NO305078B1 - Heteroatomholdige ligander og metallkomplekser av disse, anvendelse av kompleksene og sett for fremstilling av dem - Google Patents

Heteroatomholdige ligander og metallkomplekser av disse, anvendelse av kompleksene og sett for fremstilling av dem

Info

Publication number
NO305078B1
NO305078B1 NO942231A NO942231A NO305078B1 NO 305078 B1 NO305078 B1 NO 305078B1 NO 942231 A NO942231 A NO 942231A NO 942231 A NO942231 A NO 942231A NO 305078 B1 NO305078 B1 NO 305078B1
Authority
NO
Norway
Prior art keywords
complexes
sets
preparation
heteroatomic ligands
metal complexes
Prior art date
Application number
NO942231A
Other languages
English (en)
Other versions
NO942231L (no
NO942231D0 (no
Inventor
Kondareddiar Ramalingam
Natarajan Raju
Original Assignee
Bracco Int Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22141146&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO305078(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bracco Int Bv filed Critical Bracco Int Bv
Publication of NO942231D0 publication Critical patent/NO942231D0/no
Publication of NO942231L publication Critical patent/NO942231L/no
Publication of NO305078B1 publication Critical patent/NO305078B1/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C07D233/62Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with triarylmethyl radicals attached to ring nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/70Nitro radicals
    • C07D307/71Nitro radicals attached in position 5
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/0474Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0478Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/32Oximes
    • C07C251/34Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C07C251/36Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with the carbon atoms of the oxyimino groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C251/38Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with the carbon atoms of the oxyimino groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of a saturated carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/91Nitro radicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00Preparations for use in therapy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00Preparations for testing in vivo

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Optics & Photonics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Furan Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
NO942231A 1993-06-15 1994-06-14 Heteroatomholdige ligander og metallkomplekser av disse, anvendelse av kompleksene og sett for fremstilling av dem NO305078B1 (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US7798193A 1993-06-15 1993-06-15

Publications (3)

Publication Number Publication Date
NO942231D0 NO942231D0 (no) 1994-06-14
NO942231L NO942231L (no) 1994-12-16
NO305078B1 true NO305078B1 (no) 1999-03-29

Family

ID=22141146

Family Applications (1)

Application Number Title Priority Date Filing Date
NO942231A NO305078B1 (no) 1993-06-15 1994-06-14 Heteroatomholdige ligander og metallkomplekser av disse, anvendelse av kompleksene og sett for fremstilling av dem

Country Status (19)

Country Link
US (5) US5608110A (no)
EP (1) EP0629617B2 (no)
JP (1) JP3835831B2 (no)
KR (1) KR100346795B1 (no)
CN (1) CN1055685C (no)
AT (1) ATE165598T1 (no)
AU (1) AU678001B2 (no)
CA (1) CA2125895C (no)
CZ (1) CZ295519B6 (no)
DE (1) DE69409870T3 (no)
DK (1) DK0629617T3 (no)
ES (1) ES2115805T3 (no)
FI (1) FI942795A (no)
HU (1) HU9401777D0 (no)
IL (1) IL109925A (no)
NO (1) NO305078B1 (no)
PL (1) PL303843A1 (no)
RU (1) RU94022254A (no)
ZA (1) ZA944201B (no)

Families Citing this family (65)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6359120B1 (en) * 1991-10-29 2002-03-19 Bracco International B.V. Rhenium and technetium complexes containing a hypoxia-localizing moiety
JP3953509B2 (ja) * 1992-10-08 2007-08-08 ジーイー・ヘルスケア・リミテッド 放射性薬剤として使用する金属オキシムキレート
AU6953294A (en) 1993-05-20 1994-12-20 Regents Of The University Of California, The Macromolecular contrast media for mr imaging
IL111592A0 (en) * 1993-12-14 1995-01-24 Bracco Int Bv Stable multilayer lyophile
CA2190727C (en) * 1994-05-19 2006-07-18 Sudhakar Kasina Aromatic amine substituted bridged nitrogen and sulfur donor atom ligands for imaging
US5632969A (en) * 1994-10-13 1997-05-27 Merck & Co., Inc. N3 S2 chelating ligands optionally radiolabelled with Tc or Re, useful for diagnostic or therapeutic applications
US6107519A (en) 1997-11-07 2000-08-22 Pharmacia & Upjohn Company Process to produce oxazolidinones
AU5676398A (en) * 1997-01-31 1998-08-25 University Of Alberta, The Method for detecting exogenous gene expression
US6004529A (en) * 1997-04-11 1999-12-21 Nycomed Imaging As Chelating agents
US7745142B2 (en) 1997-09-15 2010-06-29 Molecular Devices Corporation Molecular modification assays
ATE384075T1 (de) * 1998-05-15 2008-02-15 Ge Healthcare Ltd Markierte glutamin- und lysinanaloge
JP3519302B2 (ja) 1999-02-09 2004-04-12 株式会社東海理化電機製作所 ウエビング巻取装置用プリテンショナー
US6465785B1 (en) * 2000-05-05 2002-10-15 Infrared Solutions, Inc. Apparatus and method for compensating for pixel non-uniformity in a bolometer
JP5078212B2 (ja) 2000-06-02 2012-11-21 ブラッコ・スイス・ソシエテ・アノニム 内皮細胞を標的とするための化合物、それを含む組成物およびその使用方法
WO2002032294A2 (en) * 2000-10-19 2002-04-25 Bracco Research Usa Radiopharmaceutical formulations
JP4262480B2 (ja) * 2000-11-29 2009-05-13 ブラッコ インターナショナル ビー.ヴイ. 結合能を有するシアリル・ルイスx類似物
US6384232B1 (en) 2001-03-27 2002-05-07 Bracco International B.V. Methods of synthesizing heteroatom-bearing ligands and intermediate used thereof
ES2506142T3 (es) 2002-03-01 2014-10-13 Dyax Corp. Péptidos de unión a KDR y a VEGF/KDR y su uso en diagnóstico
US7794693B2 (en) 2002-03-01 2010-09-14 Bracco International B.V. Targeting vector-phospholipid conjugates
US7261876B2 (en) 2002-03-01 2007-08-28 Bracco International Bv Multivalent constructs for therapeutic and diagnostic applications
US8623822B2 (en) * 2002-03-01 2014-01-07 Bracco Suisse Sa KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy
US7211240B2 (en) * 2002-03-01 2007-05-01 Bracco International B.V. Multivalent constructs for therapeutic and diagnostic applications
