DE60226243D1 - Peptidsynthasegen, peptidsynthase und verfahren zur herstellung eines dipeptids - Google Patents

Peptidsynthasegen, peptidsynthase und verfahren zur herstellung eines dipeptids

Info

Publication number
DE60226243D1
DE60226243D1 DE60226243T DE60226243T DE60226243D1 DE 60226243 D1 DE60226243 D1 DE 60226243D1 DE 60226243 T DE60226243 T DE 60226243T DE 60226243 T DE60226243 T DE 60226243T DE 60226243 D1 DE60226243 D1 DE 60226243D1
Authority
DE
Germany
Prior art keywords
dipeptide
amino acid
peptidesynthases
peptidesynthase
preparing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60226243T
Other languages
English (en)
Other versions
DE60226243T2 (de
Inventor
Naoto Tonouchi
Sonoko Suzuki
Kenzo Yokozeki
Hiroyuki Nozaki
Masakazu Sugiyama
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ajinomoto Co Inc
Original Assignee
Ajinomoto Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ajinomoto Co Inc filed Critical Ajinomoto Co Inc
Application granted granted Critical
Publication of DE60226243D1 publication Critical patent/DE60226243D1/de
Publication of DE60226243T2 publication Critical patent/DE60226243T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DE60226243T 2001-07-26 2002-07-26 Peptid-bildendes Enzymgen, Pepid-bildendes Enzym und Dipeptidherstellungsverfahren Expired - Lifetime DE60226243T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP2001226568 2001-07-26
JP2001226568 2001-07-26
JP2001310547 2001-10-05
JP2001310547 2001-10-05
PCT/JP2002/007635 WO2003010307A1 (en) 2001-07-26 2002-07-26 Peptide synthase gene, peptide synthase and process for producing dipeptide

Publications (2)

Publication Number Publication Date
DE60226243D1 true DE60226243D1 (de) 2008-06-05
DE60226243T2 DE60226243T2 (de) 2009-05-14

Family

ID=26619355

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60226243T Expired - Lifetime DE60226243T2 (de) 2001-07-26 2002-07-26 Peptid-bildendes Enzymgen, Pepid-bildendes Enzym und Dipeptidherstellungsverfahren

Country Status (9)

Country Link
US (5) US7037673B2 (de)
EP (4) EP1911839B1 (de)
JP (3) JP4239819B2 (de)
KR (2) KR100635803B1 (de)
CN (4) CN1529712A (de)
DE (1) DE60226243T2 (de)
DK (2) DK1911839T3 (de)
RU (3) RU2280077C2 (de)
WO (3) WO2003010189A1 (de)

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WO2004011652A1 (ja) 2002-07-26 2004-02-05 Ajinomoto Co., Inc. トリペプチド以上のペプチドの製造方法
KR20070034103A (ko) 2002-07-26 2007-03-27 아지노모토 가부시키가이샤 신규 펩타이드 신타제 유전자
JP2005040037A (ja) 2003-07-25 2005-02-17 Ajinomoto Co Inc ジペプチドの製造方法、それに用いるペプチド生成酵素、およびペプチド生成酵素の製造方法
US20050106703A1 (en) * 2003-11-05 2005-05-19 Kyowa Hakko Kogyo Co., Ltd. Microorganisms producing dipeptides and process for producing dipeptides using the microorganisms
US20050148048A1 (en) * 2003-11-27 2005-07-07 Kyowa Hakko Kogyo Co., Ltd. Process for producing dipeptides
US20070128687A1 (en) * 2003-11-28 2007-06-07 Hajime Ikeda Process for producing dipeptides
JP2005168405A (ja) * 2003-12-11 2005-06-30 Ajinomoto Co Inc ジペプチドの製造方法
JP4507618B2 (ja) * 2004-02-05 2010-07-21 味の素株式会社 変異型微生物およびこれを用いたペプチドの製造方法
EP1767628A4 (de) * 2004-06-25 2008-08-27 Kyowa Hakko Kogyo Kk Verfahren zur herstellung von dipeptiden oder dipeptidderivaten
CN1320099C (zh) * 2005-02-04 2007-06-06 南京工业大学 利用北里孢菌PL6－3制备ε－聚赖氨酸及其盐的方法
EP1870457A4 (de) * 2005-03-29 2012-02-22 Kyowa Hakko Bio Co Ltd Dipeptidkristall und verfahren zur herstellung davon
WO2007074858A1 (ja) * 2005-12-27 2007-07-05 Kyowa Hakko Kogyo Co., Ltd. ジペプチドの製造法
JP2007319063A (ja) * 2006-05-31 2007-12-13 Okayama Prefecture ジペプチドの製造方法
US20090306340A1 (en) * 2006-06-28 2009-12-10 Kyowa Hakko Bio Co., Ltd. Method for purification of oligopeptides
EP2118299A1 (de) * 2007-01-11 2009-11-18 Danisco US, INC., Genencor Division Enzymproduktion in einem kulturmedium mit rohglycerin
JP5319521B2 (ja) 2007-04-06 2013-10-16 協和発酵バイオ株式会社 ジペプチドの製造法
US8104191B2 (en) 2008-07-31 2012-01-31 Electrolux Home Products, Inc. Laundry dryer providing moisture application during tumbling and reduced airflow
WO2011126054A1 (ja) 2010-04-07 2011-10-13 国立大学法人京都大学 生理活性ペプチド
KR101144987B1 (ko) * 2010-04-12 2012-05-11 목원대학교 산학협력단 크리세오박테리움 ｆｂｆ-7 균주 배양물 및 이를 함유하는 뿌리혹선충 방제용 조성물
RU2012129311A (ru) 2012-07-11 2014-01-20 Закрытое акционерное общество " Научно-исследовательский институт Аджиномото-Генетика" (ЗАО "АГРИ") Днк, кодирующая дипептид-синтезирующий фермер (варианты), бактерия рода escherichia и способ получения дипептидов с ее использованием
CN103114068B (zh) * 2013-03-15 2014-06-11 江苏南资环保科技有限公司 一株哌嗪降解无色杆菌菌mbpq-cg及其应用
RU2560980C2 (ru) * 2013-07-11 2015-08-20 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО "АГРИ") ДНК, КОДИРУЮЩАЯ ДИПЕПТИД-СИНТЕЗИРУЮЩИЙ ФЕРМЕНТ (ВАРИАНТЫ), БАКТЕРИЯ РОДА Escherichia И СПОСОБ ПОЛУЧЕНИЯ ДИПЕПТИДОВ С ЕЕ ИСПОЛЬЗОВАНИЕМ
CN104480172A (zh) * 2014-11-19 2015-04-01 江南大学 一种利用重组大肠杆菌生产l-丙氨酰-l-谷氨酰胺的方法
US10280202B2 (en) 2015-03-02 2019-05-07 Kyoto University Peptide
CN106565822A (zh) * 2016-10-17 2017-04-19 湖北泓肽生物科技有限公司 手性l‑丙氨酰‑苯丙氨酸的制备方法
CA3049488C (en) * 2016-12-30 2020-07-28 Innobio Corporation Limited Gene encoding alanyl-glutamine dipeptide biosynthetic enzyme and application thereof
FR3076992B1 (fr) 2018-01-23 2022-10-14 Samirath Adeyendju Akanke Alli Dispositif de protection vulvaire, kit de protection vulvaire et anale et procede d'installation d'une telle protection
CN113302310B (zh) * 2018-12-18 2024-05-03 帕西昂奥地利有限两合公司 单步生物催化酰胺化

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JPS5836387A (ja) 1981-08-24 1983-03-03 Seikagaku Kogyo Co Ltd プロリンイミノペプチダ−ゼおよびその製造法
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JPH0832717B2 (ja) 1987-10-07 1996-03-29 味の素株式会社 グルタミン誘導体の製造方法
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JPH0313391A (ja) 1989-06-13 1991-01-22 Canon Inc 感熱転写材
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JP2907479B2 (ja) 1990-02-28 1999-06-21 輝彦 別府 ニトリルヒドラターゼ活性を有するポリペプチドをコードする遺伝子ｄｎａ、これを含有する形質転換体及びアミド類の製造法
KR930002966B1 (ko) 1990-11-24 1993-04-16 주식회사 미 원 디펩티드의 제조방법
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JP2000078971A (ja) * 1998-09-04 2000-03-21 Kanegafuchi Chem Ind Co Ltd Ｄ−、ｌ−アミノ酸エステルよりオリゴペプチドを合成する新規酵素およびこれを生産する微生物
KR100878333B1 (ko) 1999-06-25 2009-01-14 백광산업 주식회사 항상성 및 적응과 관련된 단백질을 코딩하는코리네박테리움 글루타미쿰 유전자
JP4623825B2 (ja) * 1999-12-16 2011-02-02 協和発酵バイオ株式会社 新規ポリヌクレオチド
KR100635803B1 (ko) 2001-07-26 2006-10-19 아지노모토 가부시키가이샤 펩타이드 생성 효소 유전자, 펩타이드 생성 효소 및디펩타이드의 제조방법
US20050148048A1 (en) * 2003-11-27 2005-07-07 Kyowa Hakko Kogyo Co., Ltd. Process for producing dipeptides

Also Published As

Publication number Publication date
EP1411062A1 (de) 2004-04-21
EP1411116A1 (de) 2004-04-21
EP1911839B1 (de) 2011-10-26
CN1268742C (zh) 2006-08-09
RU2004105652A (ru) 2005-04-27
EP1411062A4 (de) 2006-09-13
US20070042459A1 (en) 2007-02-22
DK1911839T3 (da) 2011-12-05
US20050037453A1 (en) 2005-02-17
RU2280077C2 (ru) 2006-07-20
US20040137558A1 (en) 2004-07-15
JPWO2003010307A1 (ja) 2004-11-18
US20050054067A1 (en) 2005-03-10
KR100602808B1 (ko) 2006-07-20
CN1535279A (zh) 2004-10-06
CN1529712A (zh) 2004-09-15
EP1911839A1 (de) 2008-04-16
KR100635803B1 (ko) 2006-10-19
US7288388B2 (en) 2007-10-30
US7754466B2 (en) 2010-07-13
KR20040023686A (ko) 2004-03-18
EP1411060A4 (de) 2006-09-13
CN1558947A (zh) 2004-12-29
CN101982546A (zh) 2011-03-02
RU2003137001A (ru) 2005-05-27
JP4289151B2 (ja) 2009-07-01
RU2279440C2 (ru) 2006-07-10
RU2316596C2 (ru) 2008-02-10
JPWO2003010187A1 (ja) 2004-11-18
EP1411116A4 (de) 2005-08-24
CN100422207C (zh) 2008-10-01
JP4239819B2 (ja) 2009-03-18
US7618796B2 (en) 2009-11-17
KR20040026658A (ko) 2004-03-31
JPWO2003010189A1 (ja) 2004-11-18
WO2003010307A1 (en) 2003-02-06
DK1411116T3 (da) 2008-08-25
US7037673B2 (en) 2006-05-02
EP1411060A1 (de) 2004-04-21
WO2003010187A1 (fr) 2003-02-06
US20070048838A1 (en) 2007-03-01
DE60226243T2 (de) 2009-05-14
EP1411116B1 (de) 2008-04-23
WO2003010189A1 (en) 2003-02-06
RU2005138717A (ru) 2007-06-20
JP4273967B2 (ja) 2009-06-03

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