US20030166282A1
(en)
*
|
2002-02-01 |
2003-09-04 |
David Brown |
High potency siRNAS for reducing the expression of target genes
|
EP3415625A1
(de)
*
|
2002-02-01 |
2018-12-19 |
Life Technologies Corporation |
Doppelsträngige oligonukleotide
|
US20060009409A1
(en)
|
2002-02-01 |
2006-01-12 |
Woolf Tod M |
Double-stranded oligonucleotides
|
SI2264172T1
(sl)
|
2002-04-05 |
2017-12-29 |
Roche Innovation Center Copenhagen A/S |
Oligomerne spojine za modulacijo izražanja HIF-1alfa
|
US20040248094A1
(en)
*
|
2002-06-12 |
2004-12-09 |
Ford Lance P. |
Methods and compositions relating to labeled RNA molecules that reduce gene expression
|
US20040219565A1
(en)
|
2002-10-21 |
2004-11-04 |
Sakari Kauppinen |
Oligonucleotides useful for detecting and analyzing nucleic acids of interest
|
EP2752488B1
(de)
|
2002-11-18 |
2020-02-12 |
Roche Innovation Center Copenhagen A/S |
Antisense-Entwurf
|
US7480382B2
(en)
*
|
2003-09-30 |
2009-01-20 |
Microsoft Corporation |
Image file container
|
AU2004303464B2
(en)
|
2003-12-23 |
2009-10-01 |
Santaris Pharma A/S |
Oligomeric compounds for the modulation of BCL-2
|
AU2005304112B2
(en)
|
2004-11-09 |
2009-06-04 |
Roche Innovation Center Copenhagen A/S |
Potent LNA oligonucleotides for the inhibition of HIF-1a expression
|
US9447138B2
(en)
|
2004-11-09 |
2016-09-20 |
Roche Innovation Center Copenhagen A/S |
Potent LNA oligonucleotides for the inhibition of HIF-1a expression
|
EP1838870A2
(de)
*
|
2004-12-29 |
2007-10-03 |
Exiqon A/S |
Neue oligonukleotidzusammensetzungen und sondensequenzen mit eignung zum nachweis und zur analyse von micrornas und ihren ziel-mrnas
|
WO2007087113A2
(en)
|
2005-12-28 |
2007-08-02 |
The Scripps Research Institute |
Natural antisense and non-coding rna transcripts as drug targets
|
NZ571569A
(en)
|
2006-04-03 |
2011-09-30 |
Santaris Pharma As |
Pharmaceutical compositions comprising anti miRNA antisense oligonucleotides
|
AU2012216487B2
(en)
*
|
2006-04-03 |
2015-05-14 |
Roche Innovation Center Copenhagen A/S |
Pharmaceutical composition comprising anti-miRNA antisense oligonucleotides
|
CA2649045C
(en)
*
|
2006-04-03 |
2019-06-11 |
Santaris Pharma A/S |
Pharmaceutical composition comprising anti-mirna antisense oligonucleotides
|
ES2386578T3
(es)
*
|
2006-05-05 |
2012-08-23 |
Isis Pharmaceuticals, Inc. |
Compuestos y procedimientos para modular la expresión de PCSK9
|
EP2444494B1
(de)
|
2006-10-09 |
2016-09-28 |
Roche Innovation Center Copenhagen A/S |
Rna-antagonistenverbindungen zur modulation von pcsk9
|
JP5665317B2
(ja)
|
2006-10-18 |
2015-02-04 |
アイシス ファーマシューティカルズ, インコーポレーテッド |
アンチセンス化合物
|
EP2453016A1
(de)
*
|
2006-11-27 |
2012-05-16 |
Isis Pharmaceuticals, Inc. |
Verfahren zur Behandlung von Hypercholesterinämie
|
US8093222B2
(en)
|
2006-11-27 |
2012-01-10 |
Isis Pharmaceuticals, Inc. |
Methods for treating hypercholesterolemia
|
WO2008113830A1
(en)
|
2007-03-22 |
2008-09-25 |
Santaris Pharma A/S |
Rna antagonist compounds for the inhibition of apo-b100 expression
|
DK2149605T3
(da)
|
2007-03-22 |
2013-09-30 |
Santaris Pharma As |
Korte RNA antagonist forbindelser til modulering af det ønskede mRNA
|
CN101679979A
(zh)
|
2007-03-24 |
2010-03-24 |
基酶有限公司 |
施用与人载脂蛋白b互补的反义寡核苷酸
|
CN101842483A
(zh)
|
2007-05-01 |
2010-09-22 |
桑塔里斯制药公司 |
用于调节β-联蛋白的RNA拮抗剂化合物
|
WO2008138904A2
(en)
|
2007-05-11 |
2008-11-20 |
Santaris Pharma A/S |
Rna antagonist compounds for the modulation of her3
|
EP2170917B1
(de)
*
|
2007-05-30 |
2012-06-27 |
Isis Pharmaceuticals, Inc. |
Über n-substituiertes aminomethylen verbrückte, bicyclische nukleinsäureanaloga
|
DK2176280T4
(en)
†
|
2007-07-05 |
2015-07-20 |
Isis Pharmaceuticals Inc |
6-Disubstituerede bicykliske nukleinsyreanaloge
|
EP2548962B1
(de)
|
2007-09-19 |
2016-01-13 |
Applied Biosystems, LLC |
Sirna-sequenz-unabhängige Modifikationsformate zur Verringerung von das Ziel verfehlenden phänotypischen Effekten bei RNAI und stabilisierte Formen davon
|
WO2009043353A2
(en)
|
2007-10-04 |
2009-04-09 |
Santaris Pharma A/S |
Micromirs
|
US8450290B2
(en)
|
2007-11-26 |
2013-05-28 |
Enzon Pharmaceuticals, Inc. |
Methods for treating androgen receptor dependent disorders including cancers
|
TW200930382A
(en)
|
2007-11-26 |
2009-07-16 |
Santaris Pharma As |
LNA antagonists targeting the androgen receptor
|
US7863437B2
(en)
|
2007-12-03 |
2011-01-04 |
Enzon Pharmaceuticals, Inc. |
RNA antagonist compounds for the modulation of PIK3CA expression
|
US8404659B2
(en)
|
2008-03-07 |
2013-03-26 |
Santaris Pharma A/S |
Pharmaceutical compositions for treatment of MicroRNA related diseases
|
WO2009124295A2
(en)
*
|
2008-04-04 |
2009-10-08 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds comprising bicyclic nucleosides and having reduced toxicity
|
EP2315832B1
(de)
|
2008-08-01 |
2015-04-08 |
Roche Innovation Center Copenhagen A/S |
Micro-rna-vermittelte modulation koloniestimulierender faktoren
|
ES2727549T3
(es)
*
|
2008-10-03 |
2019-10-17 |
Curna Inc |
Tratamiento de las enfermedades relacionadas con la apolipoproteína a1 por inhibición del transcrito antisentido natural a la apolipoproteína a1
|
JP5923306B2
(ja)
|
2008-12-04 |
2016-05-24 |
クルナ・インコーポレーテッド |
腫瘍抑制遺伝子に対する天然アンチセンス転写物の抑制による腫瘍抑制遺伝子関連疾患の治療
|
KR101829469B1
(ko)
*
|
2008-12-04 |
2018-03-30 |
큐알엔에이, 인크. |
Epo에 대한 천연 안티센스 전사체의 억제에 의해 에리트로포에틴(epo) 관련된 질환의 치료
|
ES2600781T3
(es)
|
2008-12-04 |
2017-02-10 |
Curna, Inc. |
Tratamiento para enfermedades relacionadas con el factor de crecimiento del endotelio vascular (vegf) mediante la inhibición de transcritos antisentido naturales de vegf
|
WO2010093904A2
(en)
|
2009-02-12 |
2010-08-19 |
Curna, Inc. |
Treatment of brain derived neurotrophic factor (bdnf) related diseases by inhibition of natural antisense transcript to bdnf
|
EP2408919B1
(de)
|
2009-03-16 |
2017-10-18 |
CuRNA, Inc. |
Behandlung von erkrankungen im zusammenhang mit dem nuklearfaktor (erythroid-derived)-like 2 (nrf2) mittels hemmung des natürlichen antisense-transkripts gegen nrf2
|
WO2010107838A1
(en)
|
2009-03-16 |
2010-09-23 |
Isis Pharmaceuticals, Inc. |
Targeting apolipoprotein b for the reduction of apolipoprotein c-iii
|
ES2627763T3
(es)
|
2009-03-17 |
2017-07-31 |
Curna, Inc. |
Tratamiento de enfermedades relacionadas con el homólogo tipo delta 1 (dlk1) por inhibición de transcrito antisentido natural a dlk1
|
ES2599979T3
(es)
|
2009-04-24 |
2017-02-06 |
Roche Innovation Center Copenhagen A/S |
Composiciones farmacéuticas para el tratamiento de pacientes de VHC que no responden al interferón
|
JP6250930B2
(ja)
|
2009-05-06 |
2017-12-20 |
クルナ・インコーポレーテッド |
トリステトラプロリン(ttp)に対する天然アンチセンス転写物の抑制によるttp関連疾患の治療
|
CN102459596B
(zh)
|
2009-05-06 |
2016-09-07 |
库尔纳公司 |
通过针对脂质转运和代谢基因的天然反义转录物的抑制治疗脂质转运和代谢基因相关疾病
|
EP2427554B1
(de)
|
2009-05-08 |
2016-11-16 |
CuRNA, Inc. |
Behandlung von dystrophin-bedingten erkrankungen mittels hemmung des natürlichen antisense-transkripts gegen die dmd-familie
|
CN102575251B
(zh)
|
2009-05-18 |
2018-12-04 |
库尔纳公司 |
通过抑制针对重编程因子的天然反义转录物来治疗重编程因子相关的疾病
|
JP2012527248A
(ja)
|
2009-05-22 |
2012-11-08 |
クルナ・インコーポレーテッド |
転写因子e3(tfe3)に対する天然アンチセンス転写物の阻害によるtfe3およびインスリン受容体基質2(irs2)関連疾患の処置
|
KR101704988B1
(ko)
|
2009-05-28 |
2017-02-08 |
큐알엔에이, 인크. |
항바이러스 유전자에 대한 천연 안티센스 전사체의 억제에 의한 항바이러스 유전자 관련된 질환의 치료
|
JP2012529279A
(ja)
|
2009-06-12 |
2012-11-22 |
サンタリス ファーマ アー/エス |
新規の強力な抗apobアンチセンス化合物
|
CA2765509C
(en)
|
2009-06-16 |
2021-08-17 |
Joseph Collard |
Treatment of paraoxonase 1 (pon1) related diseases by inhibition of natural antisense transcript to pon1
|
WO2010148050A2
(en)
|
2009-06-16 |
2010-12-23 |
Curna, Inc. |
Treatment of collagen gene related diseases by inhibition of natural antisense transcript to a collagen gene
|
KR101807323B1
(ko)
|
2009-06-24 |
2017-12-08 |
큐알엔에이, 인크. |
Tnfr2에 대한 천연 안티센스 전사체의 억제에 의한 종양 괴사 인자 수용체 2(tnfr2) 관련된 질환의 치료
|
CA2765815A1
(en)
|
2009-06-26 |
2010-12-29 |
Opko Curna, Llc |
Treatment of down syndrome gene related diseases by inhibition of natural antisense transcript to a down syndrome gene
|
WO2011009697A1
(en)
|
2009-07-21 |
2011-01-27 |
Santaris Pharma A/S |
Antisense oligomers targeting pcsk9
|
CA2768947C
(en)
|
2009-07-24 |
2018-06-19 |
Opko Curna, Llc |
Treatment of sirtuin (sirt) related diseases by inhibition of natural antisense transcript to a sirtuin (sirt)
|
EP2462229B1
(de)
|
2009-08-05 |
2016-05-11 |
CuRNA, Inc. |
Behandlung von durch insulingene bedingten erkrankungen mittels hemmung des natürlichen antisense-transkripts gegen ein insulingen
|
CN102625841A
(zh)
|
2009-08-11 |
2012-08-01 |
欧科库尔纳有限责任公司 |
通过抑制脂连蛋白(adipoq)的天然反义转录物治疗脂连蛋白(adipoq)相关疾病
|
US8791087B2
(en)
|
2009-08-21 |
2014-07-29 |
Curna, Inc. |
Treatment of ‘C terminus of HSP70-interacting protein’ (CHIP)related diseases by inhibition of natural antisense transcript to CHIP
|
CA2771172C
(en)
|
2009-08-25 |
2021-11-30 |
Opko Curna, Llc |
Treatment of 'iq motif containing gtpase activating protein' (iqgap) related diseases by inhibition of natural antisense transcript to iqgap
|
JP6175236B2
(ja)
|
2009-09-25 |
2017-08-09 |
カッパーアールエヌエー,インコーポレイテッド |
フィラグリン(flg)の発現および活性の調整によるflg関連疾患の処置
|
ES2651308T3
(es)
|
2009-10-16 |
2018-01-25 |
Glaxo Group Limited |
Inhibidores antisentido de HBV
|
EP2490699A1
(de)
|
2009-10-20 |
2012-08-29 |
Santaris Pharma A/S |
Orale freisetzung von therapeutisch wirksamen lna-oligonukleotiden
|
WO2011054811A1
(en)
|
2009-11-03 |
2011-05-12 |
Santaris Pharma A/S |
Rna antagonists targeting hsp27 combination therapy
|
KR101823702B1
(ko)
|
2009-12-16 |
2018-01-30 |
큐알엔에이, 인크. |
막 결합 전사 인자 펩티다제, 부위 1(mbtps1)에 대한 천연 안티센스 전사체의 억제에 의한 mbtps1 관련 질환의 치료
|
RU2619185C2
(ru)
|
2009-12-23 |
2017-05-12 |
Курна, Инк. |
Лечение заболеваний, связанных с разобщающим белком 2 (ucp2), путем ингибирования природного антисмыслового транскрипта к ucp2
|
CN102869776B
(zh)
|
2009-12-23 |
2017-06-23 |
库尔纳公司 |
通过抑制肝细胞生长因子(hgf)的天然反义转录物而治疗hgf相关疾病
|
WO2011090740A2
(en)
|
2009-12-29 |
2011-07-28 |
Opko Curna, Llc |
Treatment of nuclear respiratory factor 1 (nrf1) related diseases by inhibition of natural antisense transcript to nrf1
|
US8962585B2
(en)
|
2009-12-29 |
2015-02-24 |
Curna, Inc. |
Treatment of tumor protein 63 (p63) related diseases by inhibition of natural antisense transcript to p63
|
KR101853511B1
(ko)
|
2009-12-31 |
2018-06-20 |
큐알엔에이, 인크. |
인슐린 수용체 기질 2 및 전사 인자 e3(tfe3)에 대한 천연 안티센스 전사체의 억제에 의한 irs2 관련된 질환의 치료
|
KR101878501B1
(ko)
|
2010-01-04 |
2018-08-07 |
큐알엔에이, 인크. |
인터페론 조절 인자 8 (irf8)에 대한 자연 안티센스 전사체의 저해에 의한 인터페론 조절 인자 8 (irf8) 관련된 질환의 치료
|
KR101853509B1
(ko)
|
2010-01-06 |
2018-04-30 |
큐알엔에이, 인크. |
췌장 발달 유전자에 대한 천연 안티센스 전사체의 억제에 의한 췌장 발달 유전자와 관련된 질환의 치료
|
CA2786535C
(en)
|
2010-01-11 |
2019-03-26 |
Curna, Inc. |
Treatment of sex hormone binding globulin (shbg) related diseases by inhibition of natural antisense transcript to shbg
|
JP5981850B2
(ja)
|
2010-01-25 |
2016-08-31 |
カッパーアールエヌエー,インコーポレイテッド |
RNaseH1に対する天然アンチセンス転写物の阻害によるRNaseH1関連疾患の治療
|
JP5976548B2
(ja)
|
2010-02-22 |
2016-08-23 |
カッパーアールエヌエー,インコーポレイテッド |
Pycr1に対する天然アンチセンス転写物の阻害によるピロリン−5−カルボン酸レダクターゼ1(pycr1)関連疾患の治療
|
US8980856B2
(en)
|
2010-04-02 |
2015-03-17 |
Curna, Inc. |
Treatment of colony-stimulating factor 3 (CSF3) related diseases by inhibition of natural antisense transcript to CSF3
|
WO2011127337A2
(en)
|
2010-04-09 |
2011-10-13 |
Opko Curna Llc |
Treatment of fibroblast growth factor 21 (fgf21) related diseases by inhibition of natural antisense transcript to fgf21
|
CA2798218A1
(en)
|
2010-05-03 |
2011-11-10 |
Curna, Inc. |
Treatment of sirtuin (sirt) related diseases by inhibition of natural antisense transcript to a sirtuin (sirt)
|
TWI531370B
(zh)
|
2010-05-14 |
2016-05-01 |
可娜公司 |
藉由抑制par4天然反股轉錄本治療par4相關疾病
|
EP2576783B1
(de)
|
2010-05-26 |
2017-11-29 |
CuRNA, Inc. |
Behandlung von durch atonal homolog 1 (atoh1) vermittelten erkrankungen durch hemmung des natürlichen antisense-transkripts für atoh1
|
JP5917497B2
(ja)
|
2010-05-26 |
2016-05-18 |
カッパーアールエヌエー,インコーポレイテッド |
メチオニンスルホキシドレダクターゼa(msra)に対する天然アンチセンス転写物の阻害によるmsra関連疾患の治療
|
CN103025873B
(zh)
|
2010-06-23 |
2018-05-08 |
库尔纳公司 |
通过抑制电压门控钠通道α亚基(SCNA)的天然反义转录物而治疗SCNA相关疾病
|
WO2012007477A1
(en)
|
2010-07-12 |
2012-01-19 |
Santaris Pharma A/S |
Anti hcv oligomers
|
JP5998131B2
(ja)
|
2010-07-14 |
2016-09-28 |
カッパーアールエヌエー,インコーポレイテッド |
Discslargehomolog(dlg)dlg1への天然アンチセンス転写物の阻害によるdlg関連疾患の治療
|
GB201012418D0
(en)
|
2010-07-23 |
2010-09-08 |
Santaris Pharma As |
Process
|
WO2012034942A1
(en)
|
2010-09-13 |
2012-03-22 |
Santaris Pharma A/S |
Compounds for the modulation of aurora kinase b expression
|
RU2624048C2
(ru)
|
2010-10-06 |
2017-06-30 |
Курна, Инк. |
Лечение заболеваний, связанных с геном сиалидазы 4 (neu4), путем ингибирования природного антисмыслового транскрипта гена neu4
|
WO2012054723A2
(en)
|
2010-10-22 |
2012-04-26 |
Opko Curna Llc |
Treatment of alpha-l-iduronidase (idua) related diseases by inhibition of natural antisense transcript to idua
|
EP2646553A4
(de)
|
2010-11-12 |
2015-01-07 |
Santaris Pharma As |
Zusammensetzungen und verfahren zur behandlung androgenrezeptorabhängiger erkrankungen einschliesslich krebs
|
US9920317B2
(en)
|
2010-11-12 |
2018-03-20 |
The General Hospital Corporation |
Polycomb-associated non-coding RNAs
|
AU2011325956B2
(en)
|
2010-11-12 |
2016-07-14 |
The General Hospital Corporation |
Polycomb-associated non-coding RNAs
|
US10000752B2
(en)
|
2010-11-18 |
2018-06-19 |
Curna, Inc. |
Antagonat compositions and methods of use
|
WO2012066092A1
(en)
|
2010-11-19 |
2012-05-24 |
Santaris Pharma A/S |
Compounds for the modulation of aurora kinase a expression
|
WO2012066093A1
(en)
|
2010-11-19 |
2012-05-24 |
Santaris Pharma A/S |
Compounds for the modulation of pdz-binding kinase (pbk) expression
|
KR102010598B1
(ko)
|
2010-11-23 |
2019-08-13 |
큐알엔에이, 인크. |
Nanog에 대한 자연 안티센스 전사체의 저해에 의한 nanog 관련된 질환의 치료
|
JP2014504857A
(ja)
|
2010-12-15 |
2014-02-27 |
ミラゲン セラピューティクス |
ロックドヌクレオチドを含むmicroRNA阻害剤
|
EP2673361B1
(de)
|
2011-02-08 |
2016-04-13 |
Ionis Pharmaceuticals, Inc. |
Oligomere verbindungen mit bicyclischen nukleotiden und ihre verwendung
|
WO2012110457A2
(en)
|
2011-02-14 |
2012-08-23 |
Santaris Pharma A/S |
Compounds for the modulation of osteopontin expression
|
WO2012143427A1
(en)
|
2011-04-19 |
2012-10-26 |
Santaris Pharma A/S |
Anti polyomavirus compounds
|
RU2620980C2
(ru)
|
2011-06-09 |
2017-05-30 |
Курна, Инк. |
Лечение заболеваний, связанных с фратаксином (fxn), путем ингибирования природного антисмыслового транскрипта fxn
|
US9752142B2
(en)
|
2011-08-11 |
2017-09-05 |
Ionis Pharmaceuticals, Inc. |
Gapped oligomeric compounds comprising 5′-modified deoxyribonucleosides in the gap and uses thereof
|
EA029151B1
(ru)
|
2011-09-06 |
2018-02-28 |
Курна, Инк. |
ЛЕЧЕНИЕ ЗАБОЛЕВАНИЙ, СВЯЗАННЫХ С АЛЬФА-СУБЪЕДИНИЦАМИ ПОТЕНЦИАЛЗАВИСИМЫХ НАТРИЕВЫХ КАНАЛОВ (SCNxA), С ПОМОЩЬЮ МАЛЫХ МОЛЕКУЛ
|
EP2756080B1
(de)
|
2011-09-14 |
2019-02-20 |
Translate Bio MA, Inc. |
Multimere oligonukleotidverbindungen
|
EP2763703B1
(de)
|
2011-10-06 |
2018-02-14 |
Miragen Therapeutics, Inc. |
Steuerung von energiehomöostasen im ganzen körper durch mikro-rna regulierung
|
US10184151B2
(en)
|
2011-10-11 |
2019-01-22 |
The Brigham And Women's Hospital, Inc. |
Micrornas in neurodegenerative disorders
|
WO2013138374A2
(en)
|
2012-03-15 |
2013-09-19 |
Curna, Inc. |
Treatment of brain derived neurotrophic factor (bdnf) related diseases by inhibition of natural antisense transcript to bdnf
|
EP3336189A1
(de)
|
2012-04-20 |
2018-06-20 |
Ionis Pharmaceuticals, Inc. |
Oligomere verbindungen mit bicyclischen nukleotiden und verwendungen davon
|
EA201492116A1
(ru)
|
2012-05-16 |
2015-05-29 |
Рана Терапьютикс, Инк. |
Композиции и способы для модулирования экспрессии mecp2
|
AU2013262700A1
(en)
|
2012-05-16 |
2015-01-22 |
Rana Therapeutics, Inc. |
Compositions and methods for modulating hemoglobin gene family expression
|
AU2013262649A1
(en)
|
2012-05-16 |
2015-01-22 |
Rana Therapeutics, Inc. |
Compositions and methods for modulating smn gene family expression
|
US10837014B2
(en)
|
2012-05-16 |
2020-11-17 |
Translate Bio Ma, Inc. |
Compositions and methods for modulating SMN gene family expression
|
WO2013173645A1
(en)
|
2012-05-16 |
2013-11-21 |
Rana Therapeutics, Inc. |
Compositions and methods for modulating utrn expression
|
EA201492120A1
(ru)
|
2012-05-16 |
2015-10-30 |
Рана Терапьютикс, Инк. |
Композиции и способы для модулирования экспрессии atp2a2
|
US9388408B2
(en)
|
2012-06-21 |
2016-07-12 |
MiRagen Therapeutics, Inc. |
Oligonucleotide-based inhibitors comprising locked nucleic acid motif
|
JP2015529469A
(ja)
|
2012-09-14 |
2015-10-08 |
ラナ セラピューティクス インコーポレイテッド |
多量体オリゴヌクレオチド化合物
|
EP2906699A4
(de)
|
2012-10-11 |
2016-06-08 |
Ionis Pharmaceuticals Inc |
Oligomere verbindungen mit bicyclischen nukleosiden und verwendungen davon
|
CN104884618A
(zh)
|
2012-11-15 |
2015-09-02 |
罗氏创新中心哥本哈根有限公司 |
寡核苷酸缀合物
|
CN104903448B
(zh)
|
2012-11-26 |
2017-07-11 |
罗氏创新中心哥本哈根有限公司 |
用于调节fgfr3的表达的组合物和方法
|
CA2893801A1
(en)
|
2013-01-30 |
2014-08-07 |
F. Hoffmann-La Roche Ag |
Lna oligonucleotide carbohydrate conjugates
|
BR112015029327A2
(pt)
|
2013-05-24 |
2017-09-19 |
Roche Innovation Ct Copenhagen As |
Moduladores de oligonucleotídeo de linfoma 11a/cll de célula b (bcl11a) e usos dos mesmos
|
EP3591054A1
(de)
|
2013-06-27 |
2020-01-08 |
Roche Innovation Center Copenhagen A/S |
Gegen pcsk9 gerichtete antisense-oligomere und konjugate
|
CA2921556A1
(en)
*
|
2013-08-16 |
2015-02-19 |
Rana Therapeutics, Inc. |
Compositions and methods for modulating rna
|
EP3052632A4
(de)
|
2013-10-04 |
2017-03-29 |
Rana Therapeutics, Inc. |
Zusammensetzungen und verfahren zur behandlung von amyotropher lateralsklerose (als)
|
GB201408623D0
(en)
|
2014-05-15 |
2014-07-02 |
Santaris Pharma As |
Oligomers and oligomer conjugates
|
GB201410693D0
(en)
|
2014-06-16 |
2014-07-30 |
Univ Southampton |
Splicing modulation
|
WO2016024205A1
(en)
|
2014-08-15 |
2016-02-18 |
Pfizer Inc. |
Oligomers targeting hexanucleotide repeat expansion in human c9orf72 gene
|
WO2016040589A1
(en)
|
2014-09-12 |
2016-03-17 |
Alnylam Pharmaceuticals, Inc. |
Polynucleotide agents targeting complement component c5 and methods of use thereof
|
JP6867945B2
(ja)
|
2014-10-03 |
2021-05-12 |
コールド スプリング ハーバー ラボラトリー |
核内遺伝子出力の標的とされた増強
|
US20170327524A1
(en)
|
2014-10-10 |
2017-11-16 |
Hoffmann-La Roche, Inc. |
Galnac phosphoramidites, nucleic acid conjugates thereof and their use
|
EP3207138B1
(de)
|
2014-10-17 |
2020-07-15 |
Alnylam Pharmaceuticals, Inc. |
Gegen aminolävulinsäuresynthase-1 (alas1) gerichtete polynukleotidmittel und verwendungen davon
|
WO2016069694A2
(en)
|
2014-10-30 |
2016-05-06 |
Alnylam Pharmaceuticals, Inc. |
Polynucleotide agents targeting serpinc1 (at3) and methods of use thereof
|
WO2016070060A1
(en)
|
2014-10-30 |
2016-05-06 |
The General Hospital Corporation |
Methods for modulating atrx-dependent gene repression
|
EP3020813A1
(de)
|
2014-11-16 |
2016-05-18 |
Neurovision Pharma GmbH |
Antisense-Oligonukleotide als Inhibitoren der TGF-R-Signalgebung
|
DK3234131T3
(da)
|
2014-12-16 |
2020-06-29 |
Roche Innovation Ct Copenhagen As |
Fremgangsmåde til screening af kiral toksicitet
|
JP2018503646A
(ja)
|
2015-01-20 |
2018-02-08 |
ミラゲン セラピューティクス, インコーポレイテッド |
miR−92阻害剤およびその使用
|
EP3253871A1
(de)
*
|
2015-02-04 |
2017-12-13 |
Bristol-Myers Squibb Company |
Lna-oligonukleotide mit alternierenden flanken
|
CN107636159B
(zh)
|
2015-02-04 |
2022-06-14 |
百时美施贵宝公司 |
选择治疗性分子的方法
|
EP3253875B1
(de)
*
|
2015-02-04 |
2020-01-08 |
H. Hoffnabb-La Roche Ag |
Tau-antisense-oligomere und verwendungen davon
|
EP3256591A4
(de)
|
2015-02-13 |
2018-08-08 |
Translate Bio Ma, Inc. |
Hybride oligonukleotide und verwendungen davon
|
US10900036B2
(en)
|
2015-03-17 |
2021-01-26 |
The General Hospital Corporation |
RNA interactome of polycomb repressive complex 1 (PRC1)
|
MX2017012610A
(es)
|
2015-04-08 |
2018-03-16 |
Alnylam Pharmaceuticals Inc |
Composiciones y metodos para inhibir la expresion del gen lect2.
|
WO2016205323A1
(en)
|
2015-06-18 |
2016-12-22 |
Alnylam Pharmaceuticals, Inc. |
Polynucleotde agents targeting hydroxyacid oxidase (glycolate oxidase, hao1) and methods of use thereof
|
DK3341479T3
(da)
|
2015-08-24 |
2020-02-24 |
Roche Innovation Ct Copenhagen As |
LNA-G-Proces
|
WO2017060731A1
(en)
|
2015-10-09 |
2017-04-13 |
University Of Southampton |
Modulation of gene expression and screening for deregulated protein expression
|
US10955407B2
(en)
|
2015-10-22 |
2021-03-23 |
Roche Innovation Center Copenhagen A/S |
In vitro toxicity screening assay
|
WO2017068087A1
(en)
|
2015-10-22 |
2017-04-27 |
Roche Innovation Center Copenhagen A/S |
Oligonucleotide detection method
|
CN108350431A
(zh)
|
2015-11-12 |
2018-07-31 |
豪夫迈·罗氏有限公司 |
用于确定候选药物的功效特征的方法
|
SG11201804443UA
(en)
|
2015-12-14 |
2018-06-28 |
Cold Spring Harbor Laboratory |
Antisense oligomers for treatment of autosomal dominant mental retardation-5 and dravet syndrome
|
US11096956B2
(en)
|
2015-12-14 |
2021-08-24 |
Stoke Therapeutics, Inc. |
Antisense oligomers and uses thereof
|
UA127432C2
(uk)
|
2016-03-14 |
2023-08-23 |
Ф. Хоффманн-Ля Рош Аг |
Олігонуклеотид для зниження експресії pd-l1
|
KR102468177B1
(ko)
|
2016-04-14 |
2022-11-16 |
에프. 호프만-라 로슈 아게 |
트리틸-모노-GalNAc 화합물 및 이의 용도
|
WO2017216340A1
(en)
|
2016-06-17 |
2017-12-21 |
F. Hoffmann-La Roche Ag |
In vitro nephrotoxicity screening assay
|
MA45496A
(fr)
|
2016-06-17 |
2019-04-24 |
Hoffmann La Roche |
Molécules d'acide nucléique pour la réduction de l'arnm de padd5 ou pad7 pour le traitement d'une infection par l'hépatite b
|
JP7012033B2
(ja)
|
2016-06-17 |
2022-02-10 |
エフ.ホフマン-ラ ロシュ アーゲー |
インビトロ腎毒性スクリーニングアッセイ
|
PE20190381A1
(es)
|
2016-07-01 |
2019-03-08 |
Hoffmann La Roche |
Oligonucleotidos antisentido para modular la expresion de htra1
|
US20190284621A1
(en)
|
2016-11-11 |
2019-09-19 |
Roche Innovation Center Copenhagen A/S |
Therapeutic oligonucleotides capture and detection
|
WO2018130581A1
(en)
|
2017-01-13 |
2018-07-19 |
Roche Innovation Center Copenhagen A/S |
Antisense oligonucleotides for modulating rela expression
|
US20190345495A1
(en)
|
2017-01-13 |
2019-11-14 |
Roche Innovation Center Copenhagen A/S |
Antisense oligonucleotides for modulating nfkb2 expression
|
US20190338286A1
(en)
|
2017-01-13 |
2019-11-07 |
Roche Innovation Center Copenhagen A/S |
Antisense oligonucleotides for modulating rel expression
|
EP3568479A1
(de)
|
2017-01-13 |
2019-11-20 |
Roche Innovation Center Copenhagen A/S |
Antisense-oligonukleotide zur modulierung der nfkb1-expression
|
WO2018130585A1
(en)
|
2017-01-13 |
2018-07-19 |
Roche Innovation Center Copenhagen A/S |
Antisense oligonucleotides for modulating relb expression
|
US20190055564A1
(en)
|
2017-06-01 |
2019-02-21 |
F. Hoffmann-La Roche Ag |
Antisense oligonucleotides for modulating htra1 expression
|
WO2019030313A2
(en)
|
2017-08-11 |
2019-02-14 |
Roche Innovation Center Copenhagen A/S |
OLIGONUCLEOTIDES FOR MODULATION OF UBE3C EXPRESSION
|
WO2019038228A1
(en)
|
2017-08-22 |
2019-02-28 |
Roche Innovation Center Copenhagen A/S |
OLIGONUCLEOTIDES FOR MODULATION OF TOM1 EXPRESSION
|
LT3673080T
(lt)
|
2017-08-25 |
2023-12-27 |
Stoke Therapeutics, Inc. |
Priešprasminiai oligomerai, skirti būklėms ir ligoms gydyti
|
CN111226114A
(zh)
|
2017-10-13 |
2020-06-02 |
罗氏创新中心哥本哈根有限公司 |
用部分立体限定的寡核苷酸子文库鉴定反义寡核苷酸改进的立体限定硫代磷酸酯寡核苷酸变体的方法
|
TWI816066B
(zh)
|
2017-10-16 |
2023-09-21 |
瑞士商赫孚孟拉羅股份公司 |
用於降低PAPD5及PAPD7 mRNA以治療B型肝炎感染之核酸分子
|
JP2021505175A
(ja)
|
2017-12-11 |
2021-02-18 |
ロシュ イノベーション センター コペンハーゲン エーエス |
Fndc3bの発現を調節するためのオリゴヌクレオチド
|
WO2019115417A2
(en)
|
2017-12-12 |
2019-06-20 |
Roche Innovation Center Copenhagen A/S |
Oligonucleotides for modulating rb1 expression
|
EP3729095A1
(de)
|
2017-12-21 |
2020-10-28 |
F. Hoffmann-La Roche AG |
Begleitdiagnostik für htra1-rna-antagonisten
|
CN111448316A
(zh)
|
2017-12-22 |
2020-07-24 |
罗氏创新中心哥本哈根有限公司 |
新的硫代亚磷酰胺
|
CA3085406A1
(en)
|
2017-12-22 |
2019-06-27 |
Roche Innovation Center Copenhagen A/S |
Oligonucleotides comprising a phosphorodithioate internucleoside linkage
|
WO2019122282A1
(en)
|
2017-12-22 |
2019-06-27 |
Roche Innovation Center Copenhagen A/S |
Gapmer oligonucleotides comprising a phosphorodithioate internucleoside linkage
|
JP2021511022A
(ja)
|
2018-01-10 |
2021-05-06 |
ロシュ イノベーション センター コペンハーゲン エーエス |
Pias4発現を調節するためのオリゴヌクレオチド
|
SG11202006142PA
(en)
|
2018-01-12 |
2020-07-29 |
Roche Innovation Ct Copenhagen As |
Alpha-synuclein antisense oligonucleotides and uses thereof
|
KR20200140240A
(ko)
|
2018-01-12 |
2020-12-15 |
브리스톨-마이어스 스큅 컴퍼니 |
알파-시누클레인을 표적화하는 안티센스 올리고뉴클레오티드 및 그의 용도
|
CA3088112A1
(en)
|
2018-01-12 |
2019-07-18 |
Bristol-Myers Squibb Company |
Antisense oligonucleotides targeting alpha-synuclein and uses thereof
|
EP3737760A1
(de)
|
2018-01-12 |
2020-11-18 |
Roche Innovation Center Copenhagen A/S |
Oligonukleotide zur modulierung der gsk3b-expression
|
CN111615558A
(zh)
|
2018-01-17 |
2020-09-01 |
罗氏创新中心哥本哈根有限公司 |
用于调节erc1表达的寡核苷酸
|
JP2021511029A
(ja)
|
2018-01-18 |
2021-05-06 |
ロシュ イノベーション センター コペンハーゲン エーエス |
Srebp1を標的とするアンチセンスオリゴヌクレオチド
|
WO2019145386A1
(en)
|
2018-01-26 |
2019-08-01 |
Roche Innovation Center Copenhagen A/S |
Oligonucleotides for modulating csnk1d expression
|
KR20200108315A
(ko)
|
2018-02-09 |
2020-09-17 |
제넨테크, 인크. |
Tmem106b의 발현을 조절하기 위한 올리고뉴클레오티드
|
SG11202007652UA
(en)
*
|
2018-02-21 |
2020-09-29 |
Bristol Myers Squibb Co |
Camk2d antisense oligonucleotides and uses thereof
|
JP7515400B2
(ja)
|
2018-04-05 |
2024-07-12 |
エフ. ホフマン-ラ ロシュ アーゲー |
B型肝炎ウイルス感染を治療するためのfubp1阻害剤の使用
|
CN112424376A
(zh)
|
2018-05-07 |
2021-02-26 |
罗氏创新中心哥本哈根有限公司 |
使用大规模平行测序对lna寡核苷酸治疗药物进行质量控制
|
US20210371860A1
(en)
|
2018-05-08 |
2021-12-02 |
Roche Innovation Center Copenhagen A/S |
Oligonucleotides for modulating myh7 expression
|
JP2021524450A
(ja)
|
2018-05-18 |
2021-09-13 |
エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft |
マイクロrna関連疾患の処置のための薬学的組成物
|
WO2019224172A1
(en)
|
2018-05-25 |
2019-11-28 |
Roche Innovation Center Copenhagen A/S |
Novel process for making allofuranose from glucofuranose
|
WO2019233921A1
(en)
|
2018-06-05 |
2019-12-12 |
F. Hoffmann-La Roche Ag |
Oligonucleotides for modulating atxn2 expression
|
WO2020007702A1
(en)
|
2018-07-02 |
2020-01-09 |
Roche Innovation Center Copenhagen A/S |
Antisense oligonucleotides targeting bcl2l11
|
WO2020007772A1
(en)
|
2018-07-02 |
2020-01-09 |
Roche Innovation Center Copenhagen A/S |
Antisense oligonucleotides targeting gbp-1
|
WO2020007700A1
(en)
|
2018-07-02 |
2020-01-09 |
Roche Innovation Center Copenhagen A/S |
Antisense oligonucleotides targeting spi1
|
PE20210346A1
(es)
|
2018-07-03 |
2021-02-25 |
Hoffmann La Roche |
Oligonucleotidos para modular la expresion de tau
|
WO2020007826A1
(en)
|
2018-07-05 |
2020-01-09 |
Roche Innovation Center Copenhagen A/S |
Antisense oligonucleotides targeting mbtps1
|
WO2020007889A1
(en)
|
2018-07-05 |
2020-01-09 |
Roche Innovation Center Copenhagen A/S |
Antisense oligonucleotides targeting stat1
|
WO2020011743A1
(en)
|
2018-07-09 |
2020-01-16 |
Roche Innovation Center Copenhagen A/S |
Antisense oligonucleotides targeting mafb
|
WO2020011653A1
(en)
|
2018-07-09 |
2020-01-16 |
Roche Innovation Center Copenhagen A/S |
Antisense oligonucleotides targeting kynu
|
WO2020011869A2
(en)
|
2018-07-11 |
2020-01-16 |
Roche Innovation Center Copenhagen A/S |
Antisense oligonucleotides targeting tlr2
|
WO2020011744A2
(en)
|
2018-07-11 |
2020-01-16 |
Roche Innovation Center Copenhagen A/S |
Antisense oligonucleotides targeting cers5
|
WO2020011745A2
(en)
|
2018-07-11 |
2020-01-16 |
Roche Innovation Center Copenhagen A/S |
Antisense oligonucleotides targeting cers6
|
CA3106288A1
(en)
|
2018-07-13 |
2020-01-16 |
F.Hoffmann-La Roche Ag |
Oligonucleotides for modulating rtel1 expression
|
WO2020025527A1
(en)
|
2018-07-31 |
2020-02-06 |
Roche Innovation Center Copenhagen A/S |
Oligonucleotides comprising a phosphorotrithioate internucleoside linkage
|
WO2020025563A1
(en)
|
2018-07-31 |
2020-02-06 |
Roche Innovation Center Copenhagen A/S |
Oligonucleotides comprising a phosphorotrithioate internucleoside linkage
|
JP2021533200A
(ja)
|
2018-08-02 |
2021-12-02 |
ダイン セラピューティクス, インコーポレーテッドDyne Therapeutics, Inc. |
顔面・肩甲・上腕筋ジストロフィーを処置するための筋標的化複合体およびそれらの使用
|
US11911484B2
(en)
|
2018-08-02 |
2024-02-27 |
Dyne Therapeutics, Inc. |
Muscle targeting complexes and uses thereof for treating myotonic dystrophy
|
US12018087B2
(en)
|
2018-08-02 |
2024-06-25 |
Dyne Therapeutics, Inc. |
Muscle-targeting complexes comprising an anti-transferrin receptor antibody linked to an oligonucleotide and methods of delivering oligonucleotide to a subject
|
EP3841220A1
(de)
|
2018-08-23 |
2021-06-30 |
Roche Innovation Center Copenhagen A/S |
Mikrorna-134-biomarker
|
WO2020038976A1
(en)
|
2018-08-23 |
2020-02-27 |
Roche Innovation Center Copenhagen A/S |
Antisense oligonucleotides targeting usp8
|
WO2020038973A1
(en)
|
2018-08-23 |
2020-02-27 |
Roche Innovation Center Copenhagen A/S |
Antisense oligonucleotides targeting sptlc1
|
WO2020038971A1
(en)
|
2018-08-23 |
2020-02-27 |
Roche Innovation Center Copenhagen A/S |
Antisense oligonucleotides targeting vcan
|
WO2020043750A1
(en)
|
2018-08-28 |
2020-03-05 |
Roche Innovation Center Copenhagen A/S |
Neoantigen engineering using splice modulating compounds
|
EP3620519A1
(de)
|
2018-09-04 |
2020-03-11 |
F. Hoffmann-La Roche AG |
Verwendung von isolierten extrazellulären vesikeln aus milch zur oralen verabreichung von oligonukleotiden
|
EP3873920A1
(de)
|
2018-11-01 |
2021-09-08 |
F. Hoffmann-La Roche AG |
Gegen tia1 gerichtete antisense-oligonukleotide
|
CN113166185A
(zh)
|
2018-11-22 |
2021-07-23 |
罗氏创新中心哥本哈根有限公司 |
作为立体限定的寡核苷酸合成中的活化剂的吡啶鎓盐
|
WO2020109343A1
(en)
|
2018-11-29 |
2020-06-04 |
F. Hoffmann-La Roche Ag |
Combination therapy for treatment of macular degeneration
|
WO2020109344A1
(en)
|
2018-11-29 |
2020-06-04 |
F. Hoffmann-La Roche Ag |
Occular administration device for antisense oligonucleotides
|
EP3898975A2
(de)
|
2018-12-21 |
2021-10-27 |
Boehringer Ingelheim International GmbH |
Gegen card9 gerichtete antisense-oligonukleotide
|
CN113365607A
(zh)
|
2019-01-25 |
2021-09-07 |
豪夫迈·罗氏有限公司 |
用于口服药物递送的脂质囊泡
|
TW202102516A
(zh)
|
2019-02-20 |
2021-01-16 |
丹麥商羅氏創新中心哥本哈根有限公司 |
膦醯基乙酸酯間隙子寡核苷酸
|
EP3927716A1
(de)
|
2019-02-20 |
2021-12-29 |
Roche Innovation Center Copenhagen A/S |
Neuartige phosphoramidite
|
CN113474633A
(zh)
|
2019-02-26 |
2021-10-01 |
罗氏创新中心哥本哈根有限公司 |
寡核苷酸配制方法
|
JP2022522898A
(ja)
|
2019-03-05 |
2022-04-20 |
エフ.ホフマン-ラ ロシュ アーゲー |
分子の細胞内標的化
|
JP2022525924A
(ja)
|
2019-03-21 |
2022-05-20 |
コディアック バイオサイエンシーズ, インコーポレイテッド |
細胞外小胞コンジュゲート及びその使用
|
BR112021019182A2
(pt)
|
2019-04-03 |
2022-05-31 |
Bristol Myers Squibb Co |
Oligonucleotídeos angptl2 antissenso e seus usos
|
US11286485B2
(en)
|
2019-04-04 |
2022-03-29 |
Hoffmann-La Roche Inc. |
Oligonucleotides for modulating ATXN2 expression
|
EP3947677A1
(de)
|
2019-04-04 |
2022-02-09 |
F. Hoffmann-La Roche AG |
Oligonukleotide zur modulierung der atxn2-expression
|
EP3956340A1
(de)
|
2019-04-16 |
2022-02-23 |
Roche Innovation Center Copenhagen A/S |
Neuartiges verfahren zur herstellung von nukleotid-p(v)-monomeren
|
JP2022530537A
(ja)
|
2019-04-30 |
2022-06-29 |
ロシュ イノベーション センター コペンハーゲン エーエス |
レニウムキレート化mag3オリゴヌクレオチドを調製するための新規の方法
|
JP2022535735A
(ja)
|
2019-05-31 |
2022-08-10 |
アリゴス セラピューティクス インコーポレイテッド |
修飾ギャップマーオリゴヌクレオチドおよび使用方法
|
WO2020245233A1
(en)
|
2019-06-06 |
2020-12-10 |
F. Hoffmann-La Roche Ag |
Antisense oligonucleotides targeting atxn3
|
CN114829586A
(zh)
|
2019-08-14 |
2022-07-29 |
科迪亚克生物科学公司 |
细胞外囊泡-nlrp3拮抗剂
|
BR112022002599A2
(pt)
|
2019-08-14 |
2022-07-19 |
Codiak Biosciences Inc |
Vesícula extracelular ligada a moléculas e usos da mesma
|
AU2020330133A1
(en)
|
2019-08-14 |
2022-03-17 |
Lonza Sales Ag |
Extracellular vesicle-ASO constructs targeting CEBP/beta
|
US20230018254A1
(en)
|
2019-08-14 |
2023-01-19 |
Codiak Biosciences, Inc. |
Extracellular vesicles with antisense oligonucleotides targeting kras
|
EP4013877A1
(de)
|
2019-08-14 |
2022-06-22 |
Codiak BioSciences, Inc. |
Extrazelluläre vesikel mit aso-konstrukten gegen stat6
|
WO2021030769A1
(en)
|
2019-08-14 |
2021-02-18 |
Codiak Biosciences, Inc. |
Extracellular vesicles with nras antisense oligonucleotides
|
US20230241089A1
(en)
|
2019-09-25 |
2023-08-03 |
Codiak Biosciences, Inc. |
Sting agonist comprising exosomes for treating neuroimmunological disorders
|
WO2021122921A1
(en)
|
2019-12-19 |
2021-06-24 |
F. Hoffmann-La Roche Ag |
Use of cops3 inhibitors for treating hepatitis b virus infection
|
CN114829601A
(zh)
|
2019-12-19 |
2022-07-29 |
豪夫迈·罗氏有限公司 |
Sbds抑制剂用于治疗乙型肝炎病毒感染的用途
|
EP4077667A1
(de)
|
2019-12-19 |
2022-10-26 |
F. Hoffmann-La Roche AG |
Verwendung von sept9-inhibitoren zum behandeln von hepatitis-b-virus-infektionen
|
EP4077668A1
(de)
|
2019-12-19 |
2022-10-26 |
F. Hoffmann-La Roche AG |
Verwendung von scamp3-inhibitoren zum behandeln von hepatitis-b-virus-infektionen
|
WO2021122993A1
(en)
|
2019-12-19 |
2021-06-24 |
F. Hoffmann-La Roche Ag |
Use of saraf inhibitors for treating hepatitis b virus infection
|
EP4077672A1
(de)
|
2019-12-20 |
2022-10-26 |
F. Hoffmann-La Roche AG |
Verbesserte oligonukleotide zur hemmung der scn9a-expression
|
MX2022007908A
(es)
|
2019-12-24 |
2022-07-21 |
Hoffmann La Roche |
Combinacion farmaceutica de un oligonucleotido terapeutico que actua sobre hbv y un agonista de tlr7 para el tratamiento de hbv.
|
EP4081217A1
(de)
|
2019-12-24 |
2022-11-02 |
F. Hoffmann-La Roche AG |
Pharmazeutische kombination von antivirusmitteln, die hbv und/oder einen immunmodulator zur behandlung von hbv steuern
|
WO2021158810A1
(en)
|
2020-02-05 |
2021-08-12 |
Bristol-Myers Squibb Company |
Oligonucleotides for splice modulation of camk2d
|
JP2023516142A
(ja)
|
2020-02-28 |
2023-04-18 |
エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト |
Cd73エクソン7スプライシングを調節するためのオリゴヌクレオチド
|
WO2021184021A1
(en)
|
2020-03-13 |
2021-09-16 |
Codiak Biosciences, Inc. |
Extracellular vesicle-aso constructs targeting pmp22
|
WO2021184020A1
(en)
|
2020-03-13 |
2021-09-16 |
Codiak Biosciences, Inc. |
Methods of treating neuroinflammation
|
WO2021188611A1
(en)
|
2020-03-18 |
2021-09-23 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for treating subjects having a heterozygous alanine-glyoxylate aminotransferase gene (agxt) variant
|
WO2021231210A1
(en)
|
2020-05-11 |
2021-11-18 |
Genentech, Inc. |
Complement component c1r inhibitors for treating a neurological disease, and related compositions, systems and methods of using same
|
WO2021231204A1
(en)
|
2020-05-11 |
2021-11-18 |
Genentech, Inc. |
Complement component 4 inhibitors for treating neurological diseases, and related compositons, systems and methods of using same
|
MX2022014151A
(es)
|
2020-05-11 |
2022-11-30 |
Stoke Therapeutics Inc |
Oligomeros antisentido de opa1 para tratamiento de afecciones y enfermedades.
|
JP2023527684A
(ja)
|
2020-05-11 |
2023-06-30 |
ジェネンテック, インコーポレイテッド |
神経疾患を治療するための補体成分c1s阻害剤、並びにそれを使用する関連組成物、システム及び方法
|
US20210388357A1
(en)
|
2020-05-13 |
2021-12-16 |
Hoffmann-La Roche Inc. |
Oligonucleotide agonists targeting progranulin
|
JP2023526096A
(ja)
|
2020-05-22 |
2023-06-20 |
エフ. ホフマン-ラ ロシュ アーゲー |
Card9のスプライス調節のためのオリゴヌクレオチド
|
WO2021249993A1
(en)
|
2020-06-09 |
2021-12-16 |
Roche Innovation Center Copenhagen A/S |
Guanosine analogues for use in therapeutic polynucleotides
|
AR122731A1
(es)
|
2020-06-26 |
2022-10-05 |
Hoffmann La Roche |
Oligonucleótidos mejorados para modular la expresión de fubp1
|
TW202219273A
(zh)
|
2020-07-23 |
2022-05-16 |
瑞士商赫孚孟拉羅股份公司 |
靶向rna結合蛋白位點之寡核苷酸
|
WO2022018155A1
(en)
|
2020-07-23 |
2022-01-27 |
F. Hoffmann-La Roche Ag |
Lna oligonucleotides for splice modulation of stmn2
|
CN116157522A
(zh)
|
2020-08-21 |
2023-05-23 |
豪夫迈·罗氏有限公司 |
A1cf抑制剂用于治疗乙型肝炎病毒感染的用途
|
WO2022076596A1
(en)
|
2020-10-06 |
2022-04-14 |
Codiak Biosciences, Inc. |
Extracellular vesicle-aso constructs targeting stat6
|
WO2022117747A2
(en)
|
2020-12-03 |
2022-06-09 |
F. Hoffmann-La Roche Ag |
Antisense oligonucleotides targeting atxn3
|
US20220177883A1
(en)
|
2020-12-03 |
2022-06-09 |
Hoffmann-La Roche Inc. |
Antisense Oligonucleotides Targeting ATXN3
|
JP2023553069A
(ja)
|
2020-12-08 |
2023-12-20 |
エフ. ホフマン-ラ ロシュ アーゲー |
ホスホロジチオエートオリゴヌクレオチドの新規合成
|
US20220204973A1
(en)
|
2020-12-18 |
2022-06-30 |
Hoffmann-La Roche Inc. |
Antisense Oligonucleotide for Targeting Progranulin
|
CN116670282A
(zh)
|
2020-12-22 |
2023-08-29 |
豪夫迈·罗氏有限公司 |
靶向xbp1的寡核苷酸
|
TW202246500A
(zh)
|
2021-02-02 |
2022-12-01 |
瑞士商赫孚孟拉羅股份公司 |
用於抑制 rtel1 表現之增強型寡核苷酸
|
JP2024512236A
(ja)
|
2021-02-17 |
2024-03-19 |
ロンザ セールス アーゲー |
細胞外ベシクル-nlrp3アンタゴニスト
|
JP2024506711A
(ja)
|
2021-02-17 |
2024-02-14 |
ロンザ セールス アーゲー |
最適化リンカー及びアンカー部分を介して生物学的に活性な分子に連結した細胞外ベシクル
|
JP2024513841A
(ja)
|
2021-04-01 |
2024-03-27 |
ロンザ セールス アーゲー |
細胞外小胞組成物
|
TW202313976A
(zh)
|
2021-06-08 |
2023-04-01 |
瑞士商赫孚孟拉羅股份公司 |
寡核苷酸顆粒蛋白前體促效劑
|
EP4105328A1
(de)
|
2021-06-15 |
2022-12-21 |
Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. |
Antisense-oligonukleotide zur prävention von nierenfunktionsstörungen, die durch endotheliale dysfunktion gefördert werden, durch unterdrückung von ephrin-b2
|
US11638761B2
(en)
|
2021-07-09 |
2023-05-02 |
Dyne Therapeutics, Inc. |
Muscle targeting complexes and uses thereof for treating Facioscapulohumeral muscular dystrophy
|
US11633498B2
(en)
|
2021-07-09 |
2023-04-25 |
Dyne Therapeutics, Inc. |
Muscle targeting complexes and uses thereof for treating myotonic dystrophy
|
WO2023003805A1
(en)
|
2021-07-19 |
2023-01-26 |
Alnylam Pharmaceuticals, Inc. |
Methods and compositions for treating subjects having or at risk of developing a non-primary hyperoxaluria disease or disorder
|
EP4388094A1
(de)
|
2021-08-16 |
2024-06-26 |
Vib Vzw |
Oligonukleotide zur modulation der synaptogyrin-3-expression
|
WO2023044094A1
(en)
|
2021-09-20 |
2023-03-23 |
Alnylam Pharmaceuticals, Inc. |
Inhibin subunit beta e (inhbe) modulator compositions and methods of use thereof
|
AR127158A1
(es)
|
2021-09-29 |
2023-12-27 |
Hoffmann La Roche |
Oligonucléotido antisentido para la edición de arn asociado a enfermedades de poliglutamina
|
CN118318042A
(zh)
|
2021-11-03 |
2024-07-09 |
豪夫迈·罗氏有限公司 |
用于调节载脂蛋白e4表达的寡核苷酸
|
CN118284695A
(zh)
|
2021-11-11 |
2024-07-02 |
豪夫迈·罗氏有限公司 |
用于治疗hbv的药物组合
|
WO2023104693A1
(en)
|
2021-12-07 |
2023-06-15 |
F. Hoffmann-La Roche Ag |
Antisense oligonucleotides targeting actl6b
|
WO2023111210A1
(en)
|
2021-12-17 |
2023-06-22 |
F. Hoffmann-La Roche Ag |
Combination of oligonucleotides for modulating rtel1 and fubp1
|
WO2023111336A1
(en)
|
2021-12-17 |
2023-06-22 |
F. Hoffmann-La Roche Ag |
Oligonucleotide gba agonists
|
WO2023117738A1
(en)
|
2021-12-20 |
2023-06-29 |
F. Hoffmann-La Roche Ag |
Threose nucleic acid antisense oligonucleotides and methods thereof
|
CA3242118A1
(en)
|
2021-12-22 |
2023-06-29 |
Alfica Sehgal |
Modulation of gene transcription using antisense oligonucleotides targeting regulatory rnas
|
WO2023141507A1
(en)
|
2022-01-20 |
2023-07-27 |
Genentech, Inc. |
Antisense oligonucleotides for modulating tmem106b expression
|
AR128558A1
(es)
|
2022-02-21 |
2024-05-22 |
Hoffmann La Roche |
Oligonucleótido antisentido
|
US11931421B2
(en)
|
2022-04-15 |
2024-03-19 |
Dyne Therapeutics, Inc. |
Muscle targeting complexes and formulations for treating myotonic dystrophy
|
WO2023217890A1
(en)
|
2022-05-10 |
2023-11-16 |
F. Hoffmann-La Roche Ag |
Antisense oligonucleotides targeting cfp-elk1 intergene region
|
WO2023222858A1
(en)
|
2022-05-18 |
2023-11-23 |
F. Hoffmann-La Roche Ag |
Improved oligonucleotides targeting rna binding protein sites
|
WO2023240277A2
(en)
|
2022-06-10 |
2023-12-14 |
Camp4 Therapeutics Corporation |
Methods of modulating progranulin expression using antisense oligonucleotides targeting regulatory rnas
|
WO2023242324A1
(en)
|
2022-06-17 |
2023-12-21 |
F. Hoffmann-La Roche Ag |
Antisense oligonucleotides for targeting progranulin
|
WO2024026474A1
(en)
|
2022-07-29 |
2024-02-01 |
Regeneron Pharmaceuticals, Inc. |
Compositions and methods for transferrin receptor (tfr)-mediated delivery to the brain and muscle
|
EP4332221A1
(de)
|
2022-08-29 |
2024-03-06 |
Roche Innovation Center Copenhagen A/S |
Threose-nukleinsäure-antisense-oligonukleotide und verfahren dafür
|
WO2024052403A1
(en)
|
2022-09-06 |
2024-03-14 |
F. Hoffmann-La Roche Ag |
Double-stranded rna molecule for administration to the eye
|
WO2024098061A2
(en)
|
2022-11-04 |
2024-05-10 |
Genkardia Inc. |
Oligonucleotide-based therapeutics targeting cyclin d2 for the treatment of heart failure
|
WO2024098002A1
(en)
|
2022-11-04 |
2024-05-10 |
Regeneron Pharmaceuticals, Inc. |
Calcium voltage-gated channel auxiliary subunit gamma 1 (cacng1) binding proteins and cacng1-mediated delivery to skeletal muscle
|
WO2024107765A2
(en)
|
2022-11-14 |
2024-05-23 |
Regeneron Pharmaceuticals, Inc. |
Compositions and methods for fibroblast growth factor receptor 3-mediated delivery to astrocytes
|
WO2024119145A1
(en)
|
2022-12-01 |
2024-06-06 |
Camp4 Therapeutics Corporation |
Modulation of syngap1 gene transcription using antisense oligonucleotides targeting regulatory rnas
|
WO2024126654A1
(en)
|
2022-12-14 |
2024-06-20 |
F. Hoffmann-La Roche Ag |
Antisense oligonucleotides targeting actl6b
|