AU2003278807A1 (en) * 2002-03-01 2004-08-13 Bracco International B.V. Kdr and vegf/kdr binding peptides and their use in diagnosis and therapy
WO2003086563A2 (en) * 2002-04-11 2003-10-23 Carbomer, Inc. Diabetes imaging probes
DE60325766D1 (de) * 2002-09-25 2009-02-26 Daiso Co Ltd Verfahren zur Herstellung von Glycidylphthalimide
EP1569678A4 (en) * 2002-11-25 2008-01-02 Attenuon Llc PEPTIDES, THE TUMOR AND ENDOTHEL CELL CONTROLS, COMPOSITIONS AND ITS USES
US7226577B2 (en) 2003-01-13 2007-06-05 Bracco Imaging, S. P. A. Gastrin releasing peptide compounds
HUE039154T2 (hu) 2003-03-03 2018-12-28 Dyax Corp HGF receptort (cMet) specifikusan kötõ peptidek és alkalmazásaik
CA2783275A1 (en) * 2003-07-24 2005-02-03 Bracco Imaging S.P.A. Stable radiopharmaceutical compositions and methods for their preparation
KR20060130588A (ko) * 2003-11-18 2006-12-19 아테뉴온, 엘엘씨 우로키나제의 아미노 말단 단편에 결합하는 항체 및/또는이의 접합체, 조성물 및 이의 용도
CA2581639C (en) 2004-09-30 2016-07-26 Molecular Devices Corporation Luminescent lanthanide complexes
KR100675356B1 (ko) * 2005-04-29 2007-02-01 경희대학교 산학협력단 액체 또는 초임계상태의 유체를 이용하여 금속이온 및금속산화물을 추출하는 금속추출에 사용되는 신규한 아미드화합물을 포함하는 킬레이트제와 상기 킬레이트제를이용한 금속추출방법 및 금속추출시스템
CA2680606C (en) 2006-03-29 2014-08-05 Wayne State University Liposomal nanoparticles and other formulations of fenretinide for use in therapy and drug delivery
JP2007297305A (ja) * 2006-04-28 2007-11-15 Daiso Co Ltd N−(2,3−エポキシ−2−メチルプロピル)フタルイミドの製造法
PL2117571T3 (pl) * 2006-12-08 2017-08-31 Monopar Therapeutics Inc. Epitop receptora aktywatora plazminogenu typu urokinazy
JP5364589B2 (ja) 2006-12-11 2013-12-11 ブラッコ・イメージング・ソシエタ・ペル・アチオニ 診断および治療適用用フィブリン結合ペプチドコンジュゲート
GB0804406D0 (en) * 2008-03-10 2008-04-16 Univ Zuerich Metal complexes
EP2147684A1 (en) 2008-07-22 2010-01-27 Bracco Imaging S.p.A Diagnostic Agents Selective Against Metalloproteases
US20120045393A1 (en) 2009-03-17 2012-02-23 Linder Karen E Lhrh-ii peptide analogs
US20130195756A1 (en) 2012-01-31 2013-08-01 General Electric Company 99mTc IMAGING AGENTS AND METHODS OF USE
FR2989085A1 (fr) * 2012-04-05 2013-10-11 Commissariat Energie Atomique Radiotraceurs, procedes de preparation et applications
WO2015171543A1 (en) 2014-05-05 2015-11-12 California Institute Of Technology Mutant akt-specific capture agents, compositions, and methods of using and making
CN108290927B (zh) 2015-07-15 2022-06-24 加州理工学院 Il-17f-特异性捕获剂、组合物以及使用和制造的方法
JP7011830B2 (ja) 2015-10-14 2022-01-27 エックス-サーマ インコーポレイテッド 氷晶形成を低減するための組成物および方法
JP6991148B2 (ja) 2016-02-09 2022-01-12 ブラッコ・スイス・ソシエテ・アノニム セレクチン標的化のための組み換えキメラタンパク質
EP3440101B1 (en) 2016-04-04 2021-10-06 Indi Molecular, Inc. Cd8-specific capture agents, compositions, and methods of using and making
US9643939B1 (en) 2016-04-18 2017-05-09 Optimus Drugs Private Limited Process for the preparation of linezolid
USRE47606E1 (en) 2016-04-21 2019-09-17 Optimus Drugs Private Limited Process for the preparation of linezolid
AU2017291838B2 (en) 2016-07-06 2021-01-28 The Regents Of The University Of Michigan Multifunctional inhibitors of MEK/PI3K and mTOR/MEK/PI3K biological pathways and therapeutic methods using the same
WO2018064597A1 (en) 2016-09-29 2018-04-05 Indi Molecular, Inc. Compositions for detection, inhibition and imaging of indoleamine 2,3-dioxygenase 1 (ido1) and methods of making and using same
US11358982B2 (en) 2016-11-01 2022-06-14 Ohio State Innovation Foundation Methods for the iodination of biomolecules
KR102413731B1 (ko) * 2016-11-09 2022-06-27 주식회사 쿠라레 산소 흡수제
US11719705B2 (en) 2017-06-15 2023-08-08 Indi Molecular, Inc. IL-17F and IL-17A-specific capture agents, compositions, and methods of using and making
KR102083180B1 (ko) * 2017-11-09 2020-03-02 서울대학교산학협력단 셀레노사마필린 a와 그 유도체, 이의 제조방법, 및 이를 유효성분으로 포함하는 암 예방 및 치료용 조성물
WO2019093699A1 (ko) * 2017-11-09 2019-05-16 서울대학교 산학협력단 셀레노사마필린 a와 그 유도체, 이의 제조방법 및 이를 유효성분으로 포함하는 암 예방 및 치료용 조성물
KR20210004990A (ko) * 2018-04-19 2021-01-13 주식회사 쿠라레 불포화 이중 결합 함유 화합물, 그것을 사용한 산소 흡수제, 및 수지 조성물
IL271681A (en) 2018-07-18 2020-01-30 Vyripharm Entpr Llc Systems and methods for integrated and comprehensive management of cannabis products
US11638764B2 (en) 2018-11-08 2023-05-02 Indi Molecular, Inc. Theranostic capture agents, compositions, and methods of using and making
WO2020186091A1 (en) 2019-03-12 2020-09-17 Indi Molecular, Inc. Cross-linked epitopes and methods of use thereof
WO2020236969A1 (en) 2019-05-20 2020-11-26 Indi Molecular, Inc. Compositions and methods relating to detection, inhibition, and imaging of indoleamine 2,3-dioxygenase 1 (ido1)
US11414460B2 (en) 2019-07-19 2022-08-16 Institute For Systems Biology KRAS-specific capture agents, compositions, and methods of making and using
WO2022098743A1 (en) 2020-11-03 2022-05-12 Indi Molecular, Inc. Compositions, imaging, and therapeutic methods targeting folate receptor 1 (folr1)
WO2022098745A1 (en) 2020-11-03 2022-05-12 Indi Molecular, Inc. Compositions, delivery systems, and methods useful in tumor therapy
EP4377296A1 (en) 2021-07-26 2024-06-05 Arvinas Operations, Inc. Methods of manufacturing a bifunctional compound
CN114907562B (zh) * 2022-01-29 2023-08-18 华东理工大学 β-内酰胺单体的合成及聚合方法

Family Cites Families (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3369121A (en) * 1966-04-06 1968-02-13 Squibb & Sons Inc Radioactive package and container therefor
US3920995A (en) * 1973-05-04 1975-11-18 Squibb & Sons Inc Radioactive material generator
US4071613A (en) * 1976-02-26 1978-01-31 Abbott Laboratories Stabilized alcohol solution of reducing salt formulations for use in preparing radioisotope labeled scanning agents: liver scanning technetium-99m colloid and method of preparation
JPS54126597A (en) * 1978-03-02 1979-10-01 Radiochemical Centre Ltd Method of and device for fabricating diagnostic scan agent
US4193979A (en) * 1978-05-22 1980-03-18 G. D. Searle & Co. Sodium 3-[[[2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl]-amino]carbonyl]-2-pyridinecarboxylic acid and related compounds labeled with technetium-99m
US4272503A (en) * 1978-05-25 1981-06-09 New England Nuclear Corporation Reductant composition for technetium-99m and method for making technetium-99m labelled ligands
US4363793A (en) * 1979-08-30 1982-12-14 State University Of New York Diagnostic radiopharmaceuticals for localization in target tissues exhibiting a regional pH shift relative to surrounding tissues
GB2093451B (en) * 1981-02-24 1984-10-31 May & Baker Ltd Nitroimidazole derivatives
US4431626A (en) * 1981-05-27 1984-02-14 The Regents Of The University Of California Tc-99m Labeled carrier for imaging
US4462992A (en) * 1982-02-08 1984-07-31 Research Corporation Nitroimidazole radiosensitizers for hypoxic tumor cells and compositions thereof
US4444690A (en) * 1982-02-25 1984-04-24 University Patents, Inc. Technetium chelates
US4758682A (en) * 1983-03-17 1988-07-19 California Institute Of Technology Homogeneous coordination compounds as oxidation catalysts
US4615876A (en) * 1983-04-25 1986-10-07 Curators Of The University Of Missouri Macrocyclic complexes of technetium-99m for use as diagnostic radionuclides
US4638051A (en) * 1984-04-30 1987-01-20 The Johns Hopkins University Brain imaging radiopharmaceuticals
US4980147A (en) * 1984-06-25 1990-12-25 University Of Utah Research Foundation Radiolabeled technetium chelates for use in renal function determinations
GB8426845D0 (en) * 1984-10-24 1984-11-28 Amersham Int Plc Complexes of technetium-99m
JPS61103841A (ja) * 1984-10-26 1986-05-22 Nippon Mejifuijitsukusu Kk 放射性テクネチウム標識に供する安定な塩化第一スズ組成物
EP0194843B1 (en) * 1985-03-11 1993-01-13 AMERSHAM INTERNATIONAL plc Complexes of technetium-99m with propylene amine oximes
US5187264A (en) * 1986-05-28 1993-02-16 Mallinckrodt Medical, Inc. Technetium chelates to be used for determining the renal function
EP0250013B1 (en) * 1986-05-28 1990-05-09 MALLINCKRODT, INC.(a Missouri corporation) Technetium chelates to be used for determining the renal function
DE3728599A1 (de) * 1986-12-10 1988-06-23 Hoechst Ag Verfahren zur herstellung einer mit technetium-99m-markierten organspezifischen substanz
US5164175A (en) * 1986-12-10 1992-11-17 Hoechst Aktiengesellschaft Diagnostic aid containing an organ-specific substance labeled with technetium-99m
US5091514A (en) * 1987-03-26 1992-02-25 Neorx Corporation Metal-radionuclide-labeled proteins and glycoproteins for diagnosis and therapy
US4871836A (en) * 1987-10-13 1989-10-03 E. R. Squibb & Sons, Inc. Boronic acid adducts of rhenium and radioactive isotopes of rhenium dioxime complexes
US5071636A (en) * 1987-12-29 1991-12-10 Nihon Medi-Physics Co., Ltd. Chelating compounds and their use
WO1989010759A1 (en) * 1988-04-29 1989-11-16 Mallinckrodt, Inc. Diaminedithiol chelating agents for radiopharmaceuticals
US4988496A (en) * 1988-05-31 1991-01-29 Neorx Corporation Metal radionuclide chelating compounds for improved chelation kinetics
US5075099A (en) * 1988-05-31 1991-12-24 Neorx Corporation Metal radionuclide chelating compounds for improved chelation kinetics
US5089249A (en) * 1988-06-10 1992-02-18 Neorx Corporation Conjugates for bone imaging and bone cancer therapy
US4925650A (en) * 1988-11-16 1990-05-15 Mallinckrodt, Inc. Technetium -99m complex for examining the renal function
US4895960A (en) * 1989-01-23 1990-01-23 University Of Cincinnati Cyclo substituted propyleneamine oxime and its use as a brain imaging agent
US5026829A (en) * 1989-01-23 1991-06-25 University Of Cincinnati Cyclo substituted propyleneamine oxime and its use as a brain imaging agent
US4986979A (en) * 1989-03-14 1991-01-22 Neorx Corporation Imaging tissue sites of inflammation
CN1022562C (zh) * 1989-04-08 1993-10-27 中国人民解放军第二军医大学 一种消瘤药——甲硝唑氨酸的合成方法
US5101041A (en) * 1989-04-26 1992-03-31 The Curators Of The University Of Missouri Triamines and their derivatives as bifunctional chelating agents
US5164176A (en) * 1989-06-16 1992-11-17 Neorx Corporation Radionuclide metal chelates for the radiolabeling of proteins
DE3930674A1 (de) * 1989-09-11 1991-03-21 Diagnostikforschung Inst Bifunktionelle chelatbildner zur komplexierung von tc- und re-isotopen, verfahren zu ihrer herstellung und darstellung von konjugaten daraus sowie deren verwendung in diagnostik und therapie
CA2034042C (en) * 1990-01-18 1999-08-17 Adrian D. Nunn Boronic acid adducts of rhenium dioxime and technetium-99m dioxime complexes containing a biochemically active group
WO1991018908A1 (de) * 1990-06-01 1991-12-12 Institut für Diagnostikforschung GmbH an der Freien Universität Berlin CYCLOPENTADIENYLCARBONYL-99mTc-KOMPLEXE, VERFAHREN ZU IHRER HERSTELLUNG SOWIE IHRE VERWENDUNG IN DER DIAGNOSTIK
DE4025788C2 (de) * 1990-08-10 1994-04-14 Diagnostikforschung Inst Technetium- und Rhenium-Komplexe, Verfahren zu ihrer Herstellung sowie deren Verwendung in Diagnostik und Therapie
US5104638A (en) * 1990-10-29 1992-04-14 Mallinckrodt Medical, Inc. Method of making a radiopharmaceutical complex from a kit
US5037631A (en) * 1990-10-29 1991-08-06 Mallinckrodt Medical, Inc. Technetium-99M complex for examinating the renal function
US5116598A (en) * 1990-10-29 1992-05-26 Mallinckrodt Medical, Inc. N4 technetium-99 m complexes for use as radiopharmaceuticals
GB9028105D0 (en) * 1990-12-27 1991-02-13 Erba Carlo Spa Process for the preparation of substituted benzofuran derivatives
JP2703408B2 (ja) * 1990-12-28 1998-01-26 麒麟麦酒株式会社 1,4‐ベンゾチアゼピン誘導体
DE4107570A1 (de) * 1991-03-07 1992-11-19 Diagnostikforschung Inst Chelate, deren metallkomplexe sowie ihre verwendung in diagnostik und therapie
DE4107571A1 (de) * 1991-03-07 1992-11-19 Diagnostikforschung Inst Amid-chelate, deren metallkomplexe sowie ihre verwendung in diagnostik und therapie
GB9113487D0 (en) * 1991-06-21 1991-08-07 Amersham Int Plc Agents for hypoxic cells
US5385719A (en) * 1991-09-24 1995-01-31 Unger; Evan C. Copolymers and their use as contrast agents in magnetic resonance imaging and in other applications
NZ244613A (en) * 1991-10-29 1996-05-28 Bracco International B V Subst A ligand containing a hypoxia-localising moiety, preparation thereof; a kit (optionally multivial) for preparing a metal complex containing the ligand
JP3953509B2 (ja) * 1992-10-08 2007-08-08 ジーイー・ヘルスケア・リミテッド 放射性薬剤として使用する金属オキシムキレート
EP0618191A1 (en) * 1993-04-02 1994-10-05 AMERSHAM INTERNATIONAL plc Metal chelating compounds

Also Published As

Publication number Publication date
IL109925A (en) 2005-12-18
HU9401777D0 (en) 1994-09-28
FI942795A (fi) 1994-12-16
DE69409870D1 (de) 1998-06-04
CZ145594A3 (en) 1995-05-17
CA2125895A1 (en) 1994-12-16
DK0629617T3 (da) 1998-10-07
PL303843A1 (en) 1994-12-27
CN1099388A (zh) 1995-03-01
EP0629617A1 (en) 1994-12-21
AU6467294A (en) 1994-12-22
DE69409870T2 (de) 1998-12-10
RU94022254A (ru) 1996-04-20
KR950000671A (ko) 1995-01-03
CN1055685C (zh) 2000-08-23
CA2125895C (en) 2000-03-14
DE69409870T3 (de) 2008-03-13
CZ295519B6 (cs) 2005-08-17
AU678001B2 (en) 1997-05-15
ES2115805T3 (es) 1998-07-01
ZA944201B (en) 1995-02-08
US5656254A (en) 1997-08-12
US5741912A (en) 1998-04-21
IL109925A0 (en) 1994-10-07
EP0629617B2 (en) 2007-09-26
JPH0789922A (ja) 1995-04-04
KR100346795B1 (ko) 2002-11-29
ATE165598T1 (de) 1998-05-15
NO942231L (no) 1994-12-16
NO942231D0 (no) 1994-06-14
JP3835831B2 (ja) 2006-10-18
US5665329A (en) 1997-09-09
FI942795A0 (fi) 1994-06-13
EP0629617B1 (en) 1998-04-29
US5608110A (en) 1997-03-04
US5627286A (en) 1997-05-06

Similar Documents

Publication Publication Date Title
NO305078B1 (no) Heteroatomholdige ligander og metallkomplekser av disse, anvendelse av kompleksene og sett for fremstilling av dem
ATE84537T1 (de) Neue titankatalysatoren.
NZ330023A (en) Fused pyrrolecarboxanilides and their use as a GABA brain receptor ligands
IL128425A0 (en) Taxane derivatives their preparation and pharmaceutical compositions containing them
DK0587555T3 (da) Biofunktionel ligand af DTPA-type
ATE182148T1 (de) Neue deazapurinderivate; eine neue klasse von crf1-spezifischen liganden
DE68908273D1 (de) Metal radionukleid-chelatverbindungen mit verbesserter chelatierungskinetik.
FI960849A0 (fi) Metallikomplekseja sisältäviä farmaseuttisia koostumuksia
DE68916345D1 (de) Thermit-Überzug.
ATE248859T1 (de) Metallion-ligand koordinationskomplexe, antikorper dagegen und tests die solche antikorper verwenden
DE69112015D1 (de) Schutzgasgemisch zum Schweissen von Superlegierungen.
FI941728A0 (fi) Menetelmä sellaisten siirtymämetallikompleksien valmistamiseksi, joissa on monosubstituoituja syklopentadienyyligandeja
DE69122282D1 (de) Komplexe und Chelate des Azithromycins als Antiulcus-Mittel
NO895236L (no) Fremgangsmaate for fremstilling av isotiocyanato-funksjonaliserte metall-komplekser.
DK0596586T3 (da) Fremgangsmåde til fremstilling af metalkomplekser af N-beta-hydroxyalkyl-tri-N-carboxyalkyl-1,4,7,10-tetraazacyklododecan- og N-beta-hydroxyalkyl-tri-N-carboxyalkyl-1,4,8,11-tetraazacyklotetradecan-derivater.
DE58908552D1 (de) Übergangsmetallkomplexe.
ES2143515T3 (es) Combinaciones ciclicas del fosforo trivalente.
DE69100396D1 (de) Metalldichtring.
ATE161899T1 (de) Komplexverbindungen mit oligomerem bis polymerem charakter
FR2704120B1 (fr) Fermoir dépliant pour bracelet.
FR2706023B1 (fr) Programmeur analogique amélioré pour fours.
DE69117741D1 (de) Neue vorangeordnete sechszähnige liganden verwendbar in röntgenologischen bildformenden wirkstoffen
FR2708876B1 (fr) Machine de nettoyage-rinçage-séchage de pièces industrielles.
EP0792170A4 (en) METAL CHELATES OF RADIONUCLIDES USED FOR RADIOTARKING LIGANDS, ANTI-LIGANDS AND OTHER PROTEINS
DE3575560D1 (de) Neue isoindolinverbindungen, deren metallkomplexe und deren verwendung.

Legal Events

Date Code Title Description
MM1K Lapsed by not paying the annual fees