ES2108977T3 - Derivados del acido hidroximetilfurazanocarboxilico y su utilizacion en el tratamiento de enfermedades cardiovasculares. - Google Patents

Derivados del acido hidroximetilfurazanocarboxilico y su utilizacion en el tratamiento de enfermedades cardiovasculares.

Info

Publication number
ES2108977T3
ES2108977T3 ES94908337T ES94908337T ES2108977T3 ES 2108977 T3 ES2108977 T3 ES 2108977T3 ES 94908337 T ES94908337 T ES 94908337T ES 94908337 T ES94908337 T ES 94908337T ES 2108977 T3 ES2108977 T3 ES 2108977T3
Authority
ES
Spain
Prior art keywords
derivatives
hydroximetilfurazanocarboxilico
acid
treatment
cardiovascular diseases
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94908337T
Other languages
English (en)
Inventor
Karl Schonafinger
Helmut Bohn
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Application granted granted Critical
Publication of ES2108977T3 publication Critical patent/ES2108977T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/04—1,2,3-Oxadiazoles; Hydrogenated 1,2,3-oxadiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/08—1,2,5-Oxadiazoles; Hydrogenated 1,2,5-oxadiazoles

Abstract

LA PRESENTE INVENCION SE REFIERE A DERIVADOS DE ACIDO CARBOXILICO FURAZANO HIDROXIMETILO DE LA FORMULA GENERAL (I), DONDE UNO DE LOS RESTOS R{SUP,1} Y R{SUP,2} ES HIDROXIMETILO Y EL OTRO ES (A), DONDE X ES NR{SUB,3}R{SUP,4}, OH O OR{SUP,7} Y R{SUP,3}, R{SUP,4} Y R{SUP,7} SE DEFINEN COMO EN LA REIVINDICACION 1, PROCESO PARA SU ELABORACION Y SU UTILIZACION.
ES94908337T 1993-03-06 1994-02-18 Derivados del acido hidroximetilfurazanocarboxilico y su utilizacion en el tratamiento de enfermedades cardiovasculares. Expired - Lifetime ES2108977T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4307105A DE4307105A1 (de) 1993-03-06 1993-03-06 Hydroxymethylfurazancarbonsäurederivate

Publications (1)

Publication Number Publication Date
ES2108977T3 true ES2108977T3 (es) 1998-01-01

Family

ID=6482135

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94908337T Expired - Lifetime ES2108977T3 (es) 1993-03-06 1994-02-18 Derivados del acido hidroximetilfurazanocarboxilico y su utilizacion en el tratamiento de enfermedades cardiovasculares.

Country Status (21)

Country Link
US (1) US5486531A (es)
EP (1) EP0687256B1 (es)
JP (1) JP3578456B2 (es)
KR (1) KR960701029A (es)
CN (1) CN1043140C (es)
AT (1) ATE157660T1 (es)
AU (1) AU676718B2 (es)
CA (1) CA2155840C (es)
CZ (1) CZ284264B6 (es)
DE (2) DE4307105A1 (es)
DK (1) DK0687256T3 (es)
ES (1) ES2108977T3 (es)
FI (1) FI954138A0 (es)
GR (1) GR3024928T3 (es)
HU (1) HUT72641A (es)
IL (1) IL108856A (es)
PL (1) PL177603B1 (es)
RU (1) RU2134687C1 (es)
SK (1) SK280354B6 (es)
WO (1) WO1994020478A1 (es)
ZA (1) ZA941533B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4401150A1 (de) * 1994-01-17 1995-07-20 Cassella Ag Furazancarbonsäurederivate
US6124289A (en) * 1996-07-24 2000-09-26 Dupont Pharmaceuticals Co. Azolo triazines and pyrimidines
US7094782B1 (en) * 1996-07-24 2006-08-22 Bristol-Myers Squibb Company Azolo triazines and pyrimidines
US6313124B1 (en) 1997-07-23 2001-11-06 Dupont Pharmaceuticals Company Tetrazine bicyclic compounds
US6060478A (en) * 1996-07-24 2000-05-09 Dupont Pharmaceuticals Azolo triazines and pyrimidines
US6191131B1 (en) 1997-07-23 2001-02-20 Dupont Pharmaceuticals Company Azolo triazines and pyrimidines
PT1636215E (pt) * 2003-05-23 2008-04-29 Basilea Pharmaceutica Ag Furazanobenzimidazoles
US8822509B2 (en) 2006-12-29 2014-09-02 The University Of Queensland Pain-relieving compositions and uses therefor
CN112125865B (zh) * 2020-09-30 2022-08-12 北京理工大学 氧化呋咱化合物的合成方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3012862A1 (de) * 1980-04-02 1981-10-08 Cassella Ag, 6000 Frankfurt Substituierte 1,2,5-oxdiazol-2-oxide als pharmazeutische wirkstoffe, ihre verwendung und sie enthaltende arzneimittel
DE3047730A1 (de) * 1980-12-18 1982-07-15 Cassella Ag, 6000 Frankfurt 3,4-bis-substituierte 1,2,5-oxdiazol-2-oxide, verfahren zu ihrer herstellung, ihre verwendung und sie enthaltende pharmazeutische zubereitungen

Also Published As

Publication number Publication date
CN1043140C (zh) 1999-04-28
US5486531A (en) 1996-01-23
HU9502603D0 (en) 1995-11-28
PL177603B1 (pl) 1999-12-31
AU6141494A (en) 1994-09-26
HUT72641A (en) 1996-05-28
WO1994020478A1 (de) 1994-09-15
EP0687256A1 (de) 1995-12-20
GR3024928T3 (en) 1998-01-30
RU2134687C1 (ru) 1999-08-20
DK0687256T3 (da) 1998-03-30
CZ284264B6 (cs) 1998-10-14
KR960701029A (ko) 1996-02-24
SK110095A3 (en) 1996-01-10
EP0687256B1 (de) 1997-09-03
CZ228195A3 (en) 1995-12-13
PL310655A1 (en) 1995-12-27
JPH08507299A (ja) 1996-08-06
DE59403966D1 (de) 1997-10-09
CA2155840A1 (en) 1994-09-15
ATE157660T1 (de) 1997-09-15
JP3578456B2 (ja) 2004-10-20
SK280354B6 (sk) 1999-12-10
CA2155840C (en) 2005-05-24
FI954138A (fi) 1995-09-04
FI954138A0 (fi) 1995-09-04
CN1119013A (zh) 1996-03-20
AU676718B2 (en) 1997-03-20
IL108856A (en) 1997-07-13
DE4307105A1 (de) 1994-09-08
ZA941533B (en) 1994-10-06
IL108856A0 (en) 1994-06-24

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