Немур Енд Компані Мезоіонні пестициди
UA107804C2 (en) 2009-08-05 2015-02-25 Du Pont Mixtures of pesticides mezoionnyh
JP2013501059A (ja) 2009-08-05 2013-01-10 イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー メソイオン性殺虫剤
BRPI1002023A2 (pt) 2010-03-01 2011-10-25 Nanocore Biotecnologia S A forma farmacêutica sólida de dissolução rápida para tratamento de infecções bacterianas
MY156670A (en) 2010-05-27 2016-03-15 Du Pont Crystalline form of 4-[5-[3-chloro-5-(trifluoromethly)phenyl]-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-n-[2-oxo-2-[(2,2,2-trifluoroethyl) amino]ethyl]-1-naphthalenecarboxamide
WO2012087630A1 (en) 2010-12-20 2012-06-28 E.I. Du Pont De Nemours And Company Pyridine and pyrimidine compounds for controlling invertebrate
WO2013158422A1 (en) 2012-04-17 2013-10-24 E. I. Du Pont De Nemours And Company Heterocyclic compounds for controlling invertebrate pests
CN102911133B (zh) * 2012-10-31 2014-07-02 绍兴民生医药有限公司 (4r,5r)-2-二氯甲基-4,5-二氢-5-(4-甲砜基苯基)-4-恶唑甲醇的纯化方法
CN103254147B (zh) * 2013-04-19 2016-04-06 浙江科技学院 一种d-苏式-2-(二氯甲基)-4,5-二氢-5-[对-（甲砜基）苯基]-4-噁唑甲醇的制备方法
CN106278964B (zh) * 2016-07-31 2018-01-16 浙江润康药业有限公司 氟苯尼考的制备方法
CN106631872A (zh) * 2016-12-13 2017-05-10 浙江普洛家园药业有限公司 一种氟苯尼考类似物中间体的合成方法
CN110272856B (zh) * 2019-05-08 2022-05-03 江南大学 一种表达d-苏氨酸醛缩酶的重组菌及其构建方法与应用
CN117466787B (zh) * 2023-12-28 2024-03-22 山东国邦药业有限公司 一种氟苯尼考中间体的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2759001A (en) * 1952-03-01 1956-08-14 Parke Davis & Co Process for the production of delta2-oxazolines
US4361557A (en) * 1980-01-28 1982-11-30 Schering Corporation 1-Aryl-2-acylamido-3-fluoro-1-propanol acylates, methods for their use as anti-bacterial agents and compositions useful therefor
EP0677511A3 (de) * 1983-06-02 1996-07-24 Zambon Spa Zwischenprodukte zur Herstellung von 1-Phenyl-1-hydroxy-2-amino-3-fluorpropan-Derivaten.
US4876352A (en) * 1988-09-14 1989-10-24 Schering Corporation Pressurized fluorination of hydroxy alkyl groups
WO1990014434A1 (en) † 1989-05-15 1990-11-29 Schering Corporation Process for preparing antibacterial compounds and intermediates thereto
CA2094810C (en) * 1990-10-25 2002-06-04 Jon E. Clark Process for preparing florfenicol, its analogs and oxazoline intermediates thereto

Also Published As

Publication number Publication date
NO312962B1 (no) 2002-07-22
CZ54099A3 (cs) 1999-07-14
JP2000501424A (ja) 2000-02-08
AU714495B2 (en) 2000-01-06
NO990756L (no) 1999-02-18
CZ297915B6 (cs) 2007-04-25
IL128574A (en) 2002-04-21
SK19999A3 (en) 2000-02-14
AU4063897A (en) 1998-03-06
DE69731835T2 (de) 2005-07-21
ES2234026T3 (es) 2005-06-16
TR200800474T2 (tr) 2008-04-21
PT922040E (pt) 2005-02-28
PL198553B1 (pl) 2008-06-30
ES2234026T5 (es) 2013-11-12
MY115679A (en) 2003-08-30
NZ334111A (en) 1999-10-28
CO4560550A1 (es) 1998-02-10
DK0922040T3 (da) 2005-04-04
ID18047A (id) 1998-02-19
SK286124B6 (sk) 2008-04-07
PE99798A1 (es) 1998-12-28
SI0922040T1 (en) 2005-02-28
ZA977406B (en) 1998-02-18
HUP9904166A2 (hu) 2000-05-28
EP0922040B1 (de) 2004-12-01
CN1233244A (zh) 1999-10-27
IL128574A0 (en) 2000-01-31
CA2264116A1 (en) 1998-02-26
KR20000068178A (ko) 2000-11-25
KR100286851B1 (ko) 2001-04-16
HU229610B1 (en) 2014-03-28
BR9711318B1 (pt) 2009-01-13
NO990756D0 (no) 1999-02-18
EP0922040B2 (de) 2013-07-17
PL331644A1 (en) 1999-08-02
BR9711318A (pt) 1999-08-17
JP3274868B2 (ja) 2002-04-15
HUP9904166A3 (en) 2001-11-28
AR008298A1 (es) 1999-12-29
PL196454B1 (pl) 2008-01-31
ATE283847T1 (de) 2004-12-15
HK1017890A1 (en) 1999-12-03
WO1998007709A1 (en) 1998-02-26
TW381075B (en) 2000-02-01
EP0922040A1 (de) 1999-06-16
CN1097583C (zh) 2003-01-01
TR199900354T2 (xx) 1999-05-21
CA2264116C (en) 2002-07-02
US5663361A (en) 1997-09-02
DE69731835T3 (de) 2013-12-05

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Legal Events

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8363 Opposition against the patent