DE68908374T2 - Propenonoximether, Verfahren zu dessen Herstellung sowie diese enthaltende Arzneinmittel. - Google Patents

Propenonoximether, Verfahren zu dessen Herstellung sowie diese enthaltende Arzneinmittel.

Info

Publication number: DE68908374T2
Authority: DE; Germany
Prior art keywords: preparation; same; compositions containing; medicinal compositions; oxime ether
Prior art date: 1988-12-02
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE89403339T

Other languages

English (en)

Other versions

DE68908374D1 (de

Inventor

Christian Congy

Bernard Labeeuw

Patrick Gueule

Murielle Rinaldi

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Sanofi Aventis France

Original Assignee

Elf Sanofi SA

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-12-02

Filing date

1989-12-01

Publication date

1994-01-05

1989-12-01 Application filed by Elf Sanofi SA filed Critical Elf Sanofi SA

1993-09-16 Publication of DE68908374D1 publication Critical patent/DE68908374D1/de

1994-01-05 Application granted granted Critical

1994-01-05 Publication of DE68908374T2 publication Critical patent/DE68908374T2/de

2009-12-02 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/15—Oximes (>C=N—O—); Hydrazines (>N—N<); Hydrazones (>N—N=) ; Imines (C—N=C)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C249/00—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C249/04—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton of oximes
- C07C249/08—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton of oximes by reaction of hydroxylamines with carbonyl compounds
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C251/32—Oximes
- C07C251/50—Oximes having oxygen atoms of oxyimino groups bound to carbon atoms of substituted hydrocarbon radicals
- C07C251/58—Oximes having oxygen atoms of oxyimino groups bound to carbon atoms of substituted hydrocarbon radicals of hydrocarbon radicals substituted by nitrogen atoms not being part of nitro or nitroso groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/673—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by change of size of the carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C07C45/72—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups
- C07C45/74—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups combined with dehydration
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
- C07C49/82—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups
- C07C49/835—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups having unsaturation outside an aromatic ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
- C07C49/84—Ketones containing a keto group bound to a six-membered aromatic ring containing ether groups, groups, groups, or groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/22—Radicals substituted by doubly bound hetero atoms, or by two hetero atoms other than halogen singly bound to the same carbon atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
- C07C2603/22—Ortho- or ortho- and peri-condensed systems containing three rings containing only six-membered rings
- C07C2603/24—Anthracenes; Hydrogenated anthracenes

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Epidemiology (AREA)
Psychiatry (AREA)
Hematology (AREA)
Pain & Pain Management (AREA)
Diabetes (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Furan Compounds (AREA)
Pyridine Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Hydrogenated Pyridines (AREA)

DE89403339T 1988-12-02 1989-12-01 Propenonoximether, Verfahren zu dessen Herstellung sowie diese enthaltende Arzneinmittel. Expired - Lifetime DE68908374T2 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR8815860A FR2639942B1 (fr)	1988-12-02	1988-12-02	Ethers oximes de propenone, procede pour leur preparation et compositions pharmaceutiques les contenant

Publications (2)

Publication Number	Publication Date
DE68908374D1 DE68908374D1 (de)	1993-09-16
DE68908374T2 true DE68908374T2 (de)	1994-01-05

Family

ID=9372544

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE89403339T Expired - Lifetime DE68908374T2 (de)	1988-12-02	1989-12-01	Propenonoximether, Verfahren zu dessen Herstellung sowie diese enthaltende Arzneinmittel.

Country Status (21)

Country	Link
US (2)	US5166416A (de)
EP (1)	EP0373998B1 (de)
JP (1)	JP2562503B2 (de)
KR (1)	KR0156910B1 (de)
AR (1)	AR245704A1 (de)
AU (2)	AU623706B2 (de)
CA (1)	CA2004350C (de)
CZ (1)	CZ419091A3 (de)
DE (1)	DE68908374T2 (de)
DK (1)	DK174434B1 (de)
ES (1)	ES2059804T3 (de)
FI (1)	FI94752C (de)
FR (1)	FR2639942B1 (de)
HK (1)	HK1001557A1 (de)
HU (1)	HU211463A9 (de)
IE (1)	IE63400B1 (de)
IL (1)	IL92519A (de)
NO (1)	NO171269C (de)
NZ (2)	NZ240166A (de)
PT (1)	PT92446B (de)
ZA (1)	ZA899201B (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HU207988B (en) *	1988-10-20	1993-07-28	Biorex Kutato Fejlesztoe Kft	Process for producing halogenides of o-/3-amino-2-hydroxy-propyl/hydroximic acid and pharmaceutical compositions containing them as active components
FR2639942B1 (fr) *	1988-12-02	1991-03-29	Sanofi Sa	Ethers oximes de propenone, procede pour leur preparation et compositions pharmaceutiques les contenant
IL103106A (en) *	1991-09-25	1998-06-15	Sanofi Elf	Sites of tynocyclopentanone oximes, their preparation and pharmaceutical preparations containing them
HU213421B (en) *	1993-04-09	1997-06-30	Egyt Gyogyszervegyeszeti Gyar	New basic ethers, pharmaceutical compns. containing the said compds. and process for prepg. them
US5844000A (en) *	1997-06-12	1998-12-01	Sanofi	Propenone oxime ethers and pharmaceutical compositions containing them
FR2765107B1 (fr) *	1997-06-26	2000-03-24	Sanofi Sa	Utilisation d'un antagoniste specifique des recepteurs 5ht2 pour la preparation de medicaments utiles dans le traitement du syndrome d'apnee du sommeil
FR2787328A1 (fr)	1998-12-22	2000-06-23	Sanofi Sa	Utilisation d'un antagoniste des recepteurs 5ht2a pour la preparation de medicaments utiles dans le traitement des ronflements et du syndrome de haute resistance ou de resistance des voies aeriennes superieures
CN1674901A (zh) *	2002-08-05	2005-09-28	桑多斯股份公司	新的地氯雷他定半富马酸盐及其多晶型物
US20050070577A1 (en) *	2003-07-03	2005-03-31	Pfizer Inc.	Compositions containing a serotonin selective reuptake inhibitor and a 5-HT2A receptor antagonist
PT1691811E (pt)	2003-12-11	2014-10-30	Sunovion Pharmaceuticals Inc	Combinação de um sedativo e de um modulador de neurotransmissores e métodos para melhorar a qualidade do sono e tratamento da depressão
EP1701934B1 (de) *	2003-12-26	2009-02-25	Allergan, Inc.	DISUBSTITUIERTE CHALCOGENOXIME MIT ANTAGONISTISCHER WIRKUNG AM RAR(Gamma)-RETINOIDREZEPTOR
ES2359725T3 (es)	2004-09-30	2011-05-26	F. Hoffmann-La Roche Ag	Composiciones y métodos para el tratamiento de trastornos cognitivos.
US20090076159A1 (en) *	2007-09-19	2009-03-19	Protia, Llc	Deuterium-enriched eplivanserin
WO2009082268A2 (ru)	2007-12-21	2009-07-02	Alla Chem, Llc	ЛИГАНДЫ α-АДРЕНОЦЕПТОРОВ, ДОПАМИНОВЫХ, ГИСТАМИНОВЫХ, ИМИДАЗОЛИНОВЫХ И СЕРОТОНИНОВЫХ РЕЦЕПТОРОВ И ИХ ПРИМЕНЕНИЕ
EP2266554A1 (de)	2009-05-26	2010-12-29	Sanofi-Aventis	Verfahren zur Behandlung von Schlafstörungen mit Eplivanserin
JP2012508792A (ja) *	2008-11-13	2012-04-12	サノフイ	エプリバンセリンを使用して睡眠障害を治療する方法
EP2186511A1 (de)	2008-11-13	2010-05-19	Sanofi-Aventis	Verfahren zur Behandlung von Schlafstörungen mittels Epilvanserin
FR2938534B1 (fr) *	2008-11-14	2012-10-26	Sanofi Aventis	Procede de preparation de l'hemifumarate d'eplivanserine
JPWO2010092771A1 (ja) *	2009-02-10	2012-08-16	日本曹達株式会社	含窒素化合物および有害生物防除剤
EP2255726A1 (de)	2009-05-26	2010-12-01	Sanofi-Aventis	Spektralprofil für SWS-erweiternde Arzneimittel
EP2255807A1 (de)	2009-05-26	2010-12-01	Sanofi-Aventis	Verfahren zur Behandlung von Schlafstörungen mit der Kombination von Eplivanserin und Zolpidem
EP2269600A1 (de)	2009-07-02	2011-01-05	Sanofi-Aventis	Behandlung von Schlafstörungen mit Eplivanserin bei COPD-Patienten
CN101941919B (zh) *	2009-07-07	2014-07-02	天津药物研究院	一种制备顺式肟及肟醚衍生物的方法
CN106883141B (zh) *	2017-03-15	2018-08-10	何黎琴	一种丹皮酚肟醚类化合物、其制备方法及医药用途

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1094374A (en) *	1963-11-21	1967-12-13	Gen Aniline & Film Corp	Diazotype materials
NL7503310A (nl) *	1975-03-20	1976-09-22	Philips Nv	Verbindingen met antidepressieve werking.
NL7503311A (nl) *	1975-03-20	1976-09-22	Philips Nv	Verbindingen met antidepressieve werking.
NL7503312A (nl) *	1975-03-20	1976-09-22	Philips Nv	Verbindingen met antidepressieve werking.
US4279930A (en) *	1978-10-10	1981-07-21	The Upjohn Company	Process for treating inflammation
AU532700B2 (en) *	1979-04-02	1983-10-13	Sumitomo Chemical Company, Limited	Diphenylalkanoether
FI92189C (fi) *	1986-03-17	1994-10-10	Eisai Co Ltd	Menetelmä lääkeaineina käyttökelpoisen difenyylimetaanijohdannaisen valmistamiseksi
GB8617648D0 (en) *	1986-07-18	1986-08-28	Ici Plc	Fungicides
KR0139296B1 (ko) *	1988-11-21	1998-05-15	가와무라 시게꾸니	칼콘 유도체 및 그 제조 방법
FR2639942B1 (fr) *	1988-12-02	1991-03-29	Sanofi Sa	Ethers oximes de propenone, procede pour leur preparation et compositions pharmaceutiques les contenant

1988
- 1988-12-02 FR FR8815860A patent/FR2639942B1/fr not_active Expired - Fee Related
1989
- 1989-11-29 AU AU45688/89A patent/AU623706B2/en not_active Expired
- 1989-11-29 PT PT92446A patent/PT92446B/pt not_active IP Right Cessation
- 1989-11-30 DK DK198906059A patent/DK174434B1/da not_active IP Right Cessation
- 1989-11-30 NO NO894786A patent/NO171269C/no not_active IP Right Cessation
- 1989-12-01 US US07/444,823 patent/US5166416A/en not_active Expired - Lifetime
- 1989-12-01 FI FI895757A patent/FI94752C/fi active IP Right Grant
- 1989-12-01 NZ NZ240166A patent/NZ240166A/en not_active IP Right Cessation
- 1989-12-01 CA CA002004350A patent/CA2004350C/en not_active Expired - Lifetime
- 1989-12-01 JP JP1313121A patent/JP2562503B2/ja not_active Expired - Lifetime
- 1989-12-01 ES ES89403339T patent/ES2059804T3/es not_active Expired - Lifetime
- 1989-12-01 AR AR89315585A patent/AR245704A1/es active
- 1989-12-01 EP EP89403339A patent/EP0373998B1/de not_active Expired - Lifetime
- 1989-12-01 NZ NZ231606A patent/NZ231606A/en unknown
- 1989-12-01 IL IL9251989A patent/IL92519A/en not_active IP Right Cessation
- 1989-12-01 ZA ZA899201A patent/ZA899201B/xx unknown
- 1989-12-01 IE IE384889A patent/IE63400B1/en not_active IP Right Cessation
- 1989-12-01 DE DE89403339T patent/DE68908374T2/de not_active Expired - Lifetime
- 1989-12-02 KR KR1019890017809A patent/KR0156910B1/ko not_active IP Right Cessation
1991
- 1991-12-31 CZ CS914190A patent/CZ419091A3/cs unknown
1992
- 1992-03-10 AU AU12183/92A patent/AU640310B2/en not_active Expired
- 1992-07-10 US US07/911,736 patent/US5290951A/en not_active Expired - Lifetime
1995
- 1995-06-28 HU HU95P/P00484P patent/HU211463A9/hu unknown
1997
- 1997-11-26 HK HK97102253A patent/HK1001557A1/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
AU1218392A (en)	1992-05-28
DK605989D0 (da)	1989-11-30
KR0156910B1 (ko)	1998-12-01
PT92446A (pt)	1990-06-29
DE68908374D1 (de)	1993-09-16
AU4568889A (en)	1990-06-07
US5166416A (en)	1992-11-24
DK174434B1 (da)	2003-03-03
NO894786D0 (no)	1989-11-30
FI895757A0 (fi)	1989-12-01
NO171269B (no)	1992-11-09
PT92446B (pt)	1995-07-18
CZ419091A3 (en)	1993-05-12
FI94752B (fi)	1995-07-14
AR245704A1 (es)	1994-02-28
ES2059804T3 (es)	1994-11-16
NO894786L (no)	1990-06-05
JP2562503B2 (ja)	1996-12-11
CA2004350A1 (en)	1990-06-02
IE63400B1 (en)	1995-04-19
US5290951A (en)	1994-03-01
KR900009572A (ko)	1990-07-04
FI94752C (fi)	1995-10-25
IE893848L (en)	1990-06-02
HU211463A9 (en)	1995-11-28
JPH02262552A (ja)	1990-10-25
IL92519A (en)	1994-05-30
DK605989A (da)	1990-06-03
EP0373998B1 (de)	1993-08-11
NO171269C (no)	1993-02-17
NZ240166A (en)	1992-02-25
NZ231606A (en)	1992-02-25
EP0373998A1 (de)	1990-06-20
FR2639942A1 (fr)	1990-06-08
AU640310B2 (en)	1993-08-19
FR2639942B1 (fr)	1991-03-29
AU623706B2 (en)	1992-05-21
ZA899201B (en)	1990-09-26
CA2004350C (en)	1997-06-03
HK1001557A1 (en)	1998-06-26

Legal Events

Date	Code	Title	Description
1994-09-08	8364	No opposition during term of opposition
1998-02-05	8327	Change in the person/name/address of the patent owner	Owner name: SANOFI, PARIS, FR
2000-11-23	8327	Change in the person/name/address of the patent owner	Owner name: SANOFI-SYNTHELABO, PARIS, FR
2005-04-21	8327	Change in the person/name/address of the patent owner	Owner name: SANOFI-AVENTIS, PARIS, FR

Publication	Publication Date	Title
DE68908374T2 (de)	1994-01-05	Propenonoximether, Verfahren zu dessen Herstellung sowie diese enthaltende Arzneinmittel.
DE3582447D1 (de)	1991-05-16	Neue pyrrolo-benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel sowie zwischenprodukte.
DE3582952D1 (de)	1991-07-04	Dihydropyridin-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen.
DE3575724D1 (de)	1990-03-08	Quinolizinon-verbindungen, verfahren zu ihrer herstellung und diese enthaltende arzneimittel.
DE3680877D1 (de)	1991-09-19	Thiazolverbindungen, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzungen.
DE3881950D1 (de)	1993-07-29	Azabicyclische verbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen.
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DE68909412T2 (de)	1994-02-03	Salze von glykosaminoglykanen, verfahren zu ihrer herstellung und diese salze enthaltende pharmazeutische zusammensetzungen.
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DE3684803D1 (de)	1992-05-21	Dihydropyridin-alkanolamine, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen.
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