DE69610880D1 - Zyklische Peptide mit antifungischer Wirkung - Google Patents

Zyklische Peptide mit antifungischer Wirkung

Info

Publication number
DE69610880D1
DE69610880D1 DE69610880T DE69610880T DE69610880D1 DE 69610880 D1 DE69610880 D1 DE 69610880D1 DE 69610880 T DE69610880 T DE 69610880T DE 69610880 T DE69610880 T DE 69610880T DE 69610880 D1 DE69610880 D1 DE 69610880D1
Authority
DE
Germany
Prior art keywords
hydrogen
chem
alkyl
benzyl
independently
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69610880T
Other languages
English (en)
Other versions
DE69610880T2 (de
Inventor
Michael John Rodriguez
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of DE69610880D1 publication Critical patent/DE69610880D1/de
Application granted granted Critical
Publication of DE69610880T2 publication Critical patent/DE69610880T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE69610880T 1995-07-25 1996-07-22 Zyklische Peptide mit antifungischer Wirkung Expired - Fee Related DE69610880T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/506,790 US5629289A (en) 1995-07-25 1995-07-25 Cyclic peptide antifungal agents

Publications (2)

Publication Number Publication Date
DE69610880D1 true DE69610880D1 (de) 2000-12-14
DE69610880T2 DE69610880T2 (de) 2001-05-10

Family

ID=24016022

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69610880T Expired - Fee Related DE69610880T2 (de) 1995-07-25 1996-07-22 Zyklische Peptide mit antifungischer Wirkung

Country Status (13)

Country Link
US (1) US5629289A (de)
EP (1) EP0757058B1 (de)
JP (1) JPH11510165A (de)
AT (1) ATE197460T1 (de)
AU (1) AU6593896A (de)
CA (1) CA2227364A1 (de)
DE (1) DE69610880T2 (de)
DK (1) DK0757058T3 (de)
ES (1) ES2151638T3 (de)
GR (1) GR3035351T3 (de)
PT (1) PT757058E (de)
SI (1) SI0757058T1 (de)
WO (1) WO1997005163A1 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6743777B1 (en) * 1992-03-19 2004-06-01 Eli Lilly And Company Cyclic peptide antifungal agents and process for preparation thereof
US6384013B1 (en) * 1992-03-19 2002-05-07 Eli Lilly And Company Cyclic peptide antifungal agents and process for preparation thereof
WO1996015142A1 (en) * 1994-11-15 1996-05-23 Eli Lilly And Company Process for performing retro-aldol reaction
US6146872A (en) * 1996-06-13 2000-11-14 Fukisawa Pharmaceutical Co., Ltd. Cyclic lipopeptide acylase
CN1240713C (zh) * 1998-02-09 2006-02-08 藤泽药品工业株式会社 化合物
US6323176B1 (en) * 1998-02-25 2001-11-27 Eli Lilly And Company Cyclic peptide antifungal agents
AU765660B2 (en) 1998-08-20 2003-09-25 Eli Lilly And Company Ring modified cyclic peptide analogs
BR9916101A (pt) 1998-12-09 2002-06-04 Lilly Co Eli Purificação de compostos de ciclopeptìdeos equinocandinos
AU2189500A (en) * 1998-12-16 2000-07-03 Eli Lilly And Company Cyclic peptide antifungal agents having a sugar substituent
KR20010112302A (ko) * 1999-03-03 2001-12-20 피터 지. 스트링거 제약학적 경구용 ｅｃｂ 조제물 및 조성물의 제조 방법
EP1582204B1 (de) * 1999-03-03 2013-09-25 Eli Lilly & Company Echinocandin pharmazeutische Zusammensetzungen enthaltend Mizellen bildende Tenside
DK1155034T3 (da) 1999-03-03 2007-01-08 Lilly Co Eli Dannelse og anionbytning af indre krystallinske echinocandin B-ammoniumsalte
CA2362016A1 (en) 1999-03-03 2000-09-08 Kenneth Philip Moder Echinocandin/carbohydrate complexes
US6991800B2 (en) * 2002-06-13 2006-01-31 Vicuron Pharmaceuticals Inc. Antifungal parenteral products

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5260214A (en) * 1988-07-19 1993-11-09 Takara Shuzo Co. Aureobasidium pullulans which produces antibiotic R106
US5057493A (en) * 1988-07-19 1991-10-15 Takara Shuzo Co., Ltd. Novel antibiotics r106
US5166135A (en) * 1988-09-12 1992-11-24 Merck & Company, Inc. Method for the control of pneumocystis carinii
JPH0826071B2 (ja) * 1989-07-11 1996-03-13 寶酒造株式会社 抗真菌抗生物質ｒ１０６誘導体
JP2639737B2 (ja) * 1990-01-23 1997-08-13 寳酒造株式会社 新規ｒ１０６類化合物
US5059540A (en) * 1990-08-13 1991-10-22 City Of Hope Sequential C-terminal degradation of peptides and proteins using cleaving reagents such as sodium trimethylsilanolate or trimethylamine N-oxide
US5159059A (en) * 1990-05-29 1992-10-27 Merck & Co., Inc. Process for reduction of certain cyclohexapeptide compounds
FI912873A (fi) * 1990-06-18 1991-12-19 Fujisawa Pharmaceutical Co Ny polypeptidfoerening och foerfarande foer dess framstaellning.
CA2091663C (en) * 1992-03-19 2007-10-30 Frederick Joseph Burkhardt Cyclic peptide antifungal agents and process for preparation thereof
JP3480848B2 (ja) * 1992-06-19 2003-12-22 タカラバイオ株式会社 環状ペプチドの合成方法
US6268338B1 (en) * 1993-04-30 2001-07-31 Merck & Co., Inc. Cyclohexapeptidyl amine compounds
US5948753A (en) * 1993-05-04 1999-09-07 Merck & Co., Inc. Cyclohexapeptidyl propanolamine compounds
AU674233B2 (en) * 1993-05-04 1996-12-12 Merck & Co., Inc. Cyclohexapeptidyl aminoalkyl ethers
AU7874494A (en) * 1993-09-22 1995-04-10 Merck & Co., Inc. Antifungal and anti-pneumocystis compounds, compositions containing such compounds, and methods of use
WO1996015142A1 (en) * 1994-11-15 1996-05-23 Eli Lilly And Company Process for performing retro-aldol reaction

Also Published As

Publication number Publication date
DK0757058T3 (da) 2000-12-27
US5629289A (en) 1997-05-13
WO1997005163A1 (en) 1997-02-13
JPH11510165A (ja) 1999-09-07
EP0757058A1 (de) 1997-02-05
ATE197460T1 (de) 2000-11-11
SI0757058T1 (en) 2001-04-30
GR3035351T3 (en) 2001-05-31
EP0757058B1 (de) 2000-11-08
AU6593896A (en) 1997-02-26
DE69610880T2 (de) 2001-05-10
PT757058E (pt) 2001-04-30
ES2151638T3 (es) 2001-01-01
CA2227364A1 (en) 1997-02-13

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee