DE60317214D1 - Kristallines gamma-lacton der17beta-hydroxy-7alpha-(5'-methyl-2'-furyl)-pregna-4,9(11)-dien-3-one-21-carbonsäure - Google Patents

Kristallines gamma-lacton der17beta-hydroxy-7alpha-(5'-methyl-2'-furyl)-pregna-4,9(11)-dien-3-one-21-carbonsäure

Info

Publication number
DE60317214D1
DE60317214D1 DE60317214T DE60317214T DE60317214D1 DE 60317214 D1 DE60317214 D1 DE 60317214D1 DE 60317214 T DE60317214 T DE 60317214T DE 60317214 T DE60317214 T DE 60317214T DE 60317214 D1 DE60317214 D1 DE 60317214D1
Authority
DE
Germany
Prior art keywords
7alpha
der17beta
lacton
pregna
furyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60317214T
Other languages
English (en)
Other versions
DE60317214T2 (de
Inventor
Bruce Allen Pearlman
Frederick J Antosz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co LLC
Original Assignee
Pharmacia and Upjohn Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia and Upjohn Co LLC filed Critical Pharmacia and Upjohn Co LLC
Publication of DE60317214D1 publication Critical patent/DE60317214D1/de
Application granted granted Critical
Publication of DE60317214T2 publication Critical patent/DE60317214T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
DE60317214T 2002-09-19 2003-09-19 Kristallines gamma-lacton der 17beta-hydroxy-7alpha-(5'-methyl-2'-furyl)-pregna-4,9(11)-dien-3-on-21-carbonsäure Expired - Fee Related DE60317214T2 (de)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US41187402P 2002-09-19 2002-09-19
US411874P 2002-09-19
US42559602P 2002-11-12 2002-11-12
US425596P 2002-11-12
US392833 2003-03-21
US10/392,833 US7235655B2 (en) 2002-03-22 2003-03-21 Processes to prepare eplerenone
PCT/US2003/029923 WO2004037844A1 (en) 2002-09-19 2003-09-19 Crystalline 17beta-hydroxy-7alpha- (5'-methyl-2'-furyl)-pregna-4,9(11)-dien-3-one-21-carboxylic acid, gamma-lactone

Publications (2)

Publication Number Publication Date
DE60317214D1 true DE60317214D1 (de) 2007-12-13
DE60317214T2 DE60317214T2 (de) 2008-08-07

Family

ID=32180478

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60317214T Expired - Fee Related DE60317214T2 (de) 2002-09-19 2003-09-19 Kristallines gamma-lacton der 17beta-hydroxy-7alpha-(5'-methyl-2'-furyl)-pregna-4,9(11)-dien-3-on-21-carbonsäure

Country Status (8)

Country Link
US (6) US7235655B2 (de)
EP (1) EP1539795B1 (de)
JP (1) JP2006505624A (de)
AT (1) ATE377020T1 (de)
AU (1) AU2003282868A1 (de)
DE (1) DE60317214T2 (de)
ES (1) ES2295663T3 (de)
WO (1) WO2004037844A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7235655B2 (en) * 2002-03-22 2007-06-26 Pharmacia & Upjohn Company Processes to prepare eplerenone
WO2003082895A2 (en) * 2002-03-22 2003-10-09 Pharmacia & Upjohn Company Process to prepare eplerenone
CL2004000574A1 (es) * 2003-03-21 2005-02-11 Pharmacia Corp Sa Organizada B Proceso para preparar un compuesto 17-espirolactona o la sal de lactona abierta por carbonilacion del correspondiente 17-alquenil o alquinil derivado, los intermediarios que se usan y su proceso de obtencion.
US8110699B2 (en) * 2008-09-12 2012-02-07 University Of South Florida Cobalt-catalyzed asymmetric cyclopropanation of alkenes with α-nitrodiazoacetates
EP3426737B1 (de) 2016-03-08 2021-11-24 3D Systems, Incorporated Nicht-isocyanat-polyurethantinten für den 3d-druck
CN112980910B (zh) * 2021-03-19 2024-01-05 上海应用技术大学 一种在相转移催化剂体系中微生物转化11α-羟基坎利酮的方法

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US3413288A (en) 1965-07-07 1968-11-26 Parke Davis & Co Process for the production of steroidal c-17 spirolactones
US3565924A (en) 1968-07-01 1971-02-23 Wisconsin Alumni Res Found 25-hydroxycholfcalciferol
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IE44711B1 (en) 1976-03-05 1982-03-10 Schering Ag 17 -hydroxypropyl-4-3-keto-steroids and esters thereof, and process for their manufacture
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EP0123734A1 (de) 1983-04-29 1984-11-07 Gist-Brocades N.V. 17-(Isocyano-sulfonylmethylen)-Steroide, 17-(Formamido-sulfonylmethylen)-Steroide und ihre Herstellung
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US5352809A (en) 1986-10-10 1994-10-04 Gist-Brocades N.V. 9-alpha-hydroxy steroids, process for their preparation, process for the preparation of the corresponding 9(11)-dehydro derivatives and pharmaceutical preparations containing such steroids
FR2610933B1 (fr) 1987-02-18 1989-06-09 Roussel Uclaf Nouveaux 19-nor steroides substitues en position 7, leur preparation, leur application comme medicaments, les compositions pharmaceutiques les renfermant
DE3903988A1 (de) * 1989-02-10 1990-08-30 Basf Ag Oxidierte diphenylheteroalkane, ihre herstellung und verwendung
EP0697015A1 (de) * 1993-05-06 1996-02-21 PHARMACIA & UPJOHN COMPANY Optisch aktive 3-(1-(alkylamino)-alkyl)-pyrrolidine
US5962697A (en) * 1993-05-06 1999-10-05 Pharmacia & Upjohn Company Optically active 3-(1-(alkylamino))alkyl pyrrolidines
US5502222A (en) 1994-06-01 1996-03-26 Schering Corporation Process for preparing delta 9,11 and 21-chloro corticosteroids
US5655888A (en) * 1994-10-14 1997-08-12 Tlv Co., Ltd. Pump and combination pump and trap with snap-over mechanism and double-seal outlet valve
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AT404597B (de) * 1995-11-24 1998-12-28 Immuno Ag Verfahren zur herstellung von proteinen
ATE365171T1 (de) * 1995-12-11 2007-07-15 Searle Llc Verfahren zur herstellung einer epoxyverbindung
ES2293944T3 (es) 1996-12-11 2008-04-01 G.D. Searle Llc. Procedimiento de epoxidacion.
US6638937B2 (en) * 1998-07-06 2003-10-28 Bristol-Myers Squibb Co. Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists
UA74141C2 (uk) * 1998-12-09 2005-11-15 Дж.Д. Сірл Енд Ко. Фармацевтична композиція на основі тонкоподрібненого еплеренону (варіанти), спосіб її одержання та спосіб лікування розладів, опосередкованих альдостероном (варіанти)
HUP0203032A3 (en) 1999-12-08 2003-04-28 Pharmacia Corp Chicago Eplerenone crystalline form exhibiting enhanced dissolution rate, process for their preparation and pharmaceutical compositions containing them and their use
CN100413881C (zh) 1999-12-08 2008-08-27 法马西亚公司 依匹乐酮晶形
US6444813B2 (en) 2000-02-02 2002-09-03 Pharmacia & Upjohn Company Linezolid-crystal form II
US6716829B2 (en) * 2000-07-27 2004-04-06 Pharmacia Corporation Aldosterone antagonist and cyclooxygenase-2 inhibitor combination therapy to prevent or treat inflammation-related cardiovascular disorders
WO2003082895A2 (en) * 2002-03-22 2003-10-09 Pharmacia & Upjohn Company Process to prepare eplerenone
US7235655B2 (en) * 2002-03-22 2007-06-26 Pharmacia & Upjohn Company Processes to prepare eplerenone
PL376919A1 (pl) * 2002-11-06 2006-01-09 Pharmacia & Upjohn Company Llc Sposoby wytwarzania 7-karboksy-podstawionych steroidów
DE60312029T2 (de) * 2002-11-07 2007-06-21 Pharmacia & Upjohn Co. Llc, Kalamazoo Verfahren zur herstellung c-7 substituierter 5-androstene

Also Published As

Publication number Publication date
US20070100140A1 (en) 2007-05-03
US7411062B2 (en) 2008-08-12
ATE377020T1 (de) 2007-11-15
EP1539795A1 (de) 2005-06-15
US20070106072A1 (en) 2007-05-10
US20040127702A1 (en) 2004-07-01
US7112670B2 (en) 2006-09-26
US20030232981A1 (en) 2003-12-18
US7414127B2 (en) 2008-08-19
US20070123704A1 (en) 2007-05-31
WO2004037844A1 (en) 2004-05-06
EP1539795B1 (de) 2007-10-31
AU2003282868A1 (en) 2004-05-13
ES2295663T3 (es) 2008-04-16
JP2006505624A (ja) 2006-02-16
US20070117780A1 (en) 2007-05-24
US7417140B2 (en) 2008-08-26
WO2004037844A8 (en) 2004-06-10
DE60317214T2 (de) 2008-08-07
US7235655B2 (en) 2007-06-26

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8339 Ceased/non-payment of the annual fee