ES2175066T3 - Antagonistas triciclicos de la vasopresina. - Google Patents
Antagonistas triciclicos de la vasopresina.Info
- Publication number
- ES2175066T3 ES2175066T3 ES96902143T ES96902143T ES2175066T3 ES 2175066 T3 ES2175066 T3 ES 2175066T3 ES 96902143 T ES96902143 T ES 96902143T ES 96902143 T ES96902143 T ES 96902143T ES 2175066 T3 ES2175066 T3 ES 2175066T3
- Authority
- ES
- Spain
- Prior art keywords
- vasopresine
- tricycle
- antagonists
- oxitocine
- anastervastic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/06—Antiabortive agents; Labour repressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Cardiology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Hospice & Palliative Care (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Reproductive Health (AREA)
- Emergency Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Pulmonology (AREA)
- Psychiatry (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Obesity (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
DIAZEPINAS TRICICLICAS DE FORMULA (I), DONDE A, B, D, E, F, Y Y Z SE DEFINEN EN LA ESPECIFICACION Y CUYOS COMPUESTOS TIENEN ACTIVIDAD ANTAGONISTA DE VASOPRESINA Y OXITOCINA.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/373,125 US5521173A (en) | 1995-01-17 | 1995-01-17 | Tricyclic benzazepine vasopressin antagonists |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2175066T3 true ES2175066T3 (es) | 2002-11-16 |
Family
ID=23471074
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES96902143T Expired - Lifetime ES2175066T3 (es) | 1995-01-17 | 1996-01-16 | Antagonistas triciclicos de la vasopresina. |
Country Status (24)
Country | Link |
---|---|
US (2) | US5521173A (es) |
EP (1) | EP0805813B1 (es) |
JP (2) | JP4156664B2 (es) |
CN (1) | CN1052725C (es) |
AR (1) | AR002021A1 (es) |
AT (1) | ATE217625T1 (es) |
AU (1) | AU707881B2 (es) |
BR (1) | BR9607177A (es) |
CA (1) | CA2210708C (es) |
CZ (1) | CZ224797A3 (es) |
DE (1) | DE69621225T2 (es) |
DK (1) | DK0805813T3 (es) |
EA (1) | EA000056B1 (es) |
ES (1) | ES2175066T3 (es) |
HK (1) | HK1003891A1 (es) |
HU (1) | HUP9702459A3 (es) |
IL (1) | IL116774A (es) |
MX (1) | MX9705414A (es) |
NZ (1) | NZ301198A (es) |
PT (1) | PT805813E (es) |
TW (1) | TW472056B (es) |
UA (1) | UA48960C2 (es) |
WO (1) | WO1996022292A1 (es) |
ZA (1) | ZA96303B (es) |
Families Citing this family (53)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5736540A (en) * | 1993-07-29 | 1998-04-07 | American Cyanamid Company | Tricyclic diazepine vasopressin antagonists and oxytocin antagonists |
US5753648A (en) * | 1995-01-17 | 1998-05-19 | American Cyanamid Company | Tricyclic benzazepine vasopressin antagonists |
US5700796A (en) * | 1995-01-17 | 1997-12-23 | American Cyanamid Company | Tricyclic benzazepine vasopressin antagonists |
US5880122A (en) * | 1996-11-01 | 1999-03-09 | American Home Products Corporation | 3-Carboxamide derivatives of 5H-pyrrolo 2,1-c! 1,4!-benzodiazepines |
CA2285343A1 (en) | 1997-03-31 | 1998-10-08 | Wakamoto Pharmaceutical Co., Ltd. | Biphenyl derivatives and medicinal compositions |
US6511974B1 (en) | 1997-07-30 | 2003-01-28 | Wyeth | Tricyclic vasopressin agonists |
US6194407B1 (en) | 1997-07-30 | 2001-02-27 | American Home Products Corporation | Tricyclic pyrido vasopressin agonists |
PT1000062E (pt) * | 1997-07-30 | 2004-12-31 | Wyeth Corp | Agonistas triciclicos de vasopressina |
US6090803A (en) * | 1998-07-24 | 2000-07-18 | American Home Products Corporation | Tricyclic vasopressin agonists |
US7138393B2 (en) * | 1998-07-24 | 2006-11-21 | Wyeth | Biologically active vasopressin agonist metabolites |
BRPI9917086B8 (pt) * | 1999-01-19 | 2016-05-24 | Ortho Mcneil Pharm Inc | benzodiazepina tricíclica, suas composições farmacêuticas bem como compostos intermediários |
US6235900B1 (en) | 1999-02-04 | 2001-05-22 | American Home Products Corporation | Tricyclic pyridine N-oxides vasopressin agonists |
US6297234B1 (en) * | 1999-02-04 | 2001-10-02 | American Home Products Corporation | Arylthiophene vasopressin agonists |
WO2000046227A1 (en) * | 1999-02-04 | 2000-08-10 | American Home Products Corporation | Thienylbenzoylbenzazepines as vasopressin agonists |
US6620807B1 (en) | 1999-02-04 | 2003-09-16 | Wyeth | Pyridobenzodiazepine and pyridobenzoxazepine carboxyamide vasopressin agonists |
US6344451B1 (en) | 1999-02-04 | 2002-02-05 | American Home Products | Pyrrolobenzodiazepine carboxyamide vasopressin agonists |
AU7615200A (en) * | 1999-09-27 | 2001-04-30 | American Cyanamid Company | Vasopressin agonist formulation and process |
CA2440002A1 (en) * | 2001-03-20 | 2002-09-26 | Applied Research Systems Ars Holding N.V. | Pyrrolidine ester derivatives with oxytocin modulating activity |
US7202239B2 (en) * | 2001-04-12 | 2007-04-10 | Wyeth | Cyclohexylphenyl carboxamides tocolytic oxytocin receptor antagonists |
US7109193B2 (en) | 2001-04-12 | 2006-09-19 | Wyeth | Tricyclic diazepines tocolytic oxytocin receptor antagonists |
US6903087B2 (en) * | 2001-04-12 | 2005-06-07 | Wyeth | Pyrido cyclohexenyl phenyl carboxamides tocolytic oxytocin receptor antagonists |
US7326700B2 (en) * | 2001-04-12 | 2008-02-05 | Wyeth | Cyclohexenyl phenyl carboxamides tocolytic oxytocin receptor antagonists |
US7064120B2 (en) * | 2001-04-12 | 2006-06-20 | Wyeth | Tricyclic pyridyl carboxamides and derivatives thereof tocolytic oxytocin receptor antagonists |
US7022699B2 (en) | 2001-04-12 | 2006-04-04 | Wyeth | Cyclohexenyl phenyl diazepines vasopressin and oxytocin receptor modulators |
EP1381370B1 (en) * | 2001-04-12 | 2007-03-07 | Wyeth | N-biphenylcarbonyl- and n-phenylpyridylcarbonyl substituted bi- and tricyclic azepines and diazepines as vasopressing agonists |
US6977254B2 (en) * | 2001-04-12 | 2005-12-20 | Wyeth | Hydroxy cyclohexenyl phenyl carboxamides tocolytic oxytocin receptor antagonists |
BR0208824A (pt) * | 2001-04-12 | 2004-03-09 | Wyeth Corp | Composto, métodos de tratamento de distúrbios que são remediados ou aliviados por atividade de agonista de vasopressina em um mamìfero, e de indução de retardamento temporário de urinação em um mamìfero, e, composição farmacêutica |
US6900200B2 (en) | 2001-04-12 | 2005-05-31 | Wyeth | Tricyclic hydroxy carboxamides and derivatives thereof tocolytic oxytocin receptor antagonists |
ES2287326T3 (es) * | 2001-10-29 | 2007-12-16 | Ortho-Mcneil Pharmaceutical, Inc. | Antagonistas del receptor de vasopresina de (,4) benzodiazepina biciclica enlazada. |
US7119088B2 (en) * | 2003-02-19 | 2006-10-10 | Pfizer Inc. | Triazole compounds useful in therapy |
EP2061795B1 (en) * | 2006-08-14 | 2014-01-15 | Council of Scientific & Industrial Research | Pyrrolo[2,1-c][1,4]benzodiazepine hybrids and a process for the preparation thereof |
KR20110017431A (ko) | 2008-06-10 | 2011-02-21 | 아보트 러보러터리즈 | 신규한 트리사이클릭 화합물 |
CN102216305B (zh) | 2008-11-13 | 2013-12-18 | 弗·哈夫曼-拉罗切有限公司 | 螺-5,6-二氢-4H-2,3,5,10b-四氮杂-苯并[e]薁类 |
AU2009317386B2 (en) | 2008-11-18 | 2013-07-25 | F. Hoffmann-La Roche Ag | Alkylcyclohexylethers of dihydrotetraazabenzoazulenes |
ES2431279T3 (es) | 2008-11-28 | 2013-11-25 | F. Hoffmann-La Roche Ag | Arilciclohexiléteres de dihidro-tetraazabenzoazulenos para uso como antagonistas del receptor V1A de la vasopresina |
CR20170159A (es) | 2009-12-01 | 2017-06-26 | Abbvie Inc | Nuevos compuestos tricíclicos |
SG181147A1 (en) | 2009-12-01 | 2012-07-30 | Abbott Lab | Novel tricyclic compounds |
US8420633B2 (en) | 2010-03-31 | 2013-04-16 | Hoffmann-La Roche Inc. | Aryl-cyclohexyl-tetraazabenzo[e]azulenes |
US8461151B2 (en) | 2010-04-13 | 2013-06-11 | Hoffmann-La Roche Inc. | Aryl-/heteroaryl-cyclohexenyl-tetraazabenzo[e]azulenes |
US8492376B2 (en) | 2010-04-21 | 2013-07-23 | Hoffmann-La Roche Inc. | Heteroaryl-cyclohexyl-tetraazabenzo[e]azulenes |
US8481528B2 (en) | 2010-04-26 | 2013-07-09 | Hoffmann-La Roche Inc. | Heterobiaryl-cyclohexyl-tetraazabenzo[e]azulenes |
AU2011261164A1 (en) | 2010-06-01 | 2012-12-13 | The University Of Queensland | Haematopoietic-prostaglandin D2 synthase inhibitors |
CN103288829A (zh) * | 2012-02-24 | 2013-09-11 | 中国科学院大连化学物理研究所 | 一种合成手性二氢-5H-吡咯并[2,1-c][1,4]-苯并二氮杂卓-5-酮的方法 |
WO2014060381A1 (de) | 2012-10-18 | 2014-04-24 | Bayer Cropscience Ag | Heterocyclische verbindungen als schädlingsbekämpfungsmittel |
BR112015009751A2 (pt) | 2012-10-31 | 2017-07-11 | Bayer Cropscience Ag | novos compostos heterocíclicos como pesticidas |
KR102334260B1 (ko) | 2013-03-14 | 2021-12-02 | 스미토모 다이니폰 파마 온콜로지, 인크. | Jak2 및 alk2 억제제 및 이들의 사용 방법 |
US11365198B2 (en) | 2015-10-16 | 2022-06-21 | Abbvie Inc. | Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof |
US11524964B2 (en) | 2015-10-16 | 2022-12-13 | Abbvie Inc. | Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-n-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof |
EP3362455A1 (en) | 2015-10-16 | 2018-08-22 | AbbVie Inc. | PROCESSES FOR THE PREPARATION OF (3S,4R)-3-ETHYL-4-(3H-IMIDAZO[1,2-a]PYRROLO[2,3-e]-PYRAZIN-8-YL)-N-(2,2,2-TRIFLUOROETHYL)PYRROLIDINE-1-CARBOXAMIDE AND SOLID STATE FORMS THEREOF |
US11780848B2 (en) | 2015-10-16 | 2023-10-10 | Abbvie Inc. | Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-n-(2,2,2-trifluoroethyl)pyrrolidine-1- carboxamide and solid state forms thereof |
