DE69017174T2 - Substituierte Oxophtalazinyl-Essigsäuren und deren Analogen. - Google Patents

Substituierte Oxophtalazinyl-Essigsäuren und deren Analogen.

Info

Publication number
DE69017174T2
DE69017174T2 DE69017174T DE69017174T DE69017174T2 DE 69017174 T2 DE69017174 T2 DE 69017174T2 DE 69017174 T DE69017174 T DE 69017174T DE 69017174 T DE69017174 T DE 69017174T DE 69017174 T2 DE69017174 T2 DE 69017174T2
Authority
DE
Germany
Prior art keywords
substituted
acetic acids
analogs
oxophthalazinyl acetic
oxophthalazinyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69017174T
Other languages
English (en)
Other versions
DE69017174D1 (de
Inventor
Banavara Lakshmana Mylari
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Application granted granted Critical
Publication of DE69017174D1 publication Critical patent/DE69017174D1/de
Publication of DE69017174T2 publication Critical patent/DE69017174T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
    • C07D237/30—Phthalazines
    • C07D237/32—Phthalazines with oxygen atoms directly attached to carbon atoms of the nitrogen-containing ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hematology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Chemical And Physical Treatments For Wood And The Like (AREA)
  • Peptides Or Proteins (AREA)
  • Pyrrole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE69017174T 1989-12-15 1990-12-04 Substituierte Oxophtalazinyl-Essigsäuren und deren Analogen. Expired - Fee Related DE69017174T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1989/005637 WO1991009019A1 (en) 1989-12-15 1989-12-15 Substituted oxophthalazinyl acetic acids and analogs thereof

Publications (2)

Publication Number Publication Date
DE69017174D1 DE69017174D1 (de) 1995-03-30
DE69017174T2 true DE69017174T2 (de) 1995-06-14

Family

ID=22215419

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69017174T Expired - Fee Related DE69017174T2 (de) 1989-12-15 1990-12-04 Substituierte Oxophtalazinyl-Essigsäuren und deren Analogen.

Country Status (13)

Country Link
US (1) US5304557A (de)
EP (1) EP0436307B1 (de)
JP (1) JPH0660163B2 (de)
AT (1) ATE118768T1 (de)
CA (1) CA2032231C (de)
DE (1) DE69017174T2 (de)
DK (1) DK0436307T3 (de)
ES (1) ES2068350T3 (de)
FI (1) FI922308A0 (de)
GR (1) GR3015852T3 (de)
IE (1) IE65294B1 (de)
PT (1) PT96175B (de)
WO (1) WO1991009019A1 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2682108B1 (fr) * 1991-10-07 1994-01-07 Lipha Acide 3,4-dihydro-4-oxo-3(prop-2-enyl)-1-phtalazineacetiques et derives, leurs preparations et medicaments les contenant.
IL124236A (en) * 1997-05-05 2003-01-12 Pfizer Pharmaceutical composition for treating or reversing diabetic cardiomyopathy comprising aldose reductase inhibitor
CN1205207C (zh) * 1998-03-31 2005-06-08 药品发现学会公司 取代的吲哚链烷酸
TNSN99224A1 (fr) * 1998-12-01 2005-11-10 Inst For Pharm Discovery Inc Methodes de reduction des niveaux de glucose et triglyceride en serum et pour suppression de l'antigenese utilisant les acides la indolealkanoique
KR20050026002A (ko) * 2002-07-26 2005-03-14 디 인스티튜트스 포 파마슈티컬 디스커버리, 엘엘씨 치환된 인돌알칸산 유도체 및 이를 함유하는 당뇨 합병증치료용 제형
KR100843352B1 (ko) * 2007-01-30 2008-07-03 한국과학기술연구원 세로토닌 수용체 5-ＨＴ2ａ 또는 5-ＨＴ2ｃ의 길항제로활성을 갖는 1,2-다이하이드로-1-옥소프탈라지닐 피페라진화합물 및 이의 제조방법
CN105732640B (zh) 2010-07-16 2019-01-08 纽约市哥伦比亚大学理事会 醛糖还原酶抑制剂及其用途
US8916563B2 (en) * 2010-07-16 2014-12-23 The Trustees Of Columbia University In The City Of New York Aldose reductase inhibitors and uses thereof
MX2018016122A (es) 2016-06-21 2019-08-01 Univ Columbia Inhibidores de aldosa reductasa y metodos de uso.
CN111065392A (zh) 2017-07-28 2020-04-24 应用治疗公司 用于治疗半乳糖血症的组合物和方法
CA3131792C (en) * 2019-02-28 2024-04-16 Cspc Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd. Salt of aldose reductase inhibitor, and preparation method and application thereof
CA3132136A1 (en) 2019-04-01 2020-10-08 Andrew Wasmuth Inhibitors of aldose reductase
KR20230016658A (ko) * 2020-05-28 2023-02-02 얀센 파마슈티카 엔.브이. 화합물

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE47592B1 (en) * 1977-12-29 1984-05-02 Ici Ltd Enzyme inhibitory phthalazin-4-ylacetic acid derivatives, pharmaceutical compositions thereof,and process for their manufacture
DE3003249A1 (de) * 1980-01-30 1981-08-06 Henkel KGaA, 4000 Düsseldorf Mittel zum nachbehandeln gewaschener waesche in einem waeschetrockner
US4904478A (en) * 1983-08-11 1990-02-27 Mission Pharmacal Company Slow-release sodium fluoride tablet and method for treatment of osteoporosis
US4939140A (en) * 1985-11-07 1990-07-03 Pfizer Inc. Heterocyclic oxophthalazinyl acetic acids
DE3684410D1 (de) * 1985-11-07 1992-04-23 Pfizer Heterocyclische oxophthalazinylessigsaeure.
US4868301A (en) * 1987-06-09 1989-09-19 Pfizer Inc. Processes and intermediates for the preparation of oxophthalazinyl acetic acids having benzothiazole or other heterocyclic side chains
JPH0676391B2 (ja) * 1987-06-09 1994-09-28 フアイザー・インコーポレイテツド ベンゾチアゾール等の複素環側鎖を有するオキソフタラジニル酢酸類の製造方法
US4904782A (en) * 1988-02-29 1990-02-27 Pfizer Inc. Process for the production of phthalazineacetic acid ester derivatives and a novel intermediate

Also Published As

Publication number Publication date
JPH03258766A (ja) 1991-11-19
WO1991009019A1 (en) 1991-06-27
FI922308A (fi) 1992-05-21
ATE118768T1 (de) 1995-03-15
CA2032231A1 (en) 1991-06-16
IE904508A1 (en) 1991-06-19
EP0436307B1 (de) 1995-02-22
PT96175A (pt) 1991-09-30
GR3015852T3 (en) 1995-07-31
CA2032231C (en) 1995-08-22
DK0436307T3 (da) 1995-05-08
ES2068350T3 (es) 1995-04-16
FI922308A0 (fi) 1992-05-21
DE69017174D1 (de) 1995-03-30
US5304557A (en) 1994-04-19
EP0436307A1 (de) 1991-07-10
IE65294B1 (en) 1995-10-18
JPH0660163B2 (ja) 1994-08-10
PT96175B (pt) 1998-04-30

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee