DE60238669D1 - Neues elongasegen und verfahren zur herstellung von delta-9-polyunsättigten fettsäuren - Google Patents

Neues elongasegen und verfahren zur herstellung von delta-9-polyunsättigten fettsäuren

Info

Publication number
DE60238669D1
DE60238669D1 DE60238669T DE60238669T DE60238669D1 DE 60238669 D1 DE60238669 D1 DE 60238669D1 DE 60238669 T DE60238669 T DE 60238669T DE 60238669 T DE60238669 T DE 60238669T DE 60238669 D1 DE60238669 D1 DE 60238669D1
Authority
DE
Germany
Prior art keywords
polyunated
delta
production
fatty acids
elongases
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60238669T
Other languages
English (en)
Inventor
Johnathan A Napier
Colin M Lazarus
Baoxiu Qi
Jens Lerchl
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Bristol
Original Assignee
University of Bristol
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Bristol filed Critical University of Bristol
Application granted granted Critical
Publication of DE60238669D1 publication Critical patent/DE60238669D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
    • C12N15/8247—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine involving modified lipid metabolism, e.g. seed oil composition
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Nutrition Science (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Fodder In General (AREA)
  • Edible Oils And Fats (AREA)
DE60238669T 2001-03-26 2002-03-26 Neues elongasegen und verfahren zur herstellung von delta-9-polyunsättigten fettsäuren Expired - Lifetime DE60238669D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0107510.0A GB0107510D0 (en) 2001-03-26 2001-03-26 New elongase gene and a process for the production of -9-polyunsaturated fatty acids
PCT/EP2002/003418 WO2002077213A2 (en) 2001-03-26 2002-03-26 New elongase gene and production of δ9-polyunsaturated fatty acids

Publications (1)

Publication Number Publication Date
DE60238669D1 true DE60238669D1 (de) 2011-02-03

Family

ID=9911561

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60238669T Expired - Lifetime DE60238669D1 (de) 2001-03-26 2002-03-26 Neues elongasegen und verfahren zur herstellung von delta-9-polyunsättigten fettsäuren

Country Status (17)

Country Link
US (1) US7601889B2 (de)
EP (1) EP1373519B1 (de)
JP (1) JP2004531248A (de)
CN (1) CN1537166A (de)
AR (1) AR033449A1 (de)
AT (1) ATE492641T1 (de)
AU (1) AU2002310891B2 (de)
BR (1) BR0208202A (de)
CA (1) CA2442010C (de)
DE (1) DE60238669D1 (de)
DK (1) DK1373519T3 (de)
EE (1) EE200300471A (de)
ES (1) ES2383451T3 (de)
GB (1) GB0107510D0 (de)
IL (1) IL157562A0 (de)
NO (1) NO20034276L (de)
WO (1) WO2002077213A2 (de)

Families Citing this family (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR0306883A (pt) * 2002-01-30 2004-12-07 Basf Plant Science Gmbh ácido nucléico isolado, sequências de ácido nucléico isolado e de aminoácido, construção de gene, vetor, organismo, processo para a produção de pufas, óleo, lipìdeo ou ácido graxo ou uma fração destes, composição de óleo, lipìdeo ou de ácido graxo, e, uso da mesma
GB0229578D0 (en) * 2002-12-19 2003-01-22 Univ Bristol Novel method for the production of polyunsaturated fatty acids
EP1576166B1 (de) * 2002-12-19 2014-10-15 University Of Bristol Verfahren zur herstellung von mehrfach ungesättigten fettsäuren
US20040172682A1 (en) * 2003-02-12 2004-09-02 Kinney Anthony J. Production of very long chain polyunsaturated fatty acids in oilseed plants
JP4685762B2 (ja) * 2003-03-12 2011-05-18 ネステク ソシエテ アノニム 食事制限のための膨化ペットフード
EP2166090B1 (de) 2003-08-01 2015-07-01 BASF Plant Science GmbH Verfahren zur Herstellung mehrfach ungesättigter Fettsäuren in transgenen Organismen
US11952581B2 (en) 2003-08-01 2024-04-09 Basf Plant Science Gmbh Process for the production of polyunsaturated fatty acids in transgenic organisms
JP4567047B2 (ja) 2004-02-27 2010-10-20 ビーエーエスエフ プラント サイエンス ゲーエムベーハー トランスジェニック植物における多価不飽和脂肪酸の製造方法
AU2005217080B2 (en) 2004-02-27 2011-02-24 Basf Plant Science Gmbh Method for producing unsaturated omega-3 fatty acids in transgenic organisms
EP2357244A3 (de) 2004-04-22 2011-11-23 Commonwealth Scientific and Industrial Research Organisation Synthese von langkettigen polyungesättigten Fettsäuren durch rekombinante Zellen
DK1756280T3 (en) 2004-04-22 2015-02-02 Commw Scient Ind Res Org SYNTHESIS OF CHAIN, polyunsaturated fatty acids BY RECOMBINANT CELLS
EP1766023B1 (de) 2004-06-04 2010-09-01 Fluxome Sciences A/S Stoffwechseltechnisch hergestellte zellen zur produktion mehrfach ungesättigter fettsäuren
WO2006012325A1 (en) * 2004-06-25 2006-02-02 E.I. Dupont De Nemours And Company Delta-8 desaturase and its use in making polyunsaturated fatty acids
US7550286B2 (en) * 2004-11-04 2009-06-23 E. I. Du Pont De Nemours And Company Docosahexaenoic acid producing strains of Yarrowia lipolytica
DE102005013779A1 (de) 2005-03-22 2006-09-28 Basf Plant Science Gmbh Verfahren zur Herstellung von mehrfach ungesättigten C20- und C22-Fettsäuren mit mindestens vier Doppelbindungen in transgenen Pflanzen
DE102005038036A1 (de) 2005-08-09 2007-02-15 Basf Plant Science Gmbh Verfahren zur Herstellung von Arachidonsäure und/oder Eicosapentaensäure in transgenen Nutzpflanzen
BRPI0620552A2 (pt) 2005-11-23 2011-11-22 Du Pont polinucleotìdeo isolado, polipeptìdeo delta-9 elongase, construção recombinante, célula vegetal, método para transformar uma célula, método para produção de uma planta transgênica, sementes transgênicas, método para fabricar ácidos graxos poliinsaturados de cadeia longa, óleos, método para produzir pelo menos um ácido graxo poliinsaturado, plantas de semente oleaginosa, sementes, alimentos, fragmento de ácido nucléico isolado e progênies de plantas
GB0603160D0 (en) 2006-02-16 2006-03-29 Rothamsted Res Ltd Nucleic acid
AR059376A1 (es) 2006-02-21 2008-03-26 Basf Plant Science Gmbh Procedimiento para la produccion de acidos grasos poliinsaturados
US7943823B2 (en) 2006-04-28 2011-05-17 E.I. Du Pont De Nemours And Company Delta-8 desaturase and its use in making polyunsaturated fatty acids
US7678560B2 (en) 2006-05-17 2010-03-16 E.I. Du Pont De Nemours And Company Δ 5 desaturase and its use in making polyunsaturated fatty acids
US7695950B2 (en) 2006-05-17 2010-04-13 E. I. Du Pont De Nemours And Company Δ5 desaturase and its use in making polyunsaturated fatty acids
BRPI0716075A2 (pt) 2006-08-29 2013-08-06 Commw Scient Ind Res Org sÍntese de Ácidos graxos
ES2531391T3 (es) 2006-10-06 2015-03-13 Basf Plant Science Gmbh Delta-5 desaturasas y procedimiento para la preparación de ácidos grasos poliinsaturados en organismos transgénicos no humanos
WO2008063340A2 (en) 2006-10-23 2008-05-29 E.I. Du Pont De Nemours And Company Delta-8 desaturases and their use in making polyunsaturated fatty acids
US8916361B2 (en) 2006-11-17 2014-12-23 Abbott Laboratories Elongase gene and uses thereof
US20080125487A1 (en) * 2006-11-17 2008-05-29 Tapas Das Elongase gene and uses thereof
EP2441843A1 (de) 2007-02-12 2012-04-18 E. I. du Pont de Nemours and Company Herstellung von Arachindonsäure in Ölsaatpflanzen
JP5083941B2 (ja) * 2007-03-07 2012-11-28 学校法人北里研究所 食用動物の肥育仕上がり判定方法
EP3290520B1 (de) 2007-03-09 2021-07-14 Monsanto Technology LLC Zubereitung und verwendung von embryoexplantaten aus pflanzen für die transformation
ES2559312T3 (es) 2007-04-03 2016-02-11 E. I. Du Pont De Nemours And Company Multienzimas y su uso en la fabricación de ácidos grasos poliinsaturados
US8188338B2 (en) 2007-04-10 2012-05-29 E. I. Du Pont De Nemours And Company Delta-8 desaturases and their use in making polyunsaturated fatty acids
US7794701B2 (en) 2007-04-16 2010-09-14 E.I. Du Pont De Nemours And Company Δ-9 elongases and their use in making polyunsaturated fatty acids
US7943365B2 (en) 2007-05-03 2011-05-17 E.I. Du Pont De Nemours And Company Δ-5 desaturases and their use in making polyunsaturated fatty acids
EP2572712A3 (de) 2007-06-01 2013-11-20 The Trustees Of Princeton University Behandlung von Virusinfektionen durch Modulation von Hostzellen-Stoffwechselpfaden
EP2176416B1 (de) 2007-07-31 2016-03-16 BASF Plant Science GmbH Elongasen und verfahren zur herstellung mehrfach ungesättigter fettsäuren in transgenen organismen
WO2009097331A1 (en) * 2008-01-28 2009-08-06 The Board Of Regents Of The University Of Oklahoma Very long chain polyunsaturated fatty acids, methods of production, and uses
US8168858B2 (en) 2008-06-20 2012-05-01 E. I. Du Pont De Nemours And Company Delta-9 fatty acid elongase genes and their use in making polyunsaturated fatty acids
EP2310512A1 (de) * 2008-06-27 2011-04-20 Institute National de la Recherche Agronomique Rekombinante zellen und pflanzen zur synthese sehr langkettiger fettsäure (vlcfa)
CA2734810C (en) 2008-08-26 2018-06-19 Basf Plant Science Gmbh Nucleic acids encoding desaturases and modified plant oil
CA3082380A1 (en) 2008-11-18 2010-05-27 Commonwealth Scientific And Industrial Research Organisation Recombinant cells comprisng exogenous .delta.6 desaturase and methods for producing oil containing unsaturated fatty acids
EP2821492A3 (de) 2009-05-13 2015-04-08 BASF Plant Science Company GmbH Acyltransferasen und Verwendungen davon zur Fettsäureherstellung
EP2440662B1 (de) 2009-06-08 2018-08-01 BASF Plant Science Company GmbH Neuartige fettsäurenverlängernde bestandteile und ihre verwendung
CA3161358A1 (en) 2009-07-17 2011-01-20 Basf Plant Science Company Gmbh Novel fatty acid desaturases and elongases and uses thereof
CN106222166B (zh) 2009-08-31 2020-09-08 巴斯夫植物科学有限公司 用于在植物中增强种子特异性基因表达而促进增强的多不饱和脂肪酸合成的调节性核酸分子
EP2504438A1 (de) 2009-11-24 2012-10-03 BASF Plant Science Company GmbH Neuartige fettsäureelongase und ihre verwendung
WO2011064181A1 (en) 2009-11-24 2011-06-03 Basf Plant Science Company Gmbh Novel fatty acid desaturase and uses thereof
CN101724637B (zh) * 2009-12-23 2011-10-26 南开大学 球等鞭金藻δ9延长酶的核苷酸序列及其应用
CA2804925A1 (en) 2010-06-25 2011-12-29 Basf Plant Science Company Gmbh Acyltransferases from thraustochytrium species and uses thereof in fatty acid production
JP5963749B2 (ja) 2010-08-26 2016-08-03 イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニーＥ．Ｉ．Ｄｕ Ｐｏｎｔ Ｄｅ Ｎｅｍｏｕｒｓ Ａｎｄ Ｃｏｍｐａｎｙ 変異δ９エロンガーゼおよび多価不飽和脂肪酸の製造におけるそれらの使用
BR112013004351A2 (pt) 2010-08-26 2016-05-31 Du Pont célula hospedeira microbiana recombinante e método para a produção de um óleo microbiano compreendendo ácido eicosapentaenócio.
EP2630235B1 (de) 2010-10-21 2017-04-05 BASF Plant Science Company GmbH Neuartige fettsäuredesaturasen und -elongasen, verlängerungsbestandteile und ihre verwendung
AU2013273934B2 (en) 2012-06-15 2016-12-01 Commonwealth Scientific And Industrial Research Organisation Production of long chain polyunsaturated fatty acids in plant cells
EP2880050B1 (de) 2012-08-03 2018-07-04 BASF Plant Science Company GmbH Neuartige enzyme, enzymbestandteile und verwendungen davon
CA2917099A1 (en) 2013-07-05 2015-01-08 Basf Plant Science Company Gmbh Gene expression or activity enhancing elements
MX2016008270A (es) 2013-12-18 2017-05-26 Commw Scient Ind Res Org Lipido que comprende acidos grasos poliinsaturados de cadena larga.
EP3160482A4 (de) 2014-06-27 2018-02-14 Commonwealth Scientific and Industrial Research Organisation Lipid mit docosapentensäure
FR3053052B1 (fr) * 2016-06-28 2021-02-12 Fermentalg Microalgue modifiee pour une production enrichie en tag
CN110506676B (zh) * 2019-08-23 2022-03-08 上海海洋大学 Elovl1基因及其应用

Family Cites Families (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5352605A (en) 1983-01-17 1994-10-04 Monsanto Company Chimeric genes for transforming plant cells using viral promoters
EP0131623B2 (de) 1983-01-17 1999-07-28 Monsanto Company Chimärische gene geeignet zur expression in pflanzenzellen
US5504200A (en) 1983-04-15 1996-04-02 Mycogen Plant Science, Inc. Plant gene expression
US5420034A (en) 1986-07-31 1995-05-30 Calgene, Inc. Seed-specific transcriptional regulation
EP0264166B1 (de) 1986-04-09 1996-08-21 Genzyme Corporation Genetisch transformierte Tiere, die ein gewünschtes Protein in Milch absondern
US4962028A (en) 1986-07-09 1990-10-09 Dna Plant Technology Corporation Plant promotors
US4987071A (en) 1986-12-03 1991-01-22 University Patents, Inc. RNA ribozyme polymerases, dephosphorylases, restriction endoribonucleases and methods
US5116742A (en) 1986-12-03 1992-05-26 University Patents, Inc. RNA ribozyme restriction endoribonucleases and methods
US4873316A (en) 1987-06-23 1989-10-10 Biogen, Inc. Isolation of exogenous recombinant proteins from the milk of transgenic mammals
EP0397687B1 (de) 1987-12-21 1994-05-11 The University Of Toledo Transformation von keimenden pflanzensamen mit hilfe von agrobacterium
US4934293A (en) 1987-12-28 1990-06-19 Pegasus Sewing Machine Mfg., Co., Ltd. Chaining thread sew-in device
US5614395A (en) 1988-03-08 1997-03-25 Ciba-Geigy Corporation Chemically regulatable and anti-pathogenic DNA sequences and uses thereof
DE3843628A1 (de) 1988-12-21 1990-07-05 Inst Genbiologische Forschung Wundinduzierbare und kartoffelknollenspezifische transkriptionale regulation
KR920701453A (ko) 1989-03-17 1992-08-11 미리엄 디. 멕코나헤이 유전자발현의 외부조절
WO1991013980A1 (en) 1990-03-16 1991-09-19 Calgene, Inc. Novel sequences preferentially expressed in early seed development and methods related thereto
US5187267A (en) 1990-06-19 1993-02-16 Calgene, Inc. Plant proteins, promoters, coding sequences and use
US5475099A (en) 1990-08-15 1995-12-12 Calgene Inc. Plant fatty acid synthases
ES2164659T3 (es) 1992-04-13 2002-03-01 Syngenta Ltd Construcciones de dna y plantas que las incorporan.
GB9324707D0 (en) 1993-12-02 1994-01-19 Olsen Odd Arne Promoter
US5576198A (en) 1993-12-14 1996-11-19 Calgene, Inc. Controlled expression of transgenic constructs in plant plastids
US6043411A (en) 1993-12-28 2000-03-28 Kirin Beer Kabushiki Kaisha Gene for fatty acid desaturase, vector containing said gene, plant transformed with said gene, and process for creating said plant
GB9403512D0 (en) 1994-02-24 1994-04-13 Olsen Odd Arne Promoter
AU703838B2 (en) 1995-08-10 1999-04-01 Rutgers University Nuclear-encoded transcription system in plastids of higher plants
US5850026A (en) 1996-07-03 1998-12-15 Cargill, Incorporated Canola oil having increased oleic acid and decreased linolenic acid content
JP2781783B2 (ja) 1996-07-30 1998-07-30 山形日本電気株式会社 半導体装置用パッケージ
EP0964922A4 (de) 1996-09-27 2000-10-25 Maxygen Inc Verfahren zur optimierung der gentherapie durch widerholtes sequenzmischen und selektion
US5977436A (en) 1997-04-09 1999-11-02 Rhone Poulenc Agrochimie Oleosin 5' regulatory region for the modification of plant seed lipid composition
SK139999A3 (en) 1997-04-11 2000-05-16 Calgene Llc A nucleic acids construct, isolated nucleotide sequence, recombinant plant cell, method of biosynthesis of polyunsaturated long chain fatty acids, pharmaceutical, food and cosmetic preparation and use thereof
US6051754A (en) 1997-04-11 2000-04-18 Abbott Laboratories Methods and compositions for synthesis of long chain poly-unsaturated fatty acids in plants
AR013633A1 (es) 1997-04-11 2001-01-10 Calgene Llc METODO PARA LA ALTERACIoN DE LA COMPOSICIoN DE ÁCIDOS GRASOS DE CADENA MEDIA EN SEMILLAS VEGETALES QUE EXPRESAN UNA TIOESTERASA QUE PREFIERE CADENA MEDIA VEGETAL HETERoLOGA.
US5972664A (en) 1997-04-11 1999-10-26 Abbott Laboratories Methods and compositions for synthesis of long chain poly-unsaturated fatty acids
WO1998055625A1 (en) * 1997-06-04 1998-12-10 Calgene, Llc Production of polyunsaturated fatty acids by expression of polyketide-like synthesis genes in plants
US6642437B1 (en) 1997-09-30 2003-11-04 The Regents Of The University Of California Production of proteins in plant seeds
AU1774899A (en) 1997-12-23 1999-07-19 University Of Bristol, The Desaturase
BR9908624A (pt) 1998-03-11 2000-11-14 Novartis Ag Sequência de promotor de plastìdio de planta
WO1999064616A2 (en) 1998-06-12 1999-12-16 Abbott Laboratories Polyunsaturated fatty acids in plants
US6677145B2 (en) 1998-09-02 2004-01-13 Abbott Laboratories Elongase genes and uses thereof
US6403349B1 (en) 1998-09-02 2002-06-11 Abbott Laboratories Elongase gene and uses thereof
WO2000034439A1 (en) 1998-12-07 2000-06-15 Washington State University Research Foundation Desaturases and methods of using them for synthesis of polyunsaturated fatty acids
JP2002538826A (ja) * 1999-03-18 2002-11-19 ザ ユニバーシティ オブ ブリストル カエノラブジチス・エレガンス由来の多飽和脂肪酸（ｐｕｆａ）エロンガーゼ
CN1247784C (zh) 2000-02-09 2006-03-29 巴斯福股份公司 新延伸酶基因以及制备多不饱和脂肪酸的方法
PL2233153T3 (pl) 2005-08-17 2015-06-30 Glaxosmithkline Biologicals Sa Szczepionka rotawirusowa wywołująca heterotypową ochronę krzyżową

Also Published As

Publication number Publication date
DK1373519T3 (da) 2011-04-18
GB0107510D0 (en) 2001-05-16
ES2383451T3 (es) 2012-06-21
NO20034276D0 (no) 2003-09-25
CN1537166A (zh) 2004-10-13
US7601889B2 (en) 2009-10-13
CA2442010A1 (en) 2002-10-03
ATE492641T1 (de) 2011-01-15
JP2004531248A (ja) 2004-10-14
IL157562A0 (en) 2004-03-28
NO20034276L (no) 2003-10-22
EE200300471A (et) 2003-12-15
US20050089981A1 (en) 2005-04-28
BR0208202A (pt) 2004-04-13
WO2002077213A2 (en) 2002-10-03
EP1373519B1 (de) 2010-12-22
EP1373519A2 (de) 2004-01-02
AU2002310891B2 (en) 2008-01-24
CA2442010C (en) 2013-07-30
AR033449A1 (es) 2003-12-17
WO2002077213A3 (en) 2003-03-13

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