DE69326163D1 - Verfahren zur herstellung von arzneiformen und kontrollierte freigabe und die soerhaltenen arzneiformen - Google Patents

Verfahren zur herstellung von arzneiformen und kontrollierte freigabe und die soerhaltenen arzneiformen

Info

Publication number
DE69326163D1
DE69326163D1 DE69326163T DE69326163T DE69326163D1 DE 69326163 D1 DE69326163 D1 DE 69326163D1 DE 69326163 T DE69326163 T DE 69326163T DE 69326163 T DE69326163 T DE 69326163T DE 69326163 D1 DE69326163 D1 DE 69326163D1
Authority
DE
Germany
Prior art keywords
pct
medicinal forms
controlled release
excipients
sec
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69326163T
Other languages
English (en)
Other versions
DE69326163T2 (de
Inventor
Giuseppe Motta
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
IMA Industria Macchine Automatiche SpA
Original Assignee
Saitec SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IT92BO455 external-priority patent/IT1260242B/it
Priority claimed from ITBO930294A external-priority patent/IT1263445B/it
Priority claimed from IT93BO000460A external-priority patent/IT1268454B1/it
Application filed by Saitec SRL filed Critical Saitec SRL
Application granted granted Critical
Publication of DE69326163D1 publication Critical patent/DE69326163D1/de
Publication of DE69326163T2 publication Critical patent/DE69326163T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE69326163T 1992-12-23 1993-12-23 Verfahren zur herstellung von arzneiformen und kontrollierte freigabe und die soerhaltenen arzneiformen Expired - Lifetime DE69326163T2 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
IT92BO455 IT1260242B (it) 1992-12-23 1992-12-23 Procedimento per preparare forme farmaceutiche a rilascio controllato ritardato del principio attivo e le forme farmaceutiche cosi' ottenute.
ITBO930294A IT1263445B (it) 1993-06-24 1993-06-24 Procedimento per preparare forme farmaceutiche a rilascio controllato/ritardato del principio attivo e le forme farmaceutiche cosi' ottenute
IT93BO000460A IT1268454B1 (it) 1993-11-12 1993-11-12 Procedimento per preparare forme farmaceutiche a rilascio controllato del principio attivo e le forme farmaceutiche cosi' ottenute.
PCT/IT1993/000136 WO1994014421A2 (en) 1992-12-23 1993-12-23 Process for preparing controlled release pharmaceutical forms and the forms thus obtained

Publications (2)

Publication Number Publication Date
DE69326163D1 true DE69326163D1 (de) 1999-09-30
DE69326163T2 DE69326163T2 (de) 2000-05-04

Family

ID=27273889

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69326163T Expired - Lifetime DE69326163T2 (de) 1992-12-23 1993-12-23 Verfahren zur herstellung von arzneiformen und kontrollierte freigabe und die soerhaltenen arzneiformen

Country Status (14)

Country Link
US (1) US5662935A (de)
EP (1) EP0675710B1 (de)
JP (1) JP3459421B2 (de)
KR (1) KR100297541B1 (de)
AT (1) ATE183641T1 (de)
AU (1) AU683044B2 (de)
BR (1) BR9307736A (de)
CA (1) CA2151396C (de)
DE (1) DE69326163T2 (de)
DK (1) DK0675710T3 (de)
ES (1) ES2138070T3 (de)
GR (1) GR3031936T3 (de)
RU (1) RU2128499C1 (de)
WO (1) WO1994014421A2 (de)

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5821237A (en) * 1995-06-07 1998-10-13 The Procter & Gamble Company Compositions for visually improving skin
TW487582B (en) * 1995-08-11 2002-05-21 Nissan Chemical Ind Ltd Method for converting sparingly water-soluble medical substance to amorphous state
FR2757397B1 (fr) * 1996-12-23 1999-03-05 Mazal Pharma Composition pharmaceutique a base de rheine ou de diacerheine a biodisponibilite amelioree
US6046177A (en) * 1997-05-05 2000-04-04 Cydex, Inc. Sulfoalkyl ether cyclodextrin based controlled release solid pharmaceutical formulations
IT1292588B1 (it) * 1997-05-28 1999-02-08 Saitec Srl Procedimento per preparare forme alimentari ad elevata resa di sapore e le forme alimentari cosi' ottenute.
US6555139B2 (en) 1999-06-28 2003-04-29 Wockhardt Europe Limited Preparation of micron-size pharmaceutical particles by microfluidization
FR2806307B1 (fr) * 2000-03-20 2002-11-15 Mane Fils V Preparation parfumee solide sous forme de microbilles et utilisation de ladite preparation
US7201891B1 (en) * 2000-05-19 2007-04-10 Otsuka Pharmaceutical Co., Ltd. Pharmaceutical preparation for the diagnosis of helicobacter pylori infection
SG98393A1 (en) 2000-05-19 2003-09-19 Inst Materials Research & Eng Injectable drug delivery systems with cyclodextrin-polymer based hydrogels
US20030099703A1 (en) * 2000-08-11 2003-05-29 Shigeru Aoki Drug-containing solid dispersion having improved solubility
BR0102252B1 (pt) * 2001-04-10 2013-10-22 Sistema de liberação controlada para antagonista do receptor AT1 da angiotensina II, composição farmacêutica e seu uso
ITBO20020094A1 (it) 2002-02-22 2003-08-22 Tecnea Engineering S R L Procedimento per la realizzazione di composizioni ed apparecchiatura realizzante tale procedimento
JP2005298338A (ja) * 2002-02-27 2005-10-27 Eisai Co Ltd 速崩壊性圧縮成形製剤
US7776314B2 (en) 2002-06-17 2010-08-17 Grunenthal Gmbh Abuse-proofed dosage system
DE10315640A1 (de) * 2003-04-04 2004-10-14 Ignatov, Konstantin Verfahren zur kontrollierten Freisetzung von Komponenten in eine Lösung
US20070048228A1 (en) 2003-08-06 2007-03-01 Elisabeth Arkenau-Maric Abuse-proofed dosage form
DE10361596A1 (de) 2003-12-24 2005-09-29 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
DE102005005446A1 (de) 2005-02-04 2006-08-10 Grünenthal GmbH Bruchfeste Darreichungsformen mit retardierter Freisetzung
US8075872B2 (en) 2003-08-06 2011-12-13 Gruenenthal Gmbh Abuse-proofed dosage form
DE102004032051A1 (de) 2004-07-01 2006-01-19 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten, festen Darreichungsform
DE10336400A1 (de) 2003-08-06 2005-03-24 Grünenthal GmbH Gegen Missbrauch gesicherte Darreichungsform
WO2005049306A1 (en) * 2003-11-18 2005-06-02 Eurand Pharmaceuticals Limited Ultrasound-assisted compaction process with a compaction device made of coupled plastic-metal materials
DE102004032049A1 (de) 2004-07-01 2006-01-19 Grünenthal GmbH Gegen Missbrauch gesicherte, orale Darreichungsform
DE102005005449A1 (de) 2005-02-04 2006-08-10 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
DE102005024171A1 (de) * 2005-03-22 2006-09-28 Grünenthal GmbH Verfahren und Vorrichtung zur Ultraschallverpressung einer Tablette oder einer multipartikulären Arzneiform
DE102007011485A1 (de) 2007-03-07 2008-09-11 Grünenthal GmbH Darreichungsform mit erschwertem Missbrauch
WO2008109723A1 (en) * 2007-03-08 2008-09-12 Smithkline Beecham Corporation Pharmaceutical analysis apparatus and method
RU2351352C2 (ru) * 2007-04-09 2009-04-10 Закрытое акционерное общество "Санкт-Петербургский институт фармации" Твердая нанокомпозиция для доставки биологически активных веществ
US8383152B2 (en) 2008-01-25 2013-02-26 Gruenenthal Gmbh Pharmaceutical dosage form
SI2273983T1 (sl) 2008-05-09 2016-11-30 Gruenenthal Gmbh Postopek za pripravo intermediatne praškaste formulacije in končne trdne odmerne oblike z uporabo stopnje strjevanja z razprševanjem
TWI473610B (zh) * 2008-10-28 2015-02-21 Twi Biotechnology Inc 包含雙醋瑞因（ｄｉａｃｅｒｅｉｎ）之醫藥組合物
TW201105316A (en) 2009-07-22 2011-02-16 Gruenenthal Gmbh Hot-melt extruded pharmaceutical dosage form
AU2010275755B2 (en) 2009-07-22 2014-04-24 Grünenthal GmbH Oxidation-stabilized tamper-resistant dosage form
MX2013002377A (es) 2010-09-02 2013-04-29 Gruenenthal Gmbh Forma de dosificacion resistente a manipulacion que comprende una sal inorganica.
CN103179954A (zh) 2010-09-02 2013-06-26 格吕伦塔尔有限公司 包含阴离子聚合物的抗破碎剂型
US10201502B2 (en) 2011-07-29 2019-02-12 Gruenenthal Gmbh Tamper-resistant tablet providing immediate drug release
RS56527B1 (sr) 2011-07-29 2018-02-28 Gruenenthal Gmbh Tableta za trenutno oslobađanje leka rezistentna na zloupotrebu
MX356421B (es) 2012-02-28 2018-05-29 Gruenenthal Gmbh Forma de dosificacion resistente a la manipulacion indebida que comprende un compuesto farmacologicamente activo y un polimero anionico.
EA201401139A1 (ru) 2012-04-18 2015-03-31 Грюненталь Гмбх Устойчивая к разрушению и к сбросу дозы фармацевтическая лекарственная форма
US10064945B2 (en) 2012-05-11 2018-09-04 Gruenenthal Gmbh Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc
BR112015026549A2 (pt) 2013-05-29 2017-07-25 Gruenenthal Gmbh forma de dosagem à prova de violação contendo uma ou mais partículas
CA2913209A1 (en) 2013-05-29 2014-12-04 Grunenthal Gmbh Tamper resistant dosage form with bimodal release profile
CA2917136C (en) 2013-07-12 2022-05-31 Grunenthal Gmbh Tamper-resistant dosage form containing ethylene-vinyl acetate polymer
CN105555847B (zh) 2013-09-19 2018-08-10 微仙美国有限公司 聚合物膜
CN110279885B (zh) 2013-09-19 2022-07-26 泰尔茂株式会社 聚合物颗粒
CN105916495B (zh) 2013-11-08 2019-11-12 泰尔茂株式会社 聚合物颗粒
WO2015078891A1 (en) 2013-11-26 2015-06-04 Farmaceutici Formenti S.P.A. Preparation of a powdery pharmaceutical composition by means of cryo-milling
WO2015173195A1 (en) 2014-05-12 2015-11-19 Grünenthal GmbH Tamper resistant immediate release capsule formulation comprising tapentadol
MX2016015417A (es) 2014-05-26 2017-02-22 Gruenenthal Gmbh Multiparticulas protegidas contra vertido de dosis etanolico.
WO2016154592A1 (en) 2015-03-26 2016-09-29 Microvention, Inc. Embiolic particles
EP3285745A1 (de) 2015-04-24 2018-02-28 Grünenthal GmbH Manipulationssichere darreichungsform mit sofortiger freisetzung und widerstand gegen lösungsmittelextraktion
JP2018526414A (ja) 2015-09-10 2018-09-13 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング 乱用抑止性の即放性製剤を用いた経口過剰摂取に対する保護
AU2017336786B2 (en) 2016-09-28 2020-04-09 Terumo Corporation Polymer particles

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2828206A (en) * 1954-02-24 1958-03-25 Roseuberg Adolf Stabilized fat-soluble vitamins and methods of making same
US3078216A (en) * 1961-04-11 1963-02-19 American Cyanamid Co Prolonged release oral pharmaceutical preparations
US3137630A (en) * 1961-06-09 1964-06-16 Eastman Kodak Co Process for preparing a dry, finely divided, gelatin particle product
US3146167A (en) * 1961-10-05 1964-08-25 Smith Kline French Lab Method of preparing sustained release pellets and products thereof
BR6457270D0 (pt) * 1963-03-04 1973-09-20 Merck & Co Inc Processo de preparacao de uma composicao farmaceutica provendo uma liberacao prolongada de uma droga no aparelho gastro intestinal
US3432593A (en) * 1963-09-18 1969-03-11 Key Pharm Inc Delayed and sustained release type pharmaceutical preparation
US3492397A (en) * 1967-04-07 1970-01-27 Warner Lambert Pharmaceutical Sustained release dosage in the pellet form and process thereof
US3922339A (en) * 1974-06-20 1975-11-25 Kv Pharm Co Sustained release medicant
SE418247B (sv) * 1975-11-17 1981-05-18 Haessle Ab Sett att framstella kroppar med reglerad frigoring av en aktiv komponent
DE2904310A1 (de) * 1979-02-05 1980-08-07 Boehringer Mannheim Gmbh Formlinge mit retardierter wirkstofffreisetzung und verfahren zu deren herstellung
DK150008C (da) * 1981-11-20 1987-05-25 Benzon As Alfred Fremgangsmaade til fremstilling af et farmaceutisk oralt polydepotpraeparat
JPS58172311A (ja) * 1982-04-02 1983-10-11 Kodama Kk 持続性製剤及びその製法
DK151608C (da) * 1982-08-13 1988-06-20 Benzon As Alfred Fremgangsmaade til fremstilling af et farmaceutisk peroralt polydepotpraeparat med kontrolleret afgivelse
PH18946A (en) * 1983-04-21 1985-11-14 Elan Corp Plc Controlled absorption pharmaceutical composition
JPS6094403A (ja) * 1983-10-27 1985-05-27 Nippon Sangaria Bebaretsuji Co:Kk 超音波を利用した粉末製剤の製造方法
US4779806A (en) * 1984-07-23 1988-10-25 Massachusetts Institute Of Technology Ultrasonically modulated polymeric devices for delivering compositions
US4657543A (en) * 1984-07-23 1987-04-14 Massachusetts Institute Of Technology Ultrasonically modulated polymeric devices for delivering compositions
JPS649932A (en) * 1987-07-01 1989-01-13 Toyo Capsel Kk Soft capsule preparation using newly combined component as the base
ES2073507T3 (es) * 1989-04-12 1995-08-16 Procter & Gamble Composiciones de productos solidos de consumo que contienen complejos con ciclodextrina en forma de pequeñas particulas.
JP2958103B2 (ja) * 1989-12-12 1999-10-06 エーザイ株式会社 プラズマ照射固形製剤
JPH03287544A (ja) * 1990-04-05 1991-12-18 Biomaterial Universe Kk 生体分解吸収性高分子材料を用いた徐放性薬剤
FR2664851B1 (fr) * 1990-07-20 1992-10-16 Oreal Procede de compactage d'un melange pulverulent permettant d'obtenir un produit compact absorbant ou partiellement delitable et produit obtenu par ce procede.
DE4031881C2 (de) * 1990-10-08 1994-02-24 Sanol Arznei Schwarz Gmbh Lösungsmittelfreie, oral zu verabreichende pharmazeutische Zubereitung mit verzögerter Wirkstoffreisetzung und Verfahren zu deren Herstellung

Also Published As

Publication number Publication date
DK0675710T3 (da) 2000-03-27
CA2151396A1 (en) 1994-07-07
DE69326163T2 (de) 2000-05-04
US5662935A (en) 1997-09-02
ES2138070T3 (es) 2000-01-01
EP0675710B1 (de) 1999-08-25
GR3031936T3 (en) 2000-03-31
ATE183641T1 (de) 1999-09-15
AU683044B2 (en) 1997-10-30
EP0675710A1 (de) 1995-10-11
KR100297541B1 (ko) 2001-11-26
WO1994014421A3 (en) 1994-08-18
CA2151396C (en) 2006-08-22
JPH08504807A (ja) 1996-05-28
AU6043494A (en) 1994-07-19
BR9307736A (pt) 1999-08-31
WO1994014421A2 (en) 1994-07-07
RU2128499C1 (ru) 1999-04-10
JP3459421B2 (ja) 2003-10-20
KR960700043A (ko) 1996-01-19

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: I.M.A. INDUSTRIA MACCHINE AUTOMATICHE S.P.A., , IT