ATE215605T1 - In langzeitkultur gehaltene hormon-absondernde pankreatische zellen - Google Patents
In langzeitkultur gehaltene hormon-absondernde pankreatische zellenInfo
- Publication number
- ATE215605T1 ATE215605T1 AT92914162T AT92914162T ATE215605T1 AT E215605 T1 ATE215605 T1 AT E215605T1 AT 92914162 T AT92914162 T AT 92914162T AT 92914162 T AT92914162 T AT 92914162T AT E215605 T1 ATE215605 T1 AT E215605T1
- Authority
- AT
- Austria
- Prior art keywords
- cells
- hormone
- secretion
- insulin
- respond
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0681—Cells of the genital tract; Non-germinal cells from gonads
- C12N5/0682—Cells of the female genital tract, e.g. endometrium; Non-germinal cells from ovaries, e.g. ovarian follicle cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0603—Embryonic cells ; Embryoid bodies
- C12N5/0605—Cells from extra-embryonic tissues, e.g. placenta, amnion, yolk sac, Wharton's jelly
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0613—Cells from endocrine organs
- C12N5/0617—Thyroid and parathyroid glands
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0676—Pancreatic cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/32—Amino acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/32—Amino acids
- C12N2500/33—Amino acids other than alpha-amino carboxylic acids, e.g. beta-amino acids, taurine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/34—Sugars
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/36—Lipids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/38—Vitamins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/30—Hormones
- C12N2501/31—Pituitary sex hormones, e.g. follicle-stimulating hormone [FSH], luteinising hormone [LH]; Chorionic gonadotropins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2503/00—Use of cells in diagnostics
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US71997791A | 1991-06-24 | 1991-06-24 | |
PCT/US1992/005267 WO1993000441A1 (en) | 1991-06-24 | 1992-06-23 | Hormone-secreting cells maintained in long-term culture |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE215605T1 true ATE215605T1 (de) | 2002-04-15 |
Family
ID=24892163
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT92914162T ATE215605T1 (de) | 1991-06-24 | 1992-06-23 | In langzeitkultur gehaltene hormon-absondernde pankreatische zellen |
Country Status (10)
Country | Link |
---|---|
US (2) | US5928942A (de) |
EP (1) | EP0605428B9 (de) |
JP (1) | JPH06508527A (de) |
AT (1) | ATE215605T1 (de) |
AU (2) | AU2228592A (de) |
CA (1) | CA2112112A1 (de) |
DE (2) | DE69232535T4 (de) |
DK (1) | DK0605428T5 (de) |
ES (1) | ES2179821T3 (de) |
WO (1) | WO1993000441A1 (de) |
Families Citing this family (44)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6231881B1 (en) | 1992-02-24 | 2001-05-15 | Anton-Lewis Usala | Medium and matrix for long-term proliferation of cells |
US6352707B1 (en) | 1992-02-24 | 2002-03-05 | Anton-Lewis Usala | Transplant encapsulation in a hydrogel matrix to obscure immune recognition |
JP2813467B2 (ja) * | 1993-04-08 | 1998-10-22 | ヒューマン・セル・カルチャーズ・インコーポレーテッド | 細胞培養法および培地 |
US6008047A (en) * | 1993-04-08 | 1999-12-28 | Livercell L.L.C. | Cell culturing method and medium |
US5534404A (en) * | 1993-12-10 | 1996-07-09 | Cytotherapeutics, Inc. | Glucose responsive insulin secreting β-cell lines and method for producing same |
US6703017B1 (en) | 1994-04-28 | 2004-03-09 | Ixion Biotechnology, Inc. | Reversal of insulin-dependent diabetes by islet-producing stem cells, islet progenitor cells and islet-like structures |
US5834308A (en) * | 1994-04-28 | 1998-11-10 | University Of Florida Research Foundation, Inc. | In vitro growth of functional islets of Langerhans |
US6001647A (en) * | 1994-04-28 | 1999-12-14 | Ixion Biotechnology, Inc. | In vitro growth of functional islets of Langerhans and in vivo uses thereof |
US5695998A (en) * | 1995-02-10 | 1997-12-09 | Purdue Research Foundation | Submucosa as a growth substrate for islet cells |
US6485723B1 (en) | 1995-02-10 | 2002-11-26 | Purdue Research Foundation | Enhanced submucosal tissue graft constructs |
