DE69231507D1 - Verfahren zur Zubereitung von biologisch aktiven Komponenten enthaltenden Mikrospheren - Google Patents
Verfahren zur Zubereitung von biologisch aktiven Komponenten enthaltenden MikrospherenInfo
- Publication number
- DE69231507D1 DE69231507D1 DE69231507T DE69231507T DE69231507D1 DE 69231507 D1 DE69231507 D1 DE 69231507D1 DE 69231507 T DE69231507 T DE 69231507T DE 69231507 T DE69231507 T DE 69231507T DE 69231507 D1 DE69231507 D1 DE 69231507D1
- Authority
- DE
- Germany
- Prior art keywords
- biologically active
- preparation
- active components
- microspheres containing
- containing biologically
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/185—Nerve growth factor [NGF]; Brain derived neurotrophic factor [BDNF]; Ciliary neurotrophic factor [CNTF]; Glial derived neurotrophic factor [GDNF]; Neurotrophins, e.g. NT-3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/23—Calcitonins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Psychology (AREA)
- Reproductive Health (AREA)
- Diabetes (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Gynecology & Obstetrics (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITPD910102A IT1247472B (it) | 1991-05-31 | 1991-05-31 | Processo per la preparazione di microsfere contenenti componenti biologicamente attivi. |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69231507D1 true DE69231507D1 (de) | 2000-11-23 |
DE69231507T2 DE69231507T2 (de) | 2001-05-03 |
Family
ID=11389598
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69231507T Expired - Lifetime DE69231507T2 (de) | 1991-05-31 | 1992-05-26 | Verfahren zur Zubereitung von biologisch aktiven Komponenten enthaltenden Mikrospheren |
Country Status (9)
Country | Link |
---|---|
US (2) | US6066340A (de) |
EP (2) | EP0517565B1 (de) |
JP (1) | JPH07179363A (de) |
AT (1) | ATE196991T1 (de) |
CA (1) | CA2070095C (de) |
DE (1) | DE69231507T2 (de) |
ES (1) | ES2153355T3 (de) |
GR (1) | GR3034789T3 (de) |
IT (1) | IT1247472B (de) |
Families Citing this family (74)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9221329D0 (en) * | 1992-10-10 | 1992-11-25 | Delta Biotechnology Ltd | Preparation of further diagnostic agents |
IT1263144B (it) * | 1993-02-04 | 1996-08-01 | Lanfranco Callegaro | Composizioni farmaceutiche comprendenti materiale spugnoso costituito da derivati esterei dell'acido ialuronico in associazione con altre sostanze farmacologicamente attive |
JPH0827018A (ja) * | 1994-07-22 | 1996-01-30 | Sanwa Kagaku Kenkyusho Co Ltd | 生理活性ペプチド又は蛋白質を含有する薬剤組成物 |
WO1996029998A1 (en) * | 1995-03-28 | 1996-10-03 | Fidia Advanced Biopolymers S.R.L. | Nanospheres comprising a biocompatible polysaccharide |
US7276251B2 (en) * | 1997-04-01 | 2007-10-02 | Lg Life Sciences, Ltd., Inc. | Sustained-release composition of drugs encapsulated in microparticles of hyaluronic acid |
KR100236771B1 (ko) * | 1997-04-01 | 2000-02-01 | 성재갑 | 히아루론산을 이용한 약물의 서방성 미세입자 제형 |
IT1294797B1 (it) | 1997-07-28 | 1999-04-15 | Fidia Advanced Biopolymers Srl | Uso dei derivati dell'acido ialuronico nella preparazione di biomateriali aventi attivita' emostatica fisica e tamponante |
EP1079801A1 (de) | 1998-05-20 | 2001-03-07 | Highchem Company., Ltd. | Pharmazeutische zusammensetzung zur nasalen verabreichung |
JP4610735B2 (ja) * | 1998-06-01 | 2011-01-12 | ノバルティス バクシンズ アンド ダイアグノスティックス,インコーポレーテッド | ワクチン抗原およびアジュバントの粘膜送達のためのヒアルロン酸ポリマーの使用 |
US6824793B1 (en) | 1998-06-01 | 2004-11-30 | Chiron Corporation | Use of hyaluronic acid polymers for mucosal delivery of vaccine antigens and adjuvants |
ATE481108T1 (de) | 1999-02-26 | 2010-10-15 | Novartis Vaccines & Diagnostic | Verwendung von bioadhaesiven und adjuvantien für die mukosale anwendung von antigenen |
AU5624400A (en) * | 1999-06-18 | 2001-01-09 | Collaborative Group, Ltd., The | Hyaluronic acid film and matrix for sustained gene transfer |
US7582311B1 (en) * | 1999-10-15 | 2009-09-01 | Genentech, Inc. | Injection vehicle for polymer-based formulations |
GB0004827D0 (en) * | 2000-02-29 | 2000-04-19 | Quadrant Holdings Cambridge | Compositions |
US9700866B2 (en) | 2000-12-22 | 2017-07-11 | Baxter International Inc. | Surfactant systems for delivery of organic compounds |
DE10064219B9 (de) * | 2000-12-22 | 2009-02-12 | Nasalis Pain Relief International Gmbh | Neue Fentanyl und/oder dessen Derivate enthaltende pharmazeutische Zusammensetzung zur nasalen Anwendung |
US6869617B2 (en) | 2000-12-22 | 2005-03-22 | Baxter International Inc. | Microprecipitation method for preparing submicron suspensions |
US20050048126A1 (en) | 2000-12-22 | 2005-03-03 | Barrett Rabinow | Formulation to render an antimicrobial drug potent against organisms normally considered to be resistant to the drug |
US8067032B2 (en) | 2000-12-22 | 2011-11-29 | Baxter International Inc. | Method for preparing submicron particles of antineoplastic agents |
EP1249247B1 (de) * | 2001-03-30 | 2007-02-28 | Chisso Corporation | Pharmazeutische Zusammensetzung zur Behandlung gynäkologischer Erkrankungen |
FR2825273B1 (fr) * | 2001-05-29 | 2006-11-24 | Oreal | Composition pour le traitement des signes cutanes du vieillissement |
AU2002337692B2 (en) | 2001-09-26 | 2007-09-13 | Baxter International Inc. | Preparation of submicron sized nanoparticles via dispersion and solvent or liquid phase removal |
US20060003012A9 (en) | 2001-09-26 | 2006-01-05 | Sean Brynjelsen | Preparation of submicron solid particle suspensions by sonication of multiphase systems |
US7276254B2 (en) * | 2002-05-07 | 2007-10-02 | Xerox Corporation | Emulsion/aggregation polymeric microspheres for biomedical applications and methods of making same |
CN1665525A (zh) * | 2002-05-17 | 2005-09-07 | 惠氏公司 | 用于递送骨生成蛋白质的可注入固体透明质酸载体 |
US20040197264A1 (en) * | 2003-04-04 | 2004-10-07 | Alexander Schwarz | Microspheres comprising therapeutic and diagnostic radioactive isotopes |
ES2226567B1 (es) * | 2003-06-20 | 2006-07-01 | Universidad De Santiago De Compostela | Nanoparticulas de acido hialuronico. |
ES2232287B1 (es) * | 2003-07-04 | 2006-11-01 | Advanced In Vitro Cell Technologies, S.L. | Nanoparticulas de derivados polioxietilenados. |
US8124120B2 (en) * | 2003-12-22 | 2012-02-28 | Anika Therapeutics, Inc. | Crosslinked hyaluronic acid compositions for tissue augmentation |
ES2246695B1 (es) * | 2004-04-29 | 2007-05-01 | Instituto Cientifico Y Tecnologico De Navarra, S.A. | Composicion estimuladora de la respuesta inmunitaria que comprende nanoparticulas a base de un copolimero de metil vinil eter y anhidrido maleico. |
