DE68914211T2 - Verfahren zur Herstellung von Zwischenprodukten in der Synthese von Diltiazem. - Google Patents

Verfahren zur Herstellung von Zwischenprodukten in der Synthese von Diltiazem.

Info

Publication number
DE68914211T2
DE68914211T2 DE68914211T DE68914211T DE68914211T2 DE 68914211 T2 DE68914211 T2 DE 68914211T2 DE 68914211 T DE68914211 T DE 68914211T DE 68914211 T DE68914211 T DE 68914211T DE 68914211 T2 DE68914211 T2 DE 68914211T2
Authority
DE
Germany
Prior art keywords
diltiazem
synthesis
intermediates
preparation
dimethylaminoethanol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE68914211T
Other languages
German (de)
English (en)
Other versions
DE68914211D1 (de
Inventor
Silvia Cavicchioli
Maurizio Paiocchi
Claudio Giordano
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zambon SpA
Original Assignee
Zambon SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zambon SpA filed Critical Zambon SpA
Publication of DE68914211D1 publication Critical patent/DE68914211D1/de
Application granted granted Critical
Publication of DE68914211T2 publication Critical patent/DE68914211T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02—Seven-membered rings
    • C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
DE68914211T 1988-07-26 1989-07-18 Verfahren zur Herstellung von Zwischenprodukten in der Synthese von Diltiazem. Expired - Fee Related DE68914211T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT8821479A IT1226301B (it) 1988-07-26 1988-07-26 Processo per la preparazione di intermedi per la sintesi del diltiazem.

Publications (2)

Publication Number Publication Date
DE68914211D1 DE68914211D1 (de) 1994-05-05
DE68914211T2 true DE68914211T2 (de) 1994-07-07

Family

ID=11182442

Family Applications (1)

Application Number Title Priority Date Filing Date
DE68914211T Expired - Fee Related DE68914211T2 (de) 1988-07-26 1989-07-18 Verfahren zur Herstellung von Zwischenprodukten in der Synthese von Diltiazem.

Country Status (7)

Country Link
US (1) US4937334A (it)
EP (1) EP0355395B1 (it)
JP (1) JP3101819B2 (it)
AT (1) ATE103598T1 (it)
DE (1) DE68914211T2 (it)
ES (1) ES2061819T3 (it)
IT (1) IT1226301B (it)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1244878B (it) * 1990-12-11 1994-09-12 Lusochimica Spa Processo per la preparazione del (+)-cis-3-(acetossi)-5-!2-( dimetilammino)etil!-2,3-diidro-2-(4-metossifenil)-1,5-benzotiazepin- 4-(5h)-one cloridrato
TW438787B (en) 1997-02-27 2001-06-07 Tanabe Seiyaku Co Process for preparing optically active trans-3-substituted glycidic acid ester
FR3033701B1 (fr) 2015-03-19 2021-01-15 Univ Claude Bernard Lyon Nouvelles compositions antivirales pour le traitement de la grippe

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3562257A (en) * 1967-10-28 1971-02-09 Tanabe Seiyaku Co Benzothiazepine derivatives
JPS5899471A (ja) * 1981-12-07 1983-06-13 Tanabe Seiyaku Co Ltd ベンゾチアゼピン誘導体の新規製造法
US4567175A (en) * 1983-06-03 1986-01-28 Tanabe Seiyaku Co., Ltd. 8-Chloro-1,5-benzothiazepine derivatives
HU195795B (en) * 1985-11-06 1988-07-28 Richter Gedeon Vegyeszet Process for preparing (2s,3s)-3-acetoxy-5-(n,n-dimethyl-amino-ethyl)-2-(h-methoxy-phenyl)-2,3-dihydro-1,5-benzothiazepin-h(5h)-one

Also Published As

Publication number Publication date
ATE103598T1 (de) 1994-04-15
US4937334A (en) 1990-06-26
JP3101819B2 (ja) 2000-10-23
ES2061819T3 (es) 1994-12-16
DE68914211D1 (de) 1994-05-05
IT8821479A0 (it) 1988-07-26
EP0355395B1 (en) 1994-03-30
IT1226301B (it) 1990-12-27
EP0355395A1 (en) 1990-02-28
JPH0278673A (ja) 1990-03-19

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee