DE69415690D1 - (e)-20(22)-dehydrovitamin-d-verbindungen - Google Patents

(e)-20(22)-dehydrovitamin-d-verbindungen

Info

Publication number
DE69415690D1
DE69415690D1 DE69415690T DE69415690T DE69415690D1 DE 69415690 D1 DE69415690 D1 DE 69415690D1 DE 69415690 T DE69415690 T DE 69415690T DE 69415690 T DE69415690 T DE 69415690T DE 69415690 D1 DE69415690 D1 DE 69415690D1
Authority
DE
Germany
Prior art keywords
compounds
dehydrovitamin
treatment
diseases
osteoporosis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69415690T
Other languages
English (en)
Other versions
DE69415690T2 (de
Inventor
Hector Deluca
Rafal Sicinski
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wisconsin Alumni Research Foundation
Original Assignee
Wisconsin Alumni Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wisconsin Alumni Research Foundation filed Critical Wisconsin Alumni Research Foundation
Application granted granted Critical
Publication of DE69415690D1 publication Critical patent/DE69415690D1/de
Publication of DE69415690T2 publication Critical patent/DE69415690T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0036—Nitrogen-containing hetero ring
    • C07J71/0042—Nitrogen only
DE69415690T 1993-11-03 1994-10-19 (e)-20(22)-dehydrovitamin-d-verbindungen Expired - Fee Related DE69415690T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/147,663 US5565589A (en) 1993-11-03 1993-11-03 17-formyl-5,6-trans-vitamin D compounds
PCT/US1994/012084 WO1995012575A1 (en) 1993-11-03 1994-10-19 (e)-20(22)-dehydrovitamin d compounds

Publications (2)

Publication Number Publication Date
DE69415690D1 true DE69415690D1 (de) 1999-02-11
DE69415690T2 DE69415690T2 (de) 1999-05-20

Family

ID=22522410

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69415690T Expired - Fee Related DE69415690T2 (de) 1993-11-03 1994-10-19 (e)-20(22)-dehydrovitamin-d-verbindungen

Country Status (10)

Country Link
US (5) US5565589A (de)
EP (1) EP0726892B1 (de)
JP (1) JPH09504549A (de)
AT (1) ATE175194T1 (de)
AU (1) AU8051594A (de)
DE (1) DE69415690T2 (de)
DK (1) DK0726892T3 (de)
ES (1) ES2126157T3 (de)
GR (1) GR3029449T3 (de)
WO (1) WO1995012575A1 (de)