ES2246694B1 (es) * | 2004-04-29 | 2007-05-01 | Instituto Cientifico Y Tecnologico De Navarra, S.A. | Nanoparticulas pegiladas. |
DK2314623T3 (da) | 2005-06-21 | 2012-09-17 | Xoma Technology Ltd | Il-1 beta-bindende antistoffer og fragmenter deraf |
RU2554747C9 (ru) | 2006-12-20 | 2015-10-20 | Ксома (Сша) Ллс | Способы лечения il-1бета-зависимых заболеваний |
EP2152304B1 (de) | 2007-05-02 | 2018-08-22 | The Regents of the University of Michigan | Therapeutische zusammensetzungen in nanoemulsionsform und anwendungsverfahren dafür |
US8426467B2 (en) | 2007-05-22 | 2013-04-23 | Baxter International Inc. | Colored esmolol concentrate |
US8722736B2 (en) | 2007-05-22 | 2014-05-13 | Baxter International Inc. | Multi-dose concentrate esmolol with benzyl alcohol |
ES2527326T3 (es) | 2007-12-20 | 2015-01-22 | Xoma (Us) Llc | Métodos para el tratamiento de la gota |
ITMI20080981A1 (it) * | 2008-05-27 | 2009-11-28 | Fidia Advanced Biopolymers Srl | Processo per la preparazione di microsfere di polimeri semi-sintetici |
EP2349209A2 (de) | 2008-09-26 | 2011-08-03 | Nanobio Corporation | Therapeutische zusammensetzungen in nanoemulsionsform und anwendungsverfahren dafür |
WO2010057197A1 (en) | 2008-11-17 | 2010-05-20 | The Regents Of The University Of Michigan | Cancer vaccine compositions and methods of using the same |
CA2765511C (en) | 2009-06-16 | 2015-05-12 | The Regents Of The University Of Michigan | Nanoemulsion vaccines |
US8658603B2 (en) | 2010-06-16 | 2014-02-25 | The Regents Of The University Of Michigan | Compositions and methods for inducing an immune response |
GB201017889D0 (en) * | 2010-10-22 | 2010-12-01 | Univ Dublin | A polymeric nanoparticle |
WO2012092539A2 (en) | 2010-12-31 | 2012-07-05 | Takeda Pharmaceutical Company Limited | Antibodies to dll4 and uses thereof |
WO2013096516A1 (en) | 2011-12-19 | 2013-06-27 | Xoma Technology Ltd. | Methods for treating acne |
US20150011431A1 (en) | 2012-01-09 | 2015-01-08 | The Scripps Research Institute | Humanized antibodies |
AU2013208003B2 (en) | 2012-01-09 | 2017-12-14 | The Scripps Research Institute | Ultralong complementarity determining regions and uses thereof |
JP6373961B2 (ja) | 2013-03-13 | 2018-08-15 | バイオスフィア メディカル,インコーポレイテッド | ラジオアイソトープ結合微粒子の組成物及び結合方法 |
JP6687520B2 (ja) | 2013-07-18 | 2020-04-22 | トーラス バイオサイエンシズ リミテッド ライアビリティ カンパニー | 極めて長い相補性決定領域を有するヒト化抗体 |
US20160168231A1 (en) | 2013-07-18 | 2016-06-16 | Fabrus, Inc. | Antibodies with ultralong complementarity determining regions |
CN105792851B (zh) | 2013-09-13 | 2023-10-10 | 斯克利普斯研究所 | 修饰的治疗剂及其组合物 |
JP6734774B2 (ja) | 2013-10-15 | 2020-08-05 | ザ スクリプス リサーチ インスティテュート | ペプチドキメラ抗原受容体t細胞スイッチおよびその使用 |
US20150238631A1 (en) | 2013-10-15 | 2015-08-27 | The California Institute For Biomedical Research | Chimeric antigen receptor t cell switches and uses thereof |
CA2928700C (en) | 2013-11-01 | 2019-01-15 | University Of Oslo | Albumin variants and uses thereof |
WO2015071763A2 (en) | 2013-11-15 | 2015-05-21 | Oslo Universitetssykehus Hf | Ctl peptide epitopes and antigen-specific t cells, methods for their discovery, and uses thereof |
CN106456589B (zh) | 2013-12-18 | 2020-07-07 | 斯克利普斯研究所 | 修饰的治疗剂、订合的肽脂质缀合物及其组合物 |
JP7158853B2 (ja) | 2014-10-10 | 2022-10-24 | ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン | 対象における食物アレルギーまたは呼吸器アレルギーを処置するための、かつ上記対象の鼻腔内に投与するための免疫原性組成物 |
US10647964B2 (en) | 2015-03-05 | 2020-05-12 | Northwestern University | Non-neuroinvasive viruses and uses thereof |
WO2016154621A1 (en) | 2015-03-26 | 2016-09-29 | The California Institute For Biomedical Research | SWITCHABLE NON-scFv CHIMERIC RECEPTORS, SWITCHES, AND USES THEREOF |
WO2016168773A2 (en) | 2015-04-15 | 2016-10-20 | The California Institute For Biomedical Research | Optimized pne-based chimeric receptor t cell switches and uses thereof |
WO2016205488A1 (en) | 2015-06-17 | 2016-12-22 | The California Institute For Biomedical Research | Modified therapeutic agents and compositions thereof |
WO2016207730A1 (en) | 2015-06-22 | 2016-12-29 | The University Of Oslo | Targeting of vaccine antigen to an intracellular compartment |
CN105663052B (zh) * | 2016-02-05 | 2019-03-15 | 舒泰神(北京)生物制药股份有限公司 | 神经生长因子缓释微球制剂及其制备方法 |
WO2017201390A1 (en) | 2016-05-19 | 2017-11-23 | The Regents Of The University Of Michigan | Novel adjuvant compositions |
KR20230172612A (ko) | 2016-10-19 | 2023-12-22 | 더 스크립스 리서치 인스티튜트 | 인간화된 표적화 모이어티 및/또는 최적화된 키메라 항원 수용체-상호작용 도메인을 갖는 키메라 항원 수용체 효과기 세포 스위치 및 이의 용도 |
WO2018096396A1 (en) | 2016-11-22 | 2018-05-31 | University Of Oslo | Albumin variants and uses thereof |
WO2019048928A1 (en) | 2017-09-07 | 2019-03-14 | University Of Oslo | VACCINE MOLECULES |
EP3678699A1 (de) | 2017-09-07 | 2020-07-15 | University Of Oslo | Impfstoffmoleküle |
MX2022001732A (es) | 2019-08-12 | 2022-05-06 | Purinomia Biotech Inc | Metodos y composiciones para promover y potenciar la respuesta inmunitaria mediada por linfocitos t dirigida a la adcc de las celulas con expresion de cd39. |
EP4048405A2 (de) | 2019-10-24 | 2022-08-31 | Minotaur Therapeutics, Inc. | Chimäre cytokin-modifizierte antikörper und verfahren zu deren verwendung |
KR102296304B1 (ko) | 2020-11-30 | 2021-09-01 | 조광용 | 고팽윤성 히알루론산 비드 겔 제조 방법 |
KR102366394B1 (ko) | 2021-01-05 | 2022-02-23 | 조광용 | 고팽윤성 히알루론산 비드 겔 |
US20240156935A1 (en) | 2021-03-31 | 2024-05-16 | Vib Vzw | Vaccine Compositions for Trypanosomatids |
CA3217865A1 (en) | 2021-04-28 | 2022-11-03 | Minotaur Therapeutics, Inc. | Humanized chimeric bovine antibodies and methods of use |
Family Cites Families (28)
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---|---|---|---|---|
DE2750090A1 (de) * | 1976-11-19 | 1978-06-01 | Sandoz Ag | Neue verabreichungsformen fuer organische verbindungen |
JPS59163313A (ja) * | 1983-03-09 | 1984-09-14 | Teijin Ltd | 経鼻投与用ペプチドホルモン類組成物 |
US4636524A (en) | 1984-12-06 | 1987-01-13 | Biomatrix, Inc. | Cross-linked gels of hyaluronic acid and products containing such gels |
SE8501022L (sv) | 1985-03-01 | 1986-09-02 | Pharmacia Ab | Format alster och forfarande for dess framstellning |
US4851521A (en) | 1985-07-08 | 1989-07-25 | Fidia, S.P.A. | Esters of hyaluronic acid |
WO1987003197A1 (en) * | 1985-11-29 | 1987-06-04 | Fisons Plc | Pharmaceutical composition including sodium cromoglycate |
GB8601100D0 (en) * | 1986-01-17 | 1986-02-19 | Cosmas Damian Ltd | Drug delivery system |
US4946870A (en) * | 1986-06-06 | 1990-08-07 | Union Carbide Chemicals And Plastics Company Inc. | Delivery systems for pharmaceutical or therapeutic actives |
IT1203814B (it) | 1986-06-30 | 1989-02-23 | Fidia Farmaceutici | Esteri dell'acido alginico |
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JPH0725689B2 (ja) * | 1986-10-07 | 1995-03-22 | 中外製薬株式会社 | 顆粒球コロニ−刺激因子を含有する徐放性製剤 |
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US4883666A (en) * | 1987-04-29 | 1989-11-28 | Massachusetts Institute Of Technology | Controlled drug delivery system for treatment of neural disorders |
GB8712176D0 (en) * | 1987-05-22 | 1987-06-24 | Cosmas Damian Ltd | Drug delivery system |
GB8723846D0 (en) * | 1987-10-10 | 1987-11-11 | Danbiosyst Ltd | Bioadhesive microsphere drug delivery system |
JP2670680B2 (ja) | 1988-02-24 | 1997-10-29 | 株式会社ビーエムジー | 生理活性物質含有ポリ乳酸系微小球およびその製造法 |
IT1219587B (it) | 1988-05-13 | 1990-05-18 | Fidia Farmaceutici | Polisaccaridi carbossiilici autoreticolati |
US5073543A (en) * | 1988-07-21 | 1991-12-17 | G. D. Searle & Co. | Controlled release formulations of trophic factors in ganglioside-lipsome vehicle |
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GB2237510B (en) * | 1989-11-04 | 1993-09-15 | Danbiosyst Uk | Small particle drug compositions for nasal administration |
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US5874029A (en) * | 1996-10-09 | 1999-02-23 | The University Of Kansas | Methods for particle micronization and nanonization by recrystallization from organic solutions sprayed into a compressed antisolvent |
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CA2256400A1 (en) * | 1996-05-28 | 1997-12-04 | Brown University Research Foundation | Hyaluronan based biodegradable scaffolds for tissue repair |
-
1991
- 1991-05-31 IT ITPD910102A patent/IT1247472B/it active IP Right Grant
-
1992
- 1992-05-26 ES ES92401433T patent/ES2153355T3/es not_active Expired - Lifetime
- 1992-05-26 DE DE69231507T patent/DE69231507T2/de not_active Expired - Lifetime
- 1992-05-26 EP EP92401433A patent/EP0517565B1/de not_active Expired - Lifetime
- 1992-05-26 EP EP99202579A patent/EP0979648A3/de not_active Withdrawn
- 1992-05-26 AT AT92401433T patent/ATE196991T1/de not_active IP Right Cessation
- 1992-05-29 JP JP4139012A patent/JPH07179363A/ja active Pending
- 1992-05-29 CA CA002070095A patent/CA2070095C/en not_active Expired - Lifetime
-
1993
- 1993-12-20 US US08/169,558 patent/US6066340A/en not_active Expired - Lifetime
-
1999
- 1999-01-13 US US09/231,353 patent/US6039970A/en not_active Expired - Lifetime
-
2000
- 2000-11-08 GR GR20000402482T patent/GR3034789T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
ITPD910102A0 (it) | 1991-05-31 |
EP0517565B1 (de) | 2000-10-18 |
EP0517565A3 (en) | 1992-12-30 |
ES2153355T3 (es) | 2001-03-01 |
IT1247472B (it) | 1994-12-17 |
EP0979648A3 (de) | 2000-10-04 |
EP0979648A2 (de) | 2000-02-16 |
CA2070095A1 (en) | 1992-12-01 |
DE69231507T2 (de) | 2001-05-03 |
JPH07179363A (ja) | 1995-07-18 |
US6066340A (en) | 2000-05-23 |
ATE196991T1 (de) | 2000-11-15 |
GR3034789T3 (en) | 2001-02-28 |
CA2070095C (en) | 2000-04-25 |
US6039970A (en) | 2000-03-21 |
EP0517565A2 (de) | 1992-12-09 |
ITPD910102A1 (it) | 1992-12-01 |
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