DE69526738T2 - Endothelin-rezeptor-antagonisten - Google Patents
Endothelin-rezeptor-antagonistenInfo
- Publication number
- DE69526738T2 DE69526738T2 DE69526738T DE69526738T DE69526738T2 DE 69526738 T2 DE69526738 T2 DE 69526738T2 DE 69526738 T DE69526738 T DE 69526738T DE 69526738 T DE69526738 T DE 69526738T DE 69526738 T2 DE69526738 T2 DE 69526738T2
- Authority
- DE
- Germany
- Prior art keywords
- endothelin receptor
- receptor antagonist
- novel
- compounds
- pharmaceutical compositions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pulmonology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US30082994A | 1994-09-02 | 1994-09-02 | |
US37531895A | 1995-01-18 | 1995-01-18 | |
US47699295A | 1995-06-07 | 1995-06-07 | |
PCT/US1995/010885 WO1996007653A1 (en) | 1994-09-02 | 1995-08-28 | Endothelin receptor antagonists |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69526738D1 DE69526738D1 (de) | 2002-06-20 |
DE69526738T2 true DE69526738T2 (de) | 2003-02-06 |
Family
ID=27404770
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69526738T Expired - Lifetime DE69526738T2 (de) | 1994-09-02 | 1995-08-28 | Endothelin-rezeptor-antagonisten |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP0778833B1 (de) |
JP (1) | JPH10505085A (de) |
AT (1) | ATE217619T1 (de) |
AU (1) | AU3416995A (de) |
DE (1) | DE69526738T2 (de) |
WO (1) | WO1996007653A1 (de) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RO115802B1 (ro) * | 1995-08-02 | 2000-06-30 | Smithkline Beecham Corporation | Derivaţi ai acidului pirazol dihidrobenzofuranil propenoic, intermediar pentru prepararea acestora, compoziţii farmaceutice ale acestora şi metodă de tratament |
US6030970A (en) * | 1995-08-02 | 2000-02-29 | Smithkline Beecham Corporation | Endothelin receptor antagonists |
EP0841926B1 (de) * | 1995-08-02 | 2003-03-26 | Smithkline Beecham Corporation | Endothelinrezeptorantagonist |
JP2000502104A (ja) * | 1995-12-21 | 2000-02-22 | スミスクライン・ビーチャム・コーポレイション | エンドセリン受容体アンタゴニスト |
JP2000504012A (ja) * | 1996-02-01 | 2000-04-04 | スミスクライン・ビーチャム・コーポレイション | エンドセリンレセプターアンタゴニスト |
EP0885217A4 (de) * | 1996-02-01 | 1999-04-21 | Smithkline Beecham Corp | Endothelinrezeptor-antagonisten |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4006137A (en) * | 1975-08-21 | 1977-02-01 | E. R. Squibb & Sons, Inc. | 2-Ethenyl imidazolium derivatives |
JPH0680057B2 (ja) * | 1986-04-28 | 1994-10-12 | 保土谷化学工業株式会社 | トリフエニルイミダゾ−ル及びその二量体 |
DE69034103T2 (de) * | 1989-06-14 | 2004-07-15 | Smithkline Beecham Corp. | Imidazoalkensäure |
CA2018443A1 (en) * | 1989-06-14 | 1990-12-14 | Joseph A. Finkelstein | Imidazolyl-alkenoic acids |
JP3214856B2 (ja) * | 1990-12-14 | 2001-10-02 | スミスクライン・ビーチャム・コーポレイション | イミダゾリル−アルケン酸 |
EP0650484B1 (de) * | 1992-07-17 | 2000-01-26 | Smithkline Beecham Corporation | Endothelin rezeptor antagonisten |
-
1995
- 1995-08-28 JP JP8509542A patent/JPH10505085A/ja not_active Ceased
- 1995-08-28 DE DE69526738T patent/DE69526738T2/de not_active Expired - Lifetime
- 1995-08-28 AU AU34169/95A patent/AU3416995A/en not_active Abandoned
- 1995-08-28 AT AT95930974T patent/ATE217619T1/de not_active IP Right Cessation
- 1995-08-28 EP EP95930974A patent/EP0778833B1/de not_active Expired - Lifetime
- 1995-08-28 WO PCT/US1995/010885 patent/WO1996007653A1/en active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
ATE217619T1 (de) | 2002-06-15 |
EP0778833B1 (de) | 2002-05-15 |
JPH10505085A (ja) | 1998-05-19 |
AU3416995A (en) | 1996-03-27 |
EP0778833A1 (de) | 1997-06-18 |
WO1996007653A1 (en) | 1996-03-14 |
DE69526738D1 (de) | 2002-06-20 |
EP0778833A4 (de) | 1998-12-16 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
TR200101398T2 (tr) | Pirolidin türevleri-CCR-3 reseptörü antagonistleri. | |
BR0010215A (pt) | Derivados de indolina como antagonistas de progesterona | |
PT935465E (pt) | Compostos novos de imidazole substituido | |
BR9706973A (pt) | Novos compostos de imidazol substituídos | |
TR199801255T2 (xx) | Vitronektin resept�r antagonistleri. | |
BR0016396A (pt) | Novos antagonistas do receptor p2x7 para uso no tratamento de doenças inflamatórias, imunes ou cardiovasculares | |
DK0747050T4 (da) | Farmaceutiske sammensætninger, der indeholder irbesartan | |
ES2175066T3 (es) | Antagonistas triciclicos de la vasopresina. | |
TR200101155T2 (tr) | 4-Aroil Piperidin CCR-3 Reseptör Antagonistleri III | |
AR010062A1 (es) | Nuevos benzamidaldehidos y su utilizacion | |
TR200002896T2 (tr) | Kalsilitik Bileşimler | |
YU80902A (sh) | Novi indolin-2-on derivati, njihovo dobijanje i farmaceuski oblici koji ih sadrže | |
TR200200795T2 (tr) | 5-HT1B antagonistleri olarak piperazin türevleri | |
SE9702773D0 (sv) | Novel compounds | |
MX9801890A (es) | Nuevos compuestos antagonistas selectivos del receptor nk3 humano, procedimiento para su obtencion y composiciones farmaceuticas que los contienen. | |
EP1244452A4 (de) | Urotensin-ii rezeptorantagonisten | |
BG106930A (en) | Substituted phenyl-piperazine derivatives, their preparation and use | |
SE9802937D0 (sv) | Novel compounds | |
TR199800152T1 (xx) | Endotelin Resept�r Antagonistleri | |
DE50008020D1 (de) | Substituierte pyrrolidin-2,3,4-trion-derivate wirksam als nmda-rezeptor-antagonisten | |
DE69703242T2 (de) | Indolin-derivate verwendbar als 5-ht-2c rezeptor-antagonisten | |
DE69526738T2 (de) | Endothelin-rezeptor-antagonisten | |
DE60015187D1 (de) | Urotensin-ii rezeptorantagonisten | |
ES2166462T3 (es) | Antagonistas del receptor de la endotelina. | |
DE69717449D1 (de) | Indolin-derivate verwendbar als 5-ht-2c rezeptor-antagonisten |