CA2235509A1 (en) * | 1995-10-25 | 1997-05-01 | Ammon B. Peck | In vitro growth of functional islets of langerhans and in vivo uses thereof |
US6043092A (en) * | 1996-03-18 | 2000-03-28 | University Of Pittsburgh | Cell culture media for mammalian cells |
FR2757371B1 (fr) * | 1996-12-20 | 1999-03-26 | Mxm | Dispositif elastique a grande capacite d'allongement pour l'extension de tissu vivant |
WO1998035043A1 (en) | 1997-02-06 | 1998-08-13 | Genetics Institute, Inc. | Human sdf-5 protein and compositions |
US6165748A (en) | 1997-07-11 | 2000-12-26 | Genetics Institute, Inc. | Frazzled nucleotide sequences and expression products |
US6074874A (en) * | 1997-08-29 | 2000-06-13 | University Of Pittsburgh | Epithelial cell cultures for in vitro testing |
US6667176B1 (en) | 2000-01-11 | 2003-12-23 | Geron Corporation | cDNA libraries reflecting gene expression during growth and differentiation of human pluripotent stem cells |
IL149933A0 (en) * | 1999-12-06 | 2002-11-10 | Gen Hospital Corp | Pancreatic stem cells and their use in transplantation |
US20050042749A1 (en) | 2001-05-16 | 2005-02-24 | Carpenter Melissa K. | Dopaminergic neurons and proliferation-competent precursor cells for treating Parkinson's disease |
US20020009743A1 (en) | 2000-05-17 | 2002-01-24 | Carpenter Melissa K. | Neural progenitor cell populations |
US6759039B2 (en) * | 2000-06-30 | 2004-07-06 | Amcyte, Inc. | Culturing pancreatic stem cells having a specified, intermediate stage of development |
JP2004502425A (ja) * | 2000-06-30 | 2004-01-29 | アムサイト, インコーポレイテッド | 指定された中間発生段階を有する膵臓幹細胞の培養 |
US6468989B1 (en) * | 2000-07-13 | 2002-10-22 | Dow Pharmaceutical Sciences | Gel compositions containing metronidazole |
CA2442177A1 (en) | 2001-03-29 | 2002-10-10 | Ixion Biotechnology, Inc. | Method for transdifferentiation of non-pancreatic stem cells to the pancreatic differentiation pathway |
US6642003B2 (en) | 2001-08-02 | 2003-11-04 | Cedars-Sinai Medical Center | Human glucose-dependent insulin-secreting cell line |
IL162131A0 (en) * | 2001-12-07 | 2005-11-20 | Geron Corp | Islet cells from human embryonic stem cells |
US7101546B2 (en) * | 2001-12-21 | 2006-09-05 | Amcyte, Inc. | In situ maturation of cultured pancreatic stem cells having a specified, intermediate stage of development |
US6881726B2 (en) * | 2001-12-24 | 2005-04-19 | Dow Pharmaceutical Sciences | Aqueous compositions containing metronidazole |
US7141240B2 (en) * | 2002-03-12 | 2006-11-28 | Cedars-Sinai Medical Center | Glucose-dependent insulin-secreting cells transfected with a nucleotide sequence encoding GLP-1 |
CA2530490A1 (en) | 2003-06-25 | 2005-01-13 | Stephen F. Badylak | Conditioned matrix compositions for tissue restoration |
WO2005110394A1 (ja) * | 2004-05-19 | 2005-11-24 | Ajinomoto Co., Inc. | 糖尿病治療薬 |
CN100446051C (zh) * | 2006-05-19 | 2008-12-24 | 刘芳 | 一种胚胎体外着床模型的建立方法及其用途 |
WO2007149182A2 (en) | 2006-06-19 | 2007-12-27 | Geron Corporation | Differentiation and enrichment of islet-like cells from human pluripotent stem cells |
US8298586B2 (en) | 2009-07-22 | 2012-10-30 | Acell Inc | Variable density tissue graft composition |
US8652500B2 (en) | 2009-07-22 | 2014-02-18 | Acell, Inc. | Particulate tissue graft with components of differing density and methods of making and using the same |
KR101436219B1 (ko) | 2009-10-26 | 2014-09-01 | 에프. 호프만-라 로슈 아게 | 글리코실화된 면역글로불린의 제조 방법 |
US9878071B2 (en) | 2013-10-16 | 2018-01-30 | Purdue Research Foundation | Collagen compositions and methods of use |
WO2016172365A1 (en) | 2015-04-21 | 2016-10-27 | Purdue Research Foundation Office Of Technology Commercialization | Cell-collagen-silica composites and methods of making and using the same |
WO2016171543A1 (en) * | 2015-04-22 | 2016-10-27 | Cadens Beheer B.V. | Improved contraceptive methods and compositions and devices for use therein |
CN106701659A (zh) * | 2016-10-31 | 2017-05-24 | 四川农业大学 | 一种猪卵巢颗粒细胞原代培养的方法 |
US10767164B2 (en) | 2017-03-30 | 2020-09-08 | The Research Foundation For The State University Of New York | Microenvironments for self-assembly of islet organoids from stem cells differentiation |
WO2018200750A1 (en) | 2017-04-25 | 2018-11-01 | Purdue Research Foundation | 3-dimensional (3d) tissue-engineered muscle for tissue restoration |
CN112048540B (zh) * | 2020-09-14 | 2022-10-11 | 北京大学 | 胰岛内源胰岛素分泌的检测方法及应用 |
CN113398251B (zh) * | 2021-07-30 | 2022-08-05 | 宁波人健药业集团股份有限公司 | 一种重组人绒毛膜***冻干粉针剂及其制备方法 |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3882233A (en) * | 1973-07-27 | 1975-05-06 | American Home Prod | Methods of increasing production of pituitary hormones |
US4288546A (en) * | 1976-04-09 | 1981-09-08 | The Regents Of The University Of Minnesota | Process for the large scale production of pituitary hormones by serial secondary suspension culture |
US4439521A (en) * | 1981-10-21 | 1984-03-27 | Ontario Cancer Institute | Method for producing self-reproducing mammalian pancreatic islet-like structures |
US4657866A (en) * | 1982-12-21 | 1987-04-14 | Sudhir Kumar | Serum-free, synthetic, completely chemically defined tissue culture media |
DK402984D0 (da) * | 1984-08-23 | 1984-08-23 | Nordisk Insulinlab | Fremgangsmaade til formering af insulin-producerende celler |
AU7281787A (en) * | 1986-04-01 | 1987-10-20 | Genelabs Incorporated | Immortalized cells which produce tissue-specific products |
DE3871206D1 (de) * | 1987-03-24 | 1992-06-25 | Grace W R & Co | Basisnaehrmedium fuer eine zellkultur. |
US4929542A (en) * | 1987-10-30 | 1990-05-29 | Cornell Research Foundation, Inc. | In vitro screening test for mutagenicity and genotoxicity during spermatogenesis |
US4980281A (en) * | 1988-02-10 | 1990-12-25 | Housey Gerard M | Method of screening for protein inhibitors and activators |
EP0363125A3 (de) * | 1988-10-03 | 1990-08-16 | Hana Biologics Inc. | Produkt, enthaltend vermehrungsfähige Bauchspeicheldrüsen-Endokrinezellen, und Verfahren |
US4983515A (en) * | 1989-02-16 | 1991-01-08 | E. I. Du Pont De Nemours And Company | Labeled cryopreserved cells for use as targets in cytotoxicity assays |
US4983527A (en) * | 1989-05-26 | 1991-01-08 | Arizona Board Of Regents | Oocyte test for detection of tumor promoting compounds |
US5328844A (en) * | 1990-05-09 | 1994-07-12 | University Of Colorado Foundation, Inc. | Culture media for mammalian cells |
JP2813467B2 (ja) * | 1993-04-08 | 1998-10-22 | ヒューマン・セル・カルチャーズ・インコーポレーテッド | 細胞培養法および培地 |
US5534404A (en) * | 1993-12-10 | 1996-07-09 | Cytotherapeutics, Inc. | Glucose responsive insulin secreting β-cell lines and method for producing same |
-
1992
- 1992-06-23 CA CA002112112A patent/CA2112112A1/en not_active Abandoned
- 1992-06-23 DK DK92914162T patent/DK0605428T5/da active
- 1992-06-23 AT AT92914162T patent/ATE215605T1/de not_active IP Right Cessation
- 1992-06-23 AU AU22285/92A patent/AU2228592A/en not_active Abandoned
- 1992-06-23 JP JP5501606A patent/JPH06508527A/ja active Pending
- 1992-06-23 ES ES92914162T patent/ES2179821T3/es not_active Expired - Lifetime
- 1992-06-23 WO PCT/US1992/005267 patent/WO1993000441A1/en active IP Right Grant
- 1992-06-23 EP EP92914162A patent/EP0605428B9/de not_active Expired - Lifetime
- 1992-06-23 DE DE69232535T patent/DE69232535T4/de not_active Expired - Lifetime
- 1992-06-23 DE DE69232535A patent/DE69232535D1/de not_active Expired - Fee Related
-
1995
- 1995-06-07 US US08/475,969 patent/US5928942A/en not_active Expired - Fee Related
-
1996
- 1996-10-23 AU AU70365/96A patent/AU700946B2/en not_active Ceased
-
1999
- 1999-04-28 US US09/301,110 patent/US6372493B1/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
JPH06508527A (ja) | 1994-09-29 |
DK0605428T3 (da) | 2002-07-29 |
US6372493B1 (en) | 2002-04-16 |
DE69232535T4 (de) | 2003-09-11 |
AU700946B2 (en) | 1999-01-14 |
EP0605428A4 (de) | 1995-01-11 |
DK0605428T5 (da) | 2003-01-06 |
DE69232535T2 (de) | 2003-01-09 |
EP0605428B9 (de) | 2003-01-02 |
EP0605428A1 (de) | 1994-07-13 |
DE69232535D1 (de) | 2002-05-08 |
ES2179821T3 (es) | 2003-02-01 |
EP0605428B1 (de) | 2002-04-03 |
CA2112112A1 (en) | 1993-01-07 |
AU7036596A (en) | 1997-02-20 |
US5928942A (en) | 1999-07-27 |
AU2228592A (en) | 1993-01-25 |
WO1993000441A1 (en) | 1993-01-07 |
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Legal Events
Date | Code | Title | Description |
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RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |