DE69409870D1 - Heteroatom-substituierte Liganden und Metallkomplexe davon - Google Patents

Heteroatom-substituierte Liganden und Metallkomplexe davon

Info

Publication number
DE69409870D1
DE69409870D1 DE69409870T DE69409870T DE69409870D1 DE 69409870 D1 DE69409870 D1 DE 69409870D1 DE 69409870 T DE69409870 T DE 69409870T DE 69409870 T DE69409870 T DE 69409870T DE 69409870 D1 DE69409870 D1 DE 69409870D1
Authority
DE
Germany
Prior art keywords
heteroatom
metal complexes
substituted ligands
complexes
novel
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69409870T
Other languages
English (en)
Other versions
DE69409870T3 (de
DE69409870T2 (de
Inventor
Kondareddiar Ramalingam
Natarajan Raju
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bracco Suisse SA
Original Assignee
Bracco International BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22141146&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69409870(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bracco International BV filed Critical Bracco International BV
Publication of DE69409870D1 publication Critical patent/DE69409870D1/de
Application granted granted Critical
Publication of DE69409870T2 publication Critical patent/DE69409870T2/de
Publication of DE69409870T3 publication Critical patent/DE69409870T3/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C07D233/62—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with triarylmethyl radicals attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/70—Nitro radicals
    • C07D307/71—Nitro radicals attached in position 5
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/32—Oximes
    • C07C251/34—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C07C251/36—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with the carbon atoms of the oxyimino groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C251/38—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with the carbon atoms of the oxyimino groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of a saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/91—Nitro radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Optics & Photonics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Furan Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE69409870T 1993-06-15 1994-06-10 Heteroatom-substituierte Liganden und Metallkomplexe davon Expired - Lifetime DE69409870T3 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7798193A 1993-06-15 1993-06-15
US77981 1993-06-15

Publications (3)

Publication Number Publication Date
DE69409870D1 true DE69409870D1 (de) 1998-06-04
DE69409870T2 DE69409870T2 (de) 1998-12-10
DE69409870T3 DE69409870T3 (de) 2008-03-13

Family

ID=22141146

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69409870T Expired - Lifetime DE69409870T3 (de) 1993-06-15 1994-06-10 Heteroatom-substituierte Liganden und Metallkomplexe davon

Country Status (19)

Country Link
US (5) US5608110A (de)
EP (1) EP0629617B2 (de)
JP (1) JP3835831B2 (de)
KR (1) KR100346795B1 (de)
CN (1) CN1055685C (de)
AT (1) ATE165598T1 (de)
AU (1) AU678001B2 (de)
CA (1) CA2125895C (de)
CZ (1) CZ295519B6 (de)
DE (1) DE69409870T3 (de)
DK (1) DK0629617T3 (de)
ES (1) ES2115805T3 (de)
FI (1) FI942795A (de)
HU (1) HU9401777D0 (de)
IL (1) IL109925A (de)
NO (1) NO305078B1 (de)
PL (1) PL303843A1 (de)
RU (1) RU94022254A (de)
ZA (1) ZA944201B (de)

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CZ295519B6 (cs) 2005-08-17
NO305078B1 (no) 1999-03-29
CA2125895C (en) 2000-03-14
DE69409870T3 (de) 2008-03-13
RU94022254A (ru) 1996-04-20
DK0629617T3 (da) 1998-10-07
US5627286A (en) 1997-05-06
IL109925A0 (en) 1994-10-07
HU9401777D0 (en) 1994-09-28
ES2115805T3 (es) 1998-07-01
CN1099388A (zh) 1995-03-01
PL303843A1 (en) 1994-12-27
IL109925A (en) 2005-12-18
JP3835831B2 (ja) 2006-10-18
CZ145594A3 (en) 1995-05-17
AU6467294A (en) 1994-12-22
CN1055685C (zh) 2000-08-23
KR100346795B1 (ko) 2002-11-29
KR950000671A (ko) 1995-01-03
CA2125895A1 (en) 1994-12-16
US5741912A (en) 1998-04-21
US5656254A (en) 1997-08-12
EP0629617A1 (de) 1994-12-21
US5665329A (en) 1997-09-09
ZA944201B (en) 1995-02-08
EP0629617B2 (de) 2007-09-26
ATE165598T1 (de) 1998-05-15
DE69409870T2 (de) 1998-12-10
FI942795A0 (fi) 1994-06-13
US5608110A (en) 1997-03-04
FI942795A (fi) 1994-12-16
JPH0789922A (ja) 1995-04-04
AU678001B2 (en) 1997-05-15
NO942231D0 (no) 1994-06-14
NO942231L (no) 1994-12-16
EP0629617B1 (de) 1998-04-29

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