DE69232535T4 - In langzeitkultur gehaltene hormon-absondernde pankreatische zellen - Google Patents

In langzeitkultur gehaltene hormon-absondernde pankreatische zellen

Info

Publication number
DE69232535T4
DE69232535T4 DE69232535T DE69232535T DE69232535T4 DE 69232535 T4 DE69232535 T4 DE 69232535T4 DE 69232535 T DE69232535 T DE 69232535T DE 69232535 T DE69232535 T DE 69232535T DE 69232535 T4 DE69232535 T4 DE 69232535T4
Authority
DE
Germany
Prior art keywords
cells
hormone
secretion
insulin
respond
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69232535T
Other languages
English (en)
Other versions
DE69232535D1 (de
DE69232535T2 (de
Inventor
Janice Brothers
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
HCELL TECHNOLOGY Inc
Original Assignee
HCELL TECHNOLOGY Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by HCELL TECHNOLOGY Inc filed Critical HCELL TECHNOLOGY Inc
Application granted granted Critical
Publication of DE69232535T2 publication Critical patent/DE69232535T2/de
Publication of DE69232535T4 publication Critical patent/DE69232535T4/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0681—Cells of the genital tract; Non-germinal cells from gonads
    • C12N5/0682—Cells of the female genital tract, e.g. endometrium; Non-germinal cells from ovaries, e.g. ovarian follicle cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0603—Embryonic cells ; Embryoid bodies
    • C12N5/0605—Cells from extra-embryonic tissues, e.g. placenta, amnion, yolk sac, Wharton's jelly
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0613—Cells from endocrine organs
    • C12N5/0617—Thyroid and parathyroid glands
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0676—Pancreatic cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/32—Amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/32—Amino acids
    • C12N2500/33—Amino acids other than alpha-amino carboxylic acids, e.g. beta-amino acids, taurine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/34—Sugars
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/36—Lipids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/38—Vitamins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30—Hormones
    • C12N2501/31—Pituitary sex hormones, e.g. follicle-stimulating hormone [FSH], luteinising hormone [LH]; Chorionic gonadotropins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2503/00—Use of cells in diagnostics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
DE69232535T 1991-06-24 1992-06-23 In langzeitkultur gehaltene hormon-absondernde pankreatische zellen Expired - Lifetime DE69232535T4 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US71997791A 1991-06-24 1991-06-24
PCT/US1992/005267 WO1993000441A1 (en) 1991-06-24 1992-06-23 Hormone-secreting cells maintained in long-term culture

Publications (2)

Publication Number Publication Date
DE69232535T2 DE69232535T2 (de) 2003-01-09
DE69232535T4 true DE69232535T4 (de) 2003-09-11

Family

ID=24892163

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69232535T Expired - Lifetime DE69232535T4 (de) 1991-06-24 1992-06-23 In langzeitkultur gehaltene hormon-absondernde pankreatische zellen
DE69232535A Expired - Fee Related DE69232535D1 (de) 1991-06-24 1992-06-23 In langzeitkultur gehaltene hormon-absondernde pankreatische zellen

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE69232535A Expired - Fee Related DE69232535D1 (de) 1991-06-24 1992-06-23 In langzeitkultur gehaltene hormon-absondernde pankreatische zellen

Country Status (10)

Country Link
US (2) US5928942A (de)
EP (1) EP0605428B9 (de)
JP (1) JPH06508527A (de)
AT (1) ATE215605T1 (de)
AU (2) AU2228592A (de)
CA (1) CA2112112A1 (de)
DE (2) DE69232535T4 (de)
DK (1) DK0605428T5 (de)
ES (1) ES2179821T3 (de)
WO (1) WO1993000441A1 (de)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6352707B1 (en) 1992-02-24 2002-03-05 Anton-Lewis Usala Transplant encapsulation in a hydrogel matrix to obscure immune recognition
US6231881B1 (en) 1992-02-24 2001-05-15 Anton-Lewis Usala Medium and matrix for long-term proliferation of cells
US6008047A (en) * 1993-04-08 1999-12-28 Livercell L.L.C. Cell culturing method and medium
AU687386B2 (en) * 1993-04-08 1998-02-26 Human Cell Cultures, Inc. Cell culturing method and medium
US5534404A (en) * 1993-12-10 1996-07-09 Cytotherapeutics, Inc. Glucose responsive insulin secreting β-cell lines and method for producing same
US6001647A (en) * 1994-04-28 1999-12-14 Ixion Biotechnology, Inc. In vitro growth of functional islets of Langerhans and in vivo uses thereof
US5834308A (en) * 1994-04-28 1998-11-10 University Of Florida Research Foundation, Inc. In vitro growth of functional islets of Langerhans
US6703017B1 (en) 1994-04-28 2004-03-09 Ixion Biotechnology, Inc. Reversal of insulin-dependent diabetes by islet-producing stem cells, islet progenitor cells and islet-like structures
US6485723B1 (en) 1995-02-10 2002-11-26 Purdue Research Foundation Enhanced submucosal tissue graft constructs
US5695998A (en) * 1995-02-10 1997-12-09 Purdue Research Foundation Submucosa as a growth substrate for islet cells
CA2235509A1 (en) * 1995-10-25 1997-05-01 Ammon B. Peck In vitro growth of functional islets of langerhans and in vivo uses thereof
US6043092A (en) * 1996-03-18 2000-03-28 University Of Pittsburgh Cell culture media for mammalian cells
FR2757371B1 (fr) * 1996-12-20 1999-03-26 Mxm Dispositif elastique a grande capacite d'allongement pour l'extension de tissu vivant
AU4899397A (en) 1997-02-06 1998-08-26 Genetics Institute, Llc Human sdf-5 protein and compositions
US6165748A (en) 1997-07-11 2000-12-26 Genetics Institute, Inc. Frazzled nucleotide sequences and expression products
US6074874A (en) * 1997-08-29 2000-06-13 University Of Pittsburgh Epithelial cell cultures for in vitro testing
US6667176B1 (en) 2000-01-11 2003-12-23 Geron Corporation cDNA libraries reflecting gene expression during growth and differentiation of human pluripotent stem cells
US6866843B2 (en) * 1999-12-06 2005-03-15 Viacell, Inc. Method of transplanting in a mammal and treating diabetes mellitus by administering a pseudo-islet like aggregate differentiated from a nestin-positive pancreatic stem cell
US20050042749A1 (en) 2001-05-16 2005-02-24 Carpenter Melissa K. Dopaminergic neurons and proliferation-competent precursor cells for treating Parkinson's disease
JP5943533B2 (ja) 2000-05-17 2016-07-06 アステリアス バイオセラピューティクス インコーポレイテッド 神経前駆細胞の集団
US6759039B2 (en) * 2000-06-30 2004-07-06 Amcyte, Inc. Culturing pancreatic stem cells having a specified, intermediate stage of development
JP2004502425A (ja) * 2000-06-30 2004-01-29 アムサイト，　インコーポレイテッド 指定された中間発生段階を有する膵臓幹細胞の培養
US6468989B1 (en) * 2000-07-13 2002-10-22 Dow Pharmaceutical Sciences Gel compositions containing metronidazole
JP2004526449A (ja) 2001-03-29 2004-09-02 イクシオン・バイオテクノロジー・インコーポレーテッド 非膵性幹細胞の膵分化経路への分化転換法
US6642003B2 (en) 2001-08-02 2003-11-04 Cedars-Sinai Medical Center Human glucose-dependent insulin-secreting cell line
KR101089591B1 (ko) * 2001-12-07 2011-12-05 제론 코포레이션 인간 배아 줄기세포 유래의 섬세포
US7101546B2 (en) * 2001-12-21 2006-09-05 Amcyte, Inc. In situ maturation of cultured pancreatic stem cells having a specified, intermediate stage of development
US6881726B2 (en) * 2001-12-24 2005-04-19 Dow Pharmaceutical Sciences Aqueous compositions containing metronidazole
US7141240B2 (en) * 2002-03-12 2006-11-28 Cedars-Sinai Medical Center Glucose-dependent insulin-secreting cells transfected with a nucleotide sequence encoding GLP-1
WO2005002601A1 (en) 2003-06-25 2005-01-13 Badylak Stephen F Conditioned matrix compositions for tissue restoration
EP1752146A4 (de) * 2004-05-19 2007-10-10 Ajinomoto Kk Therapeutisches mittel gegen diabetes
CN100446051C (zh) * 2006-05-19 2008-12-24 刘芳 一种胚胎体外着床模型的建立方法及其用途
WO2007149182A2 (en) 2006-06-19 2007-12-27 Geron Corporation Differentiation and enrichment of islet-like cells from human pluripotent stem cells
US8298586B2 (en) 2009-07-22 2012-10-30 Acell Inc Variable density tissue graft composition
US8652500B2 (en) 2009-07-22 2014-02-18 Acell, Inc. Particulate tissue graft with components of differing density and methods of making and using the same
BR112012009828B8 (pt) 2009-10-26 2022-10-25 Hoffmann La Roche Método para a produção de uma imunoglobulina glicosilada e seu uso
US9878071B2 (en) 2013-10-16 2018-01-30 Purdue Research Foundation Collagen compositions and methods of use
US11919941B2 (en) 2015-04-21 2024-03-05 Purdue Research Foundation Cell-collagen-silica composites and methods of making and using the same
WO2016171543A1 (en) * 2015-04-22 2016-10-27 Cadens Beheer B.V. Improved contraceptive methods and compositions and devices for use therein
CN106701659A (zh) * 2016-10-31 2017-05-24 四川农业大学 一种猪卵巢颗粒细胞原代培养的方法
US10767164B2 (en) 2017-03-30 2020-09-08 The Research Foundation For The State University Of New York Microenvironments for self-assembly of islet organoids from stem cells differentiation
US11739291B2 (en) 2017-04-25 2023-08-29 Purdue Research Foundation 3-dimensional (3D) tissue-engineered muscle for tissue restoration
CN112048540B (zh) * 2020-09-14 2022-10-11 北京大学 胰岛内源胰岛素分泌的检测方法及应用
CN113398251B (zh) * 2021-07-30 2022-08-05 宁波人健药业集团股份有限公司 一种重组人绒毛膜***冻干粉针剂及其制备方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3882233A (en) * 1973-07-27 1975-05-06 American Home Prod Methods of increasing production of pituitary hormones
US4288546A (en) * 1976-04-09 1981-09-08 The Regents Of The University Of Minnesota Process for the large scale production of pituitary hormones by serial secondary suspension culture
US4439521A (en) * 1981-10-21 1984-03-27 Ontario Cancer Institute Method for producing self-reproducing mammalian pancreatic islet-like structures
US4657866A (en) * 1982-12-21 1987-04-14 Sudhir Kumar Serum-free, synthetic, completely chemically defined tissue culture media
DK402984D0 (da) * 1984-08-23 1984-08-23 Nordisk Insulinlab Fremgangsmaade til formering af insulin-producerende celler
WO1987005929A1 (en) * 1986-04-01 1987-10-08 Genelabs Incorporated Immortalized cells which produce tissue-specific products
EP0283942B1 (de) * 1987-03-24 1992-05-20 W.R. Grace & Co.-Conn. Basisnährmedium für eine Zellkultur
US4929542A (en) * 1987-10-30 1990-05-29 Cornell Research Foundation, Inc. In vitro screening test for mutagenicity and genotoxicity during spermatogenesis
US4980281A (en) * 1988-02-10 1990-12-25 Housey Gerard M Method of screening for protein inhibitors and activators
EP0363125A3 (de) * 1988-10-03 1990-08-16 Hana Biologics Inc. Produkt, enthaltend vermehrungsfähige Bauchspeicheldrüsen-Endokrinezellen, und Verfahren
US4983515A (en) * 1989-02-16 1991-01-08 E. I. Du Pont De Nemours And Company Labeled cryopreserved cells for use as targets in cytotoxicity assays
US4983527A (en) * 1989-05-26 1991-01-08 Arizona Board Of Regents Oocyte test for detection of tumor promoting compounds
US5328844A (en) * 1990-05-09 1994-07-12 University Of Colorado Foundation, Inc. Culture media for mammalian cells
AU687386B2 (en) * 1993-04-08 1998-02-26 Human Cell Cultures, Inc. Cell culturing method and medium
US5534404A (en) * 1993-12-10 1996-07-09 Cytotherapeutics, Inc. Glucose responsive insulin secreting β-cell lines and method for producing same

Also Published As

Publication number Publication date
WO1993000441A1 (en) 1993-01-07
EP0605428A4 (de) 1995-01-11
AU7036596A (en) 1997-02-20
EP0605428B9 (de) 2003-01-02
EP0605428B1 (de) 2002-04-03
DE69232535D1 (de) 2002-05-08
ES2179821T3 (es) 2003-02-01
AU700946B2 (en) 1999-01-14
DK0605428T5 (da) 2003-01-06
ATE215605T1 (de) 2002-04-15
JPH06508527A (ja) 1994-09-29
DK0605428T3 (da) 2002-07-29
DE69232535T2 (de) 2003-01-09
AU2228592A (en) 1993-01-25
US6372493B1 (en) 2002-04-16
US5928942A (en) 1999-07-27
CA2112112A1 (en) 1993-01-07
EP0605428A1 (de) 1994-07-13

Similar Documents

Publication Publication Date Title
DE69232535T2 (de) In langzeitkultur gehaltene hormon-absondernde pankreatische zellen
Herbert Localization of antisera to LHβ and FSHβ in the rat pituitary gland
Bister et al. Control of ovarian follicles activity in the ewe
Dozortsev et al. Luteinizing hormone–independent rise of progesterone as the physiological trigger of the ovulatory gonadotropins surge in the human
Roser et al. Superovulation in the mare: a work in progress
Fölsch et al. Effect of somatostatin on basal and stimulated pancreatic secretion in the rat
Hammond et al. Local maintenance of the rabbit corpus luteum with oestrogen
WEICK et al. Localization of the stimulatory feedback effect of estrogen on ovulation in the rat
Van Oordt et al. Seasonal changes in endocrine organs of the male common frog, Rana temporaria: I. The pars distalis of the adenohypophysis
Kuzuya et al. Studies on the mechanism of xylitol-induced insulin secretion in dogs. Effect of its infusion into the pancreatic artery, and the inhibition by epinephrine and diazoxide of xylitol-induced hyperinsulinaemia
Bosu et al. Effect of HCG on plasma levels of estrogens and progesterone during the luteal phase of the menstrual cycle in rhesus monkeys (Macaca mulatta). Stimulation of sex steroid production in rhesus monkeys
Moses et al. Dissociation between the content of vasopressin and neurosecretory material in the rat neurohypophysis
Iyer et al. Delta sleep inducing peptide (DSIP) stimulates the release of LH but not FSH via a hypothalamic site of action in the rat
Rennie Luteal-hypophyseal interrelationship in the rabbit
CHOUDARY et al. Luteolytic effect of oestrogen on the corpora lutea of the cyclic guinea-pig
De Castro et al. Possible negative ultra-short loop feedback of luteinizing hormone releasing hormone (LHRH) in the ovariectomized rat
Lembert et al. Macroencapsulation of rat islets without alteration of insulin secretion kinetics
Gemmell et al. Granule secretion by the luteal cell of the sheep: the fate of the granule membrane
GREENWALD Dissociation of Ovulation and Progesterone Secretion Following LH or FSH Treatment of Hypophysectomized Prbestrous Hamsters
Schatz et al. Hypophysis and function of pancreatic islets. 3. Secretion and biosynthesis of insulin in isolated pancreatic islets of intact and hypophysectomized rats in the presence of growth hormone, corticotrophin and human chorionic somatotrophin in vitro
Sherwood et al. Plasma relaxin levels in pigs with corpora lutea induced during late pregnancy
Kullander Experimental studies in the production of androgen in ovarian tissue autotransplanted to the spleen of spayed rats
Foster Jr et al. On the secretion of corticotrophin by the homotransplanted pituitary gland in the rat
Foglia et al. Evolution of diabetes after early testosterone treatment in rats
Weissenberg et al. Hormonal dependence of the first spermatogenic wave in the mouse