US4948882A
(en)
*
|
1983-02-22 |
1990-08-14 |
Syngene, Inc. |
Single-stranded labelled oligonucleotides, reactive monomers and methods of synthesis
|
US5242794A
(en)
*
|
1984-12-13 |
1993-09-07 |
Applied Biosystems, Inc. |
Detection of specific sequences in nucleic acids
|
US6346413B1
(en)
|
1989-06-07 |
2002-02-12 |
Affymetrix, Inc. |
Polymer arrays
|
US6919211B1
(en)
*
|
1989-06-07 |
2005-07-19 |
Affymetrix, Inc. |
Polypeptide arrays
|
US5143854A
(en)
|
1989-06-07 |
1992-09-01 |
Affymax Technologies N.V. |
Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
|
US5800992A
(en)
|
1989-06-07 |
1998-09-01 |
Fodor; Stephen P.A. |
Method of detecting nucleic acids
|
US5925525A
(en)
*
|
1989-06-07 |
1999-07-20 |
Affymetrix, Inc. |
Method of identifying nucleotide differences
|
US5744101A
(en)
*
|
1989-06-07 |
1998-04-28 |
Affymax Technologies N.V. |
Photolabile nucleoside protecting groups
|
US6040138A
(en)
*
|
1995-09-15 |
2000-03-21 |
Affymetrix, Inc. |
Expression monitoring by hybridization to high density oligonucleotide arrays
|
US5424186A
(en)
|
1989-06-07 |
1995-06-13 |
Affymax Technologies N.V. |
Very large scale immobilized polymer synthesis
|
US6309822B1
(en)
|
1989-06-07 |
2001-10-30 |
Affymetrix, Inc. |
Method for comparing copy number of nucleic acid sequences
|
US6406844B1
(en)
|
1989-06-07 |
2002-06-18 |
Affymetrix, Inc. |
Very large scale immobilized polymer synthesis
|
US6955915B2
(en)
*
|
1989-06-07 |
2005-10-18 |
Affymetrix, Inc. |
Apparatus comprising polymers
|
US6379895B1
(en)
|
1989-06-07 |
2002-04-30 |
Affymetrix, Inc. |
Photolithographic and other means for manufacturing arrays
|
US6551784B2
(en)
|
1989-06-07 |
2003-04-22 |
Affymetrix Inc |
Method of comparing nucleic acid sequences
|
US6506558B1
(en)
|
1990-03-07 |
2003-01-14 |
Affymetrix Inc. |
Very large scale immobilized polymer synthesis
|
US5210015A
(en)
|
1990-08-06 |
1993-05-11 |
Hoffman-La Roche Inc. |
Homogeneous assay system using the nuclease activity of a nucleic acid polymerase
|
WO1992010588A1
(en)
|
1990-12-06 |
1992-06-25 |
Affymax Technologies N.V. |
Sequencing by hybridization of a target nucleic acid to a matrix of defined oligonucleotides
|
US5290925A
(en)
*
|
1990-12-20 |
1994-03-01 |
Abbott Laboratories |
Methods, kits, and reactive supports for 3' labeling of oligonucleotides
|
DE4123540A1
(de)
*
|
1991-07-16 |
1993-01-21 |
Boehringer Mannheim Gmbh |
Immobilisierung von nukleinsaeuren
|
US6335434B1
(en)
|
1998-06-16 |
2002-01-01 |
Isis Pharmaceuticals, Inc., |
Nucleosidic and non-nucleosidic folate conjugates
|
US8153602B1
(en)
|
1991-11-19 |
2012-04-10 |
Isis Pharmaceuticals, Inc. |
Composition and methods for the pulmonary delivery of nucleic acids
|
WO1993010140A1
(en)
*
|
1991-11-21 |
1993-05-27 |
Pharmagenics, Inc. |
Oligonucleotides having modified anionic moieties
|
US6943034B1
(en)
*
|
1991-11-22 |
2005-09-13 |
Affymetrix, Inc. |
Combinatorial strategies for polymer synthesis
|
US6849462B1
(en)
|
1991-11-22 |
2005-02-01 |
Affymetrix, Inc. |
Combinatorial strategies for polymer synthesis
|
EP0972564B1
(de)
*
|
1991-11-22 |
2003-05-28 |
Affymetrix, Inc. (a Delaware Corporation) |
Verfahren zur Herstellung von Polymerarrays
|
US6468740B1
(en)
|
1992-11-05 |
2002-10-22 |
Affymetrix, Inc. |
Cyclic and substituted immobilized molecular synthesis
|
IL107150A0
(en)
*
|
1992-09-29 |
1993-12-28 |
Isis Pharmaceuticals Inc |
Oligonucleotides having a conserved g4 core sequence
|
US5482698A
(en)
*
|
1993-04-22 |
1996-01-09 |
Immunomedics, Inc. |
Detection and therapy of lesions with biotin/avidin polymer conjugates
|
ATE247128T1
(de)
|
1993-09-03 |
2003-08-15 |
Isis Pharmaceuticals Inc |
Aminoderivatisierte nukleoside und oligonukleoside
|
US5925517A
(en)
*
|
1993-11-12 |
1999-07-20 |
The Public Health Research Institute Of The City Of New York, Inc. |
Detectably labeled dual conformation oligonucleotide probes, assays and kits
|
US5446137B1
(en)
*
|
1993-12-09 |
1998-10-06 |
Behringwerke Ag |
Oligonucleotides containing 4'-substituted nucleotides
|
US5824473A
(en)
|
1993-12-10 |
1998-10-20 |
California Institute Of Technology |
Nucleic acid mediated electron transfer
|
US5952172A
(en)
|
1993-12-10 |
1999-09-14 |
California Institute Of Technology |
Nucleic acid mediated electron transfer
|
US6071699A
(en)
*
|
1996-06-07 |
2000-06-06 |
California Institute Of Technology |
Nucleic acid mediated electron transfer
|
US5591578A
(en)
*
|
1993-12-10 |
1997-01-07 |
California Institute Of Technology |
Nucleic acid mediated electron transfer
|
US7323298B1
(en)
|
1994-06-17 |
2008-01-29 |
The Board Of Trustees Of The Leland Stanford Junior University |
Microarray for determining the relative abundances of polynuceotide sequences
|
US7378236B1
(en)
|
1994-06-17 |
2008-05-27 |
The Board Of Trustees Of The Leland Stanford Junior University |
Method for analyzing gene expression patterns
|
US5620850A
(en)
|
1994-09-26 |
1997-04-15 |
President And Fellows Of Harvard College |
Molecular recognition at surfaces derivatized with self-assembled monolayers
|
US8236493B2
(en)
*
|
1994-10-21 |
2012-08-07 |
Affymetrix, Inc. |
Methods of enzymatic discrimination enhancement and surface-bound double-stranded DNA
|
US6420549B1
(en)
|
1995-06-06 |
2002-07-16 |
Isis Pharmaceuticals, Inc. |
Oligonucleotide analogs having modified dimers
|
EP0880598A4
(de)
*
|
1996-01-23 |
2005-02-23 |
Affymetrix Inc |
Verfahren zur analyse von nukleinsäure
|
JP3898228B2
(ja)
*
|
1996-04-12 |
2007-03-28 |
ザ パブリック ヘルス リサーチ インスティチュート オブ ザ シティー オブ ニューヨーク インク |
検出プローブ、キット及びアッセイ
|
US9096636B2
(en)
|
1996-06-06 |
2015-08-04 |
Isis Pharmaceuticals, Inc. |
Chimeric oligomeric compounds and their use in gene modulation
|
US20070275921A1
(en)
*
|
1996-06-06 |
2007-11-29 |
Isis Pharmaceuticals, Inc. |
Oligomeric Compounds That Facilitate Risc Loading
|
US20040203024A1
(en)
*
|
1996-06-06 |
2004-10-14 |
Baker Brenda F. |
Modified oligonucleotides for use in RNA interference
|
US7812149B2
(en)
*
|
1996-06-06 |
2010-10-12 |
Isis Pharmaceuticals, Inc. |
2′-Fluoro substituted oligomeric compounds and compositions for use in gene modulations
|
US20040147022A1
(en)
*
|
1996-06-06 |
2004-07-29 |
Baker Brenda F. |
2'-methoxy substituted oligomeric compounds and compositions for use in gene modulations
|
US20050119470A1
(en)
*
|
1996-06-06 |
2005-06-02 |
Muthiah Manoharan |
Conjugated oligomeric compounds and their use in gene modulation
|
US20050042647A1
(en)
*
|
1996-06-06 |
2005-02-24 |
Baker Brenda F. |
Phosphorous-linked oligomeric compounds and their use in gene modulation
|
US20040266706A1
(en)
*
|
2002-11-05 |
2004-12-30 |
Muthiah Manoharan |
Cross-linked oligomeric compounds and their use in gene modulation
|
US20040171031A1
(en)
*
|
1996-06-06 |
2004-09-02 |
Baker Brenda F. |
Sugar surrogate-containing oligomeric compounds and compositions for use in gene modulation
|
US20050053976A1
(en)
*
|
1996-06-06 |
2005-03-10 |
Baker Brenda F. |
Chimeric oligomeric compounds and their use in gene modulation
|
US5898031A
(en)
*
|
1996-06-06 |
1999-04-27 |
Isis Pharmaceuticals, Inc. |
Oligoribonucleotides for cleaving RNA
|
US20030044941A1
(en)
|
1996-06-06 |
2003-03-06 |
Crooke Stanley T. |
Human RNase III and compositions and uses thereof
|
US6444423B1
(en)
|
1996-06-07 |
2002-09-03 |
Molecular Dynamics, Inc. |
Nucleosides comprising polydentate ligands
|
US7045285B1
(en)
*
|
1996-11-05 |
2006-05-16 |
Clinical Micro Sensors, Inc. |
Electronic transfer moieties attached to peptide nucleic acids
|
US7381525B1
(en)
|
1997-03-07 |
2008-06-03 |
Clinical Micro Sensors, Inc. |
AC/DC voltage apparatus for detection of nucleic acids
|
US7160678B1
(en)
|
1996-11-05 |
2007-01-09 |
Clinical Micro Sensors, Inc. |
Compositions for the electronic detection of analytes utilizing monolayers
|
US7393645B2
(en)
*
|
1996-11-05 |
2008-07-01 |
Clinical Micro Sensors, Inc. |
Compositions for the electronic detection of analytes utilizing monolayers
|
US7014992B1
(en)
*
|
1996-11-05 |
2006-03-21 |
Clinical Micro Sensors, Inc. |
Conductive oligomers attached to electrodes and nucleoside analogs
|
US6096273A
(en)
*
|
1996-11-05 |
2000-08-01 |
Clinical Micro Sensors |
Electrodes linked via conductive oligomers to nucleic acids
|
US6013459A
(en)
*
|
1997-06-12 |
2000-01-11 |
Clinical Micro Sensors, Inc. |
Detection of analytes using reorganization energy
|
CA2294988C
(en)
|
1997-07-01 |
2015-11-24 |
Isis Pharmaceuticals Inc. |
Compositions and methods for the delivery of oligonucleotides via the alimentary canal
|
CA2313641A1
(en)
*
|
1997-12-12 |
1999-06-24 |
Digene Corporation |
Universal collection medium
|
US6686150B1
(en)
|
1998-01-27 |
2004-02-03 |
Clinical Micro Sensors, Inc. |
Amplification of nucleic acids with electronic detection
|
JP2002500897A
(ja)
|
1998-01-27 |
2002-01-15 |
クリニカル・マイクロ・センサーズ・インコーポレイテッド |
電子的核酸検出の増幅
|
US6004755A
(en)
*
|
1998-04-07 |
1999-12-21 |
Incyte Pharmaceuticals, Inc. |
Quantitative microarray hybridizaton assays
|
US20040186071A1
(en)
|
1998-04-13 |
2004-09-23 |
Bennett C. Frank |
Antisense modulation of CD40 expression
|
US7321828B2
(en)
*
|
1998-04-13 |
2008-01-22 |
Isis Pharmaceuticals, Inc. |
System of components for preparing oligonucleotides
|
EP1080103A4
(de)
*
|
1998-05-21 |
2003-07-02 |
Isis Pharmaceuticals Inc |
Zubereitungen und verfahren zur nicht-parenteralen verabreichung von oligonukleotiden
|
AU753270B2
(en)
*
|
1998-05-21 |
2002-10-10 |
Isis Pharmaceuticals, Inc. |
Compositions and methods for topical delivery of oligonucleotides
|
US6290839B1
(en)
|
1998-06-23 |
2001-09-18 |
Clinical Micro Sensors, Inc. |
Systems for electrophoretic transport and detection of analytes
|
US7087148B1
(en)
|
1998-06-23 |
2006-08-08 |
Clinical Micro Sensors, Inc. |
Binding acceleration techniques for the detection of analytes
|
US6761816B1
(en)
|
1998-06-23 |
2004-07-13 |
Clinical Micro Systems, Inc. |
Printed circuit boards with monolayers and capture ligands
|
US6037130A
(en)
*
|
1998-07-28 |
2000-03-14 |
The Public Health Institute Of The City Of New York, Inc. |
Wavelength-shifting probes and primers and their use in assays and kits
|
US6225293B1
(en)
|
1998-09-02 |
2001-05-01 |
Isis Pharmaceuticals, Inc. |
Methods and compounds for tracking the biodistribution of macromolecule-carrier combinations
|
US6740518B1
(en)
|
1998-09-17 |
2004-05-25 |
Clinical Micro Sensors, Inc. |
Signal detection techniques for the detection of analytes
|
US6077709A
(en)
|
1998-09-29 |
2000-06-20 |
Isis Pharmaceuticals Inc. |
Antisense modulation of Survivin expression
|
AU1241000A
(en)
|
1998-10-27 |
2000-05-15 |
Clinical Micro Sensors, Inc. |
Detection of target analytes using particles and electrodes
|
US6545264B1
(en)
|
1998-10-30 |
2003-04-08 |
Affymetrix, Inc. |
Systems and methods for high performance scanning
|
WO2001027261A2
(en)
*
|
1998-11-11 |
2001-04-19 |
Pantheco A/S |
Conjugates between a peptides and a nucleic acid analog, such as a pna, lna or a morpholino
|
US6833267B1
(en)
*
|
1998-12-30 |
2004-12-21 |
Clinical Micro Sensors, Inc. |
Tissue collection devices containing biosensors
|
US6300320B1
(en)
|
1999-01-05 |
2001-10-09 |
Isis Pharmaceuticals, Inc. |
Modulation of c-jun using inhibitors of protein kinase C
|
US6127124A
(en)
*
|
1999-01-20 |
2000-10-03 |
Isis Pharmaceuticals, Inc. |
Fluorescence based nuclease assay
|
US7098192B2
(en)
|
1999-04-08 |
2006-08-29 |
Isis Pharmaceuticals, Inc. |
Antisense oligonucleotide modulation of STAT3 expression
|
US20020177135A1
(en)
*
|
1999-07-27 |
2002-11-28 |
Doung Hau H. |
Devices and methods for biochip multiplexing
|
US7312087B2
(en)
|
2000-01-11 |
2007-12-25 |
Clinical Micro Sensors, Inc. |
Devices and methods for biochip multiplexing
|
US6942771B1
(en)
*
|
1999-04-21 |
2005-09-13 |
Clinical Micro Sensors, Inc. |
Microfluidic systems in the electrochemical detection of target analytes
|
US6656730B1
(en)
|
1999-06-15 |
2003-12-02 |
Isis Pharmaceuticals, Inc. |
Oligonucleotides conjugated to protein-binding drugs
|
AU779220B2
(en)
|
1999-07-26 |
2005-01-13 |
Clinical Micro Sensors, Inc. |
Sequence determination of nucleic acids using electronic detection
|
US6613516B1
(en)
*
|
1999-10-30 |
2003-09-02 |
Affymetrix, Inc. |
Preparation of nucleic acid samples
|
US6261840B1
(en)
|
2000-01-18 |
2001-07-17 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of PTP1B expression
|
US20020055479A1
(en)
|
2000-01-18 |
2002-05-09 |
Cowsert Lex M. |
Antisense modulation of PTP1B expression
|
US20030176385A1
(en)
*
|
2000-02-15 |
2003-09-18 |
Jingfang Ju |
Antisense modulation of protein expression
|
FR2805545B1
(fr)
*
|
2000-02-24 |
2002-05-17 |
Argene Sa |
Procede electrochimique de detection d'acides nucleiques
|
US6680172B1
(en)
|
2000-05-16 |
2004-01-20 |
Regents Of The University Of Michigan |
Treatments and markers for cancers of the central nervous system
|
US7601497B2
(en)
|
2000-06-15 |
2009-10-13 |
Qiagen Gaithersburg, Inc. |
Detection of nucleic acids by target-specific hybrid capture method
|
US7439016B1
(en)
*
|
2000-06-15 |
2008-10-21 |
Digene Corporation |
Detection of nucleic acids by type-specific hybrid capture method
|
JP4382265B2
(ja)
*
|
2000-07-12 |
2009-12-09 |
日本電気株式会社 |
酸化シリコン膜の形成方法及びその形成装置
|
US8568766B2
(en)
|
2000-08-24 |
2013-10-29 |
Gattadahalli M. Anantharamaiah |
Peptides and peptide mimetics to treat pathologies associated with eye disease
|
AU2001296846B2
(en)
|
2000-10-12 |
2007-07-05 |
University Of Rochester |
Compositions that inhibit proliferation of cancer cells
|
US7767802B2
(en)
|
2001-01-09 |
2010-08-03 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of anti-apoptotic genes
|
FI115139B
(fi)
*
|
2001-01-10 |
2005-03-15 |
Valtion Teknillinen |
Menetelmä ja testipakkaus solu- tai kudosnäytteissä olevien polynukleotidien määrässä tapahtuvien vaihteluiden kvantitatiiviseen ja/tai vertailevaan arvioimiseen
|
EP1377683A4
(de)
*
|
2001-04-11 |
2004-09-08 |
Us Gov Health & Human Serv |
Modifizierte zufallsprimer zur sondenmarkierung
|
JP2004537516A
(ja)
|
2001-05-11 |
2004-12-16 |
オラセンス リミテッド |
アンチセンス浸透促進剤
|
SE0101934D0
(sv)
*
|
2001-06-01 |
2001-06-01 |
Pharmacia Ab |
New methods
|
US7803915B2
(en)
*
|
2001-06-20 |
2010-09-28 |
Genentech, Inc. |
Antibody compositions for the diagnosis and treatment of tumor
|
MXPA03011985A
(es)
|
2001-06-20 |
2004-03-26 |
Genentech Inc |
Composiciones y metodos para el diagnostico y tratamiento de tumores.
|
US20050107595A1
(en)
*
|
2001-06-20 |
2005-05-19 |
Genentech, Inc. |
Compositions and methods for the diagnosis and treatment of tumor
|
CA2451643C
(en)
|
2001-06-21 |
2012-11-13 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of superoxide dismutase 1, soluble expression
|
US7425545B2
(en)
|
2001-07-25 |
2008-09-16 |
Isis Pharmaceuticals, Inc. |
Modulation of C-reactive protein expression
|
US6964950B2
(en)
|
2001-07-25 |
2005-11-15 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of C-reactive protein expression
|
US20030096772A1
(en)
|
2001-07-30 |
2003-05-22 |
Crooke Rosanne M. |
Antisense modulation of acyl CoA cholesterol acyltransferase-2 expression
|
US7407943B2
(en)
|
2001-08-01 |
2008-08-05 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of apolipoprotein B expression
|
US7227014B2
(en)
|
2001-08-07 |
2007-06-05 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of apolipoprotein (a) expression
|
US6974671B1
(en)
|
2001-09-12 |
2005-12-13 |
Salk Institute For Biological Studies |
Methods for indentifying compounds that modulate gluconeogenesis through the binding of CREB to the PGC-1 promoter
|
KR101008758B1
(ko)
|
2001-09-18 |
2011-01-14 |
제넨테크, 인크. |
종양의 진단 및 치료를 위한 방법 및 이를 위한 조성물
|
AU2002334895B2
(en)
|
2001-10-09 |
2006-10-19 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of insulin-like growth factor binding protein 5 expression
|
US6750019B2
(en)
|
2001-10-09 |
2004-06-15 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of insulin-like growth factor binding protein 5 expression
|
US6965025B2
(en)
|
2001-12-10 |
2005-11-15 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of connective tissue growth factor expression
|
EP2067472A1
(de)
|
2002-01-02 |
2009-06-10 |
Genentech, Inc. |
Zusammensetzungen und Verfahren zur Behandlung und Diagnose von Tumoren
|
US20030180712A1
(en)
|
2002-03-20 |
2003-09-25 |
Biostratum Ab |
Inhibition of the beta3 subunit of L-type Ca2+ channels
|
NZ535925A
(en)
|
2002-04-16 |
2008-06-30 |
Genentech Inc |
An isolated antibody that binds to a particular polypeptide
|
AU2003279697A1
(en)
*
|
2002-05-17 |
2004-02-16 |
Nugen Technologies, Inc. |
Methods for fragmentation, labeling and immobilizaton of nucleic acids
|
US7199107B2
(en)
|
2002-05-23 |
2007-04-03 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of kinesin-like 1 expression
|
WO2003105780A2
(en)
*
|
2002-06-18 |
2003-12-24 |
Epigenesis Pharmaceuticals, Inc. |
A dry powder oligonucleotide formulation, preparation and its uses
|
FI20021325A0
(fi)
*
|
2002-07-05 |
2002-07-05 |
Valtion Teknillinen |
Menetelmä ja reagenssipakkaus yksittäisten polynukleotidien määrän määrittämiseksi
|
US20040019000A1
(en)
*
|
2002-07-19 |
2004-01-29 |
Muthiah Manoharan |
Polyalkyleneamine-containing oligomers
|
WO2004013160A2
(en)
|
2002-08-05 |
2004-02-12 |
University Of Rochester |
Protein transducing domain/deaminase chimeric proteins, related compounds, and uses thereof
|
US6878805B2
(en)
*
|
2002-08-16 |
2005-04-12 |
Isis Pharmaceuticals, Inc. |
Peptide-conjugated oligomeric compounds
|
CN1694959B
(zh)
|
2002-09-13 |
2013-09-18 |
雷普利瑟公司 |
非序列互补的抗病毒寡核苷酸
|
WO2004031350A2
(en)
|
2002-09-26 |
2004-04-15 |
Amgen, Inc. |
Modulation of forkhead box o1a expression
|
JP2006515318A
(ja)
*
|
2002-10-29 |
2006-05-25 |
ファルマシア・コーポレーション |
特異的に発現する癌関連遺伝子、それによってコードされるポリペプチドおよびその使用方法
|
US9150605B2
(en)
|
2002-11-05 |
2015-10-06 |
Isis Pharmaceuticals, Inc. |
Compositions comprising alternating 2′-modified nucleosides for use in gene modulation
|
CA2504694C
(en)
|
2002-11-05 |
2013-10-01 |
Isis Pharmaceuticals, Inc. |
Polycyclic sugar surrogate-containing oligomeric compounds and compositions for use in gene modulation
|
EP1578765A4
(de)
|
2002-11-05 |
2008-04-23 |
Isis Pharmaceuticals Inc |
Oligomere verbindungen,die zuckerersatzstoffe enthalten, und zusammensetzung zur verwendung in dergenmodulation
|
EP1560839A4
(de)
|
2002-11-05 |
2008-04-23 |
Isis Pharmaceuticals Inc |
Chimäre oligomere verbindungen und derenverwendung in der genmodulation
|
US9150606B2
(en)
*
|
2002-11-05 |
2015-10-06 |
Isis Pharmaceuticals, Inc. |
Compositions comprising alternating 2'-modified nucleosides for use in gene modulation
|
AU2003294281B2
(en)
|
2002-11-13 |
2010-05-20 |
Kastle Therapeutics, Llc |
Antisense modulation of apolipoprotein B expression
|
SI2336318T1
(sl)
|
2002-11-13 |
2013-07-31 |
Genzyme Corporation |
Protismiselna modulacija ekspresije apolipoproteina B
|
WO2004045520A2
(en)
|
2002-11-15 |
2004-06-03 |
Musc Foundation For Research Development |
Complement receptor 2 targeted complement modulators
|
WO2004046330A2
(en)
|
2002-11-15 |
2004-06-03 |
Morphotek, Inc. |
Methods of generating high-production of antibodies from hybridomas created by in vitro immunization
|
AU2003294462C1
(en)
|
2002-11-21 |
2011-06-30 |
University Of Utah Research Foundation |
Purinergic modulation of smell
|
US7144999B2
(en)
|
2002-11-23 |
2006-12-05 |
Isis Pharmaceuticals, Inc. |
Modulation of hypoxia-inducible factor 1 alpha expression
|
US7468356B2
(en)
|
2003-02-11 |
2008-12-23 |
Antisense Therapeutics Ltd. |
Modulation of insulin like growth factor I receptor expression
|
US7803781B2
(en)
|
2003-02-28 |
2010-09-28 |
Isis Pharmaceuticals, Inc. |
Modulation of growth hormone receptor expression and insulin-like growth factor expression
|
US20040185559A1
(en)
|
2003-03-21 |
2004-09-23 |
Isis Pharmaceuticals Inc. |
Modulation of diacylglycerol acyltransferase 1 expression
|
US7598227B2
(en)
|
2003-04-16 |
2009-10-06 |
Isis Pharmaceuticals Inc. |
Modulation of apolipoprotein C-III expression
|
US7399853B2
(en)
|
2003-04-28 |
2008-07-15 |
Isis Pharmaceuticals |
Modulation of glucagon receptor expression
|
CA2540692C
(en)
*
|
2003-06-02 |
2013-05-28 |
Isis Pharmaceuticals, Inc. |
Oligonucleotide synthesis with alternative solvents
|
BRPI0410886A
(pt)
|
2003-06-03 |
2006-07-04 |
Isis Pharmaceuticals Inc |
composto de filamento duplo, composição farmacêutica, sal farmaceuticamente aceitável, métodos de modificação do ácido nucleico que codifica a survivina humana, de inibição da expressão da suvivina em células ou tecidos, e de tratamento de uma condição associada com a expressão ou superexpressão da suvivina, e, oligonucleotìdeo de rnai de filamento único
|
US7786290B2
(en)
|
2003-06-13 |
2010-08-31 |
Alnylam Pharmaceuticals, Inc. |
Double-stranded ribonucleic acid with increased effectiveness in an organism
|
EP1636342A4
(de)
*
|
2003-06-20 |
2008-10-08 |
Isis Pharmaceuticals Inc |
Oligomere verbindungen zur verwendung bei der modulation von genen
|
US7790691B2
(en)
*
|
2003-06-20 |
2010-09-07 |
Isis Pharmaceuticals, Inc. |
Double stranded compositions comprising a 3′-endo modified strand for use in gene modulation
|
EP1648914A4
(de)
|
2003-07-31 |
2009-12-16 |
Regulus Therapeutics Inc |
Oligomere verbindungen und zusammensetzungen zur verwendung bei der modulierung von kleinen nicht-kodienderen rnas
|
US7825235B2
(en)
|
2003-08-18 |
2010-11-02 |
Isis Pharmaceuticals, Inc. |
Modulation of diacylglycerol acyltransferase 2 expression
|
US20050053981A1
(en)
*
|
2003-09-09 |
2005-03-10 |
Swayze Eric E. |
Gapped oligomeric compounds having linked bicyclic sugar moieties at the termini
|
US20070123480A1
(en)
*
|
2003-09-11 |
2007-05-31 |
Replicor Inc. |
Oligonucleotides targeting prion diseases
|
AU2004274942B2
(en)
|
2003-09-18 |
2008-02-28 |
Isis Pharmaceuticals, Inc. |
Modulation of eIF4E expression
|
CA2538252C
(en)
*
|
2003-09-18 |
2014-02-25 |
Isis Pharmaceuticals, Inc. |
4'-thionucleosides and oligomeric compounds
|
CN1882602B
(zh)
|
2003-10-10 |
2011-02-09 |
阿尔卡米亚肿瘤股份有限公司 |
在疾病治疗中乙酰透明质酸合成的调节和降解
|
US20050191653A1
(en)
|
2003-11-03 |
2005-09-01 |
Freier Susan M. |
Modulation of SGLT2 expression
|
EP2161283B1
(de)
|
2003-11-17 |
2014-06-04 |
Genentech, Inc. |
Zusammensetzungen, die Antikörper gegen CD79b enthalten, die an Wachstumshemmer oder an zytotoxische Subtanzen gekoppelt sind und Verfahren zur Behandlung von Tumoren hämatopoetischen Ursprungs
|
US20050208538A1
(en)
|
2003-12-29 |
2005-09-22 |
Nurith Kurn |
Methods for analysis of nucleic acid methylation status and methods for fragmentation, labeling and immobilization of nucleic acids
|
WO2005071080A2
(en)
|
2004-01-20 |
2005-08-04 |
Isis Pharmaceuticals, Inc. |
Modulation of glucocorticoid receptor expression
|
US7468431B2
(en)
*
|
2004-01-22 |
2008-12-23 |
Isis Pharmaceuticals, Inc. |
Modulation of eIF4E-BP2 expression
|
US8569474B2
(en)
*
|
2004-03-09 |
2013-10-29 |
Isis Pharmaceuticals, Inc. |
Double stranded constructs comprising one or more short strands hybridized to a longer strand
|
WO2005089268A2
(en)
|
2004-03-15 |
2005-09-29 |
Isis Pharmaceuticals, Inc. |
Compositions and methods for optimizing cleavage of rna by rnase h
|
AU2005230684B2
(en)
|
2004-04-05 |
2011-10-06 |
Alnylam Pharmaceuticals, Inc. |
Process and reagents for oligonucleotide synthesis and purification
|
US20050244869A1
(en)
*
|
2004-04-05 |
2005-11-03 |
Brown-Driver Vickie L |
Modulation of transthyretin expression
|
US20050260755A1
(en)
*
|
2004-04-06 |
2005-11-24 |
Isis Pharmaceuticals, Inc. |
Sequential delivery of oligomeric compounds
|
JP4584987B2
(ja)
|
2004-04-30 |
2010-11-24 |
アルニラム ファーマスーティカルズ インコーポレイテッド |
C5修飾ピリミジンを含むオリゴヌクレオチド
|
CA2564251C
(en)
|
2004-05-21 |
2018-04-10 |
The Uab Research Foundation |
Variable lymphocyte receptors, related polypeptides and nucleic acids, and uses thereof
|
US8394947B2
(en)
*
|
2004-06-03 |
2013-03-12 |
Isis Pharmaceuticals, Inc. |
Positionally modified siRNA constructs
|
EP1766052A4
(de)
*
|
2004-06-03 |
2009-12-16 |
Isis Pharmaceuticals Inc |
Chimärische oligomere zusammensetzungen mit gap
|
WO2005121372A2
(en)
*
|
2004-06-03 |
2005-12-22 |
Isis Pharmaceuticals, Inc. |
Double strand compositions comprising differentially modified strands for use in gene modulation
|
US20090048192A1
(en)
*
|
2004-06-03 |
2009-02-19 |
Isis Pharmaceuticals, Inc. |
Double Strand Compositions Comprising Differentially Modified Strands for Use in Gene Modulation
|
US7620402B2
(en)
*
|
2004-07-09 |
2009-11-17 |
Itis Uk Limited |
System and method for geographically locating a mobile device
|
US7427675B2
(en)
*
|
2004-08-23 |
2008-09-23 |
Isis Pharmaceuticals, Inc. |
Compounds and methods for the characterization of oligonucleotides
|
US7884086B2
(en)
*
|
2004-09-08 |
2011-02-08 |
Isis Pharmaceuticals, Inc. |
Conjugates for use in hepatocyte free uptake assays
|
WO2006032144A1
(en)
|
2004-09-23 |
2006-03-30 |
Arc Pharmaceuticals, Inc. |
Pharmaceutical compositions and methods relating to inhibiting fibrous adhesions or inflammatory disease using fucans from various echinoderm sources
|
BRPI0607985A2
(pt)
|
2005-03-10 |
2009-10-27 |
Genentech Inc |
modulador da dscr1, métodos de tratamento, método de melhoria de efeitos colaterais e método de inibição do crescimento de tumores
|
US7476733B2
(en)
*
|
2005-03-25 |
2009-01-13 |
The United States Of America As Represented By The Department Of Health And Human Services |
Development of a real-time PCR assay for detection of pneumococcal DNA and diagnosis of pneumococccal disease
|
EP2298829B1
(de)
|
2005-05-31 |
2017-09-20 |
École Polytechnique Fédérale de Lausanne (EPFL) |
Triblock-Copolymere zur zytoplasmischen Verabreichung gen-basierter Arzneimittel
|
WO2006138145A1
(en)
|
2005-06-14 |
2006-12-28 |
Northwestern University |
Nucleic acid functionalized nanoparticles for therapeutic applications
|
US8080534B2
(en)
|
2005-10-14 |
2011-12-20 |
Phigenix, Inc |
Targeting PAX2 for the treatment of breast cancer
|
CA2625891A1
(en)
|
2005-10-14 |
2007-04-26 |
Carlton D. Donald |
Inhibition of pax2 by defb1 induction as a therapy for cancer
|
EP1941059A4
(de)
|
2005-10-28 |
2010-11-03 |
Alnylam Pharmaceuticals Inc |
Zusammensetzungen und verfahren zur hemmung der expression des huntingtin-gens
|
US20100069461A1
(en)
|
2005-11-09 |
2010-03-18 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of factor v leiden mutant gene
|
EP1966377A2
(de)
|
2005-11-21 |
2008-09-10 |
Isis Pharmaceuticals, Inc. |
Modulation der eif4e-bp2-expression
|
NZ587704A
(en)
|
2006-03-31 |
2012-04-27 |
Alnylam Pharmaceuticals Inc |
Use of dsRNA for inhibiting expression of Eg5 gene
|
EP2013344B1
(de)
*
|
2006-05-03 |
2012-08-29 |
Baltic Technology Development, Ltd. |
Antisense-agentien mit kombination von mit stark gebundener base modifiziertem oligonukleotid und künstlicher nuklease
|
US7812150B2
(en)
|
2006-05-19 |
2010-10-12 |
Alnylam Pharmaceuticals, Inc. |
RNAi modulation of Aha and therapeutic uses thereof
|
CA2653451C
(en)
|
2006-05-22 |
2015-12-29 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of ikk-b gene
|
US20090209625A1
(en)
*
|
2006-05-23 |
2009-08-20 |
Sanjay Bhanot |
Modulation of chrebp expression
|
EP2029775B1
(de)
*
|
2006-06-05 |
2014-10-15 |
California Institute Of Technology |
Echtzeit-mikroarrays
|
US11001881B2
(en)
|
2006-08-24 |
2021-05-11 |
California Institute Of Technology |
Methods for detecting analytes
|
US20090280188A1
(en)
*
|
2006-06-23 |
2009-11-12 |
Northwestern University |
Asymmetric functionalizated nanoparticles and methods of use
|
CA2656315A1
(en)
*
|
2006-06-30 |
2008-01-10 |
Nugen Technologies, Inc. |
Methods for fragmentation and labeling of nucleic acids
|
US8198253B2
(en)
|
2006-07-19 |
2012-06-12 |
Isis Pharmaceuticals, Inc. |
Compositions and their uses directed to HBXIP
|
US11525156B2
(en)
|
2006-07-28 |
2022-12-13 |
California Institute Of Technology |
Multiplex Q-PCR arrays
|
WO2008014485A2
(en)
|
2006-07-28 |
2008-01-31 |
California Institute Of Technology |
Multiplex q-pcr arrays
|
US11560588B2
(en)
|
2006-08-24 |
2023-01-24 |
California Institute Of Technology |
Multiplex Q-PCR arrays
|
EP2104516B1
(de)
|
2006-11-01 |
2015-01-07 |
University of Rochester |
Verfahren und zusammensetzungen in zusammenhang mit der struktur und funktion von apobec3g
|
KR20090089462A
(ko)
|
2006-12-11 |
2009-08-21 |
유니버시티 오브 유타 리써치 파운데이션 |
병적 혈관형성 및 혈관 투과성을 치료하기 위한 조성물 및 방법
|
MX2009008470A
(es)
|
2007-02-09 |
2009-11-26 |
Univ Northwestern |
Particulas para detectar objetivos intracelulares.
|
AU2008232891B2
(en)
|
2007-03-29 |
2012-01-12 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of a gene from the Ebola
|
CA2689923A1
(en)
|
2007-05-30 |
2008-12-11 |
Northwestern University |
Nucleic acid functionalized nanoparticles for therapeutic applications
|
US20090215643A1
(en)
|
2007-07-26 |
2009-08-27 |
Cellay, Llc |
Highly Visible Chromosome-Specific Probes and Related Methods
|
EP2195331B1
(de)
*
|
2007-08-28 |
2013-11-20 |
Uab Research Foundation |
Synthetische, apolipoprotein e nachahmende polypeptide und anwendungsverfahren
|
CA2697957A1
(en)
|
2007-08-28 |
2009-03-12 |
Uab Research Foundation |
Synthetic apolipoprotein e mimicking polypeptides and methods of use
|
WO2009039466A1
(en)
|
2007-09-20 |
2009-03-26 |
Vanderbilt University |
Free solution measurement of molecular interactions by backscattering interferometry
|
US7951785B2
(en)
*
|
2007-09-21 |
2011-05-31 |
California Institute Of Technology |
NFIA in glial fate determination, glioma therapy and astrocytoma treatment
|
MX2010003465A
(es)
|
2007-10-02 |
2010-07-05 |
Amgen Inc |
Incremento de eritropoyetina utilizando acidos nucleicos que hibridan para micro-arn y precursores de los mismos.
|
MX2010004984A
(es)
*
|
2007-11-05 |
2010-07-29 |
Baltic Technology Dev Ltd |
Uso de oligonucleotidos con bases modificadas en hibridacion de acidos nucleicos.
|
WO2009067243A2
(en)
|
2007-11-20 |
2009-05-28 |
Isis Pharmaceuticals Inc. |
Modulation of cd40 expression
|
WO2009070742A2
(en)
|
2007-11-28 |
2009-06-04 |
Great Basin Scientific |
Methods and compositions for signal enhancement using multivalent interactions
|
EP2245159A2
(de)
|
2007-12-10 |
2010-11-03 |
Alnylam Pharmaceuticals Inc. |
Zusammensetzungen und verfahren zur hemmung der expression des faktor-vii-gens
|
EP2712926A2
(de)
|
2008-03-05 |
2014-04-02 |
Alnylam Pharmaceuticals, Inc. |
Zusammensetzungen und Verfahren zur Hemmung der Expression des Eg5- und des VEGF-Gens
|
EP2105145A1
(de)
*
|
2008-03-27 |
2009-09-30 |
ETH Zürich |
Verfahren zur muskelspezifischen Abgabe lipidkonjugierter Oligonukleotide
|
WO2009124295A2
(en)
*
|
2008-04-04 |
2009-10-08 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds comprising bicyclic nucleosides and having reduced toxicity
|
CA2721183C
(en)
|
2008-04-11 |
2019-07-16 |
Alnylam Pharmaceuticals, Inc. |
Site-specific delivery of nucleic acids by combining targeting ligands with endosomolytic components
|
US8324366B2
(en)
|
2008-04-29 |
2012-12-04 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for delivering RNAI using lipoproteins
|
WO2010017509A1
(en)
*
|
2008-08-07 |
2010-02-11 |
Isis Pharmaceuticals, Inc. |
Modulation of transthyretin expression for the treatment of cns related disorders
|
NZ601660A
(en)
|
2008-08-25 |
2014-05-30 |
Excaliard Pharmaceuticals Inc |
Antisense oligonucleotides directed against connective tissue growth factor and uses thereof
|
EP3208337A1
(de)
|
2008-09-02 |
2017-08-23 |
Alnylam Pharmaceuticals, Inc. |
Zusammensetzungen zur kombinationshemmung der expression eines mutanten egfr und il-6
|
WO2010039548A2
(en)
|
2008-09-23 |
2010-04-08 |
Alnylam Pharmaceuticals, Inc. |
Chemical modifications of monomers and oligonucleotides with cycloaddition
|
EP3109321B1
(de)
|
2008-09-25 |
2019-05-01 |
Alnylam Pharmaceuticals, Inc. |
Zusammensetzungen aus lipidformulierungen und verfahren zur hemmung der serum-amyloid-a-genexpression
|
KR20160079921A
(ko)
|
2008-10-20 |
2016-07-06 |
알닐람 파마슈티칼스 인코포레이티드 |
트랜스티레틴의 발현을 억제하기 위한 조성물 및 방법
|
US8987435B2
(en)
|
2008-10-24 |
2015-03-24 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds and methods
|
JP2012506705A
(ja)
*
|
2008-10-27 |
2012-03-22 |
キアジェン ゲイサーズバーグ インコーポレイテッド |
迅速に結果を得るハイブリッドキャプチャー法による分析およびシステム
|
CN105152939A
(zh)
|
2008-11-10 |
2015-12-16 |
阿尔尼拉姆医药品有限公司 |
用于递送治疗剂的脂质和组合物
|
WO2010060110A1
(en)
*
|
2008-11-24 |
2010-05-27 |
Northwestern University |
Polyvalent rna-nanoparticle compositions
|
JP6091752B2
(ja)
|
2008-12-04 |
2017-03-08 |
クルナ・インコーポレーテッド |
Epoに対する天然アンチセンス転写物の抑制によるエリスロポエチン(epo)関連疾患の治療
|
RU2618688C2
(ru)
|
2008-12-04 |
2017-05-10 |
КьюРНА,Инк.,US |
Лечение связанных с геном-супрессором опухолей заболеваний посредством ингибирования природного транскрипта в антисмысловой ориентации относительно этого гена
|
EP2370580B1
(de)
|
2008-12-04 |
2019-09-11 |
CuRNA, Inc. |
Behandlung von sirtuin 1 (sirt1)-bedingten erkrankungen mittels hemmung des natürlichen antisense-transkripts gegen sirtuin 1
|
EP2373382B1
(de)
|
2008-12-10 |
2017-02-15 |
Alnylam Pharmaceuticals, Inc. |
Auf gnaq zielende dsrna-zusammensetzungen und verfahren zur unterdrückung der expression
|
US20100233270A1
(en)
*
|
2009-01-08 |
2010-09-16 |
Northwestern University |
Delivery of Oligonucleotide-Functionalized Nanoparticles
|
AU2010203474B2
(en)
*
|
2009-01-08 |
2015-11-19 |
Northwestern University |
Inhibition of bacterial protein production by polyvalent oligonucleotide modified nanoparticle conjugates
|
AU2010208311B2
(en)
*
|
2009-01-28 |
2016-07-07 |
Qiagen Gaithersburg, Inc. |
Sequence-specific large volume sample preparation method and assay
|
WO2010091308A2
(en)
|
2009-02-06 |
2010-08-12 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds and methods
|
HUE026280T2
(en)
|
2009-02-12 |
2016-06-28 |
Curna Inc |
Treatment of brain-derived neurotrophic factor (BDNF) -related diseases by inhibition of natural antisense transcripts associated with BDNF \ t
|
US20110319476A1
(en)
|
2009-02-12 |
2011-12-29 |
Opko Curna, Llc |
Treatment of glial cell derived neurotrophic factor (gdnf) related diseases by inhibition of natural antisense transcript to gdnf
|
WO2010099341A1
(en)
|
2009-02-26 |
2010-09-02 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of mig-12 gene
|
EP2403863B1
(de)
|
2009-03-02 |
2013-08-28 |
Alnylam Pharmaceuticals Inc. |
Chemische modifikationen von nukleinsäure
|
US20110319317A1
(en)
|
2009-03-04 |
2011-12-29 |
Opko Curna, Llc |
Treatment of sirtuin 1 (sirt1) related diseases by inhibition of natural antisense transcript to sirt1
|
WO2010105209A1
(en)
|
2009-03-12 |
2010-09-16 |
Alnylam Pharmaceuticals, Inc. |
LIPID FORMULATED COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF Eg5 AND VEGF GENES
|
US9464287B2
(en)
|
2009-03-16 |
2016-10-11 |
Curna, Inc. |
Treatment of nuclear factor (erythroid-derived 2)-like 2 (NRF2) related diseases by inhibition of natural antisense transcript to NRF2
|
US9708604B2
(en)
|
2009-03-17 |
2017-07-18 |
Curna, Inc. |
Treatment of delta-like 1 homolog (DLK1) related diseases by inhibition of natural antisense transcript to DLK1
|
EP3248618A1
(de)
|
2009-04-22 |
2017-11-29 |
Massachusetts Institute Of Technology |
Angeborene immununterdrückung mit ermöglichung der wiederholten verabreichung von langen rna-molekülen
|
JP5738278B2
(ja)
*
|
2009-05-01 |
2015-06-24 |
キアジェン ゲイサーズバーグ インコーポレイテッド |
試料中のrnaスプライシング形態を検出するための非標的増幅法
|
US8318690B2
(en)
|
2009-05-01 |
2012-11-27 |
Curna, Inc. |
Treatment of hemoglobin (HBF/HBG) related diseases by inhibition of natural antisense transcript to HBF/HBG
|
CA2761152A1
(en)
|
2009-05-06 |
2010-11-11 |
Opko Curna, Llc |
Treatment of lipid transport and metabolism gene related diseases by inhibition of natural antisense transcript to a lipid transport and metabolism gene
|
CN102803492B
(zh)
|
2009-05-06 |
2016-06-29 |
库尔纳公司 |
通过抑制针对三重四脯氨酸(ttp)的天然反义转录物来治疗ttp相关疾病
|
US8957037B2
(en)
|
2009-05-18 |
2015-02-17 |
Curna, Inc. |
Treatment of reprogramming factor related diseases by inhibition of natural antisense transcript to a reprogramming factor
|
JP2012527248A
(ja)
|
2009-05-22 |
2012-11-08 |
クルナ・インコーポレーテッド |
転写因子e3(tfe3)に対する天然アンチセンス転写物の阻害によるtfe3およびインスリン受容体基質2(irs2)関連疾患の処置
|
KR101704988B1
(ko)
|
2009-05-28 |
2017-02-08 |
큐알엔에이, 인크. |
항바이러스 유전자에 대한 천연 안티센스 전사체의 억제에 의한 항바이러스 유전자 관련된 질환의 치료
|
SG10201912450XA
(en)
|
2009-06-10 |
2020-03-30 |
Arbutus Biopharma Corp |
Improved lipid formulation
|
EP2443237B1
(de)
|
2009-06-16 |
2017-02-22 |
CuRNA, Inc. |
Behandlung von krankheiten im zusammenhang mit dem kollagengen durch hemmung des natürlichen antisense-transkripts zu einem kollagengens
|
KR101702689B1
(ko)
|
2009-06-16 |
2017-02-06 |
큐알엔에이, 인크. |
Pon1에 대한 천연 안티센스 전사체의 억제에 의한 파라옥소나제 1(pon1) 관련된 질환의 치료
|
PL3305302T3
(pl)
|
2009-06-17 |
2019-02-28 |
Biogen Ma Inc. |
Kompozycje i sposoby modulacji składania smn2 u pacjenta
|
CN102597238B
(zh)
|
2009-06-24 |
2016-06-29 |
库尔纳公司 |
通过抑制针对肿瘤坏死因子受体2(tnfr2)的天然反义转录物来治疗tnfr2相关的疾病
|
CN102482672B
(zh)
|
2009-06-26 |
2016-11-09 |
库尔纳公司 |
通过抑制唐氏综合征基因的天然反义转录物治疗唐氏综合征基因相关疾病
|
EP2462229B1
(de)
|
2009-08-05 |
2016-05-11 |
CuRNA, Inc. |
Behandlung von durch insulingene bedingten erkrankungen mittels hemmung des natürlichen antisense-transkripts gegen ein insulingen
|
EP2810643A3
(de)
|
2009-08-14 |
2015-03-11 |
Alnylam Pharmaceuticals Inc. |
Zusammensetzungen aus Lipidformulierung und Verfahren zur Hemmung der Expression eines Gens aus dem Ebola-Virus
|
US9023822B2
(en)
|
2009-08-25 |
2015-05-05 |
Curna, Inc. |
Treatment of 'IQ motif containing GTPase activating protein' (IQGAP) related diseases by inhibition of natural antisense transcript to IQGAP
|
DK2473522T3
(en)
|
2009-09-02 |
2016-11-28 |
Genentech Inc |
Smoothened MUTANT AND METHODS OF USING THE SAME
|
WO2011032124A1
(en)
|
2009-09-14 |
2011-03-17 |
Qiagen Gaithersburg, Inc. |
Compositions and methods for recovery of nucleic acids or proteins from tissue samples fixed in cytology media
|
WO2011050194A1
(en)
|
2009-10-22 |
2011-04-28 |
Genentech, Inc. |
Methods and compositions for modulating hepsin activation of macrophage-stimulating protein
|
JP5866119B2
(ja)
|
2009-10-30 |
2016-02-17 |
ノースウェスタン ユニバーシティ |
鋳型ナノ複合体
|
CA2781887C
(en)
|
2009-11-30 |
2018-03-27 |
Genentech, Inc. |
Compositions and methods for the diagnosis and treatment of tumor
|
EP2509636B1
(de)
|
2009-12-07 |
2017-07-19 |
Arbutus Biopharma Corporation |
Zusammensetzungen für nukleinsäurefreisetzung
|
KR101823702B1
(ko)
|
2009-12-16 |
2018-01-30 |
큐알엔에이, 인크. |
막 결합 전사 인자 펩티다제, 부위 1(mbtps1)에 대한 천연 안티센스 전사체의 억제에 의한 mbtps1 관련 질환의 치료
|
WO2011075656A1
(en)
|
2009-12-18 |
2011-06-23 |
The University Of British Columbia |
Methods and compositions for delivery of nucleic acids
|
KR101793753B1
(ko)
|
2009-12-23 |
2017-11-03 |
큐알엔에이, 인크. |
커플링방지 단백질 2(ucp2)에 대한 천연 안티센스 전사체의 저해에 의한 ucp2 관련 질환의 치료
|
DK2516648T3
(en)
|
2009-12-23 |
2018-02-12 |
Curna Inc |
TREATMENT OF HEPATOCYTE GROWTH FACTOR (HGF) RELATED DISEASES BY INHIBITION OF NATURAL ANTISENSE TRANSCRIPT AGAINST HGF
|
KR101838305B1
(ko)
|
2009-12-29 |
2018-03-13 |
큐알엔에이, 인크. |
NRF1(Nuclear Respiratory Factor 1)에 대한 천연 안티센스 전사체의 억제에 의한 핵 호흡 인자 1 관련된 질환의 치료
|
CN102770540B
(zh)
|
2009-12-29 |
2017-06-23 |
库尔纳公司 |
通过抑制肿瘤蛋白63(p63)的天然反义转录物而治疗p63相关疾病
|
RU2611187C2
(ru)
|
2010-01-04 |
2017-02-21 |
Курна, Инк. |
Лечение заболеваний, связанных с интерферон-регуляторным фактором 8 (irf8), путем ингибирования природного антисмыслового транскрипта к irf8
|
CA2786056C
(en)
|
2010-01-06 |
2023-03-14 |
Curna, Inc. |
Treatment of pancreatic developmental gene related diseases by inhibition of natural antisense transcript to a pancreatic developmental gene
|
DK2524039T3
(en)
|
2010-01-11 |
2018-03-12 |
Curna Inc |
TREATMENT OF GENDER HORMON-BINDING GLOBULIN (SHBG) RELATED DISEASES BY INHIBITION OF NATURAL ANTISENCE TRANSCRIPTS TO SHBG
|
US8946182B2
(en)
|
2010-01-25 |
2015-02-03 |
Curna, Inc. |
Treatment of RNASE H1 related diseases by inhibition of natural antisense transcript to RNASE H1
|
WO2011094580A2
(en)
|
2010-01-28 |
2011-08-04 |
Alnylam Pharmaceuticals, Inc. |
Chelated copper for use in the preparation of conjugated oligonucleotides
|
US9198972B2
(en)
|
2010-01-28 |
2015-12-01 |
Alnylam Pharmaceuticals, Inc. |
Monomers and oligonucleotides comprising cycloaddition adduct(s)
|
EP2529031B1
(de)
|
2010-01-29 |
2014-07-09 |
QIAGEN Gaithersburg, Inc. |
Verfahren zur feststellung von hpv in einer probe
|
AU2011210734B2
(en)
|
2010-01-29 |
2017-02-09 |
Qiagen Gaithersburg, Inc. |
Methods and compositions for sequence-specific purification and multiplex analysis of nucleic acids
|
WO2011097407A1
(en)
|
2010-02-04 |
2011-08-11 |
Ico Therapeutics Inc. |
Dosing regimens for treating and preventing ocular disorders using c-raf antisense
|
CN102844435B
(zh)
|
2010-02-22 |
2017-05-10 |
库尔纳公司 |
通过抑制吡咯啉‑5‑羧酸还原酶1(pycr1)的天然反义转录物而治疗pycr1相关疾病
|
CA2787657A1
(en)
|
2010-02-23 |
2011-09-01 |
Genentech, Inc. |
Compositions and methods for the diagnosis and treatment of tumor
|
WO2011105901A2
(en)
|
2010-02-23 |
2011-09-01 |
Academisch Ziekenhuis Bij De Universiteit Van Amsterdam |
Antagonists of complement component 9 (c9) and uses thereof
|
WO2011105900A2
(en)
|
2010-02-23 |
2011-09-01 |
Academisch Ziekenhuis Bij De Universiteit Van Amsterdam |
Antagonists of complement component 8-alpha (c8-alpha) and uses thereof
|
WO2011105902A2
(en)
|
2010-02-23 |
2011-09-01 |
Academisch Ziekenhuis Bij De Universiteit Van Amsterdam |
Antagonists of complement component 8-beta (c8-beta) and uses thereof
|
WO2011112516A1
(en)
|
2010-03-08 |
2011-09-15 |
Ico Therapeutics Inc. |
Treating and preventing hepatitis c virus infection using c-raf kinase antisense oligonucleotides
|
US8906875B2
(en)
|
2010-03-12 |
2014-12-09 |
The Brigham And Women's Hospital, Inc. |
Methods of treating vascular inflammatory disorders
|
US20130281510A1
(en)
|
2010-03-29 |
2013-10-24 |
Kumamoto University |
siRNA Therapy for Transthyretin (TTR) Related Ocular Amyloidosis
|
US9102938B2
(en)
|
2010-04-01 |
2015-08-11 |
Alnylam Pharmaceuticals, Inc. |
2′ and 5′ modified monomers and oligonucleotides
|
CA2792561C
(en)
|
2010-04-06 |
2021-10-26 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of cd274/pd-l1 gene
|
CN102858979B
(zh)
|
2010-04-09 |
2018-01-26 |
库尔纳公司 |
通过抑制成纤维细胞生长因子21(fgf21)的天然反义转录物而治疗fgf21相关疾病
|
WO2011133876A2
(en)
|
2010-04-22 |
2011-10-27 |
Alnylam Pharmaceuticals, Inc. |
Oligonucleotides comprising acyclic and abasic nucleosides and analogs
|
WO2011133871A2
(en)
|
2010-04-22 |
2011-10-27 |
Alnylam Pharmaceuticals, Inc. |
5'-end derivatives
|
WO2011133868A2
(en)
|
2010-04-22 |
2011-10-27 |
Alnylam Pharmaceuticals, Inc. |
Conformationally restricted dinucleotide monomers and oligonucleotides
|
EP2606057B1
(de)
|
2010-04-28 |
2016-06-15 |
Ionis Pharmaceuticals, Inc. |
Modifizierte 5' diphosphat-nukleoside und daraus hergestellte oligomere verbindungen
|
CN103154014B
(zh)
|
2010-04-28 |
2015-03-25 |
Isis制药公司 |
修饰核苷、其类似物以及由它们制备的寡聚化合物
|
EP3091027B1
(de)
|
2010-04-28 |
2018-01-17 |
Ionis Pharmaceuticals, Inc. |
5'-modifizierte nukleoside und daraus hergestellte oligomere verbindungen
|
WO2011139911A2
(en)
|
2010-04-29 |
2011-11-10 |
Isis Pharmaceuticals, Inc. |
Lipid formulated single stranded rna
|
CA2994063A1
(en)
|
2010-04-29 |
2011-11-10 |
Ionis Pharmaceuticals, Inc. |
Modulation of transthyretin expression
|
KR101936011B1
(ko)
|
2010-05-03 |
2019-01-07 |
큐알엔에이, 인크. |
시르투인 (sirt)에 대한 자연 안티센스 전사체의 저해에 의한 시르투인 (sirt) 관련된 질환의 치료
|
BR112012028010A2
(pt)
|
2010-05-03 |
2017-09-26 |
Genentech Inc |
anticorpo isolado, célula, ácido nucleíco isolado, método de identificação de um primeiro anticorpo que se liga a um epítopo antigênico tat425 ligado or um anticorpo, métodos de inibir o crescimento de uma célula, de tratamento terapêutico de determinação da presença de uma proteína de tat425 e de diagnóstico da presença de um tumor em um mamífero
|
TWI531370B
(zh)
|
2010-05-14 |
2016-05-01 |
可娜公司 |
藉由抑制par4天然反股轉錄本治療par4相關疾病
|
AU2011255638B2
(en)
|
2010-05-19 |
2016-08-25 |
Qiagen Gaithersburg, Inc. |
Methods and compositions for sequence-specific purification and multiplex analysis of nucleic acids
|
CA2799205A1
(en)
|
2010-05-25 |
2011-12-01 |
Qiagen Gaithersburg, Inc. |
Fast results hybrid capture assay and associated strategically-truncated probes
|
EP3299464B1
(de)
|
2010-05-26 |
2019-10-02 |
CuRNA, Inc. |
Behandlung von durch atonal homolog 1 (atoh1) vermittelten erkrankungen durch hemmung des natürlichen antisense-transkripts für atoh1
|
WO2011153323A2
(en)
|
2010-06-02 |
2011-12-08 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods directed to treating liver fibrosis
|
WO2011153354A1
(en)
|
2010-06-03 |
2011-12-08 |
Cellay, Inc. |
Methods and kits for in situ detection of nucleotide sequences
|
WO2011156713A1
(en)
|
2010-06-11 |
2011-12-15 |
Vanderbilt University |
Multiplexed interferometric detection system and method
|
WO2011163121A1
(en)
|
2010-06-21 |
2011-12-29 |
Alnylam Pharmaceuticals, Inc. |
Multifunctional copolymers for nucleic acid delivery
|
CA2805318A1
(en)
|
2010-07-14 |
2012-01-19 |
Curna, Inc. |
Treatment of discs large homolog (dlg) related diseases by inhibition of natural antisense transcript to dlg
|
US20130202652A1
(en)
|
2010-07-30 |
2013-08-08 |
Alnylam Pharmaceuticals, Inc. |
Methods and compositions for delivery of active agents
|
US20130323269A1
(en)
|
2010-07-30 |
2013-12-05 |
Muthiah Manoharan |
Methods and compositions for delivery of active agents
|
SG10201508118WA
(en)
|
2010-09-30 |
2015-11-27 |
Agency Science Tech & Res |
Methods and reagents for detection and treatment of esophageal metaplasia
|
EP2625197B1
(de)
|
2010-10-05 |
2016-06-29 |
Genentech, Inc. |
Smoothened-mutant und verfahren zu seiner anwendung
|
US8993533B2
(en)
|
2010-10-06 |
2015-03-31 |
Curna, Inc. |
Treatment of sialidase 4 (NEU4) related diseases by inhibition of natural antisense transcript to NEU4
|
US20140031250A1
(en)
|
2010-10-07 |
2014-01-30 |
David Tsai Ting |
Biomarkers of Cancer
|
JP6049623B2
(ja)
|
2010-10-22 |
2016-12-21 |
カッパーアールエヌエー,インコーポレイテッド |
α‐L‐イズロニダーゼ(IDUA)への天然アンチセンス転写物の阻害によるIDUA関連疾患の治療
|
US20130210893A1
(en)
|
2010-10-27 |
2013-08-15 |
Curna, Inc. |
Treatment of interferon-related developmental regulator 1 (ifrd1) related diseases by inhibition of natural antisense transcript to ifrd1
|
WO2012064824A1
(en)
|
2010-11-09 |
2012-05-18 |
Alnylam Pharmaceuticals, Inc. |
Lipid formulated compositions and methods for inhibiting expression of eg5 and vegf genes
|
EP3260540A1
(de)
|
2010-11-12 |
2017-12-27 |
The General Hospital Corporation |
Polycombassoziierte nichtcodierende rnas
|
JP6071893B2
(ja)
|
2010-11-23 |
2017-02-01 |
カッパーアールエヌエー,インコーポレイテッド |
Nanogへの天然アンチセンス転写物の阻害によるnanog関連疾患の治療
|
WO2012078967A2
(en)
|
2010-12-10 |
2012-06-14 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for increasing erythropoietin (epo) production
|
EP2648763A4
(de)
|
2010-12-10 |
2014-05-14 |
Alnylam Pharmaceuticals Inc |
Zusammensetzungen und verfahren zur expressionshemmung der gene klf-1 und bcl11a
|
CA2824526C
(en)
|
2011-01-11 |
2020-07-07 |
Alnylam Pharmaceuticals, Inc. |
Pegylated lipids and their use for drug delivery
|
US9045749B2
(en)
|
2011-01-14 |
2015-06-02 |
The General Hospital Corporation |
Methods targeting miR-128 for regulating cholesterol/lipid metabolism
|
PT2670411T
(pt)
|
2011-02-02 |
2019-06-18 |
Excaliard Pharmaceuticals Inc |
Compostos anti sentido visando um fator de crescimento do tecido conetivo (ctfg) para utilização num método de tratamento de queloides ou cicatrizes hipertróficas
|
WO2012113775A1
(en)
|
2011-02-21 |
2012-08-30 |
University Of Zurich |
Ankyrin g and modulators thereof for the treatment of neurodegenerative disorders
|
US9562853B2
(en)
|
2011-02-22 |
2017-02-07 |
Vanderbilt University |
Nonaqueous backscattering interferometric methods
|
AU2012220575B2
(en)
|
2011-02-24 |
2017-01-12 |
Qiagen Gaithersburg, Inc. |
Materials and methods for detection of HPV nucleic acid
|
US9175290B2
(en)
|
2011-03-29 |
2015-11-03 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of TMPRSS6 gene
|
US9593330B2
(en)
|
2011-06-09 |
2017-03-14 |
Curna, Inc. |
Treatment of frataxin (FXN) related diseases by inhibition of natural antisense transcript to FXN
|
CN103890000B
(zh)
|
2011-06-21 |
2017-09-01 |
阿尔尼拉姆医药品有限公司 |
血管生成素样3(ANGPTL3)iRNA组合物及其使用方法
|
US9068184B2
(en)
|
2011-06-21 |
2015-06-30 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibition of expression of protein C (PROC) genes
|
KR102369777B1
(ko)
|
2011-06-21 |
2022-03-03 |
알닐람 파마슈티칼스 인코포레이티드 |
아포리포단백질 c-iii(apoc3) 유전자의 발현 억제를 위한 조성물 및 방법
|
EP4134433A1
(de)
|
2011-06-23 |
2023-02-15 |
Alnylam Pharmaceuticals, Inc. |
Serpina1-sirnas: materialzusammensetzungen und behandlungsverfahren
|
JP2014526887A
(ja)
|
2011-08-01 |
2014-10-09 |
アルナイラム ファーマシューティカルズ, インコーポレイテッド |
造血幹細胞移植の成功率を改善する方法
|
WO2013040499A1
(en)
|
2011-09-14 |
2013-03-21 |
Northwestern University |
Nanoconjugates able to cross the blood-brain barrier
|
DK2756080T3
(da)
|
2011-09-14 |
2019-05-20 |
Translate Bio Ma Inc |
Multimeriske oligonukleotidforbindelser
|
US9701623B2
(en)
|
2011-09-27 |
2017-07-11 |
Alnylam Pharmaceuticals, Inc. |
Di-aliphatic substituted pegylated lipids
|
AU2012322788B2
(en)
|
2011-10-11 |
2018-01-04 |
The Brigham And Women's Hospital, Inc. |
Micrornas in neurodegenerative disorders
|
CN104080958A
(zh)
|
2011-10-19 |
2014-10-01 |
纽亘技术公司 |
用于定向核酸扩增和测序的组合物和方法
|
JP2015502365A
(ja)
|
2011-12-12 |
2015-01-22 |
オンコイミューニン,インコーポレイティド |
オリゴヌクレオチドのイン−ビボ送達
|
JP2015505241A
(ja)
|
2011-12-12 |
2015-02-19 |
セレー,インコーポレイテッド |
生物学的試料中の標的核酸の室温インサイチュ検出のための方法およびキット
|
SG10201604896TA
(en)
|
2011-12-16 |
2016-08-30 |
Moderna Therapeutics Inc |
Modified nucleoside, nucleotide, and nucleic acid compositions
|
GB2513793B
(en)
|
2012-01-26 |
2016-11-02 |
Nugen Tech Inc |
Compositions and methods for targeted nucleic acid sequence enrichment and high efficiency library generation
|
KR20140136488A
(ko)
|
2012-03-15 |
2014-11-28 |
큐알엔에이, 인크. |
뇌 유래 신경영양 인자(bdnf)에 대한 천연 안티센스 전사체의 저해에 의한 뇌 유래 신경영양 인자(bdnf)관련 질환의 치료
|
JP2015513913A
(ja)
|
2012-04-02 |
2015-05-18 |
モデルナ セラピューティクス インコーポレイテッドModerna Therapeutics,Inc. |
修飾ポリヌクレオチド
|
WO2013151666A2
(en)
|
2012-04-02 |
2013-10-10 |
modeRNA Therapeutics |
Modified polynucleotides for the production of biologics and proteins associated with human disease
|
US9133461B2
(en)
|
2012-04-10 |
2015-09-15 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of the ALAS1 gene
|
WO2013159091A2
(en)
|
2012-04-20 |
2013-10-24 |
Aptamir Therapeutics, Inc. |
Mirna modulators of thermogenesis
|
US9127274B2
(en)
|
2012-04-26 |
2015-09-08 |
Alnylam Pharmaceuticals, Inc. |
Serpinc1 iRNA compositions and methods of use thereof
|
EP3597741A1
(de)
|
2012-04-27 |
2020-01-22 |
Duke University |
Genetische korrektur mutierter gene
|
US9273949B2
(en)
|
2012-05-11 |
2016-03-01 |
Vanderbilt University |
Backscattering interferometric methods
|
AU2013262663A1
(en)
|
2012-05-16 |
2015-01-22 |
The General Hospital Corporation D/B/A Massachusetts General Hospital |
Compositions and methods for modulating gene expression
|
EP2850186B1
(de)
|
2012-05-16 |
2018-12-19 |
Translate Bio MA, Inc. |
Zusammensetzungen und verfahren zur modulation der expression der smn-genfamilie
|
JP6181751B2
(ja)
|
2012-06-18 |
2017-08-16 |
ニューゲン テクノロジーズ, インコーポレイテッド |
望まれない核酸配列のネガティブ選択のための組成物および方法
|
US20150011396A1
(en)
|
2012-07-09 |
2015-01-08 |
Benjamin G. Schroeder |
Methods for creating directional bisulfite-converted nucleic acid libraries for next generation sequencing
|
EP2880161A1
(de)
|
2012-08-03 |
2015-06-10 |
Aptamir Therapeutics, Inc. |
Abgabe von zellspezifischen mirna-modulatoren zur behandlung von adipositas und verwandten erkrankungen
|
WO2014070460A1
(en)
|
2012-10-31 |
2014-05-08 |
Cellay, Inc. |
Methods and kits for performing in situ hybridization
|
HRP20220607T1
(hr)
|
2012-11-26 |
2022-06-24 |
Modernatx, Inc. |
Terminalno modificirana rna
|
JP2016504050A
(ja)
|
2013-01-17 |
2016-02-12 |
モデルナ セラピューティクス インコーポレイテッドModerna Therapeutics,Inc. |
細胞表現型の改変のためのシグナルセンサーポリヌクレオチド
|
WO2014130922A1
(en)
|
2013-02-25 |
2014-08-28 |
Trustees Of Boston University |
Compositions and methods for treating fungal infections
|
WO2014159813A1
(en)
|
2013-03-13 |
2014-10-02 |
Moderna Therapeutics, Inc. |
Long-lived polynucleotide molecules
|
US10258698B2
(en)
|
2013-03-14 |
2019-04-16 |
Modernatx, Inc. |
Formulation and delivery of modified nucleoside, nucleotide, and nucleic acid compositions
|
SI2970974T1
(sl)
|
2013-03-14 |
2017-12-29 |
Alnylam Pharmaceuticals, Inc. |
Komplementarna komponenta C5 sestavkov IRNA in postopki njene uporabe
|
US20140274738A1
(en)
|
2013-03-15 |
2014-09-18 |
Nugen Technologies, Inc. |
Sequential sequencing
|
US8980864B2
(en)
|
2013-03-15 |
2015-03-17 |
Moderna Therapeutics, Inc. |
Compositions and methods of altering cholesterol levels
|
EP2978446B1
(de)
|
2013-03-27 |
2020-03-04 |
The General Hospital Corporation |
Anti-cd33 antikörper zur behandlung von morbus alzheimer
|
US10590412B2
(en)
|
2013-04-19 |
2020-03-17 |
Ionis Pharmaceuticals, Inc. |
Compositions and methods for modulation nucleic acids through nonsense mediated decay
|
LT2999785T
(lt)
|
2013-05-22 |
2018-07-25 |
Alnylam Pharmaceuticals, Inc. |
Serpina1 irna kompozicijos ir jų panaudojimo būdai
|
ES2862125T3
(es)
|
2013-06-13 |
2021-10-07 |
Antisense Therapeutics Ltd |
Terapia combinada para acromegalia
|
EP3019619B1
(de)
|
2013-07-11 |
2021-08-25 |
ModernaTX, Inc. |
Zusammensetzungen mit synthetischen polynukleotiden zur codierung von crispr-verwandten proteinen und synthetischen sgrnas und verfahren zur verwendung
|
DK3041854T3
(da)
|
2013-08-08 |
2020-03-02 |
Scripps Research Inst |
En fremgangsmåde til stedspecifik enzymatisk mærkning af nukleinsyrer in vitro gennem inkorporering af unaturlige nukleotider
|
EP3041934A1
(de)
|
2013-09-03 |
2016-07-13 |
Moderna Therapeutics, Inc. |
Chimäre polynukleotide
|
US20160194368A1
(en)
|
2013-09-03 |
2016-07-07 |
Moderna Therapeutics, Inc. |
Circular polynucleotides
|
EP3052626A1
(de)
|
2013-10-02 |
2016-08-10 |
Alnylam Pharmaceuticals, Inc. |
Zusammensetzungen und verfahren zur hemmung der lect2-genexpression
|
CA2926218A1
(en)
|
2013-10-03 |
2015-04-09 |
Moderna Therapeutics, Inc. |
Polynucleotides encoding low density lipoprotein receptor
|
SG11201602631XA
(en)
|
2013-10-04 |
2016-05-30 |
Alnylam Pharmaceuticals Inc |
Compositions and methods for inhibiting expression of the alas1 gene
|
WO2015069920A1
(en)
|
2013-11-07 |
2015-05-14 |
Cellay, Inc. |
Methods and kits for detecting a prostate carcinoma and predicting disease outcomes for prostate cancers
|
JP6525473B2
(ja)
|
2013-11-13 |
2019-06-05 |
ニューゲン テクノロジーズ, インコーポレイテッド |
複製物配列決定リードを同定するための組成物および方法
|
WO2015075557A2
(en)
|
2013-11-22 |
2015-05-28 |
Mina Alpha Limited |
C/ebp alpha compositions and methods of use
|
CA2844640A1
(en)
|
2013-12-06 |
2015-06-06 |
The University Of British Columbia |
Method for treatment of castration-resistant prostate cancer
|
SG11201604692UA
(en)
|
2013-12-12 |
2016-07-28 |
Alnylam Pharmaceuticals Inc |
Complement component irna compositions and methods of use thereof
|
US20170044232A1
(en)
|
2014-02-04 |
2017-02-16 |
Genentech, Inc. |
Mutant smoothened and methods of using the same
|
JP6594902B2
(ja)
|
2014-02-11 |
2019-10-23 |
アルナイラム ファーマシューティカルズ, インコーポレイテッド |
ケトヘキソキナーゼ(KHK)iRNA組成物及びその使用方法
|
WO2015131107A1
(en)
|
2014-02-28 |
2015-09-03 |
Nugen Technologies, Inc. |
Reduced representation bisulfite sequencing with diversity adaptors
|
EP3943607A1
(de)
|
2014-04-09 |
2022-01-26 |
The Scripps Research Institute |
Import von unnatürlichen oder modifizierten nukleosid-triphosphaten in zellen mittels nukleinsäure-triphosphattransportern
|
WO2015161170A2
(en)
|
2014-04-17 |
2015-10-22 |
Isis Pharmaceuticals, Inc. |
Compositions and methods for modulation of smn2 splicing in a subject
|
WO2015171918A2
(en)
|
2014-05-07 |
2015-11-12 |
Louisiana State University And Agricultural And Mechanical College |
Compositions and uses for treatment thereof
|
WO2015175510A1
(en)
|
2014-05-12 |
2015-11-19 |
Alnylam Pharmaceuticals, Inc. |
Methods and compositions for treating a serpinc1-associated disorder
|
EA201692370A1
(ru)
|
2014-05-22 |
2017-03-31 |
Элнилэм Фармасьютикалз, Инк. |
КОМПОЗИЦИИ иРНК АНГИОТЕНЗИНОГЕНА (AGT) И СПОСОБЫ ИХ ИСПОЛЬЗОВАНИЯ
|
CA2950878C
(en)
|
2014-06-10 |
2024-01-23 |
Erasmus University Medical Center Rotterdam |
Antisense oligonucleotides useful in treatment of pompe disease
|
US10301624B2
(en)
|
2014-06-25 |
2019-05-28 |
The General Hospital Corporation |
Targeting human satellite II (HSATII)
|
EP4159741A1
(de)
|
2014-07-16 |
2023-04-05 |
ModernaTX, Inc. |
Verfahren zur herstellung eines chimären polynukleotids zur kodierung eines polypeptids mit einer triazolhaltigen internukleotid-bindung
|
EP3171895A1
(de)
|
2014-07-23 |
2017-05-31 |
Modernatx, Inc. |
Modifizierte polynukleotide zur herstellung von intrabodys
|
IL250302B
(en)
|
2014-07-31 |
2022-07-01 |
Uab Research Foundation |
Apoe mimetic peptides with high potency to clear plasma cholesterol
|
WO2016033424A1
(en)
|
2014-08-29 |
2016-03-03 |
Genzyme Corporation |
Methods for the prevention and treatment of major adverse cardiovascular events using compounds that modulate apolipoprotein b
|
US10385343B2
(en)
|
2014-08-29 |
2019-08-20 |
Children's Medical Center Corporation |
Methods and compositions for the treatment of cancer
|
EP3191591A1
(de)
|
2014-09-12 |
2017-07-19 |
Alnylam Pharmaceuticals, Inc. |
Gegen komplementkomponente c5 gerichtete polynukleotidwirkstoffe und verfahren zur verwendung davon
|
US10556020B2
(en)
|
2014-09-26 |
2020-02-11 |
University Of Massachusetts |
RNA-modulating agents
|
WO2016061487A1
(en)
|
2014-10-17 |
2016-04-21 |
Alnylam Pharmaceuticals, Inc. |
Polynucleotide agents targeting aminolevulinic acid synthase-1 (alas1) and uses thereof
|
EP3212794B1
(de)
|
2014-10-30 |
2021-04-07 |
Genzyme Corporation |
Polynukleotidwirkstoffe mit abzielung auf serpinc1 (at3) und verfahren zur verwendung davon
|
JOP20200092A1
(ar)
|
2014-11-10 |
2017-06-16 |
Alnylam Pharmaceuticals Inc |
تركيبات iRNA لفيروس الكبد B (HBV) وطرق لاستخدامها
|
CN107250362B
(zh)
|
2014-11-17 |
2021-10-22 |
阿尔尼拉姆医药品有限公司 |
载脂蛋白C3(APOC3)iRNA组合物及其使用方法
|
WO2016081060A2
(en)
|
2014-11-18 |
2016-05-26 |
Agiltron, Inc. |
Systems for detecting target biological molecules
|
CN107106493A
(zh)
|
2014-11-21 |
2017-08-29 |
西北大学 |
球形核酸纳米颗粒缀合物的序列特异性细胞摄取
|
WO2016094342A1
(en)
|
2014-12-08 |
2016-06-16 |
The Board Of Regents Of The University Of Texas System |
Lipocationic polymers and uses thereof
|
AU2015364508A1
(en)
|
2014-12-18 |
2017-07-06 |
Alnylam Pharmaceuticals, Inc. |
ReversirTM compounds
|
EP3247988A4
(de)
|
2015-01-23 |
2018-12-19 |
Vanderbilt University |
Robustes interferometer und verfahren zur verwendung davon
|
JP6929791B2
(ja)
|
2015-02-09 |
2021-09-01 |
デューク ユニバーシティ |
エピゲノム編集のための組成物および方法
|
WO2016130806A2
(en)
|
2015-02-13 |
2016-08-18 |
Alnylam Pharmaceuticals, Inc. |
Patatin-like phospholipase domain containing 3 (pnpla3) irna compositions and methods of use thereof
|
WO2016135559A2
(en)
|
2015-02-23 |
2016-09-01 |
Crispr Therapeutics Ag |
Materials and methods for treatment of human genetic diseases including hemoglobinopathies
|
US9708647B2
(en)
|
2015-03-23 |
2017-07-18 |
Insilixa, Inc. |
Multiplexed analysis of nucleic acid hybridization thermodynamics using integrated arrays
|
EP3283502A4
(de)
|
2015-04-07 |
2019-04-03 |
The General Hospital Corporation |
Verfahren zur reaktivierung von genen auf dem inaktiven x-chromosom
|
WO2016164746A1
(en)
|
2015-04-08 |
2016-10-13 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of the lect2 gene
|
EP3307316A1
(de)
|
2015-06-12 |
2018-04-18 |
Alnylam Pharmaceuticals, Inc. |
Gegen komplementkomponente c5 gerichtete irna-zusammensetzungen und verfahren zur verwendung davon
|
WO2016205323A1
(en)
|
2015-06-18 |
2016-12-22 |
Alnylam Pharmaceuticals, Inc. |
Polynucleotde agents targeting hydroxyacid oxidase (glycolate oxidase, hao1) and methods of use thereof
|
WO2016209862A1
(en)
|
2015-06-23 |
2016-12-29 |
Alnylam Pharmaceuticals, Inc. |
Glucokinase (gck) irna compositions and methods of use thereof
|
CN108139375A
(zh)
|
2015-06-26 |
2018-06-08 |
贝斯以色列女执事医疗中心股份有限公司 |
靶向髓样衍生的抑制细胞中的四跨膜蛋白33(tspan33)的癌症疗法
|
AU2016287499B2
(en)
|
2015-06-29 |
2022-08-04 |
Caris Science, Inc. |
Therapeutic oligonucleotides
|
US10494632B2
(en)
|
2015-07-10 |
2019-12-03 |
Alnylam Pharmaceuticals, Inc. |
Insulin-like growth factor binding protein, acid labile subunit (IGFALS) compositions and methods of use thereof
|
CA2989970A1
(en)
|
2015-07-17 |
2017-01-26 |
Alnylam Pharmaceuticals, Inc. |
Multi-targeted single entity conjugates
|
US10941176B2
(en)
|
2015-07-28 |
2021-03-09 |
Caris Science, Inc. |
Therapeutic oligonucleotides
|
EP3344769B1
(de)
|
2015-09-02 |
2024-04-17 |
Alnylam Pharmaceuticals, Inc. |
Programmed cell death 1 ligand 1 (pd-l1) irna-kompositionen und methoden zu deren verwendung
|
US9499861B1
(en)
|
2015-09-10 |
2016-11-22 |
Insilixa, Inc. |
Methods and systems for multiplex quantitative nucleic acid amplification
|
KR20240027890A
(ko)
|
2015-09-14 |
2024-03-04 |
더 보드 오브 리젠츠 오브 더 유니버시티 오브 텍사스 시스템 |
지질양이온성 덴드리머 및 이의 용도
|
EP3353297A1
(de)
|
2015-09-24 |
2018-08-01 |
Crispr Therapeutics AG |
Neuartige familie von rna-programmierbaren endonukleasen und deren verwendung in der genomeditierung und anderen anwendungen
|
WO2017066497A2
(en)
|
2015-10-13 |
2017-04-20 |
Duke University |
Genome engineering with type i crispr systems in eukaryotic cells
|
EP4279084A1
(de)
|
2015-10-28 |
2023-11-22 |
Vertex Pharmaceuticals Inc. |
Materialien und verfahren zur behandlung von duchenne-muskeldystrophie
|
EP3370734B1
(de)
|
2015-11-05 |
2023-01-04 |
Children's Hospital Los Angeles |
Antisense-oligo zur verwendung bei der behandlung von akuter myeloischer leukämie
|
CN109328231A
(zh)
|
2015-11-06 |
2019-02-12 |
克里斯普治疗股份公司 |
用于治疗1a型糖原贮积病的材料和方法
|
CA3005878A1
(en)
|
2015-11-19 |
2017-05-26 |
The Brigham And Women's Hospital, Inc. |
Lymphocyte antigen cd5-like (cd5l)-interleukin 12b (p40) heterodimers in immunity
|
AU2016364667A1
(en)
|
2015-12-01 |
2018-06-21 |
Crispr Therapeutics Ag |
Materials and methods for treatment of Alpha-1 antitrypsin deficiency
|
EP3387127A1
(de)
|
2015-12-07 |
2018-10-17 |
Erasmus University Medical Center Rotterdam |
Enzymatische ersatztherapie und antisense-therapie für pompe-krankheit
|
WO2017106767A1
(en)
|
2015-12-18 |
2017-06-22 |
The Scripps Research Institute |
Production of unnatural nucleotides using a crispr/cas9 system
|
CA3009308A1
(en)
|
2015-12-23 |
2017-06-29 |
Chad Albert COWAN |
Materials and methods for treatment of amyotrophic lateral sclerosis and/or frontal temporal lobular degeneration
|
EP3408649B1
(de)
|
2016-01-29 |
2023-06-14 |
Vanderbilt University |
Interferometrie mit antwortfunktion in freier lösung
|
WO2017134529A1
(en)
|
2016-02-02 |
2017-08-10 |
Crispr Therapeutics Ag |
Materials and methods for treatment of severe combined immunodeficiency (scid) or omenn syndrome
|
AU2017213826A1
(en)
|
2016-02-04 |
2018-08-23 |
Curis, Inc. |
Mutant smoothened and methods of using the same
|
WO2017141109A1
(en)
|
2016-02-18 |
2017-08-24 |
Crispr Therapeutics Ag |
Materials and methods for treatment of severe combined immunodeficiency (scid) or omenn syndrome
|
CA3054284A1
(en)
|
2016-02-25 |
2017-08-31 |
The Brigham And Women's Hospital, Inc. |
Treatment methods for fibrosis targeting smoc2
|
WO2017155858A1
(en)
|
2016-03-07 |
2017-09-14 |
Insilixa, Inc. |
Nucleic acid sequence identification using solid-phase cyclic single base extension
|
US11083799B2
(en)
|
2016-03-16 |
2021-08-10 |
Crispr Therapeutics Ag |
Materials and methods for treatment of hereditary haemochromatosis
|
KR20190008843A
(ko)
|
2016-03-18 |
2019-01-25 |
카리스 싸이언스, 인코포레이티드 |
올리고뉴클레오티드 프로브 및 이의 용도
|
KR102351329B1
(ko)
|
2016-04-18 |
2022-01-18 |
크리스퍼 테라퓨틱스 아게 |
혈색소병증의 치료를 위한 물질 및 방법
|
WO2017191503A1
(en)
|
2016-05-05 |
2017-11-09 |
Crispr Therapeutics Ag |
Materials and methods for treatment of hemoglobinopathies
|
CN114656378A
(zh)
|
2016-05-16 |
2022-06-24 |
得克萨斯州大学***董事会 |
阳离子磺酰胺氨基脂质和两亲性两性离子氨基脂质
|
IL306052A
(en)
|
2016-05-25 |
2023-11-01 |
Caris Science Inc |
Oligonucleotide probes and their uses
|
US20190256845A1
(en)
|
2016-06-10 |
2019-08-22 |
Alnylam Pharmaceuticals, Inc. |
COMPLEMENT COMPONENT C5 iRNA COMPOSITIONS AND METHODS OF USE THEREOF FOR TREATING PAROXYSMAL NOCTURNAL HEMOGLOBINURIA (PNH)
|
DK3475295T3
(da)
|
2016-06-24 |
2022-10-24 |
Scripps Research Inst |
Hidtil ukendt nukleosidtriphosphat-transportør og anvendelser deraf
|
US11427838B2
(en)
|
2016-06-29 |
2022-08-30 |
Vertex Pharmaceuticals Incorporated |
Materials and methods for treatment of myotonic dystrophy type 1 (DM1) and other related disorders
|
EP3478313B1
(de)
|
2016-06-29 |
2022-05-04 |
CRISPR Therapeutics AG |
Materialien und verfahren zur behandlung von amyotropher lateralsklerose (als) und anderen verwandten erkrankungen
|
EP3478828A1
(de)
|
2016-06-29 |
2019-05-08 |
Crispr Therapeutics AG |
Materialien und verfahren zur behandlung von friedreich-ataxie und anderen verwandten erkrankungen
|
AU2017292173B2
(en)
|
2016-07-06 |
2022-01-13 |
Vertex Pharmaceuticals Incorporated |
Materials and methods for treatment of pain related disorders
|
JP7305534B2
(ja)
|
2016-07-06 |
2023-07-10 |
バーテックス ファーマシューティカルズ インコーポレイテッド |
疼痛関連障害を処置するための物質及び方法
|
WO2018007871A1
(en)
|
2016-07-08 |
2018-01-11 |
Crispr Therapeutics Ag |
Materials and methods for treatment of transthyretin amyloidosis
|
EP3481430A4
(de)
|
2016-07-11 |
2020-04-01 |
Translate Bio Ma, Inc. |
Nukleinsäurekonjugate und verwendungen davon
|
WO2018020323A2
(en)
|
2016-07-25 |
2018-02-01 |
Crispr Therapeutics Ag |
Materials and methods for treatment of fatty acid disorders
|
NL2017294B1
(en)
|
2016-08-05 |
2018-02-14 |
Univ Erasmus Med Ct Rotterdam |
Natural cryptic exon removal by pairs of antisense oligonucleotides.
|
NL2017295B1
(en)
|
2016-08-05 |
2018-02-14 |
Univ Erasmus Med Ct Rotterdam |
Antisense oligomeric compound for Pompe disease
|
WO2018081817A2
(en)
|
2016-10-31 |
2018-05-03 |
University Of Massachusetts |
Targeting microrna-101-3p in cancer therapy
|
TW202313978A
(zh)
|
2016-11-23 |
2023-04-01 |
美商阿尼拉製藥公司 |
絲胺酸蛋白酶抑制因子A1 iRNA組成物及其使用方法
|
AU2017378153B2
(en)
|
2016-12-13 |
2024-03-28 |
Seattle Children's Hospital (dba Seattle Children's Research Institute) |
Methods of exogenous drug activation of chemical-induced signaling complexes expressed in engineered cells in vitro and in vivo
|
WO2018112320A1
(en)
|
2016-12-16 |
2018-06-21 |
Alnylam Pharmaceuticals, Inc. |
Methods for treating or preventing ttr-associated diseases using transthyretin (ttr) irna compositions
|
WO2018136758A1
(en)
|
2017-01-23 |
2018-07-26 |
Regeneron Pharmaceuticals, Inc. |
Hsd17b13 variants and uses thereof
|
JP2020508056A
(ja)
|
2017-02-22 |
2020-03-19 |
クリスパー・セラピューティクス・アクチェンゲゼルシャフトCRISPR Therapeutics AG |
遺伝子編集のための組成物および方法
|
US20200040061A1
(en)
|
2017-02-22 |
2020-02-06 |
Crispr Therapeutics Ag |
Materials and methods for treatment of early onset parkinson's disease (park1) and other synuclein, alpha (snca) gene related conditions or disorders
|
US20200216857A1
(en)
|
2017-02-22 |
2020-07-09 |
Crispr Therapeutics Ag |
Materials and methods for treatment of spinocerebellar ataxia type 2 (sca2) and other spinocerebellar ataxia type 2 protein (atxn2) gene related conditions or disorders
|
US11407997B2
(en)
|
2017-02-22 |
2022-08-09 |
Crispr Therapeutics Ag |
Materials and methods for treatment of primary hyperoxaluria type 1 (PH1) and other alanine-glyoxylate aminotransferase (AGXT) gene related conditions or disorders
|
WO2018154439A1
(en)
|
2017-02-22 |
2018-08-30 |
Crispr Therapeutics Ag |
Materials and methods for treatment of spinocerebellar ataxia type 1 (sca1) and other spinocerebellar ataxia type 1 protein (atxn1) gene related conditions or disorders
|
KR20200015895A
(ko)
|
2017-04-18 |
2020-02-13 |
알닐람 파마슈티칼스 인코포레이티드 |
B형 간염 바이러스 (hbv)에 감염된 대상체의 치료 방법
|
US11622977B2
(en)
|
2017-05-12 |
2023-04-11 |
Crispr Therapeutics Ag |
Materials and methods for engineering cells and uses thereof in immuno-oncology
|
CA3069321A1
(en)
|
2017-07-11 |
2019-01-17 |
Synthorx, Inc. |
Incorporation of unnatural nucleotides and methods thereof
|
AU2018301477A1
(en)
|
2017-07-13 |
2020-02-27 |
Alnylam Pharmaceuticals Inc. |
Lactate dehydrogenase a (LDHA) iRNA compositions and methods of use thereof
|
MX2020001332A
(es)
|
2017-08-03 |
2020-09-09 |
Synthorx Inc |
Conjugados de citoquina para el tratamiento de enfermedades proliferativas e infecciosas.
|
US11447773B2
(en)
|
2017-09-08 |
2022-09-20 |
Mina Therapeutics Limited |
Stabilized HNF4A saRNA compositions and methods of use
|
EP4219715A3
(de)
|
2017-09-08 |
2023-09-06 |
MiNA Therapeutics Limited |
Stabilisierte cebpa-sarna-zusammensetzungen und verfahren zur verwendung
|
US11999953B2
(en)
|
2017-09-13 |
2024-06-04 |
The Children's Medical Center Corporation |
Compositions and methods for treating transposon associated diseases
|
WO2019079527A1
(en)
|
2017-10-17 |
2019-04-25 |
Casebia Therapeutics Limited Liability Partnership |
COMPOSITIONS AND METHODS FOR GENETIC EDITION FOR HEMOPHILIA A
|
US11099202B2
(en)
|
2017-10-20 |
2021-08-24 |
Tecan Genomics, Inc. |
Reagent delivery system
|
MA50849A
(fr)
|
2017-10-26 |
2020-09-02 |
Vertex Pharma |
Substances et procédés pour le traitement d'hémoglobinopathies
|
EP3704252A1
(de)
|
2017-11-01 |
2020-09-09 |
Alnylam Pharmaceuticals, Inc. |
Gegen komplementkomponente c3 gerichtete irna-zusammensetzungen und verfahren zur verwendung davon
|
EP3707155A2
(de)
|
2017-11-09 |
2020-09-16 |
Vertex Pharmaceuticals Incorporated |
Crispr/cas-systeme für die behandlung von dmd
|
WO2019100039A1
(en)
|
2017-11-20 |
2019-05-23 |
Alnylam Pharmaceuticals, Inc. |
Serum amyloid p component (apcs) irna compositions and methods of use thereof
|
JP7522656B2
(ja)
|
2017-11-21 |
2024-07-25 |
クリスパー セラピューティクス アーゲー |
常染色体優性網膜色素変性の処置のための材料および方法
|
AU2018378479A1
(en)
|
2017-12-05 |
2020-06-18 |
Vertex Pharmaceuticals Incorporated |
CRISPR-Cas9 modified CD34+ human hematopoietic stem and progenitor cells and uses thereof
|
EP3724332A1
(de)
|
2017-12-14 |
2020-10-21 |
CRISPR Therapeutics AG |
Neuartige rna-programmierbare endonukleasesysteme und deren verwendung in der genombearbeitung und anderen anwendungen
|
KR20200110655A
(ko)
|
2017-12-18 |
2020-09-24 |
알닐람 파마슈티칼스 인코포레이티드 |
고이동성 그룹 박스-1 (hmgb1) irna 조성물 및 이의 사용 방법
|
EP3728595A1
(de)
|
2017-12-21 |
2020-10-28 |
CRISPR Therapeutics AG |
Materialien und verfahren zur behandlung des usher-syndroms des typs 2a und/oder von nichtsyndromaler autosomaler rezessiver retinitis pigmentosa (arrp)
|
WO2019123429A1
(en)
|
2017-12-21 |
2019-06-27 |
Casebia Therapeutics Llp |
Materials and methods for treatment of usher syndrome type 2a
|
MA51637A
(fr)
|
2018-01-12 |
2020-11-18 |
Bayer Healthcare Llc |
Compositions et méthodes pour l'édition génique par ciblage de la transferrine
|
WO2019147743A1
(en)
|
2018-01-26 |
2019-08-01 |
Massachusetts Institute Of Technology |
Structure-guided chemical modification of guide rna and its applications
|
WO2019150196A1
(en)
|
2018-02-05 |
2019-08-08 |
Crispr Therapeutics Ag |
Materials and methods for treatment of hemoglobinopathies
|
EP3749768A1
(de)
|
2018-02-05 |
2020-12-16 |
Vertex Pharmaceuticals Incorporated |
Materialien und verfahren zur behandlung von hämoglobinopathien
|
MA51869A
(fr)
|
2018-02-16 |
2020-12-23 |
Bayer Healthcare Llc |
Compositions et méthodes pour l'édition génique par ciblage du fibrinogène-alpha
|
MX2020008772A
(es)
|
2018-02-26 |
2020-10-01 |
Synthorx Inc |
Conjugados de il-15, y sus usos.
|
CN112424348A
(zh)
|
2018-03-19 |
2021-02-26 |
克里斯珀医疗股份公司 |
新颖的rna-可编程的内切核酸酶***及其用途
|
US12049631B2
(en)
|
2018-03-30 |
2024-07-30 |
Rheinische Friedrich-Wilhelms-Universitat Bonn |
Aptamers for targeted activation of T cell-mediated immunity
|
EP3772928A4
(de)
|
2018-04-06 |
2021-12-29 |
Children's Medical Center Corporation |
Zusammensetzungen und verfahren zur prägung der umprogrammierung und modulation von somatischen zellen
|
EP4242307A3
(de)
|
2018-04-12 |
2023-12-27 |
MiNA Therapeutics Limited |
Sirt1-sarna kompositionen und methoden zu deren verwendung
|
WO2019204668A1
(en)
|
2018-04-18 |
2019-10-24 |
Casebia Therapeutics Limited Liability Partnership |
Compositions and methods for knockdown of apo(a) by gene editing for treatment of cardiovascular disease
|
JP7480062B2
(ja)
|
2018-04-27 |
2024-05-14 |
シアトル チルドレンズ ホスピタル (ディービーエイ シアトル チルドレンズ リサーチ インスティテュート) |
ラパマイシン耐性細胞
|
CA3098623A1
(en)
|
2018-05-07 |
2019-11-14 |
Alnylam Pharmaceuticals, Inc. |
Extrahepatic delivery
|
ES2967713T3
(es)
|
2018-05-14 |
2024-05-03 |
Alnylam Pharmaceuticals Inc |
Composiciones de ARNi de angiotensinógeno (AGT) y métodos de uso de las mismas
|
EA202190528A1
(ru)
|
2018-08-13 |
2021-04-23 |
Элнилэм Фармасьютикалз, Инк. |
КОМПОЗИЦИИ АГЕНТОВ дцРНК ВИРУСА ГЕПАТИТА B (HBV) И СПОСОБЫ ИХ ПРИМЕНЕНИЯ
|
WO2020037125A1
(en)
|
2018-08-16 |
2020-02-20 |
Alnylam Pharmaceuticals Inc. |
Compositions and methods for inhibiting expression of the lect2 gene
|
WO2020047229A1
(en)
|
2018-08-29 |
2020-03-05 |
University Of Massachusetts |
Inhibition of protein kinases to treat friedreich ataxia
|
CA3105385A1
(en)
|
2018-09-18 |
2020-03-26 |
Alnylam Pharmaceuticals, Inc. |
Ketohexokinase (khk) irna compositions and methods of use thereof
|
TW202028465A
(zh)
|
2018-09-28 |
2020-08-01 |
美商阿尼拉製藥公司 |
甲狀腺素運載蛋白(TTR)iRNA組成物及其治療或預防TTR相關眼部疾病之使用方法
|
EP3867377A1
(de)
|
2018-10-17 |
2021-08-25 |
CRISPR Therapeutics AG |
Zusammensetzungen und verfahren zur abgabe von transgenen
|
US10913951B2
(en)
|
2018-10-31 |
2021-02-09 |
University of Pittsburgh—of the Commonwealth System of Higher Education |
Silencing of HNF4A-P2 isoforms with siRNA to improve hepatocyte function in liver failure
|
EA202191736A1
(ru)
|
2018-12-20 |
2021-10-01 |
Вир Байотекнолоджи, Инк. |
Комбинированная терапия hbv
|
CN113631709A
(zh)
|
2018-12-20 |
2021-11-09 |
普拉克西斯精密药物股份有限公司 |
用于治疗kcnt1相关病症的组合物和方法
|
EP3911335A1
(de)
|
2019-01-16 |
2021-11-24 |
Genzyme Corporation |
Serpinc1-irna-zusammensetzungen und verfahren zur verwendung davon
|
BR112021014415A2
(pt)
|
2019-02-06 |
2021-09-21 |
Synthorx, Inc. |
Conjugados de il-2 e métodos de uso dos mesmos
|
MA54951A
(fr)
|
2019-02-15 |
2021-12-22 |
Bayer Healthcare Llc |
Édition de gène pour l'hémophilie a avec une expression de facteur viii améliorée
|
WO2020171889A1
(en)
|
2019-02-19 |
2020-08-27 |
University Of Rochester |
Blocking lipid accumulation or inflammation in thyroid eye disease
|
EP3937963A2
(de)
|
2019-03-12 |
2022-01-19 |
CRISPR Therapeutics AG |
Neuartige rna-programmierbare high-fidelity-endonukleasesysteme und verwendungen davon
|
EP3937780A4
(de)
|
2019-03-14 |
2022-12-07 |
InSilixa, Inc. |
Verfahren und systeme zur zeitgesteuerten fluoreszenzbasierten detektion
|
WO2020208361A1
(en)
|
2019-04-12 |
2020-10-15 |
Mina Therapeutics Limited |
Sirt1-sarna compositions and methods of use
|
BR112021022806A2
(pt)
|
2019-05-13 |
2022-01-25 |
Vir Biotechnology Inc |
Método para tratar a infecção crônica por hbv, sirna, usos de um sirna, e de um sirna e peg-ifna e de um sirna, peg-ifna e um nrti, método, composição para uso ou uso e kit
|
AU2020279101A1
(en)
|
2019-05-17 |
2021-11-18 |
Alnylam Pharmaceuticals, Inc. |
Oral delivery of oligonucleotides
|
US11879145B2
(en)
|
2019-06-14 |
2024-01-23 |
The Scripps Research Institute |
Reagents and methods for replication, transcription, and translation in semi-synthetic organisms
|
WO2021022109A1
(en)
|
2019-08-01 |
2021-02-04 |
Alnylam Pharmaceuticals, Inc. |
SERPIN FAMILY F MEMBER 2 (SERPINF2) iRNA COMPOSITIONS AND METHODS OF USE THEREOF
|
WO2021022108A2
(en)
|
2019-08-01 |
2021-02-04 |
Alnylam Pharmaceuticals, Inc. |
CARBOXYPEPTIDASE B2 (CPB2) iRNA COMPOSITIONS AND METHODS OF USE THEREOF
|
WO2021030522A1
(en)
|
2019-08-13 |
2021-02-18 |
Alnylam Pharmaceuticals, Inc. |
SMALL RIBOSOMAL PROTEIN SUBUNIT 25 (RPS25) iRNA AGENT COMPOSITIONS AND METHODS OF USE THEREOF
|
TW202120128A
(zh)
|
2019-08-15 |
2021-06-01 |
美商欣爍克斯公司 |
使用il-2接合物之免疫腫瘤學組合療法
|
JP2022545101A
(ja)
|
2019-08-19 |
2022-10-25 |
ミナ セラピューティクス リミテッド |
オリゴヌクレオチドコンジュゲート組成物および使用方法
|
KR20220051355A
(ko)
|
2019-08-23 |
2022-04-26 |
신톡스, 인크. |
Il-15 콘쥬게이트 및 이의 용도
|
EP4025694A1
(de)
|
2019-09-03 |
2022-07-13 |
Alnylam Pharmaceuticals, Inc. |
Zusammensetzungen und verfahren zum hemmen der lect2-genexpression
|
JP2022547078A
(ja)
|
2019-09-10 |
2022-11-10 |
シンソークス, インコーポレイテッド |
Il-2コンジュゲートおよび自己免疫疾患を治療するための使用方法
|
WO2021067747A1
(en)
|
2019-10-04 |
2021-04-08 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for silencing ugt1a1 gene expression
|
US20240141358A1
(en)
|
2019-10-18 |
2024-05-02 |
Alnylam Pharmaceuticals, Inc. |
Solute carrier family member irna compositions and methods of use thereof
|
JP2022553348A
(ja)
|
2019-10-22 |
2022-12-22 |
アルナイラム ファーマシューティカルズ, インコーポレイテッド |
補体成分C3 iRNA組成物およびその使用方法
|
JP2023500661A
(ja)
|
2019-11-01 |
2023-01-10 |
アルナイラム ファーマシューティカルズ, インコーポレイテッド |
ハンチンチン(HTT)iRNA剤組成物およびその使用方法
|
EP4051796A1
(de)
|
2019-11-01 |
2022-09-07 |
Alnylam Pharmaceuticals, Inc. |
Zusammensetzungen und verfahren zum unterdrücken der dnajb1-prkaca-fusionsgenexpression
|
IL291786A
(en)
|
2019-11-04 |
2022-06-01 |
Synthorx Inc |
Interleukin 10 conjugates and their use
|
AU2020378414A1
(en)
|
2019-11-06 |
2022-05-26 |
Alnylam Pharmaceuticals, Inc. |
Extrahepatic delivery
|
WO2021092145A1
(en)
|
2019-11-06 |
2021-05-14 |
Alnylam Pharmaceuticals, Inc. |
Transthyretin (ttr) irna composition and methods of use thereof for treating or preventing ttr-associated ocular diseases
|
WO2021096763A1
(en)
|
2019-11-13 |
2021-05-20 |
Alnylam Pharmaceuticals, Inc. |
Methods and compositions for treating an angiotensinogen- (agt-) associated disorder
|
EP4061945A1
(de)
|
2019-11-22 |
2022-09-28 |
Alnylam Pharmaceuticals, Inc. |
Ataxin3 (atxn3)-rnai-wirkstoffzusammensetzungen und verfahren zu deren verwendung
|
CA3164599A1
(en)
|
2019-12-13 |
2021-06-17 |
Alnylam Pharmaceuticals, Inc. |
Human chromosome 9 open reading frame 72 (c9orf72) irna agent compositions and methods of use thereof
|
TW202138559A
(zh)
|
2019-12-16 |
2021-10-16 |
美商阿尼拉製藥公司 |
含類PATATIN磷脂酶結構域3(PNPLA3)iRNA組成物及其使用方法
|
WO2021122944A1
(en)
|
2019-12-18 |
2021-06-24 |
Alia Therapeutics Srl |
Compositions and methods for treating retinitis pigmentosa
|
WO2021154941A1
(en)
|
2020-01-31 |
2021-08-05 |
Alnylam Pharmaceuticals, Inc. |
Complement component c5 irna compositions for use in the treatment of amyotrophic lateral sclerosis (als)
|
CN113275053A
(zh)
|
2020-02-03 |
2021-08-20 |
帝肯基因组学公司 |
试剂存储***
|
TW202140786A
(zh)
|
2020-02-10 |
2021-11-01 |
美商艾爾妮蘭製藥公司 |
用於靜默vegf-a表現之組合物及方法
|
CA3171654A1
(en)
|
2020-02-18 |
2021-08-26 |
Alnylam Pharmaceuticals, Inc. |
Apolipoprotein c3 (apoc3) irna compositions and methods of use thereof
|
EP4114947A1
(de)
|
2020-03-05 |
2023-01-11 |
Alnylam Pharmaceuticals, Inc. |
Komplementkomponenten-c3-irna-zusammensetzungen und verfahren zur verwendung davon zur behandlung oder prävention von mit komplementkomponenten-c3-assoziierten erkrankungen
|
WO2021178778A1
(en)
|
2020-03-06 |
2021-09-10 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of transthyretin (ttr)
|
AU2021232014A1
(en)
|
2020-03-06 |
2022-10-06 |
Alnylam Pharmaceuticals, Inc. |
Ketohexokinase (KHK) IRNA compositions and methods of use thereof
|
EP4121534A1
(de)
|
2020-03-18 |
2023-01-25 |
Alnylam Pharmaceuticals, Inc. |
Zusammensetzungen und verfahren zur behandlung von patienten mit einer heterozygoten alaninglyoxylat-aminotransferase-genvariante (agxt)
|
WO2021195307A1
(en)
|
2020-03-26 |
2021-09-30 |
Alnylam Pharmaceuticals, Inc. |
Coronavirus irna compositions and methods of use thereof
|
EP4127171A2
(de)
|
2020-03-30 |
2023-02-08 |
Alnylam Pharmaceuticals, Inc. |
Zusammensetzungen und verfahren zur ausschaltung der dnajc15-genexpression
|
MX2022012493A
(es)
|
2020-04-06 |
2022-10-27 |
Alnylam Pharmaceuticals Inc |
Composiciones y metodos para el silenciamiento de la expresion de miocilina (myoc).
|
WO2021206917A1
(en)
|
2020-04-07 |
2021-10-14 |
Alnylam Pharmaceuticals, Inc. |
ANGIOTENSIN-CONVERTING ENZYME 2 (ACE2) iRNA COMPOSITIONS AND METHODS OF USE THEREOF
|
WO2021206922A1
(en)
|
2020-04-07 |
2021-10-14 |
Alnylam Pharmaceuticals, Inc. |
Transmembrane serine protease 2 (tmprss2) irna compositions and methods of use thereof
|
US20230159933A1
(en)
|
2020-04-07 |
2023-05-25 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for silencing scn9a expression
|
WO2021222065A1
(en)
|
2020-04-27 |
2021-11-04 |
Alnylam Pharmaceuticals, Inc. |
Apolipoprotein e (apoe) irna agent compositions and methods of use thereof
|
JP2023523790A
(ja)
|
2020-04-30 |
2023-06-07 |
アルナイラム ファーマシューティカルズ, インコーポレイテッド |
補体因子B(CFB)iRNA組成物およびその使用方法
|
WO2021231685A1
(en)
|
2020-05-15 |
2021-11-18 |
Korro Bio, Inc. |
Methods and compositions for the adar-mediated editing of transmembrane channel-like protein 1 (tmc1)
|
WO2021231691A1
(en)
|
2020-05-15 |
2021-11-18 |
Korro Bio, Inc. |
Methods and compositions for the adar-mediated editing of retinoschisin 1 (rsi)
|
EP4150086A1
(de)
|
2020-05-15 |
2023-03-22 |
Korro Bio, Inc. |
Verfahren und zusammensetzungen zur adar-vermittelten bearbeitung von leucinreicher repeat-kinase 2 (lrrk2)
|
WO2021231680A1
(en)
|
2020-05-15 |
2021-11-18 |
Korro Bio, Inc. |
Methods and compositions for the adar-mediated editing of methyl-cpg binding protein 2 (mecp2)
|
EP4150088A1
(de)
|
2020-05-15 |
2023-03-22 |
Korro Bio, Inc. |
Verfahren und zusammensetzungen zur adar-vermittelten bearbeitung von argininosuccinat-synthetase (ass1)
|
WO2021231698A1
(en)
|
2020-05-15 |
2021-11-18 |
Korro Bio, Inc. |
Methods and compositions for the adar-mediated editing of argininosuccinate lyase (asl)
|
EP4150090A1
(de)
|
2020-05-15 |
2023-03-22 |
Korro Bio, Inc. |
Verfahren und zusammensetzungen zur adar-vermittelten bearbeitung von otoflin (otof)
|
EP4150087A1
(de)
|
2020-05-15 |
2023-03-22 |
Korro Bio, Inc. |
Verfahren und zusammensetzungen zur adar-vermittelten bearbeitung des gap-junction-proteins beta 2 (gjb2)
|
US20230183707A1
(en)
|
2020-05-21 |
2023-06-15 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting marc1 gene expression
|
KR20230016201A
(ko)
|
2020-05-22 |
2023-02-01 |
웨이브 라이프 사이언시스 리미티드 |
이중 가닥 올리고뉴클레오티드 조성물 및 이와 관련된 방법
|
US11408000B2
(en)
|
2020-06-03 |
2022-08-09 |
Triplet Therapeutics, Inc. |
Oligonucleotides for the treatment of nucleotide repeat expansion disorders associated with MSH3 activity
|
WO2021252557A1
(en)
|
2020-06-09 |
2021-12-16 |
Alnylam Pharmaceuticals, Inc. |
Rnai compositions and methods of use thereof for delivery by inhalation
|
IL299063A
(en)
|
2020-06-18 |
2023-02-01 |
Alnylam Pharmaceuticals Inc |
Xanthine dehydrogenase (xdh) RNA compositions and methods of using them
|
EP4171747A1
(de)
|
2020-06-24 |
2023-05-03 |
VIR Biotechnology, Inc. |
Manipulierte hepatitis-b-virus-neutralisierende antikörper und verwendungen davon
|
WO2021263026A1
(en)
|
2020-06-25 |
2021-12-30 |
Synthorx, Inc. |
Immuno oncology combination therapy with il-2 conjugates and anti-egfr antibodies
|
BR112023000428A2
(pt)
|
2020-07-10 |
2023-03-14 |
Inst Nat Sante Rech Med |
Métodos e composições para tratar epilepsia
|
US20230257745A1
(en)
|
2020-07-10 |
2023-08-17 |
Alnylam Pharmaceuticals, Inc. |
Circular siRNAs
|
EP4217489A1
(de)
|
2020-09-24 |
2023-08-02 |
Alnylam Pharmaceuticals, Inc. |
Dipeptidylpeptidase 4 (dpp4)-irna-zusammensetzungen und verfahren zur verwendung davon
|
US20230392134A1
(en)
|
2020-09-30 |
2023-12-07 |
Crispr Therapeutics Ag |
Materials and methods for treatment of amyotrophic lateral sclerosis
|
WO2022076291A1
(en)
|
2020-10-05 |
2022-04-14 |
Alnylam Pharmaceuticals, Inc. |
G protein-coupled receptor 75 (gpr75) irna compositions and methods of use thereof
|
AU2021356610A1
(en)
|
2020-10-09 |
2023-06-15 |
Synthorx, Inc. |
Immuno oncology therapies with il-2 conjugates
|
EP4225376A1
(de)
|
2020-10-09 |
2023-08-16 |
Synthorx, Inc. |
Immunonkologische kombinationstherapie mit il-2-konjugaten und pembrolizumab
|
EP4232582A1
(de)
|
2020-10-23 |
2023-08-30 |
Alnylam Pharmaceuticals, Inc. |
Mucin-5b (muc5b)-irna-zusammensetzungen und verfahren zur verwendung davon
|
MX2023005490A
(es)
|
2020-11-13 |
2023-05-23 |
Alnylam Pharmaceuticals Inc |
Composiciones de acido ribonucleico de interferencia (arni) del factor de coagulacion v (f5) y sus metodos de uso.
|
WO2022125490A1
(en)
|
2020-12-08 |
2022-06-16 |
Alnylam Pharmaceuticals, Inc. |
Coagulation factor x (f10) irna compositions and methods of use thereof
|
EP4271695A2
(de)
|
2020-12-31 |
2023-11-08 |
Alnylam Pharmaceuticals, Inc. |
Auf 2'-modifiziertem nukleosid basierende oligonukleotid-prodrugs
|
EP4271696A2
(de)
|
2020-12-31 |
2023-11-08 |
Alnylam Pharmaceuticals, Inc. |
Oligonukleotid-prodrugs auf basis von mit cyclischem disulfid modifiziertem phosphat
|
WO2022150260A1
(en)
|
2021-01-05 |
2022-07-14 |
Alnylam Pharmaceuticals, Inc. |
COMPLEMENT COMPONENT 9 (C9) iRNA COMPOSITIONS AND METHODS OF USE THEREOF
|
JP2024508714A
(ja)
|
2021-02-12 |
2024-02-28 |
アルナイラム ファーマシューティカルズ, インコーポレイテッド |
スーパーオキシドジスムターゼ1-(SOD1-)関連神経変性疾患を治療または予防するためのスーパーオキシドジスムターゼ1(SOD1)iRNA組成物およびその使用方法
|
TW202245843A
(zh)
|
2021-02-12 |
2022-12-01 |
美商欣爍克斯公司 |
Il-2接合物及西米普利單抗(cemiplimab)之皮膚癌組合療法
|
TW202302148A
(zh)
|
2021-02-12 |
2023-01-16 |
美商欣爍克斯公司 |
使用il-2接合物和抗pd-1抗體或其抗原結合片段的肺癌組合療法
|
CN117222739A
(zh)
|
2021-02-25 |
2023-12-12 |
阿尔尼拉姆医药品有限公司 |
朊病毒蛋白(prnp)irna组合物和其使用方法
|
CA3211059A1
(en)
|
2021-02-26 |
2022-09-01 |
Alnylam Pharmaceuticals, Inc. |
Ketohexokinase (khk) irna compositions and methods of use thereof
|
BR112023017737A2
(pt)
|
2021-03-04 |
2023-10-03 |
Alnylam Pharmaceuticals Inc |
Composições de irna de angiopoietina-semelhantes 3 (angptl3) e métodos de uso das mesmas
|
EP4305169A1
(de)
|
2021-03-12 |
2024-01-17 |
Alnylam Pharmaceuticals, Inc. |
Glykogensynthasekinase-3-alpha (gsk3a)-irna-zusammensetzungen und verfahren zur verwendung davon
|
KR20230160872A
(ko)
|
2021-03-26 |
2023-11-24 |
미나 테라퓨틱스 리미티드 |
Tmem173 sarna 조성물 및 사용 방법
|
AU2022246786A1
(en)
|
2021-03-29 |
2023-10-05 |
Alnylam Pharmaceuticals, Inc. |
Huntingtin (htt) irna agent compositions and methods of use thereof
|
WO2022212153A1
(en)
|
2021-04-01 |
2022-10-06 |
Alnylam Pharmaceuticals, Inc. |
Proline dehydrogenase 2 (prodh2) irna compositions and methods of use thereof
|
WO2022226291A1
(en)
|
2021-04-22 |
2022-10-27 |
Dana-Farber Cancer Institute, Inc. |
Compositions and methods for treating cancer
|
WO2022231999A1
(en)
|
2021-04-26 |
2022-11-03 |
Alnylam Pharmaceuticals, Inc. |
Transmembrane protease, serine 6 (tmprss6) irna compositions and methods of use thereof
|
EP4330396A1
(de)
|
2021-04-29 |
2024-03-06 |
Alnylam Pharmaceuticals, Inc. |
Signalwandler und aktivator von transkriptionsfaktor 6 (stat6)-irna-zusammensetzungen und verfahren zur verwendung davon
|
EP4341401A1
(de)
|
2021-05-18 |
2024-03-27 |
Alnylam Pharmaceuticals, Inc. |
Natriumglucose-cotransporter-2-(sglt2)-irna-zusammensetzungen und verfahren zur verwendung davon
|
US20240263177A1
(en)
|
2021-05-20 |
2024-08-08 |
Korro Bio, Inc. |
Methods and Compositions for Adar-Mediated Editing
|
WO2022256283A2
(en)
|
2021-06-01 |
2022-12-08 |
Korro Bio, Inc. |
Methods for restoring protein function using adar
|
WO2022256395A1
(en)
|
2021-06-02 |
2022-12-08 |
Alnylam Pharmaceuticals, Inc. |
Patatin-like phospholipase domain containing 3 (pnpla3) irna compositions and methods of use thereof
|
EP4346904A1
(de)
|
2021-06-03 |
2024-04-10 |
Synthorx, Inc. |
Kopf-hals-krebskombinationstherapie mit einem il-2-konjugat und cetuximab
|
BR112023025224A2
(pt)
|
2021-06-04 |
2024-02-27 |
Alnylam Pharmaceuticals Inc |
Quadro de leitura aberto 72 do cromossomo humano 9 (c9orf72) composições de agente de irna e métodos de uso dos mesmos
|
JP2024523000A
(ja)
|
2021-06-08 |
2024-06-25 |
アルナイラム ファーマシューティカルズ, インコーポレイテッド |
シュタルガルト病及び/又は網膜結合タンパク質4(rbp4)関連障害を治療又は予防するための組成物及び方法
|
EP4101928A1
(de)
|
2021-06-11 |
2022-12-14 |
Bayer AG |
Programmierbare typ-v-rna-endonukleasesysteme
|
IL308896A
(en)
|
2021-06-11 |
2024-01-01 |
Bayer Ag |
Programmable type V RNA endoclase systems
|
US20230194709A9
(en)
|
2021-06-29 |
2023-06-22 |
Seagate Technology Llc |
Range information detection using coherent pulse sets with selected waveform characteristics
|
EP4363574A1
(de)
|
2021-06-29 |
2024-05-08 |
Korro Bio, Inc. |
Verfahren und zusammensetzungen für adar-vermittelte bearbeitung
|
EP4363580A1
(de)
|
2021-06-30 |
2024-05-08 |
Alnylam Pharmaceuticals, Inc. |
Verfahren und zusammensetzungen zur behandlung einer angiotensinogen- (gt-) assoziierten erkrankung
|
EP4367237A2
(de)
|
2021-07-09 |
2024-05-15 |
Alnylam Pharmaceuticals, Inc. |
Bis-rnai-verbindungen zur zns-verabreichung
|
WO2023285431A1
(en)
|
2021-07-12 |
2023-01-19 |
Alia Therapeutics Srl |
Compositions and methods for allele specific treatment of retinitis pigmentosa
|
EP4373934A1
(de)
|
2021-07-19 |
2024-05-29 |
Alnylam Pharmaceuticals, Inc. |
Verfahren und zusammensetzungen zur behandlung von patienten mit oder mit einem risiko zur entwicklung einer nichtprimären hyperoxalurieerkrankung oder -störung
|
AU2022314619A1
(en)
|
2021-07-21 |
2024-01-04 |
Alnylam Pharmaceuticals, Inc. |
Metabolic disorder-associated target gene irna compositions and methods of use thereof
|
JP2024528701A
(ja)
|
2021-07-23 |
2024-07-30 |
アルナイラム ファーマシューティカルズ, インコーポレイテッド |
ベータカテニン(CTNNB1)iRNA組成物およびその使用方法
|
EP4377458A1
(de)
|
2021-07-29 |
2024-06-05 |
Alnylam Pharmaceuticals, Inc. |
3-hydroxy-3-methylglutaryl-coa-reduktase (hmgcr)-irna-zusammensetzungen und verfahren zur verwendung davon
|
TW202328445A
(zh)
|
2021-08-03 |
2023-07-16 |
美商艾拉倫製藥股份有限公司 |
甲狀腺素運載蛋白(TTR)iRNA組成物及其使用方法
|
WO2023014765A1
(en)
|
2021-08-04 |
2023-02-09 |
Alnylam Pharmaceuticals, Inc. |
iRNA COMPOSITIONS AND METHODS FOR SILENCING ANGIOTENSINOGEN (AGT)
|
WO2023019246A1
(en)
|
2021-08-13 |
2023-02-16 |
Alnylam Pharmaceuticals, Inc. |
Factor xii (f12) irna compositions and methods of use thereof
|
EP4144841A1
(de)
|
2021-09-07 |
2023-03-08 |
Bayer AG |
Neue programmierbare rna-endonuklease-systeme mit verbesserter pam-spezifität und deren verwendung
|
EP4401742A2
(de)
|
2021-09-17 |
2024-07-24 |
Alnylam Pharmaceuticals, Inc. |
Irna-zusammensetzungen und verfahren zur dämpfung der komplementkomponente 3 (c3)
|
IL311454A
(en)
|
2021-09-20 |
2024-05-01 |
Alnylam Pharmaceuticals Inc |
Inhibin subunit E (INHBE) modulator compositions and methods of using them
|
KR20240101590A
(ko)
|
2021-10-15 |
2024-07-02 |
알닐람 파마슈티칼스 인코포레이티드 |
간외 전달 irna 조성물 및 이를 이용하는 방법
|
CA3234835A1
(en)
|
2021-10-22 |
2023-04-27 |
Korro Bio, Inc. |
Methods and compositions for disrupting nrf2-keap1 protein interaction by adar mediated rna editing
|
AR127477A1
(es)
|
2021-10-29 |
2024-01-31 |
Alnylam Pharmaceuticals Inc |
COMPOSICIONES DE ARNi CONTRA EL FACTOR B DEL COMPLEMENTO (CFB) Y MÉTODOS DE USO DE LAS MISMAS
|
TW202334418A
(zh)
|
2021-10-29 |
2023-09-01 |
美商艾拉倫製藥股份有限公司 |
杭丁頓(HTT)iRNA劑組成物及其使用方法
|
WO2023099884A1
(en)
|
2021-12-01 |
2023-06-08 |
Mina Therapeutics Limited |
Pax6 sarna compositions and methods of use
|
WO2023122573A1
(en)
|
2021-12-20 |
2023-06-29 |
Synthorx, Inc. |
Head and neck cancer combination therapy comprising an il-2 conjugate and pembrolizumab
|
WO2023118349A1
(en)
|
2021-12-21 |
2023-06-29 |
Alia Therapeutics Srl |
Type ii cas proteins and applications thereof
|
WO2023118068A1
(en)
|
2021-12-23 |
2023-06-29 |
Bayer Aktiengesellschaft |
Novel small type v rna programmable endonuclease systems
|
WO2023122750A1
(en)
|
2021-12-23 |
2023-06-29 |
Synthorx, Inc. |
Cancer combination therapy with il-2 conjugates and cetuximab
|
WO2023141314A2
(en)
|
2022-01-24 |
2023-07-27 |
Alnylam Pharmaceuticals, Inc. |
Heparin sulfate biosynthesis pathway enzyme irna agent compositions and methods of use thereof
|
WO2023166425A1
(en)
|
2022-03-01 |
2023-09-07 |
Crispr Therapeutics Ag |
Methods and compositions for treating angiopoietin-like 3 (angptl3) related conditions
|
WO2023170435A1
(en)
|
2022-03-07 |
2023-09-14 |
Mina Therapeutics Limited |
Il10 sarna compositions and methods of use
|
WO2023194359A1
(en)
|
2022-04-04 |
2023-10-12 |
Alia Therapeutics Srl |
Compositions and methods for treatment of usher syndrome type 2a
|
WO2023220744A2
(en)
|
2022-05-13 |
2023-11-16 |
Alnylam Pharmaceuticals, Inc. |
Single-stranded loop oligonucleotides
|
WO2023237587A1
(en)
|
2022-06-10 |
2023-12-14 |
Bayer Aktiengesellschaft |
Novel small type v rna programmable endonuclease systems
|
WO2024006999A2
(en)
|
2022-06-30 |
2024-01-04 |
Alnylam Pharmaceuticals, Inc. |
Cyclic-disulfide modified phosphate based oligonucleotide prodrugs
|
WO2024039776A2
(en)
|
2022-08-18 |
2024-02-22 |
Alnylam Pharmaceuticals, Inc. |
Universal non-targeting sirna compositions and methods of use thereof
|
WO2024059165A1
(en)
|
2022-09-15 |
2024-03-21 |
Alnylam Pharmaceuticals, Inc. |
17b-hydroxysteroid dehydrogenase type 13 (hsd17b13) irna compositions and methods of use thereof
|
WO2024056880A2
(en)
|
2022-09-16 |
2024-03-21 |
Alia Therapeutics Srl |
Enqp type ii cas proteins and applications thereof
|
WO2024073732A1
(en)
|
2022-09-30 |
2024-04-04 |
Alnylam Pharmaceuticals, Inc. |
Modified double-stranded rna agents
|
WO2024105162A1
(en)
|
2022-11-16 |
2024-05-23 |
Alia Therapeutics Srl |
Type ii cas proteins and applications thereof
|
WO2024129743A2
(en)
|
2022-12-13 |
2024-06-20 |
Bluerock Therapeutics Lp |
Engineered type v rna programmable endonucleases and their uses
|
WO2024136899A1
(en)
|
2022-12-21 |
2024-06-27 |
Synthorx, Inc. |
Cancer therapy with il-2 conjugates and chimeric antigen receptor therapies
|
WO2024134199A1
(en)
|
2022-12-22 |
2024-06-27 |
Mina Therapeutics Limited |
Chemically modified sarna compositions and methods of use
|
WO2024149810A2
(en)
|
2023-01-11 |
2024-07-18 |
Alia Therapeutics Srl |
Type ii cas proteins and applications thereof
|
WO2024168010A2
(en)
|
2023-02-09 |
2024-08-15 |
Alnylam Pharmaceuticals, Inc. |
Reversir molecules and methods of use thereof
|