DE69532811D1 - Heterocyclische verbindungen und arzneimittel - Google Patents
Heterocyclische verbindungen und arzneimittelInfo
- Publication number
- DE69532811D1 DE69532811D1 DE69532811T DE69532811T DE69532811D1 DE 69532811 D1 DE69532811 D1 DE 69532811D1 DE 69532811 T DE69532811 T DE 69532811T DE 69532811 T DE69532811 T DE 69532811T DE 69532811 D1 DE69532811 D1 DE 69532811D1
- Authority
- DE
- Germany
- Prior art keywords
- alkyl
- substituted
- compound
- represent
- heterocyclic compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/64—One oxygen atom attached in position 2 or 6
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/34—One oxygen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/38—One sulfur atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/56—One oxygen atom and one sulfur atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/14—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom
- C07D251/22—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom to two ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP21621494 | 1994-09-09 | ||
JP21621494 | 1994-09-09 | ||
PCT/JP1995/001792 WO1996007641A1 (fr) | 1994-09-09 | 1995-09-08 | Derive heterocyclique et medicament |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69532811D1 true DE69532811D1 (de) | 2004-05-06 |
DE69532811T2 DE69532811T2 (de) | 2005-03-17 |
Family
ID=16685068
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69532811T Expired - Fee Related DE69532811T2 (de) | 1994-09-09 | 1995-09-08 | Heterocyclische Derivative und Arzneimittel |
Country Status (19)
Country | Link |
---|---|
US (2) | US5945426A (de) |
EP (1) | EP0781766B1 (de) |
JP (2) | JP3036079B2 (de) |
KR (1) | KR100358245B1 (de) |
CN (1) | CN1118454C (de) |
AT (1) | ATE263154T1 (de) |
BR (1) | BR9508900A (de) |
CA (1) | CA2199518A1 (de) |
DE (1) | DE69532811T2 (de) |
DK (1) | DK0781766T3 (de) |
ES (1) | ES2218552T3 (de) |
FI (1) | FI970967A0 (de) |
HU (1) | HU221855B1 (de) |
MX (1) | MX9701765A (de) |
NO (1) | NO312995B1 (de) |
NZ (1) | NZ292269A (de) |
PT (1) | PT781766E (de) |
RU (1) | RU2128996C1 (de) |
WO (1) | WO1996007641A1 (de) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1300056B1 (it) | 1998-04-17 | 2000-04-05 | Boehringer Ingelheim Italia | Eterocicli con anello a 6 termini difenil-sostituiti loro procedimento di preparazione e loro impiego come farmaci |
WO2000010571A1 (fr) * | 1998-08-25 | 2000-03-02 | Nippon Shinyaku Co., Ltd. | Antagonistes des canaux calciques |
US20040077709A1 (en) * | 1999-05-31 | 2004-04-22 | Daiichi Pharmaceutical Co., Ltd. | Neuronal death inhibitors |
GB0003224D0 (en) | 2000-02-11 | 2000-04-05 | Glaxo Group Ltd | Chemical compounds |
GB0021494D0 (en) | 2000-09-01 | 2000-10-18 | Glaxo Group Ltd | Chemical comkpounds |
WO2002020494A1 (fr) * | 2000-09-08 | 2002-03-14 | Nippon Shinyaku Co., Ltd. | Procede de production d'un derive de pyrimidine et intermediaire approprie |
DE60107603T2 (de) * | 2000-09-19 | 2005-10-06 | Sumitomo Chemical Co. Ltd. | Pyrimidinverbindungen und deren verwendung als pestizide |
GB0112810D0 (en) | 2001-05-25 | 2001-07-18 | Glaxo Group Ltd | Pyrimidine derivatives |
GB0112802D0 (en) | 2001-05-25 | 2001-07-18 | Glaxo Group Ltd | Pyrimidine derivatives |
GB0119477D0 (en) | 2001-08-09 | 2001-10-03 | Glaxo Group Ltd | Pyrimidine derivatives |
US7235560B2 (en) | 2002-08-19 | 2007-06-26 | Glaxo Group Limited | Pyrimidine derivative as selective COX-2 inhibitors |
GB0221443D0 (en) | 2002-09-16 | 2002-10-23 | Glaxo Group Ltd | Pyridine derivates |
EP1599468B1 (de) | 2003-01-14 | 2007-10-03 | Arena Pharmaceuticals, Inc. | 1,2,3-trisubstituierte aryl- und heteroarylderivate als modulatoren des metabolismus zur vorbeugung und behandlung von metabolismus-bedingten krankheiten wie diabetes oder hyperglykämie |
AU2003222444A1 (en) * | 2003-03-31 | 2004-10-25 | Council Of Scientific And Industrial Research | NEW PYRIMIDINE LINKED PYRROLO(2,1-c)(1,4)BENZODIAZEPINES AS POTENTIAL ANTITUMOUR AGENTS |
AR045047A1 (es) * | 2003-07-11 | 2005-10-12 | Arena Pharm Inc | Derivados arilo y heteroarilo trisustituidos como moduladores del metabolismo y de la profilaxis y tratamiento de desordenes relacionados con los mismos |
EP2287165A3 (de) | 2003-07-14 | 2011-06-22 | Arena Pharmaceuticals, Inc. | Kondensierte Aryl- und Heteroarylderivate als Modulatoren des Metabolismus sowie Vorbeugung und Behandlung von damit zusammenhängenden Störungen |
US6966680B2 (en) * | 2003-11-28 | 2005-11-22 | Edward Kratz | Decorative lighting display with changeable shades and bulbs |
DE602005011279D1 (de) * | 2004-06-04 | 2009-01-08 | Arena Pharm Inc | Substituierte aryl- und heteroarylderivate als modulatoren des stoffwechsels und für die prophylaxe und behandlung von damit in zusammenhang stehenden erkrankungen |
DOP2006000010A (es) | 2005-01-10 | 2006-07-31 | Arena Pharm Inc | Procedimiento para preparar eteres aromáticos |
MY148521A (en) * | 2005-01-10 | 2013-04-30 | Arena Pharm Inc | Substituted pyridinyl and pyrimidinyl derivatives as modulators of metabolism and the treatment of disorders related thereto |
RS20080112A (en) * | 2005-09-16 | 2009-05-06 | Arena Pharmaceuticals Inc., | Modulators of metabolism and the treatment of disorders related thereto |
TW200811140A (en) * | 2006-07-06 | 2008-03-01 | Arena Pharm Inc | Modulators of metabolism and the treatment of disorders related thereto |
TW200811147A (en) * | 2006-07-06 | 2008-03-01 | Arena Pharm Inc | Modulators of metabolism and the treatment of disorders related thereto |
EP1941879A1 (de) * | 2007-01-05 | 2008-07-09 | PAION Deutschland GmbH | Nervenschutzmittel zur Behandlung von neuronalen Schäden. |
EP2008653A1 (de) | 2007-06-28 | 2008-12-31 | Charité-Universitätsmedizin Berlin | Serotonerge Verbindungen zur Behandlung neuronaler Krankheiten |
DE102007051090A1 (de) | 2007-06-28 | 2009-01-08 | Charité - Universitätsmedizin Berlin | SSRI zur Behandlung neuronaler Krankheiten |
SG10201906876PA (en) | 2010-01-27 | 2019-09-27 | Arena Pharm Inc | Processes for the preparation of (r)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid and salts thereof |
AU2011305525B2 (en) | 2010-09-22 | 2016-08-18 | Arena Pharmaceuticals, Inc. | Modulators of the GPR119 receptor and the treatment of disorders related thereto |
CN116850181A (zh) | 2015-01-06 | 2023-10-10 | 艾尼纳制药公司 | 治疗与s1p1受体有关的病症的方法 |
ES2929526T3 (es) | 2015-06-22 | 2022-11-29 | Arena Pharm Inc | Sal cristalina de L-arginina del ácido (R)-2-(7-(4-ciclopentil-3-(trifluorometil)benciloxi)-1,2,3,4-tetrahidrociclo-penta[b]indol-3-il)acético para su uso en trastornos asociados al receptor S1P1 |
MA47504A (fr) | 2017-02-16 | 2019-12-25 | Arena Pharm Inc | Composés et méthodes de traitement de l'angiocholite biliaire primitive |
EP3953762B1 (de) * | 2019-04-09 | 2022-09-14 | Gentex Corporation | Niedrig dimerisierende elektrochrome viologenverbindungen und vorrichtungen |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3167553A (en) * | 1963-05-08 | 1965-01-26 | Searle & Co | 2-amino-4-ethereal-5-methyl-6-phenylpyrimidines |
BE756127A (fr) * | 1969-09-12 | 1971-03-15 | Hoechst Ag | Ethers heterocycliques et leur preparation |
JPS4921148B1 (de) * | 1970-12-28 | 1974-05-30 | ||
US3937712A (en) * | 1971-09-22 | 1976-02-10 | Boehringer Ingelheim Gmbh | (5-nitro-2-furyl)-pyridines |
BE789099A (fr) * | 1971-09-22 | 1973-03-21 | Boehringer Sohn Ingelheim | Nouveaux derives de la pyridine et procede pour les fabriquer |
US4115575A (en) * | 1973-02-20 | 1978-09-19 | Ciba-Geigy Corporation | 2-(3-Amino-2-hydroxy-propoxy)-pyrazines |
US4698340A (en) * | 1984-07-19 | 1987-10-06 | Fujisawa Pharmaceutical Co., Ltd. | Pyrimidine derivatives, processes for preparation thereof and composition containing the same |
US4727073A (en) * | 1984-10-01 | 1988-02-23 | Fujisawa Pharmaceutical Co., Ltd. | Pyrimidine derivatives and composition of the same |
EP0555478A4 (en) * | 1990-08-31 | 1993-11-18 | Nippon Shinyaku Company, Limited | Pyrimidine derivative and medicine |
US5294612A (en) * | 1992-03-30 | 1994-03-15 | Sterling Winthrop Inc. | 6-heterocyclyl pyrazolo [3,4-d]pyrimidin-4-ones and compositions and method of use thereof |
IL117659A (en) * | 1995-04-13 | 2000-12-06 | Dainippon Pharmaceutical Co | Substituted 2-phenyl pyrimidino amino acetamide derivative process for preparing the same and a pharmaceutical composition containing same |
-
1995
- 1995-09-08 AT AT95930725T patent/ATE263154T1/de not_active IP Right Cessation
- 1995-09-08 HU HU9800853A patent/HU221855B1/hu not_active IP Right Cessation
- 1995-09-08 DK DK95930725T patent/DK0781766T3/da active
- 1995-09-08 PT PT95930725T patent/PT781766E/pt unknown
- 1995-09-08 NZ NZ292269A patent/NZ292269A/en unknown
- 1995-09-08 DE DE69532811T patent/DE69532811T2/de not_active Expired - Fee Related
- 1995-09-08 KR KR1019970701494A patent/KR100358245B1/ko not_active IP Right Cessation
- 1995-09-08 MX MX9701765A patent/MX9701765A/es not_active IP Right Cessation
- 1995-09-08 BR BR9508900A patent/BR9508900A/pt not_active IP Right Cessation
- 1995-09-08 CA CA002199518A patent/CA2199518A1/en not_active Abandoned
- 1995-09-08 RU RU97105769A patent/RU2128996C1/ru not_active IP Right Cessation
- 1995-09-08 US US08/809,004 patent/US5945426A/en not_active Expired - Fee Related
- 1995-09-08 EP EP95930725A patent/EP0781766B1/de not_active Expired - Lifetime
- 1995-09-08 ES ES95930725T patent/ES2218552T3/es not_active Expired - Lifetime
- 1995-09-08 JP JP8509379A patent/JP3036079B2/ja not_active Expired - Fee Related
- 1995-09-08 WO PCT/JP1995/001792 patent/WO1996007641A1/ja active IP Right Grant
- 1995-09-08 CN CN95195014A patent/CN1118454C/zh not_active Expired - Fee Related
-
1997
- 1997-03-07 FI FI970967A patent/FI970967A0/fi unknown
- 1997-03-07 NO NO19971050A patent/NO312995B1/no unknown
-
1999
- 1999-06-16 US US09/334,253 patent/US6191149B1/en not_active Expired - Fee Related
- 1999-11-26 JP JP33560399A patent/JP3312616B2/ja not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US5945426A (en) | 1999-08-31 |
US6191149B1 (en) | 2001-02-20 |
KR100358245B1 (ko) | 2003-11-28 |
MX9701765A (es) | 1997-06-28 |
JP2000136184A (ja) | 2000-05-16 |
CN1157609A (zh) | 1997-08-20 |
FI970967A (fi) | 1997-03-07 |
WO1996007641A1 (fr) | 1996-03-14 |
CN1118454C (zh) | 2003-08-20 |
NO971050L (no) | 1997-05-09 |
RU2128996C1 (ru) | 1999-04-20 |
DE69532811T2 (de) | 2005-03-17 |
AU3399695A (en) | 1996-03-27 |
AU701395B2 (en) | 1999-01-28 |
FI970967A0 (fi) | 1997-03-07 |
CA2199518A1 (en) | 1996-03-14 |
BR9508900A (pt) | 1997-12-30 |
JP3036079B2 (ja) | 2000-04-24 |
ATE263154T1 (de) | 2004-04-15 |
PT781766E (pt) | 2004-07-30 |
NO312995B1 (no) | 2002-07-29 |
EP0781766A1 (de) | 1997-07-02 |
DK0781766T3 (da) | 2004-07-26 |
EP0781766A4 (de) | 1998-01-14 |
EP0781766B1 (de) | 2004-03-31 |
ES2218552T3 (es) | 2004-11-16 |
NZ292269A (en) | 1998-09-24 |
HU221855B1 (hu) | 2003-02-28 |
HUT77779A (hu) | 1998-08-28 |
NO971050D0 (no) | 1997-03-07 |
KR970705545A (ko) | 1997-10-09 |
JP3312616B2 (ja) | 2002-08-12 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE69532811D1 (de) | Heterocyclische verbindungen und arzneimittel | |
DE69321823D1 (de) | 2-amino-1, 3- propandiolverbindung und immunosuppressium | |
ATE286026T1 (de) | Amid-derivate und deren medizinische verwendung | |
DE69406900D1 (de) | Benzolsulfonamid-Derivate und Verfahren zur Herstellung | |
NO882036L (no) | Fremgangsmaate for fremstilling av terapeutisk aktive heterocykliske ketoner. | |
ATE218573T1 (de) | Substituierte 4-arylmethylene-2-imino-2,3- dihydrothiazolen, ihre derivaten, und ihre pharmazeutische verwendung | |
HUP0102793A2 (hu) | Agydaganat kezelésére szolgáló kinazolinok és ezeket tartalmazó gyógyszerkészítmények | |
DK0976748T3 (da) | Pyrrolidinderivater med phospholispase A2-hæmmende aktivitet | |
NO324219B1 (no) | Fenylpyridazin-forbindelser, medisiner og farmasoytiske preparater inneholdende disse samt anvendelse av disse for fremstilling av medikamenter for behandling av sykdom | |
DE69506197D1 (de) | Verwendung eines Ascorbyl-tocopherylphosphats zur Herstellung eines Arzneimittels zur Behandlung der Pankreatitis | |
HUP0004546A2 (hu) | N-fenilamid- és N-piridilamid-származékok, eljárás előállításukra és ezeket tartalmazó gyógyszerkészítmények | |
ATE133942T1 (de) | Cyclische amine und pharmakologische verbindungen | |
DE69117879T2 (de) | Arzneimittel für die Verhütung und Behandlung von Krankheiten der Kreislauforgane enthaltend Spiro-3-heteroazolidin-Verbindungen | |
ATE215075T1 (de) | Hydroxylamin-derivate mit anti-ischämischer wirkung und pharmazeutische zusammensetzungen diese enthaltend | |
DE69722630D1 (de) | Therapeutisches mittel zur behandlung von nierenerkrankungen | |
TH65145A (th) | อนุพันธ์ของซับสทิทิวเทด 2-พิริมิดินิล-6, 7, 8, 9-เททระไฮโดรพิริมิโด[1, 2-a]พิริมิดิน-4-โอน และ 7-พิริมิดินิล-2, 3-ไดไฮโดรอิมิดาโซ[1, 2-a]พิริมิดิน-5(1H)-โอน | |
TH3367A (th) | สารผสมกำจัดศัตรูที่มีสารประเภทฟอสฟอรัสเฮทเทอโรไซคลิคผสมอยู่ด้วย | |
IT1261958B (it) | 2-(sostituite immino)-tiazolidine e procedimento per la loro preparazione e loro impiego quali antianginose e/o analgesiche |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |