DE60317553D1 - Herstellung von tocoferylazetaten - Google Patents

Herstellung von tocoferylazetaten

Info

Publication number
DE60317553D1
DE60317553D1 DE60317553T DE60317553T DE60317553D1 DE 60317553 D1 DE60317553 D1 DE 60317553D1 DE 60317553 T DE60317553 T DE 60317553T DE 60317553 T DE60317553 T DE 60317553T DE 60317553 D1 DE60317553 D1 DE 60317553D1
Authority
DE
Germany
Prior art keywords
acetate
trimethylhydroquinone
phytyl
sup
alkylating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60317553T
Other languages
English (en)
Other versions
DE60317553T2 (de
Inventor
Werner Bonrath
Claus Dittel
Thomas Netscher
Thomas Pabst
Rudolf Schmid
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
DSM IP Assets BV
Original Assignee
DSM IP Assets BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by DSM IP Assets BV filed Critical DSM IP Assets BV
Application granted granted Critical
Publication of DE60317553D1 publication Critical patent/DE60317553D1/de
Publication of DE60317553T2 publication Critical patent/DE60317553T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6
    • C07D311/72—3,4-Dihydro derivatives having in position 2 at least one methyl radical and in position 6 one oxygen atom, e.g. tocopherols
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/28—Preparation of carboxylic acid esters by modifying the hydroxylic moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/293—Preparation of carboxylic acid esters by modifying the hydroxylic moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pyrane Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
DE60317553T 2002-11-21 2003-09-29 Herstellung von tocoferylazetaten Expired - Lifetime DE60317553T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP02025989 2002-11-21
EP02025989 2002-11-21
PCT/EP2003/010789 WO2004046126A1 (en) 2002-11-21 2003-09-29 Manufacture of tocopheryl acetate

Publications (2)

Publication Number Publication Date
DE60317553D1 true DE60317553D1 (de) 2007-12-27
DE60317553T2 DE60317553T2 (de) 2008-10-23

Family

ID=32319545

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60317553T Expired - Lifetime DE60317553T2 (de) 2002-11-21 2003-09-29 Herstellung von tocoferylazetaten

Country Status (9)

Country Link
US (2) US7169943B2 (de)
EP (1) EP1562929B1 (de)
JP (1) JP4932158B2 (de)
KR (1) KR101078957B1 (de)
CN (1) CN100503593C (de)
AT (1) ATE378325T1 (de)
AU (1) AU2003271655A1 (de)
DE (1) DE60317553T2 (de)
WO (1) WO2004046126A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2347552T3 (es) * 2003-01-13 2010-11-02 Dsm Ip Assets B.V. Proceso para la fabricacion de acetato de alfa-tocoferilo.
US20060235234A1 (en) * 2003-09-15 2006-10-19 Werner Bonrath New route to alpha-tocopherol, alpha-tocopheryl alkanoates and precursors thereof
US7622591B2 (en) 2003-09-15 2009-11-24 Dsm Ip Assets B.V. Route to α- tocopheryl alkanoates and percursors thereof
CN103080084B (zh) * 2010-08-26 2017-07-07 帝斯曼知识产权资产管理有限公司 Tmhq的制备方法
CN107001209B (zh) 2014-12-17 2021-02-19 帝斯曼知识产权资产管理有限公司 在金(i)络合物存在的情况下基于炔烃与二甲基呋喃的分子间反应形成色满
CN108203425A (zh) * 2016-12-20 2018-06-26 浙江医药股份有限公司新昌制药厂 一种dl-α生育酚醋酸酯的制备方法
US20240209132A1 (en) 2021-04-28 2024-06-27 Dsm Ip Assets B.V. Coupling of 2,3,5-trimethylhydroquinone and unsaturated alcohols

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3708505A (en) * 1971-02-25 1973-01-02 Diamond Shamrock Corp Process for preparation of d,l-alpha tocopherol
JPS5089372A (de) * 1973-12-18 1975-07-17
JPS5838434B2 (ja) * 1976-10-12 1983-08-23 日清製粉株式会社 ２，３，６−トリメチルハイドロキノン−１−ニコチン酸エステルの製造法
EP0183042B1 (de) * 1984-11-21 1989-10-11 F. Hoffmann-La Roche Ag Verfahren zur Herstellung von Hydrochinonderivaten
JP2947503B2 (ja) * 1994-03-02 1999-09-13 エーザイ株式会社 アリルキノン誘導体の製造方法および中間体
DE19757124A1 (de) * 1997-12-20 1999-06-24 Degussa Verfahren zur Herstellung von alpha-Tocopherolestern
ES2264230T3 (es) * 1998-04-06 2006-12-16 Dsm Ip Assets B.V. Procedimiento par ala obtencion de d,1-alfa-tocoferol, en un disolvente de carbonato y en presencia de un catalizador de acido conteniendo azufre.
DE10011403A1 (de) * 2000-03-09 2001-09-13 Degussa Verfahren zur Herstellung von alpha-Tocopherolacetat durch Kondensation von Trimethylhydrochinon mit Isophytol unter Recyclierung einer essigsauren Katalysatorlösung
EP1239045B1 (de) * 2001-02-21 2010-08-25 DSM IP Assets B.V. Verfahren zur Herstellung eines Vitamin E - Zwischenproduktes
CN1271065C (zh) * 2001-10-31 2006-08-23 Dsmip资产有限公司 α－生育酚的制备方法

Also Published As

Publication number Publication date
EP1562929B1 (de) 2007-11-14
KR20050083917A (ko) 2005-08-26
AU2003271655A1 (en) 2004-06-15
US20060094886A1 (en) 2006-05-04
JP2006515280A (ja) 2006-05-25
CN100503593C (zh) 2009-06-24
CN1701066A (zh) 2005-11-23
US7169943B2 (en) 2007-01-30
DE60317553T2 (de) 2008-10-23
JP4932158B2 (ja) 2012-05-16
WO2004046126A1 (en) 2004-06-03
EP1562929A1 (de) 2005-08-17
KR101078957B1 (ko) 2011-11-01
US20070112206A1 (en) 2007-05-17
ATE378325T1 (de) 2007-11-15

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition