DK0532566T3 - Cyklopentadienylcarbonyl-99mTc-komplekser, fremgangsmåde til fremstilling af disse samt deres anvendelse i diagnostikken - Google Patents

Cyklopentadienylcarbonyl-99mTc-komplekser, fremgangsmåde til fremstilling af disse samt deres anvendelse i diagnostikken

Info

Publication number
DK0532566T3
DK0532566T3 DK91910279.8T DK91910279T DK0532566T3 DK 0532566 T3 DK0532566 T3 DK 0532566T3 DK 91910279 T DK91910279 T DK 91910279T DK 0532566 T3 DK0532566 T3 DK 0532566T3
Authority
DK
Denmark
Prior art keywords
pct
complexes
cyclopentadienylcarbonyl
diagnostics
processes
Prior art date
Application number
DK91910279.8T
Other languages
English (en)
Inventor
Martin Wenzel
Paul-Eberhardt Schulze
Original Assignee
Inst F R Diagnostikforschung G
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inst F R Diagnostikforschung G filed Critical Inst F R Diagnostikforschung G
Application granted granted Critical
Publication of DK0532566T3 publication Critical patent/DK0532566T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0487—Metallocenes, i.e. complexes based on a radioactive metal complexed by two cyclopentadienyl anions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
DK91910279.8T 1990-06-01 1991-05-31 Cyklopentadienylcarbonyl-99mTc-komplekser, fremgangsmåde til fremstilling af disse samt deres anvendelse i diagnostikken DK0532566T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4018172 1990-06-01
DE4028867 1990-09-08

Publications (1)

Publication Number Publication Date
DK0532566T3 true DK0532566T3 (da) 1995-07-31

Family

ID=25893909

Family Applications (1)

Application Number Title Priority Date Filing Date
DK91910279.8T DK0532566T3 (da) 1990-06-01 1991-05-31 Cyklopentadienylcarbonyl-99mTc-komplekser, fremgangsmåde til fremstilling af disse samt deres anvendelse i diagnostikken

Country Status (10)

Country Link
US (1) US5538712A (da)
EP (1) EP0532566B1 (da)
JP (1) JPH06501450A (da)
AT (1) ATE119539T1 (da)
CA (1) CA2084315A1 (da)
DE (1) DE59104905D1 (da)
DK (1) DK0532566T3 (da)
ES (1) ES2069892T3 (da)
GR (1) GR3015362T3 (da)
WO (1) WO1991018908A1 (da)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5808091A (en) * 1991-10-29 1998-09-15 Bracco International B.V. Rhenium and technetium complexes containing a hypoxia localizing moiety
US6359120B1 (en) 1991-10-29 2002-03-19 Bracco International B.V. Rhenium and technetium complexes containing a hypoxia-localizing moiety
DE4313670A1 (de) * 1993-04-22 1994-10-27 Diagnostikforschung Inst Radioaktive Metallocen-carbonsäuren und deren Homologe zur Proteinmarkierung
US5608110A (en) * 1993-06-15 1997-03-04 Bracco International B.V. Heteroatom-bearing ligands and metal complexes thereof
US5700446A (en) * 1996-06-13 1997-12-23 Neuro Imaging Technologies, Llc Synthesis of ferrocenyl phenyltropane analogs and their radio-transformation to technetium neuroprobes for mapping monoamine reuptake sites
AU4308001A (en) * 1999-12-03 2001-06-12 Yale University Transition metal-cyclopentadienyl-tropane conjugates
JP4951798B2 (ja) * 2002-04-01 2012-06-13 モレキュラ インサイト ファーマシューティカルズ インコーポレイテッド 側基脂肪酸撮像剤
EP1797106A1 (en) * 2004-09-07 2007-06-20 Triumf, operating as a joint venture by the Governors of the Universities of Alberta, Synthesis of radiolabeled sugar metal complexes
CA2593256A1 (en) * 2005-01-05 2006-07-13 Board Of Regents, The University Of Texas System Conjugates for dual imaging and radiochemotherapy: composition, manufacturing, and applications
CN101654465B (zh) * 2009-09-11 2012-10-03 兰州大学 一种羰基锝标记的2-硝基咪唑配合物及其制备方法与用途
CN102311459B (zh) * 2011-06-03 2014-06-25 北京师范大学 新型锝-99m标记的高级脂肪酸衍生物
CN103435655B (zh) * 2013-08-06 2016-04-06 北京师范大学 结合σ1受体的三羰基环戊二烯类配体化合物、其制备方法及应用
CN103772440B (zh) * 2014-01-10 2017-02-15 北京师范大学 一种锝‑99m标记的高级脂肪酸衍生物

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3028404A (en) * 1958-11-03 1962-04-03 Ethyl Corp Manufacture of cyclopentadienyl metal carbonyl compounds
DE2246460A1 (de) * 1972-09-21 1974-04-04 Schering Ag Metallocene und metallocen-derivate mit radioaktivem zentralatom
DE3218859A1 (de) * 1982-05-15 1983-11-17 Wenzel, Martin, Prof. Dr., 1000 Berlin Amin-derivate des ruthenocens und ferrocens als radiopharmaka
DE3244886A1 (de) * 1982-12-01 1984-06-07 Byk-Mallinckrodt Cil B.V., Petten Metallocen-derivate der aminosaeuren glycin und alanin mit radioaktivem zentralatom als radiopharmaka.
DE3445782A1 (de) * 1984-12-12 1986-06-12 Martin Prof. Dr. 1000 Berlin Wenzel Metallocen-derivate zur gehirn- und lungendiagnostik
DE3523262A1 (de) * 1984-12-12 1987-01-08 Martin Prof Dr Wenzel Metallocen-derivate fuer die diagnostik des gehirns und anderer organe
US4765971A (en) * 1985-05-31 1988-08-23 Mallinckrodt, Inc. Technetium (Tc-99m)-arene complexes useful in myocardial imaging
AU1966188A (en) * 1987-08-07 1989-03-09 Mallinckrodt, Inc. Diagnostic or radiotherapeutic composition comprising a hydrogen containing compound

Also Published As

Publication number Publication date
US5538712A (en) 1996-07-23
JPH06501450A (ja) 1994-02-17
DE59104905D1 (de) 1995-04-13
ATE119539T1 (de) 1995-03-15
EP0532566B1 (de) 1995-03-08
EP0532566A1 (de) 1993-03-24
WO1991018908A1 (de) 1991-12-12
CA2084315A1 (en) 1991-12-02
ES2069892T3 (es) 1995-05-16
GR3015362T3 (en) 1995-06-30

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