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US20040167106A1 (en) * 1993-06-04 2004-08-26 Rodriguez Gustavo C. Prevention of ovarian cancer by administration of a Vitamin D compound
US6407082B1 (en) * 1996-09-13 2002-06-18 New Life Pharmaceuticals Inc. Prevention of ovarian cancer by administration of a vitamin D compound
US5869472A (en) * 1994-07-18 1999-02-09 Bone Care International, Inc. Synthesis of 1α-hydroxy vitamin D
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US5805261A (en) * 1995-04-04 1998-09-08 Oakley, Inc. Biased eyeglass frames
US5939408A (en) 1996-05-23 1999-08-17 Hoffman-La Roche Inc. Vitamin D3 analogs
US6765002B2 (en) 2000-03-21 2004-07-20 Gustavo Rodriguez Prevention of ovarian cancer by administration of products that induce transforming growth factor-β and/or apoptosis in the ovarian epithelium
US6511970B1 (en) 1996-09-13 2003-01-28 New Life Pharmaceuticals Inc. Prevention of ovarian cancer by administration of products that induce transforming growth factor-beta and/or apoptosis in the ovarian epithelium
US6034074A (en) 1996-09-13 2000-03-07 New Life Pharmaceuticals Inc. Prevention of ovarian cancer by administration of a Vitamin D compound
US6028064A (en) 1996-09-13 2000-02-22 New Life Pharmaceuticals Inc. Prevention of ovarian cancer by administration of progestin products
US5843928A (en) * 1997-03-17 1998-12-01 Wisconsin Alumni Research Foundation 2-alkylidene-19-nor-vitamin D compounds
GB9721156D0 (en) 1997-10-06 1997-12-03 Leo Pharm Prod Ltd Novel vitamin d analogues
WO2001030751A2 (en) * 1999-10-25 2001-05-03 Strakan Limited USES OF 1,25-DIHYDROXY-5,6-trans VITAMIN D COMPOUNDS AND DERIVATIVES THEREOF
US7122533B2 (en) * 1999-11-29 2006-10-17 The United States Of America As Represented By The Department Of Health And Human Services Cosalane compounds and methods for their use
US20010044431A1 (en) * 2000-03-21 2001-11-22 Rodriguez Gustavo C. Prevention of ovarian cancer by administration of products that induce biologic effects in the ovarian epithelium
PT1286962E (pt) * 2000-05-31 2008-07-30 Wisconsin Alumni Res Found Compostos de 2-etil- e 2-etilideno-19-nor-vitamina d
US7491711B2 (en) * 2001-09-21 2009-02-17 Roche Palo Alto Llc Methods of treatment using 3-desoxy vitamin D3 analogs
US20030195175A1 (en) * 2002-03-25 2003-10-16 Deluca Hector F. Use of carbon-2-modified-vitamin D analogs to induce the formation of new bone
US7241747B2 (en) * 2003-04-10 2007-07-10 Wisconsin Alumni Research Foundation 2-propylidene-19-nor-vitamin D compounds
US20080293647A1 (en) 2004-11-12 2008-11-27 Luciano Adorini Combined Use Of Vitamin D Derivatives And Anti-Proliferative Agents For Treating Bladder Cancer
US7448750B2 (en) * 2006-09-22 2008-11-11 Oakley, Inc. Quadrilateral lens
JP5676439B2 (ja) * 2008-07-03 2015-02-25 オークリー インコーポレイテッド 浮遊レンズ取り付けシステム
EP2376508A4 (de) * 2008-11-26 2012-06-13 Cytochroma Inc Verfahren zur synthese von vitamin-d-analoga
US8192015B2 (en) 2009-01-09 2012-06-05 Oakley, Inc. Eyeglass with enhanced ballistic resistance
US8469510B2 (en) 2009-01-09 2013-06-25 Oakley, Inc. Eyewear with enhanced ballistic resistance
EA026334B1 (ru) 2009-01-27 2017-03-31 БЕРГ ЭлЭлСи Применение соединения витамина d для предотвращения или снижения развития химиотерапевтически индуцированной нейтропении
CA2770683C (en) 2009-08-14 2018-09-04 Berg Biosystems, Llc Vitamin d3 and analogs thereof for treating alopecia
US8850626B2 (en) 2010-03-19 2014-10-07 Oakley, Inc. Eyewear with enhanced pressure distribution
EP2603830A1 (de) 2010-08-13 2013-06-19 Oakley, Inc. Brille mit linsenfixiermechanismus
AU2012312125B2 (en) 2011-09-22 2015-07-09 Oakley, Inc. Mounting mechanism for eyewear
US9122078B2 (en) 2011-12-01 2015-09-01 Oakley, Inc. Releasable earstem mounting mechanism for eyewear
US9241833B2 (en) 2012-08-31 2016-01-26 Oakley, Inc. Eyewear having multiple ventilation states
US10357400B2 (en) 2012-12-11 2019-07-23 Oakley, Inc. Eyewear with outriggers
WO2014138159A1 (en) 2013-03-07 2014-09-12 Oakley, Inc. Regeneratable ant-fogging element for goggle
CN112156097A (zh) 2013-05-29 2021-01-01 博格有限责任公司 使用维生素d预防或减轻化疗诱发的脱发
CN207867173U (zh) 2014-03-27 2018-09-14 奥克利有限公司 一种护目镜
WO2017062813A1 (en) 2015-10-09 2017-04-13 Oakley, Inc. Headworn supports with passive venting and removable lens
US9709817B2 (en) 2015-12-07 2017-07-18 Oakley, Inc. Eyewear retention devices and methods
CN209433137U (zh) 2015-12-08 2019-09-24 奥克利有限公司 眼镜牵引装置
US10359642B2 (en) 2016-04-22 2019-07-23 Oakley, Inc. Mounting mechanism for eyewear
CN114685337B (zh) * 2022-04-24 2023-08-29 浙江花园生物高科股份有限公司 一种艾地骨化醇的制备方法

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FR570829A (fr) * 1923-09-14 1924-05-07 Anciens Etablissements R Corne Dispositif de commande du mouvement d'écartement et de rapprochement des aiguilles dans les machines à coudre et à broder faisant les ourlets et points à jour
US4172076A (en) * 1977-04-04 1979-10-23 Diamond Shamrock Corporation Process for preparing steroidal acids and their intermediate derivatives
US4338250A (en) * 1981-04-27 1982-07-06 Wisconsin Alumni Research Foundation 1-Hydroxylation process
US4769181A (en) * 1983-11-07 1988-09-06 Wisconsin Alumni Research Foundation 1,25-dihydroxyvitamin D2 compounds
US4857518A (en) * 1984-10-04 1989-08-15 Wisconsin Alumni Research Foundation Hydroxylated 24-homo-vitamin D derivatives and methods for preparing same
DE3577552D1 (de) * 1984-11-27 1990-06-13 Chugai Pharmaceutical Co Ltd Vitamin d-derivate und verfahren zu deren herstellung.
DE3666587D1 (en) * 1985-08-02 1989-11-30 Leo Pharm Prod Ltd Novel vitamin d analogues
JPH0755960B2 (ja) * 1986-11-14 1995-06-14 日清製粉株式会社 ステロイド誘導体およびその製造方法
WO1989010351A1 (en) * 1988-04-21 1989-11-02 Leo Pharmaceutical Products Ltd. A/S (Løvens Kemis Novel vitamin d analogues
US5250523A (en) * 1988-04-29 1993-10-05 Wisconsin Alumni Research Foundation Side chain unsaturated 1α-hydroxyvitanim D homologs
KR940003360B1 (ko) 1988-04-29 1994-04-21 위스콘신 알럼나이 리써취 파운데이션 불포화 측쇄를 갖는 1α-히드록시비타민 D동족체
JPH075542B2 (ja) * 1988-09-14 1995-01-25 呉羽化学工業株式会社 ビタミンｄ▲下３▼誘導体及びその製造方法
US4973584A (en) * 1989-03-09 1990-11-27 Deluca Hector F Novel 1α-hydroxyvitamin D2 epimer and derivatives
US5401731A (en) * 1989-06-29 1995-03-28 Leo Pharmaceutical Products Ltd. A/S (Lovens Kemiske Fabrik Productionsaktieselskab) Vitamin D analogues
US5260290A (en) * 1990-02-14 1993-11-09 Wisconsin Alumni Research Foundation Homologated vitamin D2 compounds and the corresponding 1α-hydroxylated derivatives
US5089641A (en) * 1991-03-11 1992-02-18 Wisconsin Alumni Research Foundation Synthesis of 1α-hydroxy-secosterol compounds
US5206230A (en) * 1991-06-05 1993-04-27 Daikin Industries, Ltd. Fluorine-containing vitamin D3 analogues and pharmaceutical composition containing the same
DK0521550T3 (da) * 1991-07-05 1996-11-04 Duphar Int Res Vitamin D forbindelse, fremgangsmåde til fremstilling af denne forbindelse og mellemprodukt derfor
US5182393A (en) * 1991-08-09 1993-01-26 Hoffmann-La Roche Inc. Process for precursors to calcitriol and related compounds

Also Published As

Publication number Publication date
GR3029449T3 (en) 1999-05-28
DE69415690T2 (de) 1999-05-20
DK0726892T3 (da) 1999-08-30
US5536828A (en) 1996-07-16
US5488044A (en) 1996-01-30
US5484781A (en) 1996-01-16
EP0726892B1 (de) 1998-12-30
WO1995012575A1 (en) 1995-05-11
JPH09504549A (ja) 1997-05-06
US5484782A (en) 1996-01-16
ES2126157T3 (es) 1999-03-16
AU8051594A (en) 1995-05-23
EP0726892A1 (de) 1996-08-21
US5565589A (en) 1996-10-15
ATE175194T1 (de) 1999-01-15

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