US11512092B2 (en) | 2015-10-16 | 2022-11-29 | Abbvie Inc. | Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-n-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof |
US10550126B2 (en) | 2015-10-16 | 2020-02-04 | Abbvie Inc. | Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-A]pyrrolo[2,3-e]-pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof |
EP3826684A4 (en) | 2018-07-26 | 2022-04-06 | Sumitomo Dainippon Pharma Oncology, Inc. | METHODS FOR TREATING DISEASES ASSOCIATED WITH ABNORMAL ACVR1 EXPRESSION AND ACVR1 INHIBITORS FOR USE THEREOF |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3763183A (en) * | 1972-07-10 | 1973-10-02 | Sterling Drug Inc | 1,2,3,10,11,11a-hexahydro-5h-pyrrolo (2,1-c)(1,4)benzodiazepines |
US4766108A (en) * | 1986-12-04 | 1988-08-23 | Smith Kline Beckman Corporation | Tyr-Arg-vasopressin antagonists |
US5055448A (en) * | 1987-06-25 | 1991-10-08 | Medical College Of Ohio | Linear derivatives of arginine vasopressin antagonists |
DE69009785T2 (de) * | 1989-02-10 | 1994-11-03 | Otsuka Pharma Co Ltd | Carbostyrilderivate. |
DK0450097T3 (da) * | 1989-10-20 | 1996-05-20 | Otsuka Pharma Co Ltd | Benzoheterocykliske forbindelser |
US5258510A (en) * | 1989-10-20 | 1993-11-02 | Otsuka Pharma Co Ltd | Benzoheterocyclic compounds |
US5070187A (en) * | 1989-11-03 | 1991-12-03 | Trustees Of Boston University | Pharmacologically effective antagonists of arginine-vasopressin |
TW199153B (es) * | 1990-08-07 | 1993-02-01 | Dtsuka Seiyaku Kk | |
CA2066104C (en) * | 1991-04-19 | 2003-05-27 | Hidenori Ogawa | Benzazepine derivatives as vasopressin antagonists |
EP0533240A3 (en) * | 1991-09-16 | 1993-09-29 | Merck & Co. Inc. | Substituted amine derivatives of piperazinylcamphorsulfonyl oxytocin antagonists |
EP0533242A3 (en) * | 1991-09-16 | 1993-09-15 | Merck & Co. Inc. | Substituted derivatives of piperazinylcamphorsulfonyl oxytocin antagonists |
US5204349A (en) * | 1991-09-16 | 1993-04-20 | Merck & Co., Inc. | Amide-substituted derivatives of spiroindanylcamphorsulfonyl oxytocin antagonists |
DE69223573D1 (de) * | 1991-09-16 | 1998-01-29 | Merck & Co Inc | Hydantoin und Succinimid-substituierte Spiroindanylcamphorsulfonyl als Oxytocin-Antagonisten |
AU657431B2 (en) * | 1992-08-20 | 1995-03-09 | Otsuka Pharmaceutical Co., Ltd. | Benzoheterocyclic compounds as oxytocin and vasopressin antagonists |
WO1994012476A1 (en) * | 1992-11-25 | 1994-06-09 | Yamanouchi Pharmaceutical Co., Ltd. | Benzanilide derivative |
AU5692094A (en) * | 1992-12-21 | 1994-07-19 | Yamanouchi Pharmaceutical Co., Ltd. | Novel n-(pyridylcarbonyl)benzazepine derivative and intermediate therefor |
WO1994020473A1 (en) * | 1993-03-11 | 1994-09-15 | Yamanouchi Pharmaceutical Co., Ltd. | Compound with vasopressin antagonism |
GB9307527D0 (en) * | 1993-04-13 | 1993-06-02 | Fujisawa Pharmaceutical Co | New venzamide derivatives,processes for the preparation thereof and pharmaceutical composition comprising the same |
US5516774A (en) * | 1993-07-29 | 1996-05-14 | American Cyanamid Company | Tricyclic diazepine vasopressin antagonists and oxytocin antagonists |
-
1995
- 1995-01-17 US US08/373,125 patent/US5521173A/en not_active Expired - Lifetime
-
1996
- 1996-01-15 AR ARP960101024A patent/AR002021A1/es unknown
- 1996-01-15 ZA ZA96303A patent/ZA96303B/xx unknown
- 1996-01-16 AT AT96902143T patent/ATE217625T1/de not_active IP Right Cessation
- 1996-01-16 JP JP52234496A patent/JP4156664B2/ja not_active Expired - Fee Related
- 1996-01-16 BR BR9607177A patent/BR9607177A/pt not_active IP Right Cessation
- 1996-01-16 CN CN96192570A patent/CN1052725C/zh not_active Expired - Fee Related
- 1996-01-16 MX MX9705414A patent/MX9705414A/es not_active IP Right Cessation
- 1996-01-16 EP EP96902143A patent/EP0805813B1/en not_active Expired - Lifetime
- 1996-01-16 NZ NZ301198A patent/NZ301198A/xx unknown
- 1996-01-16 DE DE69621225T patent/DE69621225T2/de not_active Expired - Fee Related
- 1996-01-16 HU HU9702459A patent/HUP9702459A3/hu unknown
- 1996-01-16 PT PT96902143T patent/PT805813E/pt unknown
- 1996-01-16 CZ CZ972247A patent/CZ224797A3/cs unknown
- 1996-01-16 IL IL11677496A patent/IL116774A/xx not_active IP Right Cessation
- 1996-01-16 UA UA97084248A patent/UA48960C2/uk unknown
- 1996-01-16 ES ES96902143T patent/ES2175066T3/es not_active Expired - Lifetime
- 1996-01-16 CA CA002210708A patent/CA2210708C/en not_active Expired - Fee Related
- 1996-01-16 TW TW085100471A patent/TW472056B/zh not_active IP Right Cessation
- 1996-01-16 WO PCT/US1996/000515 patent/WO1996022292A1/en not_active Application Discontinuation
- 1996-01-16 EA EA199700118A patent/EA000056B1/ru not_active IP Right Cessation
- 1996-01-16 DK DK96902143T patent/DK0805813T3/da active
- 1996-01-16 AU AU46566/96A patent/AU707881B2/en not_active Ceased
- 1996-05-23 US US08/652,198 patent/US5780471A/en not_active Expired - Lifetime
-
1998
- 1998-04-16 HK HK98103196A patent/HK1003891A1/xx not_active IP Right Cessation
-
2007
- 2007-11-21 JP JP2007301897A patent/JP2008069176A/ja not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
EA000056B1 (ru) | 1998-04-30 |
US5780471A (en) | 1998-07-14 |
WO1996022292A1 (en) | 1996-07-25 |
EP0805813A1 (en) | 1997-11-12 |
JPH11500424A (ja) | 1999-01-12 |
CZ224797A3 (cs) | 1998-03-18 |
US5521173A (en) | 1996-05-28 |
AU707881B2 (en) | 1999-07-22 |
ATE217625T1 (de) | 2002-06-15 |
AR002021A1 (es) | 1998-01-07 |
UA48960C2 (uk) | 2002-09-16 |
IL116774A (en) | 2000-12-06 |
BR9607177A (pt) | 1997-11-11 |
DK0805813T3 (da) | 2002-08-05 |
TW472056B (en) | 2002-01-11 |
CN1178532A (zh) | 1998-04-08 |
CA2210708A1 (en) | 1996-07-25 |
MX9705414A (es) | 1997-11-29 |
CN1052725C (zh) | 2000-05-24 |
CA2210708C (en) | 2005-05-24 |
ZA96303B (en) | 1997-07-15 |
JP2008069176A (ja) | 2008-03-27 |
JP4156664B2 (ja) | 2008-09-24 |
HK1003891A1 (en) | 1998-11-13 |
HUP9702459A3 (en) | 2000-08-28 |
AU4656696A (en) | 1996-08-07 |
PT805813E (pt) | 2002-10-31 |
HUP9702459A2 (hu) | 1998-05-28 |
EA199700118A1 (ru) | 1997-12-30 |
EP0805813B1 (en) | 2002-05-15 |
DE69621225T2 (de) | 2002-11-14 |
IL116774A0 (en) | 1996-05-14 |
DE69621225D1 (de) | 2002-06-20 |
NZ301198A (en) | 1999-08-30 |
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