DE60228583D1 - Verfahren und materialien für die behandlung des testosteron-mangels bei männern - Google Patents

Verfahren und materialien für die behandlung des testosteron-mangels bei männern

Info

Publication number
DE60228583D1
DE60228583D1 DE60228583T DE60228583T DE60228583D1 DE 60228583 D1 DE60228583 D1 DE 60228583D1 DE 60228583 T DE60228583 T DE 60228583T DE 60228583 T DE60228583 T DE 60228583T DE 60228583 D1 DE60228583 D1 DE 60228583D1
Authority
DE
Germany
Prior art keywords
men
treatment
materials
testosterone
loss
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60228583T
Other languages
English (en)
Inventor
Joseph S Podolski
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Repros Therapeutics Inc
Original Assignee
Repros Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23175972&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE60228583(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Repros Therapeutics Inc filed Critical Repros Therapeutics Inc
Application granted granted Critical
Publication of DE60228583D1 publication Critical patent/DE60228583D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/26—Androgens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/28—Antiandrogens

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Diabetes (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Beans For Foods Or Fodder (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE60228583T 2001-07-09 2002-07-09 Verfahren und materialien für die behandlung des testosteron-mangels bei männern Expired - Lifetime DE60228583D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US30431301P 2001-07-09 2001-07-09
PCT/US2002/021524 WO2003005954A2 (en) 2001-07-09 2002-07-09 Methods and materials for the treatment of testosterone deficiency in men

Publications (1)

Publication Number Publication Date
DE60228583D1 true DE60228583D1 (de) 2008-10-09

Family

ID=23175972

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60228583T Expired - Lifetime DE60228583D1 (de) 2001-07-09 2002-07-09 Verfahren und materialien für die behandlung des testosteron-mangels bei männern

Country Status (24)

Country Link
US (6) US7759360B2 (de)
EP (1) EP1411916B1 (de)
JP (2) JP4845165B2 (de)
KR (1) KR100851648B1 (de)
CN (2) CN1954807A (de)
AT (1) ATE406153T1 (de)
AU (1) AU2002318225B2 (de)
BR (1) BR0211067A (de)
CA (2) CA2777199A1 (de)
CL (1) CL2004000026A1 (de)
CO (1) CO5550428A2 (de)
CY (1) CY1108563T1 (de)
DE (1) DE60228583D1 (de)
DK (1) DK1411916T3 (de)
EC (1) ECSP044937A (de)
ES (1) ES2312593T3 (de)
HK (1) HK1071521A1 (de)
MX (1) MXPA04000097A (de)
NZ (2) NZ530491A (de)
PL (1) PL211339B1 (de)
PT (1) PT1411916E (de)
RU (1) RU2297218C2 (de)
WO (1) WO2003005954A2 (de)
ZA (1) ZA200400142B (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2777199A1 (en) 2001-07-09 2003-01-23 Repros Therapeutics Inc. Methods and materials for the treatment of testosterone deficiency in men
US7737185B2 (en) 2001-07-09 2010-06-15 Repros Therapeutics Inc. Methods and compositions with trans-clomiphene
US7173064B2 (en) 2001-07-09 2007-02-06 Repros Therapeutics Inc. Methods and compositions with trans-clomiphene for treating wasting and lipodystrophy
MX2007000050A (es) * 2004-07-14 2007-07-10 Repros Therapeutics Inc Trans-clomifeno para el tratamiento de hipertrofia de prostata benigna, cancer de prostata, hipogonadismo, trigliceridos elevados y colesterol elevado.
KR20070100811A (ko) * 2005-02-04 2007-10-11 레프로스 쎄라피우틱스 아이엔씨. 남성불임의 치료를 위한 트랜스―클로미펜을 이용한 물질과치료방법
EP2392322A3 (de) * 2005-03-22 2012-02-22 Repros Therapeutics Inc. Dosierschemata für Trans-Clomiphen
WO2008157335A2 (en) * 2007-06-13 2008-12-24 Quatrx Pharmaceuticals Company Methods for the treatment of erectile dysfunction using fispemifene
US20110118355A1 (en) * 2007-09-21 2011-05-19 Harry Fisch Treatment of migraine headaches using antiestrogens
US20090105348A1 (en) * 2007-10-18 2009-04-23 Harry Fisch Treatment of migraine headaches using antiestrogens
CA2702710C (en) 2007-10-16 2013-05-07 Repros Therapeutics, Inc. Trans-clomiphene for metabolic syndrome
US20090215738A1 (en) * 2008-02-26 2009-08-27 Michael Charles Scally Prevention and treatment of an increase in cardiovascular risk, adverse cardiovascular events, infertility, and adverse psychological effects after androgen or gnrh analogue intake
TWI477276B (zh) 2008-04-28 2015-03-21 Repros Therapeutics Inc 抗黃體素給藥方案
RU2474424C2 (ru) * 2010-09-24 2013-02-10 Государственное образовательное учреждение высшего профессионального образования "Ивановская государственная медицинская академия Федерального агентства по здравоохранению и социальному развитию" Способ коррекции гиперэстрадиолемии и нормогонадотропного гипогонадизма у мужчин
UA113291C2 (xx) 2011-08-04 2017-01-10 Метаболіти транскломіфену і їх застосування
US20140235601A1 (en) * 2011-08-09 2014-08-21 Kenneth W. Adams Use of Aromatase Inhibitor Or Estrogen Blocker For Increasing Spermatogenesis Or Testosterone Levels In Males
BR112014029131B1 (pt) 2012-05-31 2021-03-09 Allergan Pharmaceuticals International Limited cápsula de mucoadesivo
MX2015001912A (es) * 2012-08-21 2015-06-05 Repros Therapeutics Inc Formulaciones de trans - clomifeno y usos de las mismas.
CN104755087A (zh) 2012-11-02 2015-07-01 利普生物药剂公司 治疗孕酮依赖性病况的方法和组合物
CA2889770A1 (en) 2012-11-02 2014-05-08 Repros Therapeutics Inc. Trans-clomiphene for use in cancer therapy
US9814687B2 (en) * 2014-08-20 2017-11-14 Professional Compounding Centers Of America Transdermal pharmaceutical compositions including C-SERMs for low testosterone levels in men
RU2586305C1 (ru) * 2015-02-02 2016-06-10 Государственное бюджетное образовательное учреждение высшего профессионального образования "Ивановская государственная медицинская академия" Министерства здравоохранения Российской Федерации Способ лечения обструктивной азооспермии и криптозооспермии у пациентов с хроническим простатитом
US10364212B2 (en) 2016-04-22 2019-07-30 F.I.S.—Fabbrica Italiana Sintetici S.p.A. Process for the preparation of enclomiphene citrate having needle shaped crystal habit

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KR20070100811A (ko) * 2005-02-04 2007-10-11 레프로스 쎄라피우틱스 아이엔씨. 남성불임의 치료를 위한 트랜스―클로미펜을 이용한 물질과치료방법
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US20140235601A1 (en) 2011-08-09 2014-08-21 Kenneth W. Adams Use of Aromatase Inhibitor Or Estrogen Blocker For Increasing Spermatogenesis Or Testosterone Levels In Males

Also Published As

Publication number Publication date
CL2004000026A1 (es) 2005-02-04
WO2003005954A2 (en) 2003-01-23
WO2003005954B1 (en) 2003-12-04
JP4845165B2 (ja) 2011-12-28
US20160354325A1 (en) 2016-12-08
CN1954807A (zh) 2007-05-02
WO2003005954A3 (en) 2003-10-23
ECSP044937A (es) 2004-04-28
BR0211067A (pt) 2006-10-31
CN1289075C (zh) 2006-12-13
RU2004100535A (ru) 2005-06-10
CA2777199A1 (en) 2003-01-23
DK1411916T3 (da) 2008-12-15
NZ530491A (en) 2007-08-31
PT1411916E (pt) 2008-12-10
MXPA04000097A (es) 2004-05-21
ES2312593T3 (es) 2009-03-01
CY1108563T1 (el) 2014-04-09
EP1411916B1 (de) 2008-08-27
EP1411916A4 (de) 2005-08-17
NZ551013A (en) 2008-04-30
CA2453337C (en) 2012-08-28
US20040097597A1 (en) 2004-05-20
KR100851648B1 (ko) 2008-08-13
CO5550428A2 (es) 2005-08-31
EP1411916A2 (de) 2004-04-28
US10561624B2 (en) 2020-02-18
US20100286281A1 (en) 2010-11-11
US20150265553A1 (en) 2015-09-24
KR20040013131A (ko) 2004-02-11
CN1551765A (zh) 2004-12-01
HK1071521A1 (en) 2005-07-22
RU2297218C2 (ru) 2007-04-20
PL211339B1 (pl) 2012-05-31
JP2009280623A (ja) 2009-12-03
US8618176B2 (en) 2013-12-31
US20040241224A1 (en) 2004-12-02
PL374121A1 (en) 2005-10-03
US7759360B2 (en) 2010-07-20
US7368480B2 (en) 2008-05-06
AU2002318225B2 (en) 2007-12-13
ATE406153T1 (de) 2008-09-15
CA2453337A1 (en) 2003-01-23
ZA200400142B (en) 2006-02-22
US20140093560A1 (en) 2014-04-03
JP2005520779A (ja) 2005-07-14

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